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Items: 1 to 50 of 159

1.

Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice.

Shirai T, Revenko AS, Tibbitts J, Ngo ATP, Mitrugno A, Healy LD, Johnson J, Tucker EI, Hinds MT, Coussens LM, McCarty OJT, Monia BP, Gruber A.

Blood Adv. 2019 Oct 22;3(20):3080-3091. doi: 10.1182/bloodadvances.2019000250.

PMID:
31648335
2.

Fondaparinux pentasaccharide reduces sepsis coagulopathy and promotes survival in the baboon model of Escherichia coli sepsis.

Keshari RS, Silasi R, Popescu NI, Georgescu C, Chaaban H, Lupu C, McCarty OJT, Esmon CT, Lupu F.

J Thromb Haemost. 2019 Sep 24. doi: 10.1111/jth.14642. [Epub ahead of print]

PMID:
31549765
3.

The contact pathway and sepsis.

Raghunathan V, Zilberman-Rudenko J, Olson SR, Lupu F, McCarty OJT, Shatzel JJ.

Res Pract Thromb Haemost. 2019 May 23;3(3):331-339. doi: 10.1002/rth2.12217. eCollection 2019 Jul. Review.

4.

Endothelial PAI-1 (Plasminogen Activator Inhibitor-1) Blocks the Intrinsic Pathway of Coagulation, Inducing the Clearance and Degradation of FXIa (Activated Factor XI).

Puy C, Ngo ATP, Pang J, Keshari RS, Hagen MW, Hinds MT, Gailani D, Gruber A, Lupu F, McCarty OJT.

Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1390-1401. doi: 10.1161/ATVBAHA.119.312619. Epub 2019 May 23.

PMID:
31242030
5.

The Safety and Efficacy of Novel Agents Targeting Factors XI and XII in Early Phase Human Trials.

DeLoughery EP, Olson SR, Puy C, McCarty OJT, Shatzel JJ.

Semin Thromb Hemost. 2019 Jul;45(5):502-508. doi: 10.1055/s-0039-1692439. Epub 2019 Jun 19.

PMID:
31216587
6.

A non-circulating pool of factor XI associated with glycosaminoglycans in mice.

Mohammed BM, Cheng Q, Matafonov A, Verhamme IM, Emsley J, McCrae KR, McCarty OJT, Gruber A, Gailani D.

J Thromb Haemost. 2019 Sep;17(9):1449-1460. doi: 10.1111/jth.14494. Epub 2019 Jun 17.

PMID:
31125187
7.

Design and Utility of a Point-of-Care Microfluidic Platform to Assess Hematocrit and Blood Coagulation.

Zilberman-Rudenko J, White RM, Zilberman DA, Lakshmanan HHS, Rigg RA, Shatzel JJ, Maddala J, McCarty OJT.

Cell Mol Bioeng. 2018 Dec;11(6):519-529. doi: 10.1007/s12195-018-0541-z. Epub 2018 Jul 19.

8.

Modeling the effect of blood vessel bifurcation ratio on occlusive thrombus formation.

Lakshmanan HHS, Shatzel JJ, Olson SR, McCarty OJT, Maddala J.

Comput Methods Biomech Biomed Engin. 2019 Aug;22(11):972-980. doi: 10.1080/10255842.2019.1610744. Epub 2019 May 8.

PMID:
31066295
9.

Identification, Quantification, and System Analysis of Protein N-ε Lysine Methylation in Anucleate Blood Platelets.

Rocheleau AD, Melrose AR, Cunliffe JM, Klimek J, Babur Ö, Tassi Yunga S, Ngo ATP, Pang J, David LL, McCarty OJT, Aslan JE.

Proteomics. 2019 Jun;19(11):e1900001. doi: 10.1002/pmic.201900001. Epub 2019 May 9.

PMID:
30977292
10.

Assessment of neonatal, cord, and adult platelet granule trafficking and secretion.

Ngo ATP, Sheriff J, Rocheleau AD, Bucher M, Jones KR, Sepp AI, Malone LE, Zigomalas A, Maloyan A, Bahou WF, Bluestein D, McCarty OJT, Haley KM.

Platelets. 2019 Feb 27:1-11. doi: 10.1080/09537104.2019.1573314. [Epub ahead of print]

PMID:
30810440
11.

Inhibition of contact-mediated activation of factor XI protects baboons against S aureus-induced organ damage and death.

Silasi R, Keshari RS, Lupu C, Van Rensburg WJ, Chaaban H, Regmi G, Shamanaev A, Shatzel JJ, Puy C, Lorentz CU, Tucker EI, Gailani D, Gruber A, McCarty OJT, Lupu F.

Blood Adv. 2019 Feb 26;3(4):658-669. doi: 10.1182/bloodadvances.2018029983.

12.

Contact system sends defensins to the rescue.

Healy LD, McCarty OJT.

Blood. 2019 Jan 31;133(5):385-386. doi: 10.1182/blood-2018-12-887547. No abstract available.

13.

Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial.

Lorentz CU, Verbout NG, Wallisch M, Hagen MW, Shatzel JJ, Olson SR, Puy C, Hinds MT, McCarty OJT, Gailani D, Gruber A, Tucker EI.

Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):799-809. doi: 10.1161/ATVBAHA.118.312328.

PMID:
30700130
14.

Thrombotic microangiopathy as a cause of cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib.

Latifi Y, Moccetti F, Wu M, Xie A, Packwood W, Qi Y, Ozawa K, Shentu W, Brown E, Shirai T, McCarty OJ, Ruggeri Z, Moslehi J, Chen J, Druker BJ, López JA, Lindner JR.

Blood. 2019 Apr 4;133(14):1597-1606. doi: 10.1182/blood-2018-10-881557. Epub 2019 Jan 28.

PMID:
30692122
15.

Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions.

Rigg RA, Healy LD, Chu TT, Ngo ATP, Mitrugno A, Zilberman-Rudenko J, Aslan JE, Hinds MT, Vecchiarelli LD, Morgan TK, Gruber A, Temple KJ, Lindsley CW, Duvernay MT, Hamm HE, McCarty OJT.

Platelets. 2019;30(1):126-135. doi: 10.1080/09537104.2017.1406076. Epub 2018 Dec 18.

PMID:
30560697
16.

Bleeding TAPs out.

Ngo ATP, Aslan JE, McCarty OJT.

J Thromb Haemost. 2019 Feb;17(2):247-249. doi: 10.1111/jth.14340. Epub 2018 Dec 13. No abstract available.

PMID:
30549218
17.

The role of coagulation and platelets in colon cancer-associated thrombosis.

Mitrugno A, Tassi Yunga S, Sylman JL, Zilberman-Rudenko J, Shirai T, Hebert JF, Kayton R, Zhang Y, Nan X, Shatzel JJ, Esener S, Duvernay MT, Hamm HE, Gruber A, Williams CD, Takata Y, Armstrong R, Morgan TK, McCarty OJT.

Am J Physiol Cell Physiol. 2019 Feb 1;316(2):C264-C273. doi: 10.1152/ajpcell.00367.2018. Epub 2018 Nov 21.

PMID:
30462538
18.

Antithrombotic Strategies After Bioprosthetic Aortic Valve Replacement: A Systematic Review.

Papak JN, Chiovaro JC, Noelck N, Healy LD, Freeman M, Quin JA, Paynter R, Low A, Kondo K, McCarty OJT, Kansagara D.

Ann Thorac Surg. 2019 May;107(5):1571-1581. doi: 10.1016/j.athoracsur.2018.10.016. Epub 2018 Nov 17. Review.

PMID:
30458159
19.

Chronic liver disease, thrombocytopenia and procedural bleeding risk; are novel thrombopoietin mimetics the solution?

Olson SR, Koprowski S, Hum J, McCarty OJT, DeLoughery TG, Shatzel JJ.

Platelets. 2019;30(6):796-798. doi: 10.1080/09537104.2018.1542125. Epub 2018 Nov 13.

PMID:
30422039
20.

Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo.

Zilberman-Rudenko J, Reitsma SE, Puy C, Rigg RA, Smith SA, Tucker EI, Silasi R, Merkulova A, McCrae KR, Maas C, Urbanus RT, Gailani D, Morrissey JH, Gruber A, Lupu F, Schmaier AH, McCarty OJT.

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1748-1760. doi: 10.1161/ATVBAHA.118.311193.

21.

Plasma contact factors as therapeutic targets.

Tillman BF, Gruber A, McCarty OJT, Gailani D.

Blood Rev. 2018 Nov;32(6):433-448. doi: 10.1016/j.blre.2018.04.001. Epub 2018 Apr 12. Review.

22.

Platelet Mechanotransduction.

Hansen CE, Qiu Y, McCarty OJT, Lam WA.

Annu Rev Biomed Eng. 2018 Jun 4;20:253-275. doi: 10.1146/annurev-bioeng-062117-121215. Review.

PMID:
29865873
23.

Effect of Pneumatic Tubing System Transport on Platelet Apheresis Units.

Zilberman-Rudenko J, Zhao FZ, Reitsma SE, Mitrugno A, Pang J, Shatzel JJ, Rick B, Tyrrell C, Hasan W, McCarty OJT, Schreiber MA.

Cardiovasc Eng Technol. 2018 Sep;9(3):515-527. doi: 10.1007/s13239-018-0361-2. Epub 2018 May 21.

24.

A Temporal Examination of Platelet Counts as a Predictor of Prognosis in Lung, Prostate, and Colon Cancer Patients.

Sylman JL, Boyce HB, Mitrugno A, Tormoen GW, Thomas IC, Wagner TH, Lee JS, Leppert JT, McCarty OJT, Mallick P.

Sci Rep. 2018 Apr 26;8(1):6564. doi: 10.1038/s41598-018-25019-1.

25.

The Predictive Value of Inflammation-Related Peripheral Blood Measurements in Cancer Staging and Prognosis.

Sylman JL, Mitrugno A, Atallah M, Tormoen GW, Shatzel JJ, Tassi Yunga S, Wagner TH, Leppert JT, Mallick P, McCarty OJT.

Front Oncol. 2018 Mar 21;8:78. doi: 10.3389/fonc.2018.00078. eCollection 2018. Review.

26.

Regulation of immune cell signaling by activated protein C.

Healy LD, Rigg RA, Griffin JH, McCarty OJT.

J Leukoc Biol. 2018 Mar 30. doi: 10.1002/JLB.3MIR0817-338R. [Epub ahead of print] Review.

27.

Platelet procoagulant phenotype is modulated by a p38-MK2 axis that regulates RTN4/Nogo proximal to the endoplasmic reticulum: utility of pathway analysis.

Babur Ö, Ngo ATP, Rigg RA, Pang J, Rub ZT, Buchanan AE, Mitrugno A, David LL, McCarty OJT, Demir E, Aslan JE.

Am J Physiol Cell Physiol. 2018 May 1;314(5):C603-C615. doi: 10.1152/ajpcell.00177.2017. Epub 2018 Feb 7.

28.

TRPing out Platelet Calcium: TRPM7 (Transient Receptor Potential Melastatin-Like 7) Modulates Calcium Mobilization and Platelet Function via Phospholipase C Interactions.

Ngo ATP, McCarty OJT, Aslan JE.

Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):285-286. doi: 10.1161/ATVBAHA.117.310493. No abstract available.

29.

Factor XI contributes to myocardial ischemia-reperfusion injury in mice.

Lorentz CU, Verbout NG, Cao Z, Liu L, Hinds MT, McCarty OJT, Ivanov I, Tucker EI, Gailani D, Gruber A.

Blood Adv. 2018 Jan 23;2(2):85-88. doi: 10.1182/bloodadvances.2017004879. No abstract available.

30.

Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions.

Garland KS, Reitsma SE, Shirai T, Zilberman-Rudenko J, Tucker EI, Gailani D, Gruber A, McCarty OJT, Puy C.

Front Med (Lausanne). 2017 Dec 20;4:232. doi: 10.3389/fmed.2017.00232. eCollection 2017.

31.

Carpe low-dose aspirin: the new anti-cancer face of an old anti-platelet drug.

Mitrugno A, Sylman JL, Rigg RA, Tassi Yunga S, Shatzel JJ, Williams CD, McCarty OJT.

Platelets. 2018 Dec;29(8):773-778. doi: 10.1080/09537104.2017.1416076. Epub 2017 Dec 21. Review.

PMID:
29265902
32.

Pilot study of novel lab methodology and testing of platelet function in adolescent women with heavy menstrual bleeding.

Rocheleau AD, Khader A, Ngo ATP, Boehnlein C, McDavitt C, Lattimore S, Recht M, McCarty OJT, Haley KM.

Pediatr Res. 2018 Mar;83(3):693-701. doi: 10.1038/pr.2017.298. Epub 2018 Jan 3.

33.

Platelet count as a predictor of metastasis and venous thromboembolism in patients with cancer.

Sylman JL, Mitrugno A, Tormoen GW, Wagner TH, Mallick P, McCarty OJT.

Converg Sci Phys Oncol. 2017 Jun;3(2). pii: 023001. doi: 10.1088/2057-1739/aa6c05. Epub 2017 May 17.

34.

Ticagrelor breaks up the tumor-platelet party.

Mitrugno A, McCarty OJT.

Blood. 2017 Sep 7;130(10):1177-1178. doi: 10.1182/blood-2017-07-795898. No abstract available.

35.

Utility and development of microfluidic platforms for platelet research.

Zilberman-Rudenko J, McCarty OJT.

Platelets. 2017 Jul;28(5):425-426. doi: 10.1080/09537104.2017.1325187. No abstract available.

36.

Dynamics of blood flow and thrombus formation in a multi-bypass microfluidic ladder network.

Zilberman-Rudenko J, Sylman JL, Lakshmanan HHS, McCarty OJT, Maddala J.

Cell Mol Bioeng. 2017 Feb;10(1):16-29. doi: 10.1007/s12195-016-0470-7. Epub 2016 Oct 20.

37.

Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395.

Mitrugno A, Rigg RA, Laschober NB, Ngo ATP, Pang J, Williams CD, Aslan JE, McCarty OJT.

Platelets. 2018 Jun;29(4):383-394. doi: 10.1080/09537104.2017.1316482. Epub 2017 May 19.

38.

Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo.

Healy LD, Puy C, Fernández JA, Mitrugno A, Keshari RS, Taku NA, Chu TT, Xu X, Gruber A, Lupu F, Griffin JH, McCarty OJT.

J Biol Chem. 2017 May 26;292(21):8616-8629. doi: 10.1074/jbc.M116.768309. Epub 2017 Apr 13.

39.

Utility of microfluidic devices to study the platelet-endothelium interface.

Zilberman-Rudenko J, Sylman JL, Garland KS, Puy C, Wong AD, Searson PC, McCarty OJT.

Platelets. 2017 Jul;28(5):449-456. doi: 10.1080/09537104.2017.1280600. Epub 2017 Mar 30. Review.

40.

Ibrutinib-associated bleeding: pathogenesis, management and risk reduction strategies.

Shatzel JJ, Olson SR, Tao DL, McCarty OJT, Danilov AV, DeLoughery TG.

J Thromb Haemost. 2017 May;15(5):835-847. doi: 10.1111/jth.13651. Epub 2017 Mar 27. Review.

41.

Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor Ly-GDI in platelet function: a spatial systems approach.

Ngo AT, Thierheimer ML, Babur Ö, Rocheleau AD, Huang T, Pang J, Rigg RA, Mitrugno A, Theodorescu D, Burchard J, Nan X, Demir E, McCarty OJ, Aslan JE.

Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C527-C536. doi: 10.1152/ajpcell.00274.2016. Epub 2017 Feb 1.

42.

Nucleic acids as cofactors for factor XI and prekallikrein activation: Different roles for high-molecular-weight kininogen.

Ivanov I, Shakhawat R, Sun MF, Dickeson SK, Puy C, McCarty OJ, Gruber A, Matafonov A, Gailani D.

Thromb Haemost. 2017 Apr 3;117(4):671-681. doi: 10.1160/TH16-09-0691. Epub 2017 Jan 26.

43.

Biorheology of platelet activation in the bloodstream distal to thrombus formation.

Zilberman-Rudenko J, Itakura A, Maddala J, Baker-Groberg SM, Vetter R, Tucker EI, Gruber A, Gerdes C, McCarty OJ.

Cell Mol Bioeng. 2016 Dec;9(4):496-508. doi: 10.1007/s12195-016-0448-5. Epub 2016 May 26.

44.

Polyphosphate nanoparticles on the platelet surface trigger contact system activation.

Verhoef JJ, Barendrecht AD, Nickel KF, Dijkxhoorn K, Kenne E, Labberton L, McCarty OJ, Schiffelers R, Heijnen HF, Hendrickx AP, Schellekens H, Fens MH, de Maat S, Renné T, Maas C.

Blood. 2017 Mar 23;129(12):1707-1717. doi: 10.1182/blood-2016-08-734988. Epub 2017 Jan 3.

45.

Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin.

Sylman JL, Daalkhaijav U, Zhang Y, Gray EM, Farhang PA, Chu TT, Zilberman-Rudenko J, Puy C, Tucker EI, Smith SA, Morrissey JH, Walker TW, Nan XL, Gruber A, McCarty OJT.

Ann Biomed Eng. 2017 May;45(5):1328-1340. doi: 10.1007/s10439-016-1771-7. Epub 2016 Dec 8.

46.

Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: Implications for the oncoprotein c-MYC.

Mitrugno A, Sylman JL, Ngo AT, Pang J, Sears RC, Williams CD, McCarty OJ.

Am J Physiol Cell Physiol. 2017 Feb 1;312(2):C176-C189. doi: 10.1152/ajpcell.00196.2016. Epub 2016 Nov 30.

47.

Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI.

Puy C, Tucker EI, Ivanov IS, Gailani D, Smith SA, Morrissey JH, Gruber A, McCarty OJ.

PLoS One. 2016 Oct 20;11(10):e0165172. doi: 10.1371/journal.pone.0165172. eCollection 2016.

48.

Thrombosis in Cancer: Research Priorities Identified by a National Cancer Institute/National Heart, Lung, and Blood Institute Strategic Working Group.

Key NS, Khorana AA, Mackman N, McCarty OJ, White GC, Francis CW, McCrae KR, Palumbo JS, Raskob GE, Chan AT, Sood AK.

Cancer Res. 2016 Jul 1;76(13):3671-5. doi: 10.1158/0008-5472.CAN-15-3100. Epub 2016 Jun 20.

49.

Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va.

Deguchi H, Sinha RK, Marchese P, Ruggeri ZM, Zilberman-Rudenko J, McCarty OJT, Cohen MJ, Griffin JH.

Blood. 2016 Oct 6;128(14):1870-1878. doi: 10.1182/blood-2016-03-707679. Epub 2016 Jul 15.

50.

Colocalization of neutrophils, extracellular DNA and coagulation factors during NETosis: Development and utility of an immunofluorescence-based microscopy platform.

Healy LD, Puy C, Itakura A, Chu T, Robinson DK, Bylund A, Phillips KG, Gardiner EE, McCarty OJ.

J Immunol Methods. 2016 Aug;435:77-84. doi: 10.1016/j.jim.2016.06.002. Epub 2016 Jun 7.

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