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Bacterial Energetic Requirements for Helicobacter pylori Cag Type IV Secretion System-Dependent Alterations in Gastric Epithelial Cells.

Lin AS, Dooyema SDR, Frick-Cheng AE, Harvey ML, Suarez G, Loh JT, McDonald WH, McClain MS, Peek RM Jr, Cover TL.

Infect Immun. 2020 Jan 22;88(2). pii: e00790-19. doi: 10.1128/IAI.00790-19. Print 2020 Jan 22.


Effect of environmental salt concentration on the Helicobacter pylori exoproteome.

Caston RR, Loh JT, Voss BJ, McDonald WH, Scholz MB, McClain MS, Cover TL.

J Proteomics. 2019 Jun 30;202:103374. doi: 10.1016/j.jprot.2019.05.002. Epub 2019 May 4.


Role of a Stem-Loop Structure in Helicobacter pylori cagA Transcript Stability.

Loh JT, Lin AS, Beckett AC, McClain MS, Cover TL.

Infect Immun. 2019 Jan 24;87(2). pii: e00692-18. doi: 10.1128/IAI.00692-18. Print 2019 Feb.


Genetic signatures for Helicobacter pylori strains of West African origin.

Bullock KK, Shaffer CL, Brooks AW, Secka O, Forsyth MH, McClain MS, Cover TL.

PLoS One. 2017 Nov 29;12(11):e0188804. doi: 10.1371/journal.pone.0188804. eCollection 2017.


Helicobacter pylori Vacuolating Toxin and Gastric Cancer.

McClain MS, Beckett AC, Cover TL.

Toxins (Basel). 2017 Oct 12;9(10). pii: E316. doi: 10.3390/toxins9100316. Review.


Magnetic Extraction of Acinetobacter baumannii Using Colistin-Functionalized γ-Fe2O3/Au Core/Shell Composite Nanoclusters.

Bell CS, Mejías R, Miller SE, Greer JM, McClain MS, Cover TL, Giorgio TD.

ACS Appl Mater Interfaces. 2017 Aug 16;9(32):26719-26730. doi: 10.1021/acsami.7b07304. Epub 2017 Aug 4.


Dynamic Computational Model of Symptomatic Bacteremia to Inform Bacterial Separation Treatment Requirements.

Miller SE, Bell CS, McClain MS, Cover TL, Giorgio TD.

PLoS One. 2016 Sep 22;11(9):e0163167. doi: 10.1371/journal.pone.0163167. eCollection 2016.


Colistin-Functionalized Nanoparticles for the Rapid Capture of Acinetobacter baumannii.

Miller SE, Bell CS, Mejias R, McClain MS, Cover TL, Giorgio TD.

J Biomed Nanotechnol. 2016 Sep;12(9):1806-19.


A Nonoligomerizing Mutant Form of Helicobacter pylori VacA Allows Structural Analysis of the p33 Domain.

González-Rivera C, Campbell AM, Rutherford SA, Pyburn TM, Foegeding NJ, Barke TL, Spiller BW, McClain MS, Ohi MD, Lacy DB, Cover TL.

Infect Immun. 2016 Aug 19;84(9):2662-70. doi: 10.1128/IAI.00254-16. Print 2016 Sep.


An Overview of Helicobacter pylori VacA Toxin Biology.

Foegeding NJ, Caston RR, McClain MS, Ohi MD, Cover TL.

Toxins (Basel). 2016 Jun 3;8(6). pii: E173. doi: 10.3390/toxins8060173. Review.


The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin.

Rumah KR, Ma Y, Linden JR, Oo ML, Anrather J, Schaeren-Wiemers N, Alonso MA, Fischetti VA, McClain MS, Vartanian T.

PLoS Pathog. 2015 May 20;11(5):e1004896. doi: 10.1371/journal.ppat.1004896. eCollection 2015 May.


Role of connexin 43 in Helicobacter pylori VacA-induced cell death.

Radin JN, González-Rivera C, Frick-Cheng AE, Sheng J, Gaddy JA, Rubin DH, Algood HM, McClain MS, Cover TL.

Infect Immun. 2014 Jan;82(1):423-32. doi: 10.1128/IAI.00827-13. Epub 2013 Nov 4.


Control of gene expression in Helicobacter pylori using the Tet repressor.

McClain MS, Duncan SS, Gaddy JA, Cover TL.

J Microbiol Methods. 2013 Dec;95(3):336-41. doi: 10.1016/j.mimet.2013.09.019. Epub 2013 Oct 8.


Genome Sequences of Three hpAfrica2 Strains of Helicobacter pylori.

Duncan SS, Bertoli MT, Kersulyte D, Valk PL, Tamma S, Segal I, McClain MS, Cover TL, Berg DE.

Genome Announc. 2013 Sep 26;1(5). pii: e00729-13. doi: 10.1128/genomeA.00729-13.


Comparative genomic analysis of East Asian and non-Asian Helicobacter pylori strains identifies rapidly evolving genes.

Duncan SS, Valk PL, McClain MS, Shaffer CL, Metcalf JA, Bordenstein SR, Cover TL.

PLoS One. 2013;8(1):e55120. doi: 10.1371/journal.pone.0055120. Epub 2013 Jan 31.


Oligomerization of Clostridium perfringens epsilon toxin is dependent upon caveolins 1 and 2.

Fennessey CM, Sheng J, Rubin DH, McClain MS.

PLoS One. 2012;7(10):e46866. doi: 10.1371/journal.pone.0046866. Epub 2012 Oct 2.


Identification of amino acids important for binding of Clostridium perfringens epsilon toxin to host cells and to HAVCR1.

Ivie SE, McClain MS.

Biochemistry. 2012 Sep 25;51(38):7588-95. doi: 10.1021/bi300690a. Epub 2012 Sep 12.


Coenzyme depletion by members of the aerolysin family of pore-forming toxins leads to diminished ATP levels and cell death.

Fennessey CM, Ivie SE, McClain MS.

Mol Biosyst. 2012 Aug;8(8):2097-105. doi: 10.1039/c2mb25142f. Epub 2012 Jun 11.


The intermediate region of Helicobacter pylori VacA is a determinant of toxin potency in a Jurkat T cell assay.

González-Rivera C, Algood HM, Radin JN, McClain MS, Cover TL.

Infect Immun. 2012 Aug;80(8):2578-88. doi: 10.1128/IAI.00052-12. Epub 2012 May 14.


Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface.

Shaffer CL, Gaddy JA, Loh JT, Johnson EM, Hill S, Hennig EE, McClain MS, McDonald WH, Cover TL.

PLoS Pathog. 2011 Sep;7(9):e1002237. doi: 10.1371/journal.ppat.1002237. Epub 2011 Sep 1.


Analysis of cagA in Helicobacter pylori strains from Colombian populations with contrasting gastric cancer risk reveals a biomarker for disease severity.

Loh JT, Shaffer CL, Piazuelo MB, Bravo LE, McClain MS, Correa P, Cover TL.

Cancer Epidemiol Biomarkers Prev. 2011 Oct;20(10):2237-49. doi: 10.1158/1055-9965.EPI-11-0548. Epub 2011 Aug 22.


Helicobacter pylori VacA induces programmed necrosis in gastric epithelial cells.

Radin JN, González-Rivera C, Ivie SE, McClain MS, Cover TL.

Infect Immun. 2011 Jul;79(7):2535-43. doi: 10.1128/IAI.01370-10. Epub 2011 Apr 11.


Gene-trap mutagenesis identifies mammalian genes contributing to intoxication by Clostridium perfringens ε-toxin.

Ivie SE, Fennessey CM, Sheng J, Rubin DH, McClain MS.

PLoS One. 2011 Mar 11;6(3):e17787. doi: 10.1371/journal.pone.0017787.


Reconstitution of Helicobacter pylori VacA toxin from purified components.

González-Rivera C, Gangwer KA, McClain MS, Eli IM, Chambers MG, Ohi MD, Lacy DB, Cover TL.

Biochemistry. 2010 Jul 13;49(27):5743-52. doi: 10.1021/bi100618g.


Analysis of a beta-helical region in the p55 domain of Helicobacter pylori vacuolating toxin.

Ivie SE, McClain MS, Algood HM, Lacy DB, Cover TL.

BMC Microbiol. 2010 Feb 23;10:60. doi: 10.1186/1471-2180-10-60.


Dominant-negative inhibitors of the Clostridium perfringens epsilon-toxin.

Pelish TM, McClain MS.

J Biol Chem. 2009 Oct 23;284(43):29446-53. doi: 10.1074/jbc.M109.021782. Epub 2009 Aug 31.


Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer.

McClain MS, Shaffer CL, Israel DA, Peek RM Jr, Cover TL.

BMC Genomics. 2009 Jan 5;10:3. doi: 10.1186/1471-2164-10-3.


Helicobacter pylori HopQ outer membrane protein attenuates bacterial adherence to gastric epithelial cells.

Loh JT, Torres VJ, Algood HM, McClain MS, Cover TL.

FEMS Microbiol Lett. 2008 Dec;289(1):53-8.


Helicobacter pylori VacA subdomain required for intracellular toxin activity and assembly of functional oligomeric complexes.

Ivie SE, McClain MS, Torres VJ, Algood HM, Lacy DB, Yang R, Blanke SR, Cover TL.

Infect Immun. 2008 Jul;76(7):2843-51. doi: 10.1128/IAI.01664-07. Epub 2008 Apr 28.


Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain.

Gangwer KA, Mushrush DJ, Stauff DL, Spiller B, McClain MS, Cover TL, Lacy DB.

Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16293-8. Epub 2007 Oct 2.


Functional analysis of neutralizing antibodies against Clostridium perfringens epsilon-toxin.

McClain MS, Cover TL.

Infect Immun. 2007 Apr;75(4):1785-93. Epub 2007 Jan 29.


Random mutagenesis of Helicobacter pylori vacA to identify amino acids essential for vacuolating cytotoxic activity.

McClain MS, Czajkowsky DM, Torres VJ, Szabo G, Shao Z, Cover TL.

Infect Immun. 2006 Nov;74(11):6188-95. Epub 2006 Sep 5.


Protein-protein interactions among Helicobacter pylori cag proteins.

Busler VJ, Torres VJ, McClain MS, Tirado O, Friedman DB, Cover TL.

J Bacteriol. 2006 Jul;188(13):4787-800.


Functional properties of the p33 and p55 domains of the Helicobacter pylori vacuolating cytotoxin.

Torres VJ, Ivie SE, McClain MS, Cover TL.

J Biol Chem. 2005 Jun 3;280(22):21107-14. Epub 2005 Apr 6.


Interactions between p-33 and p-55 domains of the Helicobacter pylori vacuolating cytotoxin (VacA).

Torres VJ, McClain MS, Cover TL.

J Biol Chem. 2004 Jan 16;279(3):2324-31. Epub 2003 Oct 30.


Expression of Helicobacter pylori vacuolating toxin in Escherichia coli.

McClain MS, Cover TL.

Infect Immun. 2003 Apr;71(4):2266-71.


Essential role of a GXXXG motif for membrane channel formation by Helicobacter pylori vacuolating toxin.

McClain MS, Iwamoto H, Cao P, Vinion-Dubiel AD, Li Y, Szabo G, Shao Z, Cover TL.

J Biol Chem. 2003 Apr 4;278(14):12101-8. Epub 2003 Jan 30.


Association of Helicobacter pylori vacuolating toxin (VacA) with lipid rafts.

Schraw W, Li Y, McClain MS, van der Goot FG, Cover TL.

J Biol Chem. 2002 Sep 13;277(37):34642-50. Epub 2002 Jul 16.


Antigenic diversity among Helicobacter pylori vacuolating toxins.

Vinion-Dubiel AD, McClain MS, Cao P, Mernaugh RL, Cover TL.

Infect Immun. 2001 Jul;69(7):4329-36.


Acid activation of Helicobacter pylori vacuolating cytotoxin (VacA) results in toxin internalization by eukaryotic cells.

McClain MS, Schraw W, Ricci V, Boquet P, Cover TL.

Mol Microbiol. 2000 Jul;37(2):433-42.


A dominant negative mutant of Helicobacter pylori vacuolating toxin (VacA) inhibits VacA-induced cell vacuolation.

Vinion-Dubiel AD, McClain MS, Czajkowsky DM, Iwamoto H, Ye D, Cao P, Schraw W, Szabo G, Blanke SR, Shao Z, Cover TL.

J Biol Chem. 1999 Dec 31;274(53):37736-42.


Kinetics and mechanisms of extracellular protein release by Helicobacter pylori.

Schraw W, McClain MS, Cover TL.

Infect Immun. 1999 Oct;67(10):5247-52.


Extracellular release of antigenic proteins by Helicobacter pylori.

Cao P, McClain MS, Forsyth MH, Cover TL.

Infect Immun. 1998 Jun;66(6):2984-6.


Humoral immunity and regulation of intrapulmonary growth of Legionella pneumophila in the immunocompetent host.

Brieland JK, Heath LA, Huffnagle GB, Remick DG, McClain MS, Hurley MC, Kunkel RK, Fantone JC, Engleberg C.

J Immunol. 1996 Dec 1;157(11):5002-8.


Construction of an alkaline phosphatase fusion-generating transposon, mTn10phoA.

McClain MS, Engleberg NC.

Gene. 1996 Apr 17;170(1):147-8.


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