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Items: 17


Vimentin expression is retained in erythroid cells differentiated from human iPSC and ESC and indicates dysregulation in these cells early in differentiation.

Trakarnsanga K, Ferguson D, Daniels DE, Griffiths RE, Wilson MC, Mordue KE, Gartner A, Andrienko TN, Calvert A, Condie A, McCahill A, Mountford JC, Toye AM, Anstee DJ, Frayne J.

Stem Cell Res Ther. 2019 Apr 29;10(1):130. doi: 10.1186/s13287-019-1231-z.


Genetic programming of macrophages generates an in vitro model for the human erythroid island niche.

Lopez-Yrigoyen M, Yang CT, Fidanza A, Cassetta L, Taylor AH, McCahill A, Sellink E, von Lindern M, van den Akker E, Mountford JC, Pollard JW, Forrester LM.

Nat Commun. 2019 Feb 20;10(1):881. doi: 10.1038/s41467-019-08705-0.


High-Efficiency Serum-Free Feeder-Free Erythroid Differentiation of Human Pluripotent Stem Cells Using Small Molecules.

Olivier EN, Marenah L, McCahill A, Condie A, Cowan S, Mountford JC.

Stem Cells Transl Med. 2016 Oct;5(10):1394-1405. Epub 2016 Jul 8.


Role of microRNAs 99b, 181a, and 181b in the differentiation of human embryonic stem cells to vascular endothelial cells.

Kane NM, Howard L, Descamps B, Meloni M, McClure J, Lu R, McCahill A, Breen C, Mackenzie RM, Delles C, Mountford JC, Milligan G, Emanueli C, Baker AH.

Stem Cells. 2012 Apr;30(4):643-54. doi: 10.1002/stem.1026.


Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells.

Burton P, Adams DR, Abraham A, Allcock RW, Jiang Z, McCahill A, Gilmour J, McAbney J, Kaupisch A, Kane NM, Baillie GS, Baker AH, Milligan G, Houslay MD, Mountford JC.

Biochem J. 2010 Dec 15;432(3):575-84. doi: 10.1042/BJ20100726.


Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells.

Burton P, Adams DR, Abraham A, Allcock RW, Jiang Z, McCahill A, Gilmour J, McAbney J, Kane NM, Baillie GS, McKenzie FR, Baker AH, Houslay MD, Mountford JC, Milligan G.

Biochem Soc Trans. 2010 Aug;38(4):1058-61. doi: 10.1042/BST0381058. Review.


In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).

McCahill A, Campbell L, McSorley T, Sood A, Lynch MJ, Li X, Yan C, Baillie GS, Houslay MD.

Cell Signal. 2008 Nov;20(11):2071-83. doi: 10.1016/j.cellsig.2008.07.017. Epub 2008 Aug 5.


PDE4 associates with different scaffolding proteins: modulating interactions as treatment for certain diseases.

McCahill AC, Huston E, Li X, Houslay MD.

Handb Exp Pharmacol. 2008;(186):125-66. doi: 10.1007/978-3-540-72843-6_6. Review.


1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.

Smith KJ, Baillie GS, Hyde EI, Li X, Houslay TM, McCahill A, Dunlop AJ, Bolger GB, Klussmann E, Adams DR, Houslay MD.

Cell Signal. 2007 Dec;19(12):2612-24. Epub 2007 Sep 1.


Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.

Bolger GB, Baillie GS, Li X, Lynch MJ, Herzyk P, Mohamed A, Mitchell LH, McCahill A, Hundsrucker C, Klussmann E, Adams DR, Houslay MD.

Biochem J. 2006 Aug 15;398(1):23-36.


The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins.

Bolger GB, McCahill A, Huston E, Cheung YF, McSorley T, Baillie GS, Houslay MD.

J Biol Chem. 2003 Dec 5;278(49):49230-8. Epub 2003 Sep 18.


The RACK1 scaffold protein: a dynamic cog in cell response mechanisms.

McCahill A, Warwicker J, Bolger GB, Houslay MD, Yarwood SJ.

Mol Pharmacol. 2002 Dec;62(6):1261-73. Review. No abstract available.


Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.

Bolger GB, McCahill A, Yarwood SJ, Steele MR, Warwicker J, Houslay MD.

BMC Biochem. 2002 Aug 23;3:24.


Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5.

Steele MR, McCahill A, Thompson DS, MacKenzie C, Isaacs NW, Houslay MD, Bolger GB.

Cell Signal. 2001 Jul;13(7):507-13.


A putative sodium-dependent inorganic phosphate co-transporter from Drosophila melanogaster.

MacIver B, McCahill A, Pathirana S, Leaper K, Bownes M.

Dev Genes Evol. 2000 Apr;210(4):207-11.


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