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Items: 20


Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3.

Noori MS, Bhatt PM, Courreges MC, Ghazanfari D, Cuckler C, Orac CM, McMills MC, Schwartz FL, Deosarkar SP, Bergmeier SC, McCall KD, Goetz DJ.

Am J Physiol Cell Physiol. 2019 Dec 1;317(6):C1289-C1303. doi: 10.1152/ajpcell.00061.2019. Epub 2019 Sep 25.


Phenylmethimazole abrogates diet-induced inflammation, glucose intolerance and NAFLD.

Patton A, Church T, Wilson C, Thuma J, Goetz DJ, Berryman DE, List EO, Schwartz F, McCall KD.

J Endocrinol. 2018 Jun;237(3):337-351. doi: 10.1530/JOE-18-0078. Epub 2018 Apr 17.


Phenylmethimazole and a thiazole derivative of phenylmethimazole inhibit IL-6 expression by triple negative breast cancer cells.

Noori MS, O'Brien JD, Champa ZJ, Deosarkar SP, Lanier OL, Qi C, Burdick MM, Schwartz FL, Bergmeier SC, McCall KD, Goetz DJ.

Eur J Pharmacol. 2017 May 15;803:130-137. doi: 10.1016/j.ejphar.2017.03.049. Epub 2017 Mar 23.


TLR signaling inhibitor, phenylmethimazole, in combination with tamoxifen inhibits human breast cancer cell viability and migration.

Schwartz AL, Dickerson E, Dagia N, Malgor R, McCall KD.

Oncotarget. 2016 Jul 1;8(69):113295-113302. doi: 10.18632/oncotarget.10358. eCollection 2017 Dec 26.


Laser capture microdissection tailored to type 1 diabetes mellitus research.

Szulawski R, Nakazawa M, McCall KD, James CB, Schwartz FL.

Biotechniques. 2016 Jun 1;60(6):293-8. doi: 10.2144/000114426. eCollection 2016.


Simple modifications to methimazole that enhance its inhibitory effect on tumor necrosis factor-α-induced vascular cell adhesion molecule-1 expression by human endothelial cells.

Alapati A, Deosarkar SP, Lanier OL, Qi C, Carlson GE, Burdick MM, Schwartz FL, McCall KD, Bergmeier SC, Goetz DJ.

Eur J Pharmacol. 2015 Mar 15;751:59-66. doi: 10.1016/j.ejphar.2015.01.032. Epub 2015 Jan 29.


Diet is critical for prolonged glycemic control after short-term insulin treatment in high-fat diet-induced type 2 diabetic male mice.

Guo A, Daniels NA, Thuma J, McCall KD, Malgor R, Schwartz FL.

PLoS One. 2015 Jan 29;10(1):e0117556. doi: 10.1371/journal.pone.0117556. eCollection 2015.


Toll-like receptor 3 is critical for coxsackievirus B4-induced type 1 diabetes in female NOD mice.

McCall KD, Thuma JR, Courreges MC, Benencia F, James CB, Malgor R, Kantake N, Mudd W, Denlinger N, Nolan B, Wen L, Schwartz FL.

Endocrinology. 2015 Feb;156(2):453-61. doi: 10.1210/en.2013-2006. Epub 2014 Nov 25.


Inhibition of LPS-induced TLR4 signaling products in murine macrophages by phenylmethimazole: an assay methodology for screening potential phenylmethimazole analogs.

Deosarkar SP, Bhatt P, Gillespie J, Goetz DJ, McCall KD.

Drug Dev Res. 2014 Dec;75(8):497-509. doi: 10.1002/ddr.21231. Epub 2014 Nov 18. Erratum in: Drug Dev Res. 2015 Mar;76(2):105.


Wnt5a, TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions.

Malgor R, Bhatt PM, Connolly BA, Jacoby DL, Feldmann KJ, Silver MJ, Nakazawa M, McCall KD, Goetz DJ.

Inflamm Res. 2014 Apr;63(4):277-85. doi: 10.1007/s00011-013-0697-x. Epub 2013 Dec 18.


Phenylmethimazole suppresses dsRNA-induced cytotoxicity and inflammatory cytokines in murine pancreatic beta cells and blocks viral acceleration of type 1 diabetes in NOD mice.

McCall KD, Schmerr MJ, Thuma JR, James CB, Courreges MC, Benencia F, Malgor R, Schwartz FL.

Molecules. 2013 Mar 27;18(4):3841-58. doi: 10.3390/molecules18043841.


Phenylmethimazole blocks dsRNA-induced IRF3 nuclear translocation and homodimerization.

Courreges MC, Kantake N, Goetz DJ, Schwartz FL, McCall KD.

Molecules. 2012 Oct 22;17(10):12365-77. doi: 10.3390/molecules171012365.


Increased Wnt5a mRNA Expression in Advanced Atherosclerotic Lesions, and Oxidized LDL Treated Human Monocyte-Derived Macrophages.

Bhatt PM, Lewis CJ, House DL, Keller CM, Kohn LD, Silver MJ, McCall KD, Goetz DJ, Malgor R.

Open Circ Vasc J. 2012;5:1-7.


Phenylmethimazole inhibits production of proinflammatory mediators and is protective in an experimental model of endotoxic shock*.

Benavides U, Gonzalez-Murguiondo M, Harii N, Lewis CJ, Schwartz AL, Giuliani C, Napolitano G, Dagia NM, Malgor R, McCall KD, Kohn LD.

Crit Care Med. 2012 Mar;40(3):886-94. doi: 10.1097/CCM.0b013e318236ef8b.


Phenylmethimazole blocks palmitate-mediated induction of inflammatory cytokine pathways in 3T3L1 adipocytes and RAW 264.7 macrophages.

McCall KD, Holliday D, Dickerson E, Wallace B, Schwartz AL, Schwartz C, Lewis CJ, Kohn LD, Schwartz FL.

J Endocrinol. 2010 Dec;207(3):343-53. doi: 10.1677/JOE-09-0370. Epub 2010 Sep 2.


A sandwich ELISA for the detection of Wnt5a.

Kummitha CM, Mayle KM, Christman MA 2nd, Deosarkar SP, Schwartz AL, McCall KD, Kohn LD, Malgor R, Goetz DJ.

J Immunol Methods. 2010 Jan 31;352(1-2):38-44. doi: 10.1016/j.jim.2009.11.005. Epub 2009 Nov 15.


Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration.

Schwartz AL, Malgor R, Dickerson E, Weeraratna AT, Slominski A, Wortsman J, Harii N, Kohn AD, Moon RT, Schwartz FL, Goetz DJ, Kohn LD, McCall KD.

Clin Cancer Res. 2009 Jun 15;15(12):4114-22. doi: 10.1158/1078-0432.CCR-09-0005. Epub 2009 May 26.


Wnt5a is expressed in murine and human atherosclerotic lesions.

Christman MA 2nd, Goetz DJ, Dickerson E, McCall KD, Lewis CJ, Benencia F, Silver MJ, Kohn LD, Malgor R.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2864-70. doi: 10.1152/ajpheart.00982.2007. Epub 2008 May 2.


Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms.

Kim WB, Lewis CJ, McCall KD, Malgor R, Kohn AD, Moon RT, Kohn LD.

J Endocrinol. 2007 Apr;193(1):93-106.


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