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ΔNp63α is a super enhancer-enriched master factor controlling the basal-to-luminal differentiation transcriptional program and gene regulatory networks in nasopharyngeal carcinoma.

Cai J, Chen S, Yi M, Tan Y, Peng Q, Ban Y, Yang J, Li X, Zeng Z, Xiong W, McCarthy JB, Li G, Li X, Xiang B.

Carcinogenesis. 2019 Dec 12. pii: bgz203. doi: 10.1093/carcin/bgz203. [Epub ahead of print]


SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis.

Smeester BA, Slipek NJ, Pomeroy EJ, Bomberger HE, Shamsan GA, Peterson JJ, Crosby MR, Draper GM, Becklin KL, Rahrmann EP, McCarthy JB, Odde DJ, Wood DK, Largaespada DA, Moriarity BS.

Oncogene. 2020 Jan;39(5):1049-1062. doi: 10.1038/s41388-019-1041-x. Epub 2019 Oct 3.


SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents.

Haranahalli K, Lazzarini C, Sun Y, Zambito J, Pathiranage S, McCarthy JB, Mallamo J, Del Poeta M, Ojima I.

J Med Chem. 2019 Sep 12;62(17):8249-8273. doi: 10.1021/acs.jmedchem.9b01004. Epub 2019 Aug 16.


Chondroitin sulfate proteoglycan 4 enhanced melanoma motility and growth requires a cysteine in the core protein transmembrane domain.

Yang J, Price MA, Wanshura LEC, He J, Yi M, Welch DR, Li G, Conner S, Sachs J, Turley EA, McCarthy JB.

Melanoma Res. 2019 Aug;29(4):365-375. doi: 10.1097/CMR.0000000000000574.


Corrigendum: Hyaluronan, Cancer-Associated Fibroblasts and the Tumor Microenvironment in Malignant Progression.

McCarthy JB, El-Ashry D, Turley EA.

Front Cell Dev Biol. 2018 Sep 24;6:112. doi: 10.3389/fcell.2018.00112. eCollection 2018.


Hyaluronan, Cancer-Associated Fibroblasts and the Tumor Microenvironment in Malignant Progression.

McCarthy JB, El-Ashry D, Turley EA.

Front Cell Dev Biol. 2018 May 8;6:48. doi: 10.3389/fcell.2018.00048. eCollection 2018. Review. Erratum in: Front Cell Dev Biol. 2018 Sep 24;6:112.


In vitro elucidation of the role of pericellular matrix in metastatic extravasation and invasion of breast carcinoma cells.

Brett ME, Bomberger HE, Doak GR, Price MA, McCarthy JB, Wood DK.

Integr Biol (Camb). 2018 Apr 23;10(4):242-252. doi: 10.1039/c7ib00173h.


Biphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level.

Klank RL, Decker Grunke SA, Bangasser BL, Forster CL, Price MA, Odde TJ, SantaCruz KS, Rosenfeld SS, Canoll P, Turley EA, McCarthy JB, Ohlfest JR, Odde DJ.

Cell Rep. 2017 Apr 18;19(3):668. doi: 10.1016/j.celrep.2017.03.074. No abstract available.


The NOR1/OSCP1 proteins in cancer: from epigenetic silencing to functional characterization of a novel tumor suppressor.

Yi M, Yang J, Li W, Li X, Xiong W, McCarthy JB, Li G, Xiang B.

J Cancer. 2017 Feb 25;8(4):626-635. doi: 10.7150/jca.17579. eCollection 2017. Review.


Hyaluronan modulates growth factor induced mammary gland branching in a size dependent manner.

Tolg C, Yuan H, Flynn SM, Basu K, Ma J, Tse KCK, Kowalska B, Vulkanesku D, Cowman MK, McCarthy JB, Turley EA.

Matrix Biol. 2017 Nov;63:117-132. doi: 10.1016/j.matbio.2017.02.003. Epub 2017 Feb 21.


Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis.

Bahrami SB, Tolg C, Peart T, Symonette C, Veiseh M, Umoh JU, Holdsworth DW, McCarthy JB, Luyt LG, Bissell MJ, Yazdani A, Turley EA.

Integr Biol (Camb). 2017 Mar 1;9(3):223-237. doi: 10.1039/c7ib00002b. Epub 2017 Feb 20.


Biphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level.

Klank RL, Decker Grunke SA, Bangasser BL, Forster CL, Price MA, Odde TJ, SantaCruz KS, Rosenfeld SS, Canoll P, Turley EA, McCarthy JB, Ohlfest JR, Odde DJ.

Cell Rep. 2017 Jan 3;18(1):23-31. doi: 10.1016/j.celrep.2016.12.024. Erratum in: Cell Rep. 2017 Apr 18;19(3):668.


RB Loss Promotes Prostate Cancer Metastasis.

Thangavel C, Boopathi E, Liu Y, Haber A, Ertel A, Bhardwaj A, Addya S, Williams N, Ciment SJ, Cotzia P, Dean JL, Snook A, McNair C, Price M, Hernandez JR, Zhao SG, Birbe R, McCarthy JB, Turley EA, Pienta KJ, Feng FY, Dicker AP, Knudsen KE, Den RB.

Cancer Res. 2017 Feb 15;77(4):982-995. doi: 10.1158/0008-5472.CAN-16-1589. Epub 2016 Dec 6.


Impact of psychotic symptoms on cognitive functioning in child and adolescent psychiatric inpatients with severe mood disorders.

McCarthy JB, Weiss SR, Segovich KT, Barbot B.

Psychiatry Res. 2016 Oct 30;244:223-8. doi: 10.1016/j.psychres.2016.07.049. Epub 2016 Jul 25.


Carcinoma Cell Hyaluronan as a "Portable" Cancerized Prometastatic Microenvironment.

Turley EA, Wood DK, McCarthy JB.

Cancer Res. 2016 May 1;76(9):2507-12. doi: 10.1158/0008-5472.CAN-15-3114. Epub 2016 Apr 20. Review.


Significance of the NOR1-FOXA1/HDAC2-Slug regulatory network in epithelial-mesenchymal transition of tumor cells.

Wang W, Yi M, Chen S, Li J, Li G, Yang J, Zheng P, Zhang H, Xiong W, McCarthy JB, Li G, Li X, Xiang B.

Oncotarget. 2016 Mar 29;7(13):16745-59. doi: 10.18632/oncotarget.7778.


Uncovering the dual role of RHAMM as an HA receptor and a regulator of CD44 expression in RHAMM-expressing mesenchymal progenitor cells.

Veiseh M, Leith SJ, Tolg C, Elhayek SS, Bahrami SB, Collis L, Hamilton S, McCarthy JB, Bissell MJ, Turley E.

Front Cell Dev Biol. 2015 Oct 15;3:63. doi: 10.3389/fcell.2015.00063. eCollection 2015.


Identification, design and synthesis of tubulin-derived peptides as novel hyaluronan mimetic ligands for the receptor for hyaluronan-mediated motility (RHAMM/HMMR).

Esguerra KV, Tolg C, Akentieva N, Price M, Cho CF, Lewis JD, McCarthy JB, Turley EA, Luyt LG.

Integr Biol (Camb). 2015 Dec;7(12):1547-60. doi: 10.1039/c5ib00222b. Epub 2015 Oct 12.


Hyaluronan, Inflammation, and Breast Cancer Progression.

Schwertfeger KL, Cowman MK, Telmer PG, Turley EA, McCarthy JB.

Front Immunol. 2015 Jun 8;6:236. doi: 10.3389/fimmu.2015.00236. eCollection 2015. Review.


The Content and Size of Hyaluronan in Biological Fluids and Tissues.

Cowman MK, Lee HG, Schwertfeger KL, McCarthy JB, Turley EA.

Front Immunol. 2015 Jun 2;6:261. doi: 10.3389/fimmu.2015.00261. eCollection 2015. Review.



McCarthy JB.

Psychol Rep. 2015 Jun;116(3):914-9. Epub 2015 Jun 1.


Hyaluronan stimulates ex vivo B lymphocyte chemotaxis and cytokine production in a murine model of fungal allergic asthma.

Ghosh S, Hoselton SA, Wanjara SB, Carlson J, McCarthy JB, Dorsam GP, Schuh JM.

Immunobiology. 2015 Jul;220(7):899-909. doi: 10.1016/j.imbio.2015.01.011. Epub 2015 Feb 7.


Hyaluronan and RHAMM in wound repair and the "cancerization" of stromal tissues.

Tolg C, McCarthy JB, Yazdani A, Turley EA.

Biomed Res Int. 2014;2014:103923. doi: 10.1155/2014/103923. Epub 2014 Aug 4. Review.


Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer.

Misra S, Ghatak S, Vyas A, O'Brien P, Markwald RR, Khetmalas M, Hascall VC, McCarthy JB, Karamanos NK, Tammi MI, Tammi RH, Prestwitch GD, Padhye S.

Med Chem Res. 2014 Aug 1;23(8):3836-3851.


Seventy-one important questions for the conservation of marine biodiversity.

Parsons EC, Favaro B, Aguirre AA, Bauer AL, Blight LK, Cigliano JA, Coleman MA, Côté IM, Draheim M, Fletcher S, Foley MM, Jefferson R, Jones MC, Kelaher BP, Lundquist CJ, McCarthy JB, Nelson A, Patterson K, Walsh L, Wright AJ, Sutherland WJ.

Conserv Biol. 2014 Oct;28(5):1206-14. doi: 10.1111/cobi.12303. Epub 2014 Apr 29.


Evaluation of protein biomarkers of prostate cancer aggressiveness.

Rizzardi AE, Rosener NK, Koopmeiners JS, Isaksson Vogel R, Metzger GJ, Forster CL, Marston LO, Tiffany JR, McCarthy JB, Turley EA, Warlick CA, Henriksen JC, Schmechel SC.

BMC Cancer. 2014 Apr 5;14:244. doi: 10.1186/1471-2407-14-244.


Elevated hyaluronan and hyaluronan-mediated motility receptor are associated with biochemical failure in patients with intermediate-grade prostate tumors.

Rizzardi AE, Vogel RI, Koopmeiners JS, Forster CL, Marston LO, Rosener NK, Akentieva N, Price MA, Metzger GJ, Warlick CA, Henriksen JC, Turley EA, McCarthy JB, Schmechel SC.

Cancer. 2014 Jun 15;120(12):1800-9. doi: 10.1002/cncr.28646. Epub 2014 Mar 25.


Oxidored-nitro domain containing protein 1 (NOR1) expression suppresses slug/vimentin but not snail in nasopharyngeal carcinoma: Inhibition of EMT in vitro and in vivo in mice.

Wang W, Li X, Zhang W, Li W, Yi M, Yang J, Zeng Z, Colvin Wanshura LE, McCarthy JB, Fan S, Zheng P, Chen S, Xiang B, Li G.

Cancer Lett. 2014 Jun 28;348(1-2):109-18. doi: 10.1016/j.canlet.2014.03.005. Epub 2014 Mar 18.


Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation.

Bohrer LR, Chuntova P, Bade LK, Beadnell TC, Leon RP, Brady NJ, Ryu Y, Goldberg JE, Schmechel SC, Koopmeiners JS, McCarthy JB, Schwertfeger KL.

Cancer Res. 2014 Jan 1;74(1):374-86. doi: 10.1158/0008-5472.CAN-13-2469. Epub 2013 Nov 6.


Tumor suppressor gene Oxidored-nitro domain-containing protein 1 regulates nasopharyngeal cancer cell autophagy, metabolism, and apoptosis in vitro.

Li W, Li X, Wang W, Yi M, Zhou Y, Zheng P, Xiong W, Yang J, Peng S, McCarthy JB, Xiang B, Li G.

Int J Biochem Cell Biol. 2013 Sep;45(9):2016-26. doi: 10.1016/j.biocel.2013.06.020. Epub 2013 Jul 3.


SPLUNC1 regulates cell progression and apoptosis through the miR-141-PTEN/p27 pathway, but is hindered by LMP1.

Chen P, Guo X, Zhou H, Zhang W, Zeng Z, Liao Q, Li X, Xiang B, Yang J, Ma J, Zhou M, Peng S, Xiang J, Li X, L E CW, Xiong W, McCarthy JB, Li G.

PLoS One. 2013;8(3):e56929. doi: 10.1371/journal.pone.0056929. Epub 2013 Mar 5.


miR-18a promotes malignant progression by impairing microRNA biogenesis in nasopharyngeal carcinoma.

Luo Z, Dai Y, Zhang L, Jiang C, Li Z, Yang J, McCarthy JB, She X, Zhang W, Ma J, Xiong W, Wu M, Lu J, Li X, Li X, Xiang J, Li G.

Carcinogenesis. 2013 Feb;34(2):415-25. doi: 10.1093/carcin/bgs329. Epub 2012 Oct 24.


A RHAMM mimetic peptide blocks hyaluronan signaling and reduces inflammation and fibrogenesis in excisional skin wounds.

Tolg C, Hamilton SR, Zalinska E, McCulloch L, Amin R, Akentieva N, Winnik F, Savani R, Bagli DJ, Luyt LG, Cowman MK, McCarthy JB, Turley EA.

Am J Pathol. 2012 Oct;181(4):1250-70. doi: 10.1016/j.ajpath.2012.06.036. Epub 2012 Aug 11.


CSPG4, a potential therapeutic target, facilitates malignant progression of melanoma.

Price MA, Colvin Wanshura LE, Yang J, Carlson J, Xiang B, Li G, Ferrone S, Dudek AZ, Turley EA, McCarthy JB.

Pigment Cell Melanoma Res. 2011 Dec;24(6):1148-57. doi: 10.1111/j.1755-148X.2011.00929.x. Review.


NOR1 is an HSF1- and NRF1-regulated putative tumor suppressor inactivated by promoter hypermethylation in nasopharyngeal carcinoma.

Li W, Li X, Wang W, Li X, Tan Y, Yi M, Yang J, McCarthy JB, Xiong W, Wu M, Ma J, Su B, Zhang Z, Liao Q, Xiang B, Li G.

Carcinogenesis. 2011 Sep;32(9):1305-14. doi: 10.1093/carcin/bgr174. Epub 2011 Jul 28.


RASSF1A suppresses melanoma development by modulating apoptosis and cell-cycle progression.

Yi M, Yang J, Chen X, Li J, Li X, Wang L, Tan Y, Xiong W, Zhou M, McCarthy JB, Li G, Xiang B, Xie H.

J Cell Physiol. 2011 Sep;226(9):2360-9. doi: 10.1002/jcp.22568.


How does a protein with dual mitotic spindle and extracellular matrix receptor functions affect tumor susceptibility and progression?

Telmer PG, Tolg C, McCarthy JB, Turley EA.

Commun Integr Biol. 2011 Mar;4(2):182-5. doi: 10.4161/cib.4.2.14270.


CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer.

Wang X, Osada T, Wang Y, Yu L, Sakakura K, Katayama A, McCarthy JB, Brufsky A, Chivukula M, Khoury T, Hsu DS, Barry WT, Lyerly HK, Clay TM, Ferrone S.

J Natl Cancer Inst. 2010 Oct 6;102(19):1496-512. doi: 10.1093/jnci/djq343. Epub 2010 Sep 17.


RHAMM promotes interphase microtubule instability and mitotic spindle integrity through MEK1/ERK1/2 activity.

Tolg C, Hamilton SR, Morningstar L, Zhang J, Zhang S, Esguerra KV, Telmer PG, Luyt LG, Harrison R, McCarthy JB, Turley EA.

J Biol Chem. 2010 Aug 20;285(34):26461-74. doi: 10.1074/jbc.M110.121491. Epub 2010 Jun 17.


CSPG4 in cancer: multiple roles.

Wang X, Wang Y, Yu L, Sakakura K, Visus C, Schwab JH, Ferrone CR, Favoino E, Koya Y, Campoli MR, McCarthy JB, DeLeo AB, Ferrone S.

Curr Mol Med. 2010 Jun;10(4):419-29. Review.


Melanoma proteoglycan modifies gene expression to stimulate tumor cell motility, growth, and epithelial-to-mesenchymal transition.

Yang J, Price MA, Li GY, Bar-Eli M, Salgia R, Jagedeeswaran R, Carlson JH, Ferrone S, Turley EA, McCarthy JB.

Cancer Res. 2009 Oct 1;69(19):7538-47. doi: 10.1158/0008-5472.CAN-08-4626. Epub 2009 Sep 8.


Cyclin D1 promotes anchorage-independent cell survival by inhibiting FOXO-mediated anoikis.

Gan L, Liu P, Lu H, Chen S, Yang J, McCarthy JB, Knudsen KE, Huang H.

Cell Death Differ. 2009 Oct;16(10):1408-17. doi: 10.1038/cdd.2009.86. Epub 2009 Jul 3. Erratum in: Cell Death Differ. 2010 May;17(5):900.


Inhibition of hyaluronan synthases decreases matrix metalloproteinase-7 (MMP-7) expression and activity.

Dunn KM, Lee PK, Wilson CM, Iida J, Wasiluk KR, Hugger M, McCarthy JB.

Surgery. 2009 Mar;145(3):322-9. doi: 10.1016/j.surg.2008.11.008.


The effect of a hyaluronan-carboxymethylcellulose membrane vs. polyglactin 910 mesh on intra-abdominal tumor formation in mice.

Lee PK, Windsperger AP, Wilson CM, McCarthy JB, Wasiluk KR, Rothenberger DA, Bullard Dunn KM.

Dis Colon Rectum. 2008 Sep;51(9):1403-7. doi: 10.1007/s10350-008-9299-z. Epub 2008 Apr 17.


Syntenin: a novel PDZ domain-containing scaffolding protein associated with human melanoma metastasis.

Yang JB, McCarthy JB.

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Apr;32(2):204-12. Review.


The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells.

Hamilton SR, Fard SF, Paiwand FF, Tolg C, Veiseh M, Wang C, McCarthy JB, Bissell MJ, Koropatnick J, Turley EA.

J Biol Chem. 2007 Jun 1;282(22):16667-80. Epub 2007 Mar 28.


Tumor progression and metastasis from genetic to microenvironmental determinants: a workshop of the tumor progression and metastasis NIH study section in honor of Dr. Martin L. Padarathsingh, May 31, 2006, Georgetown, Washington, DC.

De Clerck YA, Weissman BE, Yu D, Parsons R, Bar-Eli M, Roy-Burman P, Seewaldt VL, Cress AE, Languino LR, Batra SK, Tang CK, Sheng S, Chen WT, Chellappan S, Cheng SY, Ladisch S, McCarthy JB, Coussens LM, Cohen MB.

Cancer Biol Ther. 2006 Dec;5(12):1588-99. Epub 2006 Dec 6. No abstract available.


Cell surface chondroitin sulfate glycosaminoglycan in melanoma: role in the activation of pro-MMP-2 (pro-gelatinase A).

Iida J, Wilhelmson KL, Ng J, Lee P, Morrison C, Tam E, Overall CM, McCarthy JB.

Biochem J. 2007 May 1;403(3):553-63.


Rhamm-/- fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair.

Tolg C, Hamilton SR, Nakrieko KA, Kooshesh F, Walton P, McCarthy JB, Bissell MJ, Turley EA.

J Cell Biol. 2006 Dec 18;175(6):1017-28. Epub 2006 Dec 11.

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