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MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinoma.

Berggren KL, Restrepo Cruz S, Hixon MD, Cowan AT, Keysar SB, Craig S, James J, Barry M, Ozbun MA, Jimeno A, McCance DJ, Beswick EJ, Gan GN.

Oncogene. 2019 Aug 15. doi: 10.1038/s41388-019-0945-9. [Epub ahead of print]


Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach.

Craig SG, Anderson LA, Schache AG, Moran M, Graham L, Currie K, Rooney K, Robinson M, Upile NS, Brooker R, Mesri M, Bingham V, McQuaid S, Jones T, McCance DJ, Salto-Tellez M, McDade SS, James JA.

Br J Cancer. 2019 Apr;120(8):827-833. doi: 10.1038/s41416-019-0414-9. Epub 2019 Mar 20.


ΔNp63γ/SRC/Slug Signaling Axis Promotes Epithelial-to-Mesenchymal Transition in Squamous Cancers.

Srivastava K, Pickard A, Craig SG, Quinn GP, Lambe SM, James JA, McDade SS, McCance DJ.

Clin Cancer Res. 2018 Aug 15;24(16):3917-3927. doi: 10.1158/1078-0432.CCR-17-3775. Epub 2018 May 8.


The IGF axis in HPV associated cancers.

Pickard A, Durzynska J, McCance DJ, Barton ER.

Mutat Res Rev Mutat Res. 2017 Apr - Jun;772:67-77. doi: 10.1016/j.mrrev.2017.01.002. Epub 2017 Feb 4. Review.


HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology.

Schache AG, Powell NG, Cuschieri KS, Robinson M, Leary S, Mehanna H, Rapozo D, Long A, Cubie H, Junor E, Monaghan H, Harrington KJ, Nutting CM, Schick U, Lau AS, Upile N, Sheard J, Brougham K, West CM, Oguejiofor K, Thomas S, Ness AR, Pring M, Thomas GJ, King EV, McCance DJ, James JA, Moran M, Sloan P, Shaw RJ, Evans M, Jones TM.

Cancer Res. 2016 Nov 15;76(22):6598-6606. doi: 10.1158/0008-5472.CAN-16-0633. Epub 2016 Aug 28.


HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures.

Pickard A, McDade SS, McFarland M, McCluggage WG, Wheeler CM, McCance DJ.

PLoS Pathog. 2015 Jun 24;11(6):e1004988. doi: 10.1371/journal.ppat.1004988. eCollection 2015 Jun.


p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling.

Srivastava K, Pickard A, McDade S, McCance DJ.

Oncotarget. 2017 Mar 7;8(10):16202-16219. doi: 10.18632/oncotarget.3892.


IGF-Binding Protein 2 - Oncogene or Tumor Suppressor?

Pickard A, McCance DJ.

Front Endocrinol (Lausanne). 2015 Feb 27;6:25. doi: 10.3389/fendo.2015.00025. eCollection 2015. Review.


Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress.

McDade SS, Patel D, Moran M, Campbell J, Fenwick K, Kozarewa I, Orr NJ, Lord CJ, Ashworth AA, McCance DJ.

Nucleic Acids Res. 2014 Jun;42(10):6270-85. doi: 10.1093/nar/gku299. Epub 2014 May 13.


Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability.

Savage KI, Gorski JJ, Barros EM, Irwin GW, Manti L, Powell AJ, Pellagatti A, Lukashchuk N, McCance DJ, McCluggage WG, Schettino G, Salto-Tellez M, Boultwood J, Richard DJ, McDade SS, Harkin DP.

Mol Cell. 2014 May 8;54(3):445-59. doi: 10.1016/j.molcel.2014.03.021. Epub 2014 Apr 17.


miR-24 and miR-205 expression is dependent on HPV onco-protein expression in keratinocytes.

McKenna DJ, Patel D, McCance DJ.

Virology. 2014 Jan 5;448:210-6. doi: 10.1016/j.virol.2013.10.014. Epub 2013 Oct 29.


AKT in stromal fibroblasts controls invasion of epithelial cells.

Cichon AC, Pickard A, McDade SS, Sharpe DJ, Moran M, James JA, McCance DJ.

Oncotarget. 2013 Jul;4(7):1103-16.


Regulation of epithelial differentiation and proliferation by the stroma: a role for the retinoblastoma protein.

Pickard A, Cichon AC, Menges C, Patel D, McCance DJ.

J Invest Dermatol. 2012 Dec;132(12):2691-9. doi: 10.1038/jid.2012.201. Epub 2012 Jun 14.


Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion.

Pickard A, Cichon AC, Barry A, Kieran D, Patel D, Hamilton P, Salto-Tellez M, James J, McCance DJ.

EMBO J. 2012 May 29;31(14):3092-103. doi: 10.1038/emboj.2012.153.


Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation.

McDade SS, Henry AE, Pivato GP, Kozarewa I, Mitsopoulos C, Fenwick K, Assiotis I, Hakas J, Zvelebil M, Orr N, Lord CJ, Patel D, Ashworth A, McCance DJ.

Nucleic Acids Res. 2012 Aug;40(15):7190-206. doi: 10.1093/nar/gks389. Epub 2012 May 9.


Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes.

Hyland PL, McDade SS, McCloskey R, Dickson GJ, Arthur K, McCance DJ, Patel D.

J Virol. 2011 Nov;85(21):10999-1006. doi: 10.1128/JVI.00160-11. Epub 2011 Aug 24.


p63 maintains keratinocyte proliferative capacity through regulation of Skp2-p130 levels.

McDade SS, Patel D, McCance DJ.

J Cell Sci. 2011 May 15;124(Pt 10):1635-43. doi: 10.1242/jcs.084723. Epub 2011 Apr 21.


The DeltaNp63 proteins are key allies of BRCA1 in the prevention of basal-like breast cancer.

Buckley NE, Conlon SJ, Jirstrom K, Kay EW, Crawford NT, O'Grady A, Sheehan K, Mc Dade SS, Wang CW, McCance DJ, Johnston PG, Kennedy RD, Harkin DP, Mullan PB.

Cancer Res. 2011 Mar 1;71(5):1933-44. doi: 10.1158/0008-5472.CAN-10-2717.


Role of DeltaNp63gamma in epithelial to mesenchymal transition.

Lindsay J, McDade SS, Pickard A, McCloskey KD, McCance DJ.

J Biol Chem. 2011 Feb 4;286(5):3915-24. doi: 10.1074/jbc.M110.162511. Epub 2010 Dec 2.


Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation.

Pickard A, Wong PP, McCance DJ.

J Cell Sci. 2010 Nov 1;123(Pt 21):3718-26. doi: 10.1242/jcs.068924. Epub 2010 Oct 12.


MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6.

McKenna DJ, McDade SS, Patel D, McCance DJ.

J Virol. 2010 Oct;84(20):10644-52. doi: 10.1128/JVI.00703-10. Epub 2010 Aug 11.


Human papillomavirus type 16 E6/E7 upregulation of nucleophosmin is important for proliferation and inhibition of differentiation.

McCloskey R, Menges C, Friedman A, Patel D, McCance DJ.

J Virol. 2010 May;84(10):5131-9. doi: 10.1128/JVI.01965-09. Epub 2010 Mar 17.


p300 alters keratinocyte cell growth and differentiation through regulation of p21(Waf1/CIP1).

Wong PP, Pickard A, McCance DJ.

PLoS One. 2010 Jan 13;5(1):e8369. doi: 10.1371/journal.pone.0008369.


The role of p63 in epidermal morphogenesis and neoplasia.

McDade SS, McCance DJ.

Biochem Soc Trans. 2010 Feb;38(Pt 1):223-8. doi: 10.1042/BST0380223.


The G2 p38-mediated stress-activated checkpoint pathway becomes attenuated in transformed cells.

Mikhailov A, Patel D, McCance DJ, Rieder CL.

Curr Biol. 2007 Dec 18;17(24):2162-8. Epub 2007 Nov 29.


The E7 protein from human papillomavirus type 16 enhances keratinocyte migration in an Akt-dependent manner.

Charette ST, McCance DJ.

Oncogene. 2007 Nov 15;26(52):7386-90. Epub 2007 May 28.


Human papillomavirus type 16 E7 up-regulates AKT activity through the retinoblastoma protein.

Menges CW, Baglia LA, Lapoint R, McCance DJ.

Cancer Res. 2006 Jun 1;66(11):5555-9.


AKT1 provides an essential survival signal required for differentiation and stratification of primary human keratinocytes.

Thrash BR, Menges CW, Pierce RH, McCance DJ.

J Biol Chem. 2006 Apr 28;281(17):12155-62. Epub 2006 Mar 3.


Induction of tetraploidy through loss of p53 and upregulation of Plk1 by human papillomavirus type-16 E6.

Incassati A, Patel D, McCance DJ.

Oncogene. 2006 Apr 20;25(17):2444-51.


Transcriptional regulation by human papillomaviruses.

McCance DJ.

Curr Opin Genet Dev. 2005 Oct;15(5):515-9. Review.


Human papillomaviruses and cell signaling.

McCance DJ.

Sci STKE. 2005 Jun 14;2005(288):pe29. Review.


Role of the retinoblastoma tumor suppressor protein in cellular differentiation.

Nguyen DX, McCance DJ.

J Cell Biochem. 2005 Apr 1;94(5):870-9. Review.


Acetylation regulates the differentiation-specific functions of the retinoblastoma protein.

Nguyen DX, Baglia LA, Huang SM, Baker CM, McCance DJ.

EMBO J. 2004 Apr 7;23(7):1609-18. Epub 2004 Mar 25.


CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter.

Ionescu AM, Drissi H, Schwarz EM, Kato M, Puzas JE, McCance DJ, Rosier RN, Zuscik MJ, O'Keefe RJ.

J Cell Physiol. 2004 Mar;198(3):428-40.


E7 abolishes raf-induced arrest via mislocalization of p21(Cip1).

Westbrook TF, Nguyen DX, Thrash BR, McCance DJ.

Mol Cell Biol. 2002 Oct;22(20):7041-52.


The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300.

Patel D, Huang SM, Baglia LA, McCance DJ.

EMBO J. 1999 Sep 15;18(18):5061-72.


The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth.

Brehm A, Nielsen SJ, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T.

EMBO J. 1999 May 4;18(9):2449-58.


Human papillomaviruses and cervical cancer.

McCance DJ.

J Med Microbiol. 1998 May;47(5):371-3. Review. No abstract available.


Active domains of human papillomavirus type 11 E1 protein for origin replication.

Sun Y, Han H, McCance DJ.

J Gen Virol. 1998 Jul;79 ( Pt 7):1651-8.


Rb binds c-Jun and activates transcription.

Nead MA, Baglia LA, Antinore MJ, Ludlow JW, McCance DJ.

EMBO J. 1998 Apr 15;17(8):2342-52.

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