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MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer.

Casciano JC, Perry C, Cohen-Nowak AJ, Miller KD, Vande Voorde J, Zhang Q, Chalmers S, Sandison ME, Liu Q, Hedley A, McBryan T, Tang HY, Gorman N, Beer T, Speicher DW, Adams PD, Liu X, Schlegel R, McCarron JG, Wakelam MJO, Gottlieb E, Kossenkov AV, Schug ZT.

Br J Cancer. 2020 Jan 16. doi: 10.1038/s41416-019-0711-3. [Epub ahead of print]


Multi-plane remote refocusing epifluorescence microscopy to image dynamic Ca 2 + events.

Lawton PF, Buckley C, Saunter CD, Wilson C, Corbett AD, Salter PS, McCarron JG, Girkin JM.

Biomed Opt Express. 2019 Oct 10;10(11):5611-5624. doi: 10.1364/BOE.10.005611. eCollection 2019 Nov 1.


Hydrogen peroxide depolarizes mitochondria and inhibits IP3-evoked Ca2+ release in the endothelium of intact arteries.

Zhang X, Lee MD, Wilson C, McCarron JG.

Cell Calcium. 2019 Dec;84:102108. doi: 10.1016/j.ceca.2019.102108. Epub 2019 Nov 1.


FK506 regulates Ca2+ release evoked by inositol 1,4,5-trisphosphate independently of FK-binding protein in endothelial cells.

Buckley C, Wilson C, McCarron JG.

Br J Pharmacol. 2019 Nov 8. doi: 10.1111/bph.14905. [Epub ahead of print]


Increased Vascular Contractility in Hypertension Results From Impaired Endothelial Calcium Signaling.

Wilson C, Zhang X, Buckley C, Heathcote HR, Lee MD, McCarron JG.

Hypertension. 2019 Nov;74(5):1200-1214. doi: 10.1161/HYPERTENSIONAHA.119.13791. Epub 2019 Sep 23.


Mitochondria Structure and Position in the Local Control of Calcium Signals in Smooth Muscle Cells.

McCarron JG, Saunter C, Wilson C, Girkin JM, Chalmers S.

In: Trebak M, Earley S, editors. Signal Transduction and Smooth Muscle. Oxon (UK): CRC Press/Taylor & Francis; 2018 Aug 6. Chapter 9.


Endothelial TRPV4 channels modulate vascular tone by Ca2+ -induced Ca2+ release at inositol 1,4,5-trisphosphate receptors.

Heathcote HR, Lee MD, Zhang X, Saunter CD, Wilson C, McCarron JG.

Br J Pharmacol. 2019 Sep;176(17):3297-3317. doi: 10.1111/bph.14762. Epub 2019 Jul 24.


Heterogeneity and emergent behaviour in the vascular endothelium.

McCarron JG, Wilson C, Heathcote HR, Zhang X, Buckley C, Lee MD.

Curr Opin Pharmacol. 2019 Apr;45:23-32. doi: 10.1016/j.coph.2019.03.008. Epub 2019 Apr 18. Review.


VasoTracker, a Low-Cost and Open Source Pressure Myograph System for Vascular Physiology.

Lawton PF, Lee MD, Saunter CD, Girkin JM, McCarron JG, Wilson C.

Front Physiol. 2019 Feb 21;10:99. doi: 10.3389/fphys.2019.00099. eCollection 2019.


Spatially structured cell populations process multiple sensory signals in parallel in intact vascular endothelium.

Lee MD, Wilson C, Saunter CD, Kennedy C, Girkin JM, McCarron JG.

Sci Signal. 2018 Dec 18;11(561). pii: eaar4411. doi: 10.1126/scisignal.aar4411.


Mitochondrial ATP production provides long-range control of endothelial inositol trisphosphate-evoked calcium signaling.

Wilson C, Lee MD, Heathcote HR, Zhang X, Buckley C, Girkin JM, Saunter CD, McCarron JG.

J Biol Chem. 2019 Jan 18;294(3):737-758. doi: 10.1074/jbc.RA118.005913. Epub 2018 Nov 29.


RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry.

Patnaik SR, Zhang X, Biswas L, Akhtar S, Zhou X, Kusuluri DK, Reilly J, May-Simera H, Chalmers S, McCarron JG, Shu X.

Oncotarget. 2018 May 1;9(33):23183-23197. doi: 10.18632/oncotarget.25259. eCollection 2018 May 1.


The Endothelium Solves Problems That Endothelial Cells Do Not Know Exist.

McCarron JG, Lee MD, Wilson C.

Trends Pharmacol Sci. 2017 Apr;38(4):322-338. doi: 10.1016/ Epub 2017 Feb 16. Review.


Advancing Age Decreases Pressure-Sensitive Modulation of Calcium Signaling in the Endothelium of Intact and Pressurized Arteries.

Wilson C, Saunter CD, Girkin JM, McCarron JG.

J Vasc Res. 2016;53(5-6):358-369. doi: 10.1159/000454811. Epub 2017 Jan 19.


The transition of smooth muscle cells from a contractile to a migratory, phagocytic phenotype: direct demonstration of phenotypic modulation.

Sandison ME, Dempster J, McCarron JG.

J Physiol. 2016 Nov 1;594(21):6189-6209. doi: 10.1113/JP272729. Epub 2016 Aug 13.


Acetylcholine released by endothelial cells facilitates flow-mediated dilatation.

Wilson C, Lee MD, McCarron JG.

J Physiol. 2016 Dec 15;594(24):7267-7307. doi: 10.1113/JP272927.


Age decreases mitochondrial motility and increases mitochondrial size in vascular smooth muscle.

Chalmers S, Saunter CD, Girkin JM, McCarron JG.

J Physiol. 2016 Aug 1;594(15):4283-95. doi: 10.1113/JP271942. Epub 2016 Apr 9.


Clusters of specialized detector cells provide sensitive and high fidelity receptor signaling in the intact endothelium.

Wilson C, Saunter CD, Girkin JM, McCarron JG.

FASEB J. 2016 May;30(5):2000-13. doi: 10.1096/fj.201500090. Epub 2016 Feb 12.


Synthesis of an azido-tagged low affinity ratiometric calcium sensor.

Caldwell ST, Cairns AG, Olson M, Chalmers S, Sandison M, Mullen W, McCarron JG, Hartley RC.

Tetrahedron. 2015 Dec 23;71(51):9571-9578.


Flicker-assisted localization microscopy reveals altered mitochondrial architecture in hypertension.

Chalmers S, Saunter CD, Girkin JM, McCarron JG.

Sci Rep. 2015 Nov 23;5:16875. doi: 10.1038/srep16875.


Pressure-dependent regulation of Ca2+ signalling in the vascular endothelium.

Wilson C, Saunter CD, Girkin JM, McCarron JG.

J Physiol. 2015 Dec 15;593(24):5231-53. doi: 10.1113/JP271157. Epub 2015 Dec 7.


From structure to function: mitochondrial morphology, motion and shaping in vascular smooth muscle.

McCarron JG, Wilson C, Sandison ME, Olson ML, Girkin JM, Saunter C, Chalmers S.

J Vasc Res. 2013;50(5):357-71. doi: 10.1159/000353883. Epub 2013 Jul 24. Review.


Examining the role of mitochondria in Ca²⁺ signaling in native vascular smooth muscle.

McCarron JG, Olson ML, Wilson C, Sandison ME, Chalmers S.

Microcirculation. 2013 May;20(4):317-29. doi: 10.1111/micc.12039. Review.


Mitochondrial motility and vascular smooth muscle proliferation.

Chalmers S, Saunter C, Wilson C, Coats P, Girkin JM, McCarron JG.

Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):3000-11. doi: 10.1161/ATVBAHA.112.255174. Epub 2012 Oct 25.


Single cell and subcellular measurements of intracellular Ca²⁺ concentration.

McCarron JG, Olson ML, Chalmers S, Girkin JM.

Methods Mol Biol. 2013;937:239-51.


Microdomains of muscarinic acetylcholine and Ins(1,4,5)P₃ receptors create 'Ins(1,4,5)P₃ junctions' and sites of Ca²+ wave initiation in smooth muscle.

Olson ML, Sandison ME, Chalmers S, McCarron JG.

J Cell Sci. 2012 Nov 15;125(Pt 22):5315-28. doi: 10.1242/jcs.105163. Epub 2012 Sep 3.


ATP inhibits Ins(1,4,5)P3-evoked Ca2+ release in smooth muscle via P2Y1 receptors.

MacMillan D, Kennedy C, McCarron JG.

J Cell Sci. 2012 Nov 1;125(Pt 21):5151-8. doi: 10.1242/jcs.108498. Epub 2012 Aug 16.


Subplasma membrane Ca2+ signals.

McCarron JG, Chalmers S, Olson ML, Girkin JM.

IUBMB Life. 2012 Jul;64(7):573-85. doi: 10.1002/iub.1032. Epub 2012 Jun 1. Review.


Mitochondrial regulation of cytosolic Ca²⁺ signals in smooth muscle.

McCarron JG, Olson ML, Chalmers S.

Pflugers Arch. 2012 Jul;464(1):51-62. doi: 10.1007/s00424-012-1108-9. Epub 2012 May 4. Review.


Mitochondrial organization and Ca2+ uptake.

Olson ML, Chalmers S, McCarron JG.

Biochem Soc Trans. 2012 Feb;40(1):158-67. doi: 10.1042/BST20110705. Review.


Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore.

Chalmers S, Caldwell ST, Quin C, Prime TA, James AM, Cairns AG, Murphy MP, McCarron JG, Hartley RC.

J Am Chem Soc. 2012 Jan 18;134(2):758-61. doi: 10.1021/ja2077922. Epub 2011 Dec 30.


Agonist-evoked Ca(2+) wave progression requires Ca(2+) and IP(3).

McCarron JG, Chalmers S, MacMillan D, Olson ML.

J Cell Physiol. 2010 Aug;224(2):334-44. doi: 10.1002/jcp.22103.


Mitochondrial Ca2+ uptake increases Ca2+ release from inositol 1,4,5-trisphosphate receptor clusters in smooth muscle cells.

Olson ML, Chalmers S, McCarron JG.

J Biol Chem. 2010 Jan 15;285(3):2040-50. doi: 10.1074/jbc.M109.027094. Epub 2009 Nov 4.


The sarcoplasmic reticulum Ca2+ store arrangement in vascular smooth muscle.

Rainbow RD, Macmillan D, McCarron JG.

Cell Calcium. 2009 Nov-Dec;46(5-6):313-22. doi: 10.1016/j.ceca.2009.09.001.


Regulation by FK506 and rapamycin of Ca2+ release from the sarcoplasmic reticulum in vascular smooth muscle: the role of FK506 binding proteins and mTOR.

MacMillan D, McCarron JG.

Br J Pharmacol. 2009 Oct;158(4):1112-20. doi: 10.1111/j.1476-5381.2009.00369.x. Epub 2009 Sep 25.


Inhibition of mitochondrial calcium uptake rather than efflux impedes calcium release by inositol-1,4,5-trisphosphate-sensitive receptors.

Chalmers S, McCarron JG.

Cell Calcium. 2009 Aug;46(2):107-13. doi: 10.1016/j.ceca.2009.05.007. Epub 2009 Jul 4.


Caged AG10: new tools for spatially predefined mitochondrial uncoupling.

Avlonitis N, Chalmers S, McDougall C, Stanton-Humphreys MN, Brown CT, McCarron JG, Conway SJ.

Mol Biosyst. 2009 May;5(5):450-7. doi: 10.1039/b820415m. Epub 2009 Mar 31.


Elevations of intracellular calcium reflect normal voltage-dependent behavior, and not constitutive activity, of voltage-dependent calcium channels in gastrointestinal and vascular smooth muscle.

McCarron JG, Olson ML, Currie S, Wright AJ, Anderson KI, Girkin JM.

J Gen Physiol. 2009 Apr;133(4):439-57. doi: 10.1085/jgp.200810189. Epub 2009 Mar 16.


IP(3)R-mediated Ca(2+) release is modulated by anandamide in isolated cardiac nuclei.

Currie S, Rainbow RD, Ewart MA, Kitson S, Pliego EH, Kane KA, McCarron JG.

J Mol Cell Cardiol. 2008 Dec;45(6):804-11. doi: 10.1016/j.yjmcc.2008.07.005. Epub 2008 Jul 22.


A single luminally continuous sarcoplasmic reticulum with apparently separate Ca2+ stores in smooth muscle.

McCarron JG, Olson ML.

J Biol Chem. 2008 Mar 14;283(11):7206-18. Epub 2007 Dec 20.


The mitochondrial membrane potential and Ca2+ oscillations in smooth muscle.

Chalmers S, McCarron JG.

J Cell Sci. 2008 Jan 1;121(Pt 1):75-85. Epub 2007 Dec 11.


"Quantal" Ca2+ release at the cytoplasmic aspect of the Ins(1,4,5)P3R channel in smooth muscle.

McCarron JG, Chalmers S, Muir TC.

J Cell Sci. 2008 Jan 1;121(Pt 1):86-98. Epub 2007 Dec 11.


FK506-binding protein (FKBP12) regulates ryanodine receptor-evoked Ca2+ release in colonic but not aortic smooth muscle.

MacMillan D, Currie S, McCarron JG.

Cell Calcium. 2008 Jun;43(6):539-49. Epub 2007 Oct 24.


Ion channels in smooth muscle: regulation by the sarcoplasmic reticulum and mitochondria.

Chalmers S, Olson ML, MacMillan D, Rainbow RD, McCarron JG.

Cell Calcium. 2007 Oct-Nov;42(4-5):447-66. Epub 2007 Jul 13. Review.


Ins(1,4,5)P3 receptor regulation during 'quantal' Ca2+ release in smooth muscle.

McCarron JG, Olson ML, Rainbow RD, MacMillan D, Chalmers S.

Trends Pharmacol Sci. 2007 Jun;28(6):271-9. Epub 2007 May 7. Review.


Ca2+ microdomains in smooth muscle.

McCarron JG, Chalmers S, Bradley KN, MacMillan D, Muir TC.

Cell Calcium. 2006 Nov-Dec;40(5-6):461-93. Epub 2006 Oct 27. Review.


In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin.

MacMillan D, Currie S, Bradley KN, Muir TC, McCarron JG.

J Cell Sci. 2005 Dec 1;118(Pt 23):5443-51. Epub 2005 Nov 8.


Ca(2+) spark sites in smooth muscle cells are numerous and differ in number of ryanodine receptors, large-conductance K(+) channels, and coupling ratio between them.

Zhuge R, Fogarty KE, Baker SP, McCarron JG, Tuft RA, Lifshitz LM, Walsh JV Jr.

Am J Physiol Cell Physiol. 2004 Dec;287(6):C1577-88. Epub 2004 Aug 11.

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