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Items: 29


Matrix-guided control of mitochondrial function in cardiac myocytes.

Lyra-Leite DM, Andres AM, Cho N, Petersen AP, Ariyasinghe NR, Kim SS, Gottlieb RA, McCain ML.

Acta Biomater. 2019 Oct 1;97:281-295. doi: 10.1016/j.actbio.2019.08.007. Epub 2019 Aug 8.


Engineering cardiac microphysiological systems to model pathological extracellular matrix remodeling.

Ariyasinghe NR, Lyra-Leite DM, McCain ML.

Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H771-H789. doi: 10.1152/ajpheart.00110.2018. Epub 2018 Jun 15. Review.


Featured Article: TGF-β1 dominates extracellular matrix rigidity for inducing differentiation of human cardiac fibroblasts to myofibroblasts.

Cho N, Razipour SE, McCain ML.

Exp Biol Med (Maywood). 2018 Apr;243(7):601-612. doi: 10.1177/1535370218761628. Epub 2018 Mar 4.


Fabrication of Micromolded Gelatin Hydrogels for Long-Term Culture of Aligned Skeletal Myotubes.

Suh GC, Bettadapur A, Santoso JW, McCain ML.

Methods Mol Biol. 2017;1668:147-163. doi: 10.1007/978-1-4939-7283-8_11.


Mitochondrial function in engineered cardiac tissues is regulated by extracellular matrix elasticity and tissue alignment.

Lyra-Leite DM, Andres AM, Petersen AP, Ariyasinghe NR, Cho N, Lee JA, Gottlieb RA, McCain ML.

Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H757-H767. doi: 10.1152/ajpheart.00290.2017. Epub 2017 Jul 21.


Engineering micromyocardium to delineate cellular and extracellular regulation of myocardial tissue contractility.

Ariyasinghe NR, Reck CH, Viscio AA, Petersen AP, Lyra-Leite DM, Cho N, McCain ML.

Integr Biol (Camb). 2017 Sep 18;9(9):730-741. doi: 10.1039/c7ib00081b.


Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes.

Sheehy SP, Grosberg A, Qin P, Behm DJ, Ferrier JP, Eagleson MA, Nesmith AP, Krull D, Falls JG, Campbell PH, McCain ML, Willette RN, Hu E, Parker KK.

Exp Biol Med (Maywood). 2017 Nov;242(17):1643-1656. doi: 10.1177/1535370217701006. Epub 2017 Mar 26.


Prolonged Culture of Aligned Skeletal Myotubes on Micromolded Gelatin Hydrogels.

Bettadapur A, Suh GC, Geisse NA, Wang ER, Hua C, Huber HA, Viscio AA, Kim JY, Strickland JB, McCain ML.

Sci Rep. 2016 Jun 28;6:28855. doi: 10.1038/srep28855.


Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy.

Aratyn-Schaus Y, Pasqualini FS, Yuan H, McCain ML, Ye GJ, Sheehy SP, Campbell PH, Parker KK.

J Cell Biol. 2016 Feb 15;212(4):389-97. doi: 10.1083/jcb.201508026. Epub 2016 Feb 8.


Angiotensin II Induced Cardiac Dysfunction on a Chip.

Horton RE, Yadid M, McCain ML, Sheehy SP, Pasqualini FS, Park SJ, Cho A, Campbell P, Parker KK.

PLoS One. 2016 Jan 25;11(1):e0146415. doi: 10.1371/journal.pone.0146415. eCollection 2016.


Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes.

Lee H, Adams WJ, Alford PW, McCain ML, Feinberg AW, Sheehy SP, Goss JA, Parker KK.

Exp Biol Med (Maywood). 2015 Nov;240(11):1543-54. doi: 10.1177/1535370215583799. Epub 2015 Apr 23.


Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation.

Nesmith AP, Agarwal A, McCain ML, Parker KK.

Lab Chip. 2014 Oct 21;14(20):3925-36. doi: 10.1039/c4lc00688g.


Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies.

Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT.

Nat Med. 2014 Jun;20(6):616-23. doi: 10.1038/nm.3545. Epub 2014 May 11.


Engineering cardiac cell junctions in vitro to study the intercalated disc.

McCain ML, Desplantez T, Kléber AG.

Cell Commun Adhes. 2014 Jun;21(3):181-91. doi: 10.3109/15419061.2014.905931. Epub 2014 Apr 23. Review.


Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues.

McCain ML, Agarwal A, Nesmith HW, Nesmith AP, Parker KK.

Biomaterials. 2014 Jul;35(21):5462-71. doi: 10.1016/j.biomaterials.2014.03.052. Epub 2014 Apr 14.


Matrix elasticity regulates the optimal cardiac myocyte shape for contractility.

McCain ML, Yuan H, Pasqualini FS, Campbell PH, Parker KK.

Am J Physiol Heart Circ Physiol. 2014 Jun 1;306(11):H1525-39. doi: 10.1152/ajpheart.00799.2013. Epub 2014 Mar 28.


Micropatterning Alginate Substrates for in vitro Cardiovascular Muscle on a Chip.

Agarwal A, Farouz Y, Nesmith AP, Deravi LF, McCain ML, Parker KK.

Adv Funct Mater. 2013 Aug 12;23(30):3738-3746.


Microfluidic heart on a chip for higher throughput pharmacological studies.

Agarwal A, Goss JA, Cho A, McCain ML, Parker KK.

Lab Chip. 2013 Sep 21;13(18):3599-608. doi: 10.1039/c3lc50350j.


Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip.

McCain ML, Sheehy SP, Grosberg A, Goss JA, Parker KK.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9770-5. doi: 10.1073/pnas.1304913110. Epub 2013 May 28.


A tissue-engineered jellyfish with biomimetic propulsion.

Nawroth JC, Lee H, Feinberg AW, Ripplinger CM, McCain ML, Grosberg A, Dabiri JO, Parker KK.

Nat Biotechnol. 2012 Aug;30(8):792-7.


Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle.

McCain ML, Lee H, Aratyn-Schaus Y, Kléber AG, Parker KK.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9881-6. doi: 10.1073/pnas.1203007109. Epub 2012 Jun 6.


Muscle on a chip: in vitro contractility assays for smooth and striated muscle.

Grosberg A, Nesmith AP, Goss JA, Brigham MD, McCain ML, Parker KK.

J Pharmacol Toxicol Methods. 2012 May-Jun;65(3):126-35. doi: 10.1016/j.vascn.2012.04.001. Epub 2012 Apr 12.


Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43.

Beauchamp P, Desplantez T, McCain ML, Li W, Asimaki A, Rigoli G, Parker KK, Saffitz JE, Kleber AG.

Circ Res. 2012 May 25;110(11):1445-53. doi: 10.1161/CIRCRESAHA.111.259705. Epub 2012 Apr 19.


Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current.

Desplantez T, McCain ML, Beauchamp P, Rigoli G, Rothen-Rutishauser B, Parker KK, Kleber AG.

Cardiovasc Res. 2012 Apr 1;94(1):58-65. doi: 10.1093/cvr/cvs025. Epub 2012 Jan 27.


Cell-to-cell coupling in engineered pairs of rat ventricular cardiomyocytes: relation between Cx43 immunofluorescence and intercellular electrical conductance.

McCain ML, Desplantez T, Geisse NA, Rothen-Rutishauser B, Oberer H, Parker KK, Kleber AG.

Am J Physiol Heart Circ Physiol. 2012 Jan;302(2):H443-50. doi: 10.1152/ajpheart.01218.2010. Epub 2011 Nov 11.


Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip.

Grosberg A, Alford PW, McCain ML, Parker KK.

Lab Chip. 2011 Dec 21;11(24):4165-73. doi: 10.1039/c1lc20557a. Epub 2011 Nov 10.


Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function.

McCain ML, Parker KK.

Pflugers Arch. 2011 Jul;462(1):89-104. doi: 10.1007/s00424-011-0951-4. Epub 2011 Apr 19. Review.


Connexin 43 expression delineates two discrete pathways in the human atrioventricular junction.

Hucker WJ, McCain ML, Laughner JI, Iaizzo PA, Efimov IR.

Anat Rec (Hoboken). 2008 Feb;291(2):204-15.


Abrasive waterjet peening: a new method of surface preparation for metal orthopedic implants.

Arola DD, McCain ML.

J Biomed Mater Res. 2000 Sep;53(5):536-46.


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