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Items: 1 to 50 of 102

1.

Chemosensitizing Effect of Cernumidine Extracted from Solanum cernuum on Bladder Cancer Cells in Vitro.

Miranda MA, Mondal A, Sachdeva M, Cabral H, Neto YAAH, Khan I, Groppo M, McChesney JD, Bastos JK.

Chem Biodivers. 2019 Oct;16(10):e1900334. doi: 10.1002/cbdv.201900334. Epub 2019 Sep 12.

PMID:
31448497
2.

Formation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes.

Fasinu PS, Nanayakkara NPD, Wang YH, Chaurasiya ND, Herath HMB, McChesney JD, Avula B, Khan I, Tekwani BL, Walker LA.

Malar J. 2019 Jan 30;18(1):30. doi: 10.1186/s12936-019-2658-5.

3.

Tetra-glucopyranosyl Diterpene ent-Kaur-16-en-19-oic Acid and ent-13(S)-Hydroxyatisenoic Acid Derivatives from a Commercial Extract of Stevia rebaudiana (Bertoni) Bertoni.

Perera WH, Ghiviriga I, Rodenburg DL, Alves K, Wiggers FT, Hufford CD, Fronczek FR, Ibrahim MA, Muhammad I, Avula B, Khan IA, McChesney JD.

Molecules. 2018 Dec 15;23(12). pii: E3328. doi: 10.3390/molecules23123328.

4.

Metabolism of primaquine in normal human volunteers: investigation of phase I and phase II metabolites from plasma and urine using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry.

Avula B, Tekwani BL, Chaurasiya ND, Fasinu P, Dhammika Nanayakkara NP, Bhandara Herath HMT, Wang YH, Bae JY, Khan SI, Elsohly MA, McChesney JD, Zimmerman PA, Khan IA, Walker LA.

Malar J. 2018 Aug 13;17(1):294. doi: 10.1186/s12936-018-2433-z.

5.

A silica gel orthogonal high-performance liquid chromatography method for the analyses of steviol glycosides: novel tetra-glucopyranosyl steviol.

Perera WH, Ramsaroop T, Carvalho R, Rodenburg DL, McChesney JD.

Nat Prod Res. 2019 Jul;33(13):1876-1884. doi: 10.1080/14786419.2018.1478826. Epub 2018 Jun 11.

PMID:
29889557
6.
7.

Rebaudiosides T and U, minor C-19 xylopyranosyl and arabinopyranosyl steviol glycoside derivatives from Stevia rebaudiana (Bertoni) Bertoni.

Perera WH, Ghiviriga I, Rodenburg DL, Alves K, Bowling JJ, Avula B, Khan IA, McChesney JD.

Phytochemistry. 2017 Mar;135:106-114. doi: 10.1016/j.phytochem.2016.12.001. Epub 2016 Dec 12.

PMID:
27979591
8.

Assignment of sugar arrangement in branched steviol glycosides using electrospray ionization quadrupole time-of-flight tandem mass spectrometry.

Perera WH, Avula B, Khan IA, McChesney JD.

Rapid Commun Mass Spectrom. 2017 Feb 15;31(3):315-324. doi: 10.1002/rcm.7784.

PMID:
27862504
9.

Antibacterial Activities of Metabolites from Platanus occidentalis (American sycamore) against Fish Pathogenic Bacteria.

Schrader KK, Hamann MT, McChesney JD, Rodenburg DL, Ibrahim MA.

J Aquac Res Dev. 2015 Oct;6(10). pii: 364. Epub 2015 Oct 15.

10.

Correction to Rebaudiosides R and S, Minor Diterpene Glycosides from the Leaves of Stevia rebaudiana.

Ibrahim MA, Rodenburg DL, Alves K, Perera WH, Fronczek FR, Bowling J, McChesney JD.

J Nat Prod. 2016 Aug 26;79(8):2148. doi: 10.1021/acs.jnatprod.6b00615. Epub 2016 Jul 18. No abstract available.

PMID:
27428112
11.

Rebaudiosides R and S, Minor Diterpene Glycosides from the Leaves of Stevia rebaudiana.

Ibrahim MA, Rodenburg DL, Alves K, Perera WH, Fronczek FR, Bowling J, McChesney JD.

J Nat Prod. 2016 May 27;79(5):1468-72. doi: 10.1021/acs.jnatprod.6b00048. Epub 2016 Apr 27. Erratum in: J Nat Prod. 2016 Aug 26;79(8):2148.

PMID:
27119206
12.

Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes.

Fasinu PS, Avula B, Tekwani BL, Nanayakkara NP, Wang YH, Bandara Herath HM, McChesney JD, Reichard GA, Marcsisin SR, Elsohly MA, Khan SI, Khan IA, Walker LA.

Malar J. 2016 Apr 19;15:224. doi: 10.1186/s12936-016-1270-1.

13.

A New Antileishmanial Preparation of Combined Solamargine and Solasonine Heals Cutaneous Leishmaniasis through Different Immunochemical Pathways.

Lezama-Dávila CM, McChesney JD, Bastos JK, Miranda MA, Tiossi RF, da Costa Jde C, Bentley MV, Gaitan-Puch SE, Isaac-Márquez AP.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2732-8. doi: 10.1128/AAC.02804-15. Print 2016 May.

14.

HPLC Plasma Assay of a Novel Anti-MRSA Compound, Kaempferol-3-O-Alpha-L-(2",3"-di-p-coumaroyl)rhamnoside, from Sycamore Leaves.

Zhang Y, Valeriote F, Swartz K, Chen B, Hamann MT, Rodenburg DL, McChesney JD, Shaw J.

Nat Prod Commun. 2015 Aug;10(8):1383-6.

15.

Enantioselective pharmacokinetics of primaquine in healthy human volunteers.

Tekwani BL, Avula B, Sahu R, Chaurasiya ND, Khan SI, Jain S, Fasinu PS, Herath HM, Stanford D, Nanayakkara NP, McChesney JD, Yates TW, ElSohly MA, Khan IA, Walker LA.

Drug Metab Dispos. 2015 Apr;43(4):571-7. doi: 10.1124/dmd.114.061127. Epub 2015 Jan 30.

PMID:
25637634
16.

Enantioselective metabolism of primaquine by human CYP2D6.

Fasinu PS, Tekwani BL, Nanayakkara NP, Avula B, Herath HM, Wang YH, Adelli VR, Elsohly MA, Khan SI, Khan IA, Pybus BS, Marcsisin SR, Reichard GA, McChesney JD, Walker LA.

Malar J. 2014 Dec 17;13:507. doi: 10.1186/1475-2875-13-507.

17.

Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers.

Nanayakkara NP, Tekwani BL, Herath HM, Sahu R, Gettayacamin M, Tungtaeng A, van Gessel Y, Baresel P, Wickham KS, Bartlett MS, Fronczek FR, Melendez V, Ohrt C, Reichard GA, McChesney JD, Rochford R, Walker LA.

Antimicrob Agents Chemother. 2014 Aug;58(8):4737-44. doi: 10.1128/AAC.02674-13. Epub 2014 Jun 9.

18.

Minor diterpene glycosides from the leaves of Stevia rebaudiana.

Ibrahim MA, Rodenburg DL, Alves K, Fronczek FR, McChesney JD, Wu C, Nettles BJ, Venkataraman SK, Jaksch F.

J Nat Prod. 2014 May 23;77(5):1231-5. doi: 10.1021/np4009656. Epub 2014 Apr 23.

PMID:
24758242
19.

In vitro and in vivo evaluation of the delivery of topical formulations containing glycoalkaloids of Solanum lycocarpum fruits.

Tiossi RF, Da Costa JC, Miranda MA, Praça FS, McChesney JD, Bentley MV, Bastos JK.

Eur J Pharm Biopharm. 2014 Sep;88(1):28-33. doi: 10.1016/j.ejpb.2014.01.010. Epub 2014 Feb 6.

PMID:
24509413
20.

Preparative chromatography and natural products discovery.

McChesney JD, Rodenburg DL.

Curr Opin Biotechnol. 2014 Feb;25:111-3. doi: 10.1016/j.copbio.2013.11.002. Epub 2013 Nov 26. Review.

PMID:
24484888
21.

Synthesis of [13C6]primaquine.

Herath HM, McChesney JD, Walker LA, Nanayakkara NP.

J Labelled Comp Radiopharm. 2013 Jun 15;56(7):341-3. doi: 10.1002/jlcr.3039. Epub 2013 Mar 12.

PMID:
24285435
22.

In vitro leishmanicidal and cytotoxic activities of the glycoalkaloids from Solanum lycocarpum (Solanaceae) fruits.

Abreu Miranda M, Tiossi RF, da Silva MR, Rodrigues KC, Kuehn CC, Rodrigues Oliveira LG, Albuquerque S, McChesney JD, Lezama-Davila CM, Isaac-Marquez AP, Kenupp Bastos J.

Chem Biodivers. 2013 Apr;10(4):642-8. doi: 10.1002/cbdv.201200063.

PMID:
23576350
23.

Stevioside methanol tetra-solvate.

Wu Y, Rodenburg DL, Ibrahim MA, McChesney JD, Avery MA.

Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 1;69(Pt 3):o410-1. doi: 10.1107/S1600536813003954. Epub 2013 Feb 20.

24.

Profiling primaquine metabolites in primary human hepatocytes using UHPLC-QTOF-MS with 13C stable isotope labeling.

Avula B, Tekwani BL, Chaurasiya ND, Nanayakkara NP, Wang YH, Khan SI, Adelli VR, Sahu R, Elsohly MA, McChesney JD, Khan IA, Walker LA.

J Mass Spectrom. 2013 Feb;48(2):276-85. doi: 10.1002/jms.3122.

PMID:
23378100
25.

Immunomodulatory effect of the alkaloidic extract of Solanum lycocarpum fruits in mice infected with Schistosoma mansoni.

Miranda MA, Kuehn CC, Cardoso JF, Oliveira LG, Magalhães LG, Tiossi RF, Rodrigues V, Zucolloto S, Prado JC Jr, McChesney JD, Bastos JK.

Exp Parasitol. 2013 Apr;133(4):396-402. doi: 10.1016/j.exppara.2012.12.012. Epub 2013 Jan 5.

26.

A Validated Reverse Phase HPLC Analytical Method for Quantitation of Glycoalkaloids in Solanum lycocarpum and Its Extracts.

Tiossi RF, Miranda MA, de Sousa JP, Praça FS, Bentley MV, McChesney JD, Bastos JK.

J Anal Methods Chem. 2012;2012:947836. doi: 10.1155/2012/947836. Epub 2012 Mar 27.

27.

Evaluation of the schistosomicidal activity of the steroidal alkaloids from Solanum lycocarpum fruits.

Miranda MA, Magalhães LG, Tiossi RF, Kuehn CC, Oliveira LG, Rodrigues V, McChesney JD, Bastos JK.

Parasitol Res. 2012 Jul;111(1):257-62. doi: 10.1007/s00436-012-2827-8. Epub 2012 Jan 27.

PMID:
22281548
28.

Analysis of primaquine and its metabolite carboxyprimaquine in biological samples: enantiomeric separation, method validation and quantification.

Avula B, Khan SI, Tekwani BL, Nanayakkara NP, McChesney JD, Walker LA, Khan IA.

Biomed Chromatogr. 2011 Sep;25(9):1010-7. doi: 10.1002/bmc.1557. Epub 2010 Nov 5.

PMID:
21058417
29.

Leishmanicidal activity of racemic +/- 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline.

Isaac-Márquez AP, McChesney JD, Nanayakara NP, Satoskar AR, Lezama-Dávila CM.

Nat Prod Commun. 2010 Mar;5(3):387-90.

PMID:
20420313
30.

Detection of Actaea racemosa adulteration by thin-layer chromatography and combined thin-layer chromatography-bioluminescence.

Verbitski SM, Gourdin GT, Ikenouye LM, McChesney JD, Hildreth J.

J AOAC Int. 2008 Mar-Apr;91(2):268-75.

31.

Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate.

Nanayakkara NP, Ager AL Jr, Bartlett MS, Yardley V, Croft SL, Khan IA, McChesney JD, Walker LA.

Antimicrob Agents Chemother. 2008 Jun;52(6):2130-7. doi: 10.1128/AAC.00645-07. Epub 2008 Mar 31.

32.

Plant natural products: back to the future or into extinction?

McChesney JD, Venkataraman SK, Henri JT.

Phytochemistry. 2007 Jul;68(14):2015-22. Epub 2007 Jun 14.

PMID:
17574638
33.

In vitro propagation of Podophyllum peltatum.

Moraes-Cerdeira RM, Burandt CL Jr, Bastos JK, Nanayakkara NP, McChesney JD.

Planta Med. 1998 Feb;64(1):42-5.

PMID:
17253216
34.

Multiple myeloma regression mediated by bruceantin.

Cuendet M, Christov K, Lantvit DD, Deng Y, Hedayat S, Helson L, McChesney JD, Pezzuto JM.

Clin Cancer Res. 2004 Feb 1;10(3):1170-9.

35.

Measurement of paclitaxel in biological matrices: high-throughput liquid chromatographic-tandem mass spectrometric quantification of paclitaxel and metabolites in human and dog plasma.

Alexander MS, Kiser MM, Culley T, Kern JR, Dolan JW, McChesney JD, Zygmunt J, Bannister SJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Mar 5;785(2):253-61.

PMID:
12554138
36.

Natural products in drug discovery--organizing for success.

McChesney JD.

P R Health Sci J. 2002 Jun;21(2):91-5. No abstract available.

PMID:
12166030
37.
38.

Transformation of jervine by Cunninghamella elegans ATCC 9245.

El Sayed KA, Halim AF, Zaghloul AM, Dunbar DC, McChesney JD.

Phytochemistry. 2000 Sep;55(1):19-22.

PMID:
11021639
39.

Synthesis and biological activity of new potential antimalarial: 1H-pyrazolo[3,4-b]pyridine derivatives.

Dias LR, Freitas AC, Barreiro EJ, Goins DK, Nanayakkara D, McChesney JD.

Boll Chim Farm. 2000 Jan-Feb;139(1):14-20. Erratum in: Boll Chim Farm 2000 Sep-Oct;139(5):preceding 199. Dias RS [corrected to Dias LR].

PMID:
10829547
40.

Modified 8-aminoquinolines cure mouse Pneumocystis carinii infection.

Shaw MM, McChesney JD, Nanayakkara D, Dias LR, Lee CH, Durant PJ, Ball MD, Smith JW, Bartlett MS.

J Eukaryot Microbiol. 1997 Nov-Dec;44(6):40S. No abstract available.

PMID:
9508428
41.

Evaluation of four Narcissus cultivars as potential sources for galanthamine production.

Moraes-Cerdeira RM, Burandt CL Jr, Bastos JK, Nanayakkara D, Mikell J, Thurn J, McChesney JD.

Planta Med. 1997 Oct;63(5):472-4.

PMID:
9342954
42.

Antifungal activity of a new triterpenoid glycoside from Pithecellobium racemosum (M.).

Khan IA, Clark AM, McChesney JD.

Pharm Res. 1997 Mar;14(3):358-61.

PMID:
9098881
43.

Alkaloid content of different bulb parts of Narcissus cv. Ice Follies.

Moraes-Cerdeira RM, Bastos JK, Burandt CL Jr, Nanayakkara NP, Mikell J, McChesney JD.

Planta Med. 1997 Feb;63(1):92-3.

PMID:
17252336
44.

Effect of drying conditions on the taxane content of the needles of ornamental Taxus.

el Sohly HN, Croom EM Jr, el Kashoury EA, Joshi AS, Kopycki WJ, McChesney JD.

Planta Med. 1997 Feb;63(1):83-5.

PMID:
9063101
45.
46.

A new quassinoid from Castela texana.

Dou J, McChesney JD, Sindelar RD, Goins DK, Walker LA.

J Nat Prod. 1996 Jan;59(1):73-6.

PMID:
8984156
47.

Microbial and mammalian metabolism studies on the semisynthetic antimalarial, deoxoartemisinin.

Khalifa SI, Baker JK, Jung M, McChesney JD, Hufford CD.

Pharm Res. 1995 Oct;12(10):1493-8.

PMID:
8584488
48.

Time course and inhibition of stavaroside K, veratramine and cevine-induced hemolysis by other pregnane glycosides and Veratrum alkaloids.

Badria FA, McChesney JD, Halim AF, Zaghloul AM, el Sayed KA.

Pharmazie. 1995 Jun;50(6):421-3.

PMID:
7651981
49.

Effect of drying Taxus needles on their taxol content: the impact of drying intact clippings.

elSohly HN, el-Kashoury, Croom EM Jr, elSohly MA, Cochran KD, McChesney JD.

Planta Med. 1995 Jun;61(3):290-1.

PMID:
7617777
50.

Pregnane glycosides from Stapelia variegata.

el Sayed KA, Halim AF, Zaghloul AM, McChesney JD, Stone MP, Voehler M, Hayashi K.

Phytochemistry. 1995 May;39(2):395-403.

PMID:
7495533

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