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Items: 45

1.

Molecular Profiling of Cohorts of Tumor Samples to Guide Clinical Development of Pembrolizumab as Monotherapy.

Ayers M, Nebozhyn M, Cristescu R, McClanahan TK, Perini R, Rubin E, Cheng JD, Kaufman DR, Loboda A.

Clin Cancer Res. 2018 Nov 15. doi: 10.1158/1078-0432.CCR-18-1316. [Epub ahead of print]

PMID:
30442684
2.

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy.

Cristescu R, Mogg R, Ayers M, Albright A, Murphy E, Yearley J, Sher X, Liu XQ, Lu H, Nebozhyn M, Zhang C, Lunceford JK, Joe A, Cheng J, Webber AL, Ibrahim N, Plimack ER, Ott PA, Seiwert TY, Ribas A, McClanahan TK, Tomassini JE, Loboda A, Kaufman D.

Science. 2018 Oct 12;362(6411). pii: eaar3593. doi: 10.1126/science.aar3593.

3.

LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis.

Bauché D, Joyce-Shaikh B, Jain R, Grein J, Ku KS, Blumenschein WM, Ganal-Vonarburg SC, Wilson DC, McClanahan TK, Malefyt RW, Macpherson AJ, Annamalai L, Yearley JH, Cua DJ.

Immunity. 2018 Aug 21;49(2):342-352.e5. doi: 10.1016/j.immuni.2018.07.007. Epub 2018 Aug 7.

PMID:
30097293
4.

Establishment of engineered cell-based assays mediating LAG3 and PD1 immune suppression enables potency measurement of blocking antibodies and assessment of signal transduction.

Bhagwat B, Cherwinski H, Sathe M, Seghezzi W, McClanahan TK, de Waal Malefyt R, Willingham A.

J Immunol Methods. 2018 May;456:7-14. doi: 10.1016/j.jim.2018.02.003. Epub 2018 Feb 8.

5.

Multiplexed quantification of proteins and transcripts in single cells.

Peterson VM, Zhang KX, Kumar N, Wong J, Li L, Wilson DC, Moore R, McClanahan TK, Sadekova S, Klappenbach JA.

Nat Biotechnol. 2017 Oct;35(10):936-939. doi: 10.1038/nbt.3973. Epub 2017 Aug 30.

PMID:
28854175
6.

IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade.

Ayers M, Lunceford J, Nebozhyn M, Murphy E, Loboda A, Kaufman DR, Albright A, Cheng JD, Kang SP, Shankaran V, Piha-Paul SA, Yearley J, Seiwert TY, Ribas A, McClanahan TK.

J Clin Invest. 2017 Aug 1;127(8):2930-2940. doi: 10.1172/JCI91190. Epub 2017 Jun 26.

7.

Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells.

Sukumar S, Wilson DC, Yu Y, Wong J, Naravula S, Ermakov G, Riener R, Bhagwat B, Necheva AS, Grein J, Churakova T, Mangadu R, Georgiev P, Manfra D, Pinheiro EM, Sriram V, Bailey WJ, Herzyk D, McClanahan TK, Willingham A, Beebe AM, Sadekova S.

Cancer Res. 2017 Aug 15;77(16):4378-4388. doi: 10.1158/0008-5472.CAN-16-1439. Epub 2017 Jun 13.

8.

T-cell infiltration and clonality correlate with programmed cell death protein 1 and programmed death-ligand 1 expression in patients with soft tissue sarcomas.

Pollack SM, He Q, Yearley JH, Emerson R, Vignali M, Zhang Y, Redman MW, Baker KK, Cooper S, Donahue B, Loggers ET, Cranmer LD, Spraker MB, Seo YD, Pillarisetty VG, Ricciotti RW, Hoch BL, McClanahan TK, Murphy E, Blumenschein WM, Townson SM, Benzeno S, Riddell SR, Jones RL.

Cancer. 2017 Sep 1;123(17):3291-3304. doi: 10.1002/cncr.30726. Epub 2017 May 2.

9.

Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells.

Jain R, Chen Y, Kanno Y, Joyce-Shaikh B, Vahedi G, Hirahara K, Blumenschein WM, Sukumar S, Haines CJ, Sadekova S, McClanahan TK, McGeachy MJ, O'Shea JJ, Cua DJ.

Immunity. 2016 Jan 19;44(1):131-142. doi: 10.1016/j.immuni.2015.11.009. Epub 2015 Dec 29.

10.

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability.

Lee JS, Tato CM, Joyce-Shaikh B, Gulen MF, Cayatte C, Chen Y, Blumenschein WM, Judo M, Ayanoglu G, McClanahan TK, Li X, Cua DJ.

Immunity. 2015 Oct 20;43(4):727-38. doi: 10.1016/j.immuni.2015.09.003. Epub 2015 Sep 29. Erratum in: Immunity. 2015 Nov 17;43(5):1022. Gulan, Fatih [corrected to Gulen, Muhammet F].

11.

Clinical improvement in psoriasis with specific targeting of interleukin-23.

Kopp T, Riedl E, Bangert C, Bowman EP, Greisenegger E, Horowitz A, Kittler H, Blumenschein WM, McClanahan TK, Marbury T, Zachariae C, Xu D, Hou XS, Mehta A, Zandvliet AS, Montgomery D, van Aarle F, Khalilieh S.

Nature. 2015 May 14;521(7551):222-6. doi: 10.1038/nature14175. Epub 2015 Mar 9.

PMID:
25754330
12.

Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells.

Chan IH, Jain R, Tessmer MS, Gorman D, Mangadu R, Sathe M, Vives F, Moon C, Penaflor E, Turner S, Ayanoglu G, Chang C, Basham B, Mumm JB, Pierce RH, Yearley JH, McClanahan TK, Phillips JH, Cua DJ, Bowman EP, Kastelein RA, LaFace D.

Mucosal Immunol. 2014 Jul;7(4):842-56. doi: 10.1038/mi.2013.101. Epub 2013 Nov 27.

PMID:
24280935
13.

Autoimmune memory T helper 17 cell function and expansion are dependent on interleukin-23.

Haines CJ, Chen Y, Blumenschein WM, Jain R, Chang C, Joyce-Shaikh B, Porth K, Boniface K, Mattson J, Basham B, Anderton SM, McClanahan TK, Sadekova S, Cua DJ, McGeachy MJ.

Cell Rep. 2013 May 30;3(5):1378-88. doi: 10.1016/j.celrep.2013.03.035. Epub 2013 Apr 25.

14.

Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease.

Cayatte C, Joyce-Shaikh B, Vega F, Boniface K, Grein J, Murphy E, Blumenschein WM, Chen S, Malinao MC, Basham B, Pierce RH, Bowman EP, McKenzie BS, Elson CO, Faubion WA, Malefyt Rde W, Kastelein RA, Cua D, McClanahan TK, Beaumont M.

Clin Transl Gastroenterol. 2012 Feb 16;3:e10. doi: 10.1038/ctg.2012.2.

15.

Biomarkers of disease and treatment in murine and cynomolgus models of chronic asthma.

Louten J, Mattson JD, Malinao MC, Li Y, Emson C, Vega F, Wardle RL, Van Scott MR, Fick RB, McClanahan TK, de Waal Malefyt R, Beaumont M.

Biomark Insights. 2012;7:87-104. doi: 10.4137/BMI.S9776. Epub 2012 Jul 10.

16.

IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells.

Sherlock JP, Joyce-Shaikh B, Turner SP, Chao CC, Sathe M, Grein J, Gorman DM, Bowman EP, McClanahan TK, Yearley JH, Eberl G, Buckley CD, Kastelein RA, Pierce RH, Laface DM, Cua DJ.

Nat Med. 2012 Jul 1;18(7):1069-76. doi: 10.1038/nm.2817.

PMID:
22772566
17.

The myeloid receptor PILRβ mediates the balance of inflammatory responses through regulation of IL-27 production.

Tato CM, Joyce-Shaikh B, Banerjee A, Chen Y, Sathe M, Ewald SE, Liu MR, Gorman D, McClanahan TK, Phillips JH, Heyworth PG, Cua DJ.

PLoS One. 2012;7(3):e31680. doi: 10.1371/journal.pone.0031680. Epub 2012 Mar 27.

18.

C17 prevents inflammatory arthritis and associated joint destruction in mice.

Chao C, Joyce-Shaikh B, Grein J, Moshrefi M, Raoufi F, Laface DM, McClanahan TK, Bourne PA, Pierce RH, Gorman DM, Pflanz S.

PLoS One. 2011;6(7):e22256. doi: 10.1371/journal.pone.0022256. Epub 2011 Jul 25.

19.

Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.

Louten J, Rankin AL, Li Y, Murphy EE, Beaumont M, Moon C, Bourne P, McClanahan TK, Pflanz S, de Waal Malefyt R.

Int Immunol. 2011 May;23(5):307-15. doi: 10.1093/intimm/dxr006. Epub 2011 Mar 21.

PMID:
21422152
20.

Cutting edge: A critical functional role for IL-23 in psoriasis.

Tonel G, Conrad C, Laggner U, Di Meglio P, Grys K, McClanahan TK, Blumenschein WM, Qin JZ, Xin H, Oldham E, Kastelein R, Nickoloff BJ, Nestle FO.

J Immunol. 2010 Nov 15;185(10):5688-91. doi: 10.4049/jimmunol.1001538. Epub 2010 Oct 18.

21.

Human Th17 cells comprise heterogeneous subsets including IFN-gamma-producing cells with distinct properties from the Th1 lineage.

Boniface K, Blumenschein WM, Brovont-Porth K, McGeachy MJ, Basham B, Desai B, Pierce R, McClanahan TK, Sadekova S, de Waal Malefyt R.

J Immunol. 2010 Jul 1;185(1):679-87. doi: 10.4049/jimmunol.1000366. Epub 2010 May 28.

22.

Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis.

Joyce-Shaikh B, Bigler ME, Chao CC, Murphy EE, Blumenschein WM, Adamopoulos IE, Heyworth PG, Antonenko S, Bowman EP, McClanahan TK, Phillips JH, Cua DJ.

J Exp Med. 2010 Mar 15;207(3):579-89. doi: 10.1084/jem.20090516. Epub 2010 Mar 8.

23.

Modulation of paired immunoglobulin-like type 2 receptor signaling alters the host response to Staphylococcus aureus-induced pneumonia.

Banerjee A, Stevenaert F, Pande K, Haghjoo E, Antonenko S, Gorman DM, Sathe M, McClanahan TK, Pierce R, Turner SP, Bigler ME, Phillips JH, Heyworth PG.

Infect Immun. 2010 Mar;78(3):1353-63. doi: 10.1128/IAI.00969-09. Epub 2010 Jan 11.

24.

IL-33 induces IL-13-dependent cutaneous fibrosis.

Rankin AL, Mumm JB, Murphy E, Turner S, Yu N, McClanahan TK, Bourne PA, Pierce RH, Kastelein R, Pflanz S.

J Immunol. 2010 Feb 1;184(3):1526-35. doi: 10.4049/jimmunol.0903306. Epub 2009 Dec 30.

25.

Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis.

Hillyer P, Larché MJ, Bowman EP, McClanahan TK, de Waal Malefyt R, Schewitz LP, Giddins G, Feldmann M, Kastelein RA, Brennan FM.

Rheumatology (Oxford). 2009 Dec;48(12):1581-9. doi: 10.1093/rheumatology/kep293. Epub 2009 Oct 8.

26.

IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells.

Diveu C, McGeachy MJ, Boniface K, Stumhofer JS, Sathe M, Joyce-Shaikh B, Chen Y, Tato CM, McClanahan TK, de Waal Malefyt R, Hunter CA, Cua DJ, Kastelein RA.

J Immunol. 2009 May 1;182(9):5748-56. doi: 10.4049/jimmunol.0801162.

27.

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.

Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R.

J Exp Med. 2009 Mar 16;206(3):535-48. doi: 10.1084/jem.20082293. Epub 2009 Mar 9.

28.

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo.

McGeachy MJ, Chen Y, Tato CM, Laurence A, Joyce-Shaikh B, Blumenschein WM, McClanahan TK, O'Shea JJ, Cua DJ.

Nat Immunol. 2009 Mar;10(3):314-24. doi: 10.1038/ni.1698. Epub 2009 Feb 1.

29.

Cancer-induced expansion and activation of CD11b+ Gr-1+ cells predispose mice to adenoviral-triggered anaphylactoid-type reactions.

Pande K, Ueda R, Machemer T, Sathe M, Tsai V, Brin E, Delano MJ, Van Rooijen N, McClanahan TK, Talmadge JE, Moldawer LL, Phillips JH, LaFace DM.

Mol Ther. 2009 Mar;17(3):508-15. doi: 10.1038/mt.2008.280. Epub 2009 Jan 6.

30.

Enhanced acute responses in an experimental exposure model to biomass smoke inhalation in chronic obstructive pulmonary disease.

Mattson JD, Haus BM, Desai B, Ott W, Basham B, Agrawal M, Ding W, Hildemann LM, Abitorabi KM, Canfield J, Mak G, Guvenc-Tuncturk S, Malefyt Rde W, McClanahan TK, Fick RB Jr, Kuschner WG.

Exp Lung Res. 2008 Dec;34(10):631-62. doi: 10.1080/01902140802322256.

PMID:
19085563
31.

Development, cytokine profile and function of human interleukin 17-producing helper T cells.

Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, Basham B, Smith K, Chen T, Morel F, Lecron JC, Kastelein RA, Cua DJ, McClanahan TK, Bowman EP, de Waal Malefyt R.

Nat Immunol. 2007 Sep;8(9):950-7. Epub 2007 Aug 5.

PMID:
17676044
32.

Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice.

Elson CO, Cong Y, Weaver CT, Schoeb TR, McClanahan TK, Fick RB, Kastelein RA.

Gastroenterology. 2007 Jun;132(7):2359-70. Epub 2007 Apr 13.

PMID:
17570211
33.

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis.

Chan JR, Blumenschein W, Murphy E, Diveu C, Wiekowski M, Abbondanzo S, Lucian L, Geissler R, Brodie S, Kimball AB, Gorman DM, Smith K, de Waal Malefyt R, Kastelein RA, McClanahan TK, Bowman EP.

J Exp Med. 2006 Nov 27;203(12):2577-87. Epub 2006 Oct 30.

34.

Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection.

Chackerian AA, Chen SJ, Brodie SJ, Mattson JD, McClanahan TK, Kastelein RA, Bowman EP.

Infect Immun. 2006 Nov;74(11):6092-9. Epub 2006 Aug 21.

35.

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.

Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA.

Immunity. 2005 Nov;23(5):479-90.

36.

Microarray analysis of primary endothelial cells challenged with different inflammatory and immune cytokines.

Sana TR, Janatpour MJ, Sathe M, McEvoy LM, McClanahan TK.

Cytokine. 2005 Mar 21;29(6):256-69.

PMID:
15749026
37.

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27.

Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA.

J Immunol. 2004 Feb 15;172(4):2225-31.

38.

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.

Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA.

Immunity. 2002 Jun;16(6):779-90.

39.

The use of direct cDNA selection to rapidly and effectively identify genes in the fungus Aspergillus fumigatus.

Kessler MM, Willins DA, Zeng Q, Del Mastro RG, Cook R, Doucette-Stamm L, Lee H, Caron A, McClanahan TK, Wang L, Greene J, Hare RS, Cottarel G, Shimer GH Jr.

Fungal Genet Biol. 2002 Jun;36(1):59-70.

PMID:
12051895
40.

CCL18/DC-CK-1/PARC up-regulation in hypersensitivity pneumonitis.

Pardo A, Smith KM, Abrams J, Coffman R, Bustos M, McClanahan TK, Grein J, Murphy EE, Zlotnik A, Selman M.

J Leukoc Biol. 2001 Oct;70(4):610-6.

PMID:
11590198
41.

Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC).

Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, Müller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, Ruzicka T, Lehmann P, Oldham E, Zlotnik A.

J Immunol. 2000 Apr 1;164(7):3465-70.

42.

HNMP-1: a novel hematopoietic and neural membrane protein differentially regulated in neural development and injury.

Bolin LM, McNeil T, Lucian LA, DeVaux B, Franz-Bacon K, Gorman DM, Zurawski S, Murray R, McClanahan TK.

J Neurosci. 1997 Jul 15;17(14):5493-502.

43.

Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta.

Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A.

J Immunol. 1997 Feb 1;158(3):1033-6. Erratum in: J Immunol 1999 Jul 15;163(2):1091.

PMID:
9013939
44.

Structure and functional analysis of the multistress response gene DDR2 from Saccharomyces cerevisiae.

Kobayashi N, McClanahan TK, Simon JR, Treger JM, McEntee K.

Biochem Biophys Res Commun. 1996 Dec 13;229(2):540-7.

PMID:
8954934
45.

E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex.

Williams GT, McClanahan TK, Morimoto RI.

Mol Cell Biol. 1989 Jun;9(6):2574-87.

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