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Items: 29


Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface.

Koach J, Holien JK, Massudi H, Carter DR, Ciampa OC, Herath M, Lim T, Seneviratne JA, Milazzo G, Murray JE, McCarroll JA, Liu B, Mayoh C, Keenan B, Stevenson BW, Gorman MA, Bell JL, Doughty L, Hüttelmaier S, Oberthuer A, Fischer M, Gifford AJ, Liu T, Zhang X, Zhu S, Gustafson WC, Haber M, Norris MD, Fletcher JI, Perini G, Parker MW, Cheung BB, Marshall GM.

Cancer Res. 2019 Nov 1;79(21):5652-5667. doi: 10.1158/0008-5472.CAN-19-1112. Epub 2019 Sep 9.


Identification of Novel Medulloblastoma Cell-Targeting Peptides for Use in Selective Chemotherapy Drug Delivery.

Tjandra KC, McCarthy N, Yang L, Laos AJ, Sharbeen G, Phillips PA, Forgham H, Sagnella SM, Whan RM, Kavallaris M, Thordarson P, McCarroll JA.

J Med Chem. 2019 Aug 1. doi: 10.1021/acs.jmedchem.9b00851. [Epub ahead of print]


The Use of Star Polymer Nanoparticles for the Delivery of siRNA to Mouse Orthotopic Pancreatic Tumor Models.

McCarroll JA, Sharbeen G, Kavallaris M, Phillips PA.

Methods Mol Biol. 2019;1974:329-353. doi: 10.1007/978-1-4939-9220-1_23.


β-tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cells.

Parker AL, Teo WS, Pandzic E, Vicente JJ, McCarroll JA, Wordeman L, Kavallaris M.

Life Sci Alliance. 2018;1(2). pii: e201800059. doi: 10.26508/lsa.201800059. Epub 2018 Apr 19.


Targeted Doxorubicin-Loaded Bacterially Derived Nano-Cells for the Treatment of Neuroblastoma.

Sagnella SM, Trieu J, Brahmbhatt H, MacDiarmid JA, MacMillan A, Whan RM, Fife CM, McCarroll JA, Gifford AJ, Ziegler DS, Kavallaris M.

Mol Cancer Ther. 2018 May;17(5):1012-1023. doi: 10.1158/1535-7163.MCT-17-0738. Epub 2018 Feb 28.


An Emerging Role for Tubulin Isotypes in Modulating Cancer Biology and Chemotherapy Resistance.

Parker AL, Teo WS, McCarroll JA, Kavallaris M.

Int J Mol Sci. 2017 Jul 4;18(7). pii: E1434. doi: 10.3390/ijms18071434. Review.


Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration.

Fife CM, Sagnella SM, Teo WS, Po'uha ST, Byrne FL, Yeap YY, Ng DC, Davis TP, McCarroll JA, Kavallaris M.

Oncogene. 2017 Jan 26;36(4):501-511. doi: 10.1038/onc.2016.220. Epub 2016 Jun 20.


A Rationally Optimized Nanoparticle System for the Delivery of RNA Interference Therapeutics into Pancreatic Tumors in Vivo.

Teo J, McCarroll JA, Boyer C, Youkhana J, Sagnella SM, Duong HT, Liu J, Sharbeen G, Goldstein D, Davis TP, Kavallaris M, Phillips PA.

Biomacromolecules. 2016 Jul 11;17(7):2337-51. doi: 10.1021/acs.biomac.6b00185. Epub 2016 Jun 28.


βIII-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells.

Parker AL, Turner N, McCarroll JA, Kavallaris M.

Carcinogenesis. 2016 Aug;37(8):787-798. doi: 10.1093/carcin/bgw058. Epub 2016 May 4.


Analyses of Tumor Burden In Vivo and Metastasis Ex Vivo Using Luciferase-Expressing Cancer Cells in an Orthotopic Mouse Model of Neuroblastoma.

Byrne FL, McCarroll JA, Kavallaris M.

Methods Mol Biol. 2016;1372:61-77. doi: 10.1007/978-1-4939-3148-4_5.


Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer.

McCarroll JA, Dwarte T, Baigude H, Dang J, Yang L, Erlich RB, Kimpton K, Teo J, Sagnella SM, Akerfeldt MC, Liu J, Phillips PA, Rana TM, Kavallaris M.

Oncotarget. 2015 May 20;6(14):12020-34.


βIII-tubulin: a novel mediator of chemoresistance and metastases in pancreatic cancer.

McCarroll JA, Sharbeen G, Liu J, Youkhana J, Goldstein D, McCarthy N, Limbri LF, Dischl D, Ceyhan GO, Erkan M, Johns AL, Biankin AV, Kavallaris M, Phillips PA.

Oncotarget. 2015 Feb 10;6(4):2235-49.


TUBB3/βIII-tubulin acts through the PTEN/AKT signaling axis to promote tumorigenesis and anoikis resistance in non-small cell lung cancer.

McCarroll JA, Gan PP, Erlich RB, Liu M, Dwarte T, Sagnella SS, Akerfeldt MC, Yang L, Parker AL, Chang MH, Shum MS, Byrne FL, Kavallaris M.

Cancer Res. 2015 Jan 15;75(2):415-25. doi: 10.1158/0008-5472.CAN-14-2740. Epub 2014 Nov 20.


Microtubules and their role in cellular stress in cancer.

Parker AL, Kavallaris M, McCarroll JA.

Front Oncol. 2014 Jun 18;4:153. doi: 10.3389/fonc.2014.00153. eCollection 2014. Review.


Drug delivery: beyond active tumour targeting.

Sagnella SM, McCarroll JA, Kavallaris M.

Nanomedicine. 2014 Aug;10(6):1131-7. doi: 10.1016/j.nano.2014.04.012. Epub 2014 May 10. Review.


Role of pancreatic stellate cells in chemoresistance in pancreatic cancer.

McCarroll JA, Naim S, Sharbeen G, Russia N, Lee J, Kavallaris M, Goldstein D, Phillips PA.

Front Physiol. 2014 Apr 9;5:141. doi: 10.3389/fphys.2014.00141. eCollection 2014. Review.


Movers and shakers: cell cytoskeleton in cancer metastasis.

Fife CM, McCarroll JA, Kavallaris M.

Br J Pharmacol. 2014 Dec;171(24):5507-23. doi: 10.1111/bph.12704. Epub 2014 Jul 2. Review. Erratum in: Br J Pharmacol. 2017 Jan;174(1):116.


Dextran-based doxorubicin nanocarriers with improved tumor penetration.

Sagnella SM, Duong H, MacMillan A, Boyer C, Whan R, McCarroll JA, Davis TP, Kavallaris M.

Biomacromolecules. 2014 Jan 13;15(1):262-75. doi: 10.1021/bm401526d. Epub 2013 Dec 18.


RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model.

Byrne FL, Yang L, Phillips PA, Hansford LM, Fletcher JI, Ormandy CJ, McCarroll JA, Kavallaris M.

Oncogene. 2014 Feb 13;33(7):882-90. doi: 10.1038/onc.2013.11. Epub 2013 Feb 11.


Specific β-tubulin isotypes can functionally enhance or diminish epothilone B sensitivity in non-small cell lung cancer cells.

Gan PP, McCarroll JA, Byrne FL, Garner J, Kavallaris M.

PLoS One. 2011;6(6):e21717. doi: 10.1371/journal.pone.0021717. Epub 2011 Jun 29.


betaIII-tubulin is a multifunctional protein involved in drug sensitivity and tumorigenesis in non-small cell lung cancer.

McCarroll JA, Gan PP, Liu M, Kavallaris M.

Cancer Res. 2010 Jun 15;70(12):4995-5003. doi: 10.1158/0008-5472.CAN-09-4487. Epub 2010 May 25.


Microtubule dynamics, mitotic arrest, and apoptosis: drug-induced differential effects of betaIII-tubulin.

Gan PP, McCarroll JA, Po'uha ST, Kamath K, Jordan MA, Kavallaris M.

Mol Cancer Ther. 2010 May;9(5):1339-48. doi: 10.1158/1535-7163.MCT-09-0679. Epub 2010 May 4.


Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

Phillips PA, Dudeja V, McCarroll JA, Borja-Cacho D, Dawra RK, Grizzle WE, Vickers SM, Saluja AK.

Cancer Res. 2007 Oct 1;67(19):9407-16.


Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis.

McCarroll JA, Phillips PA, Santucci N, Pirola RC, Wilson JS, Apte MV.

Gut. 2006 Jan;55(1):79-89. Epub 2005 Jul 25.


Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells.

Apte MV, Park S, Phillips PA, Santucci N, Goldstein D, Kumar RK, Ramm GA, Buchler M, Friess H, McCarroll JA, Keogh G, Merrett N, Pirola R, Wilson JS.

Pancreas. 2004 Oct;29(3):179-87.


Pancreatic stellate cell migration: role of the phosphatidylinositol 3-kinase(PI3-kinase) pathway.

McCarroll JA, Phillips PA, Kumar RK, Park S, Pirola RC, Wilson JS, Apte MV.

Biochem Pharmacol. 2004 Mar 15;67(6):1215-25.


Pancreatic stellate cell activation by ethanol and acetaldehyde: is it mediated by the mitogen-activated protein kinase signaling pathway?

McCarroll JA, Phillips PA, Park S, Doherty E, Pirola RC, Wilson JS, Apte MV.

Pancreas. 2003 Aug;27(2):150-60.


Cell migration: a novel aspect of pancreatic stellate cell biology.

Phillips PA, Wu MJ, Kumar RK, Doherty E, McCarroll JA, Park S, Pirola RC, Wilson JS, Apte MV.

Gut. 2003 May;52(5):677-82.


Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover.

Phillips PA, McCarroll JA, Park S, Wu MJ, Pirola R, Korsten M, Wilson JS, Apte MV.

Gut. 2003 Feb;52(2):275-82.

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