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Items: 47


Neurofilament as a potential biomarker for spinal muscular atrophy.

Darras BT, Crawford TO, Finkel RS, Mercuri E, De Vivo DC, Oskoui M, Tizzano EF, Ryan MM, Muntoni F, Zhao G, Staropoli J, McCampbell A, Petrillo M, Stebbins C, Fradette S, Farwell W, Sumner CJ.

Ann Clin Transl Neurol. 2019 Apr 17;6(5):932-944. doi: 10.1002/acn3.779. eCollection 2019 May.


Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity.

Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L.

Science. 2019 Feb 15;363(6428). pii: eaav2606. doi: 10.1126/science.aav2606.


Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models.

McCampbell A, Cole T, Wegener AJ, Tomassy GS, Setnicka A, Farley BJ, Schoch KM, Hoye ML, Shabsovich M, Sun L, Luo Y, Zhang M, Comfort N, Wang B, Amacker J, Thankamony S, Salzman DW, Cudkowicz M, Graham DL, Bennett CF, Kordasiewicz HB, Swayze EE, Miller TM.

J Clin Invest. 2018 Aug 1;128(8):3558-3567. doi: 10.1172/JCI99081. Epub 2018 Jul 16.


Antisense-mediated reduction of EphA4 in the adult CNS does not improve the function of mice with amyotrophic lateral sclerosis.

Ling KK, Jackson M, Alkam D, Liu D, Allaire N, Sun C, Kiaei M, McCampbell A, Rigo F.

Neurobiol Dis. 2018 Jun;114:174-183. doi: 10.1016/j.nbd.2018.03.002. Epub 2018 Mar 6.


C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity.

Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB, Perkins EM, Dando O, Lillico SG, Lee YB, Nishimura AL, Poreci U, Thankamony S, Pray M, Vasistha NA, Magnani D, Borooah S, Burr K, Story D, McCampbell A, Shaw CE, Kind PC, Aitman TJ, Whitelaw CBA, Wilmut I, Smith C, Miles GB, Hardingham GE, Wyllie DJA, Chandran S.

Nat Commun. 2018 Jan 24;9(1):347. doi: 10.1038/s41467-017-02729-0.


Tissue Thickness Effects on Immunohistochemical Staining Intensity of Markers of Cancer.

McCampbell AS, Raghunathan V, Tom-Moy M, Workman RK, Haven R, Ben-Dor A, Rasmussen OF, Jacobsen L, Lindberg M, Yamada NA, Schembri C.

Appl Immunohistochem Mol Morphol. 2017 Oct 27. doi: 10.1097/PAI.0000000000000593. [Epub ahead of print]


Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis.

Gendron TF, Chew J, Stankowski JN, Hayes LR, Zhang YJ, Prudencio M, Carlomagno Y, Daughrity LM, Jansen-West K, Perkerson EA, O'Raw A, Cook C, Pregent L, Belzil V, van Blitterswijk M, Tabassian LJ, Lee CW, Yue M, Tong J, Song Y, Castanedes-Casey M, Rousseau L, Phillips V, Dickson DW, Rademakers R, Fryer JD, Rush BK, Pedraza O, Caputo AM, Desaro P, Palmucci C, Robertson A, Heckman MG, Diehl NN, Wiggs E, Tierney M, Braun L, Farren J, Lacomis D, Ladha S, Fournier CN, McCluskey LF, Elman LB, Toledo JB, McBride JD, Tiloca C, Morelli C, Poletti B, Solca F, Prelle A, Wuu J, Jockel-Balsarotti J, Rigo F, Ambrose C, Datta A, Yang W, Raitcheva D, Antognetti G, McCampbell A, Van Swieten JC, Miller BL, Boxer AL, Brown RH, Bowser R, Miller TM, Trojanowski JQ, Grossman M, Berry JD, Hu WT, Ratti A, Traynor BJ, Disney MD, Benatar M, Silani V, Glass JD, Floeter MK, Rothstein JD, Boylan KB, Petrucelli L.

Sci Transl Med. 2017 Mar 29;9(383). pii: eaai7866. doi: 10.1126/scitranslmed.aai7866.


Protein misfolding in neurodegenerative diseases: implications and strategies.

Sweeney P, Park H, Baumann M, Dunlop J, Frydman J, Kopito R, McCampbell A, Leblanc G, Venkateswaran A, Nurmi A, Hodgson R.

Transl Neurodegener. 2017 Mar 13;6:6. doi: 10.1186/s40035-017-0077-5. eCollection 2017. Review.


Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity.

McCampbell AS, Mittelstadt ML, Dere R, Kim S, Zhou L, Djordjevic B, Soliman PT, Zhang Q, Wei C, Hursting SD, Lu KH, Broaddus RR, Walker CL.

Curr Mol Med. 2016;16(3):252-65.


Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription.

Periz G, Lu J, Zhang T, Kankel MW, Jablonski AM, Kalb R, McCampbell A, Wang J.

PLoS Biol. 2015 Apr 2;13(4):e1002114. doi: 10.1371/journal.pbio.1002114. eCollection 2015 Apr.


Rescue of gene-expression changes in an induced mouse model of spinal muscular atrophy by an antisense oligonucleotide that promotes inclusion of SMN2 exon 7.

Staropoli JF, Li H, Chun SJ, Allaire N, Cullen P, Thai A, Fleet CM, Hua Y, Bennett CF, Krainer AR, Kerr D, McCampbell A, Rigo F, Carulli JP.

Genomics. 2015 Apr;105(4):220-8. doi: 10.1016/j.ygeno.2015.01.007. Epub 2015 Jan 31.


Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase.

Converso A, Hartingh T, Fraley ME, Garbaccio RM, Hartman GD, Huang SY, Majercak JM, McCampbell A, Na SJ, Ray WJ, Savage MJ, Wolffe C, Yeh S, Yu Y, White R, Zhang R.

Bioorg Med Chem Lett. 2014 Jun 15;24(12):2737-40. doi: 10.1016/j.bmcl.2014.04.034. Epub 2014 Apr 18.


CGRRF1 as a novel biomarker of tissue response to metformin in the context of obesity.

Zhang Q, Schmandt R, Celestino J, McCampbell A, Yates MS, Urbauer DL, Broaddus RR, Loose DS, Shipley GL, Lu KH.

Gynecol Oncol. 2014 Apr;133(1):83-9. doi: 10.1016/j.ygyno.2013.12.006.


A sensitive aβ oligomer assay discriminates Alzheimer's and aged control cerebrospinal fluid.

Savage MJ, Kalinina J, Wolfe A, Tugusheva K, Korn R, Cash-Mason T, Maxwell JW, Hatcher NG, Haugabook SJ, Wu G, Howell BJ, Renger JJ, Shughrue PJ, McCampbell A.

J Neurosci. 2014 Feb 19;34(8):2884-97. doi: 10.1523/JNEUROSCI.1675-13.2014.


Developability studies before initiation of process development: improving manufacturability of monoclonal antibodies.

Yang X, Xu W, Dukleska S, Benchaar S, Mengisen S, Antochshuk V, Cheung J, Mann L, Babadjanova Z, Rowand J, Gunawan R, McCampbell A, Beaumont M, Meininger D, Richardson D, Ambrogelly A.

MAbs. 2013 Sep-Oct;5(5):787-94. doi: 10.4161/mabs.25269. Epub 2013 Jun 7.


Critical tumor suppressor function mediated by epithelial Mig-6 in endometrial cancer.

Kim TH, Lee DK, Cho SN, Orvis GD, Behringer RR, Lydon JP, Ku BJ, McCampbell AS, Broaddus RR, Jeong JW.

Cancer Res. 2013 Aug 15;73(16):5090-9. doi: 10.1158/0008-5472.CAN-13-0241. Epub 2013 Jun 27.


Chemopreventive effects of metformin on obesity-associated endometrial proliferation.

Zhang Q, Celestino J, Schmandt R, McCampbell AS, Urbauer DL, Meyer LA, Burzawa JK, Huang M, Yates MS, Iglesias D, Broaddus RR, Lu KH.

Am J Obstet Gynecol. 2013 Jul;209(1):24.e1-24.e12. doi: 10.1016/j.ajog.2013.03.008. Epub 2013 Mar 15.


TASK-3 as a potential antidepressant target.

Gotter AL, Santarelli VP, Doran SM, Tannenbaum PL, Kraus RL, Rosahl TW, Meziane H, Montial M, Reiss DR, Wessner K, McCampbell A, Stevens J, Brunner JI, Fox SV, Uebele VN, Bayliss DA, Winrow CJ, Renger JJ.

Brain Res. 2011 Oct 6;1416:69-79. doi: 10.1016/j.brainres.2011.08.021. Epub 2011 Aug 16.


cSSMD: assessing collective activity for addressing off-target effects in genome-scale RNA interference screens.

Zhang XD, Santini F, Lacson R, Marine SD, Wu Q, Benetti L, Yang R, McCampbell A, Berger JP, Toolan DM, Stec EM, Holder DJ, Soper KA, Heyse JF, Ferrer M.

Bioinformatics. 2011 Oct 15;27(20):2775-81. doi: 10.1093/bioinformatics/btr474. Epub 2011 Aug 16.


High throughput monitoring of amyloid-β(42) assembly into soluble oligomers achieved by sensitive conformation state-dependent immunoassays.

Zhao WQ, Toolan D, Hepler RW, Wolfe AL, Yu Y, Price E, Uebele VN, Schachter JB, Reynolds IJ, Renger JJ, McCampbell A, Ray WJ.

J Alzheimers Dis. 2011;25(4):655-69. doi: 10.3233/JAD-2011-102022.


Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine.

McCampbell A, Wessner K, Marlatt MW, Wolffe C, Toolan D, Podtelezhnikov A, Yeh S, Zhang R, Szczerba P, Tanis KQ, Majercak J, Ray WJ, Savage M.

J Neurochem. 2011 Jan;116(1):82-92. doi: 10.1111/j.1471-4159.2010.07087.x. Epub 2010 Dec 2.


The use of SSMD-based false discovery and false nondiscovery rates in genome-scale RNAi screens.

Zhang XD, Lacson R, Yang R, Marine SD, McCampbell A, Toolan DM, Hare TR, Kajdas J, Berger JP, Holder DJ, Heyse JF, Ferrer M.

J Biomol Screen. 2010 Oct;15(9):1123-31. doi: 10.1177/1087057110381919. Epub 2010 Sep 17.


Sex hormone regulation of survivin gene expression.

Nabilsi NH, Broaddus RR, McCampbell AS, Lu KH, Lynch HT, Chen LM, Loose DS.

J Endocrinol. 2010 Nov;207(2):237-43. doi: 10.1677/JOE-10-0128. Epub 2010 Aug 26.


Loss of inhibitory insulin receptor substrate-1 phosphorylation: An early event in endometrial hyperplasia and progression to carcinoma.

McCampbell AS, Broaddus RR, Walker CL.

Cell Cycle. 2010 Jul 15;9(14):2698-9. Epub 2010 Jul 9. No abstract available.


Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of rapamycin-dependent endometrial hyperplasia and carcinoma.

McCampbell AS, Harris HA, Crabtree JS, Winneker RC, Walker CL, Broaddus RR.

Cancer Prev Res (Phila). 2010 Mar;3(3):290-300. doi: 10.1158/1940-6207.CAPR-09-0199. Epub 2010 Feb 23.


Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1.

Eichler FS, Hornemann T, McCampbell A, Kuljis D, Penno A, Vardeh D, Tamrazian E, Garofalo K, Lee HJ, Kini L, Selig M, Frosch M, Gable K, von Eckardstein A, Woolf CJ, Guan G, Harmon JM, Dunn TM, Brown RH Jr.

J Neurosci. 2009 Nov 18;29(46):14646-51. doi: 10.1523/JNEUROSCI.2536-09.2009.


Molecular clustering of endometrial carcinoma based on estrogen-induced gene expression.

Westin SN, Broaddus RR, Deng L, McCampbell A, Lu KH, Lacour RA, Milam MR, Urbauer DL, Mueller P, Pickar JH, Loose DS.

Cancer Biol Ther. 2009 Nov;8(22):2126-35. Epub 2009 Nov 5.


Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.

Ma L, Seager MA, Wittmann M, Jacobson M, Bickel D, Burno M, Jones K, Graufelds VK, Xu G, Pearson M, McCampbell A, Gaspar R, Shughrue P, Danziger A, Regan C, Flick R, Pascarella D, Garson S, Doran S, Kreatsoulas C, Veng L, Lindsley CW, Shipe W, Kuduk S, Sur C, Kinney G, Seabrook GR, Ray WJ.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15950-5. doi: 10.1073/pnas.0900903106. Epub 2009 Aug 26. Erratum in: Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):18040. Seager, Matthew [corrected to Seager, Matthew A].


Comparison of human and rat uterine leiomyomata: identification of a dysregulated mammalian target of rapamycin pathway.

Crabtree JS, Jelinsky SA, Harris HA, Choe SE, Cotreau MM, Kimberland ML, Wilson E, Saraf KA, Liu W, McCampbell AS, Dave B, Broaddus RR, Brown EL, Kao W, Skotnicki JS, Abou-Gharbia M, Winneker RC, Walker CL.

Cancer Res. 2009 Aug 1;69(15):6171-8. doi: 10.1158/0008-5472.CAN-08-4471. Epub 2009 Jul 21.


Enhanced estrogen-induced proliferation in obese rat endometrium.

Zhang Q, Shen Q, Celestino J, Milam MR, Westin SN, Lacour RA, Meyer LA, Shipley GL, Davies PJ, Deng L, McCampbell AS, Broaddus RR, Lu KH.

Am J Obstet Gynecol. 2009 Feb;200(2):186.e1-8. doi: 10.1016/j.ajog.2008.08.064.


Developmental reprogramming of IGF signaling and susceptibility to endometrial hyperplasia in the rat.

McCampbell AS, Walker CL, Broaddus RR, Cook JD, Davies PJ.

Lab Invest. 2008 Jun;88(6):615-26. doi: 10.1038/labinvest.2008.29. Epub 2008 Apr 21.


Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium.

McCampbell AS, Broaddus RR, Loose DS, Davies PJ.

Clin Cancer Res. 2006 Nov 1;12(21):6373-8.


Identification of a novel estrogen-regulated gene, EIG121, induced by hormone replacement therapy and differentially expressed in type I and type II endometrial cancer.

Deng L, Broaddus RR, McCampbell A, Shipley GL, Loose DS, Stancel GM, Pickar JH, Davies PJ.

Clin Cancer Res. 2005 Dec 1;11(23):8258-64.


Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy.

McCampbell A, Truong D, Broom DC, Allchorne A, Gable K, Cutler RG, Mattson MP, Woolf CJ, Frosch MP, Harmon JM, Dunn TM, Brown RH Jr.

Hum Mol Genet. 2005 Nov 15;14(22):3507-21. Epub 2005 Oct 6.


Adrenomyeloneuropathy: report of a new mutation in a French Canadian female.

Dionne A, Brunet D, McCampbell A, Dupré N.

Can J Neurol Sci. 2005 May;32(2):261-3.


Histone deacetylase inhibitors reduce polyglutamine toxicity.

McCampbell A, Taye AA, Whitty L, Penney E, Steffan JS, Fischbeck KH.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15179-84. Epub 2001 Dec 11.


Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.

Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, Schmidt E, Zhu YZ, Greenwald M, Kurokawa R, Housman DE, Jackson GR, Marsh JL, Thompson LM.

Nature. 2001 Oct 18;413(6857):739-43.


Polyglutamine and CBP: fatal attraction?

McCampbell A, Fischbeck KH.

Nat Med. 2001 May;7(5):528-30. No abstract available.


CREB-binding protein sequestration by expanded polyglutamine.

McCampbell A, Taylor JP, Taye AA, Robitschek J, Li M, Walcott J, Merry D, Chai Y, Paulson H, Sobue G, Fischbeck KH.

Hum Mol Genet. 2000 Sep 1;9(14):2197-202.


Multiple chemical sensitivity.

McCampbell A.

Am Fam Physician. 2000 Jan 1;61(1):45. No abstract available.


Dr. Kelly West and a brief history of the diabetes epidemic of American Indians.

McCampbell A.

J Okla State Med Assoc. 1999 Aug;92(8):444. No abstract available.


Understanding patients with multiple chemical sensitivity.

McCampbell A.

Am Fam Physician. 1999 Apr 15;59(8):2111-2; author reply 2115-6. No abstract available.


Comparison of site specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin.

Dornan WA, McCampbell AR, Tinkler GP, Hickman LJ, Bannon AW, Decker MW, Gunther KL.

Behav Brain Res. 1997 Jul;86(2):181-9.


Iatrogenic (physician-induced) hypochondriasis.

McCampbell A.

Psychosomatics. 1997 May-Jun;38(3):300-2. No abstract available.


Comparison of site-specific injections into the basal forebrain on water maze and radial arm maze performance in the male rat after immunolesioning with 192 IgG saporin.

Dornan WA, McCampbell AR, Tinkler GP, Hickman LJ, Bannon AW, Decker MW, Gunther KL.

Behav Brain Res. 1996 Dec;82(1):93-101.


Controversy over multiple chemical sensitivities.

McCampbell A.

Ann Intern Med. 1994 Feb 1;120(3):250; author reply 250-1. No abstract available.


Bilateral injections of beta A(25-35) + IBO into the hippocampus disrupts acquisition of spatial learning in the rat.

Dornan WA, Kang DE, McCampbell A, Kang EE.

Neuroreport. 1993 Nov 18;5(2):165-8.


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