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Highly Sensitive Quantitative Determination of Retinoic Acid Levels, Retinoic Acid Synthesis, and Catabolism in Embryonic Tissue Using a Reporter Cell-Based Method.

Lee LMY, Tam STK, McCaffery PJ, Shum ASW.

Methods Mol Biol. 2019;2019:181-192. doi: 10.1007/978-1-4939-9585-1_13.


Genomic and non-genomic pathways are both crucial for peak induction of neurite outgrowth by retinoids.

Khatib T, Marini P, Nunna S, Chisholm DR, Whiting A, Redfern C, Greig IR, McCaffery P.

Cell Commun Signal. 2019 May 2;17(1):40. doi: 10.1186/s12964-019-0352-4.


A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate Receptor.

Khatib T, Whiting A, Chisholm DR, Redfern C, Müller B, McCaffery P.

Mol Neurobiol. 2019 Oct;56(10):7074-7084. doi: 10.1007/s12035-019-1571-9. Epub 2019 Apr 10.


Radicalization Leading to Violence: A Test of the 3N Model.

Bélanger JJ, Moyano M, Muhammad H, Richardson L, Lafrenière MK, McCaffery P, Framand K, Nociti N.

Front Psychiatry. 2019 Feb 11;10:42. doi: 10.3389/fpsyt.2019.00042. eCollection 2019.


Rhythmic Diurnal Synthesis and Signaling of Retinoic Acid in the Rat Pineal Gland and Its Action to Rapidly Downregulate ERK Phosphorylation.

Ashton A, Stoney PN, Ransom J, McCaffery P.

Mol Neurobiol. 2018 Nov;55(11):8219-8235. doi: 10.1007/s12035-018-0964-5. Epub 2018 Mar 8.


Neurogenesis in Response to Synthetic Retinoids at Different Temporal Scales.

Haffez H, Khatib T, McCaffery P, Przyborski S, Redfern C, Whiting A.

Mol Neurobiol. 2018 Mar;55(3):1942-1950. doi: 10.1007/s12035-017-0440-7. Epub 2017 Feb 27.


Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes.

Lee LM, Leung MB, Kwok RC, Leung YC, Wang CC, McCaffery PJ, Copp AJ, Shum AS.

Diabetes. 2017 Apr;66(4):1041-1051. doi: 10.2337/db15-1570. Epub 2017 Jan 13.


A seasonal switch in histone deacetylase gene expression in the hypothalamus and their capacity to modulate nuclear signaling pathways.

Stoney PN, Rodrigues D, Helfer G, Khatib T, Ashton A, Hay EA, Starr R, Kociszewska D, Morgan P, McCaffery P.

Brain Behav Immun. 2017 Mar;61:340-352. doi: 10.1016/j.bbi.2016.12.013. Epub 2016 Dec 18.


A neuroendocrine role for chemerin in hypothalamic remodelling and photoperiodic control of energy balance.

Helfer G, Ross AW, Thomson LM, Mayer CD, Stoney PN, McCaffery PJ, Morgan PJ.

Sci Rep. 2016 May 26;6:26830. doi: 10.1038/srep26830.


A Vitamin on the Mind: New Discoveries on Control of the Brain by Vitamin A.

Stoney PN, McCaffery P.

World Rev Nutr Diet. 2016;115:98-108. doi: 10.1159/000442076. Epub 2016 May 19. Review.


Targeting Retinoid Receptors to Treat Schizophrenia: Rationale and Progress to Date.

Lerner V, McCaffery PJ, Ritsner MS.

CNS Drugs. 2016 Apr;30(4):269-80. doi: 10.1007/s40263-016-0316-9. Review.


Thyroid hormone activation of retinoic acid synthesis in hypothalamic tanycytes.

Stoney PN, Helfer G, Rodrigues D, Morgan PJ, McCaffery P.

Glia. 2016 Mar;64(3):425-39. doi: 10.1002/glia.22938. Epub 2015 Nov 3.


Expression of the retinoic acid catabolic enzyme CYP26B1 in the human brain to maintain signaling homeostasis.

Stoney PN, Fragoso YD, Saeed RB, Ashton A, Goodman T, Simons C, Gomaa MS, Sementilli A, Sementilli L, Ross AW, Morgan PJ, McCaffery PJ.

Brain Struct Funct. 2016 Jul;221(6):3315-26. doi: 10.1007/s00429-015-1102-z. Epub 2015 Sep 15.


Fenretinide prevents obesity in aged female mice in association with increased retinoid and estrogen signaling.

Shearer KD, Morrice N, Henderson C, Reekie J, Mcilroy GD, McCaffery PJ, Delibegovic M, Mody N.

Obesity (Silver Spring). 2015 Aug;23(8):1655-62. doi: 10.1002/oby.21164. Epub 2015 Jul 14.


The expression and roles of Nde1 and Ndel1 in the adult mammalian central nervous system.

Pei Z, Lang B, Fragoso YD, Shearer KD, Zhao L, Mccaffery PJ, Shen S, Ding YQ, McCaig CD, Collinson JM.

Neuroscience. 2014 Jun 20;271:119-36. doi: 10.1016/j.neuroscience.2014.04.031. Epub 2014 Apr 29.


The evidence for a beneficial role of vitamin A in multiple sclerosis.

Fragoso YD, Stoney PN, McCaffery PJ.

CNS Drugs. 2014 Apr;28(4):291-9. doi: 10.1007/s40263-014-0148-4. Review.


Expression in the human brain of retinoic acid induced 1, a protein associated with neurobehavioural disorders.

Fragoso YD, Stoney PN, Shearer KD, Sementilli A, Nanescu SE, Sementilli P, McCaffery P.

Brain Struct Funct. 2015 Mar;220(2):1195-203. doi: 10.1007/s00429-014-0712-1. Epub 2014 Feb 12.


The rhythm of retinoids in the brain.

Ransom J, Morgan PJ, McCaffery PJ, Stoney PN.

J Neurochem. 2014 May;129(3):366-76. doi: 10.1111/jnc.12620. Epub 2013 Dec 15. Review.


Fenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose, liver, and hypothalamus.

Mcilroy GD, Delibegovic M, Owen C, Stoney PN, Shearer KD, McCaffery PJ, Mody N.

Diabetes. 2013 Mar;62(3):825-36. doi: 10.2337/db12-0458. Epub 2012 Nov 27.


A vitamin for the brain.

Shearer KD, Stoney PN, Morgan PJ, McCaffery PJ.

Trends Neurosci. 2012 Dec;35(12):733-41. doi: 10.1016/j.tins.2012.08.005. Epub 2012 Sep 6. Review.


Astrocytes as a regulated source of retinoic acid for the brain.

Shearer KD, Fragoso YD, Clagett-Dame M, McCaffery PJ.

Glia. 2012 Dec;60(12):1964-76. doi: 10.1002/glia.22412. Epub 2012 Aug 28.


A paradoxical teratogenic mechanism for retinoic acid.

Lee LM, Leung CY, Tang WW, Choi HL, Leung YC, McCaffery PJ, Wang CC, Woolf AS, Shum AS.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13668-73. doi: 10.1073/pnas.1200872109. Epub 2012 Aug 6.


Patterning of retinoic acid signaling and cell proliferation in the hippocampus.

Goodman T, Crandall JE, Nanescu SE, Quadro L, Shearer K, Ross A, McCaffery P.

Hippocampus. 2012 Nov;22(11):2171-83. doi: 10.1002/hipo.22037. Epub 2012 Jun 11.


Photoperiodic expression of two RALDH enzymes and the regulation of cell proliferation by retinoic acid in the rat hypothalamus.

Shearer KD, Stoney PN, Nanescu SE, Helfer G, Barrett P, Ross AW, Morgan PJ, McCaffery P.

J Neurochem. 2012 Aug;122(4):789-99. doi: 10.1111/j.1471-4159.2012.07824.x. Epub 2012 Jul 9.


Photoperiod regulates vitamin A and Wnt/β-catenin signaling in F344 rats.

Helfer G, Ross AW, Russell L, Thomson LM, Shearer KD, Goodman TH, McCaffery PJ, Morgan PJ.

Endocrinology. 2012 Feb;153(2):815-24. doi: 10.1210/en.2011-1792. Epub 2011 Dec 30.


Influence of isotretinoin on hippocampal-based learning in human subjects.

Ormerod AD, Thind CK, Rice SA, Reid IC, Williams JH, McCaffery PJ.

Psychopharmacology (Berl). 2012 Jun;221(4):667-74. doi: 10.1007/s00213-011-2611-y. Epub 2011 Dec 24.


High expression of retinoic acid receptors and synthetic enzymes in the human hippocampus.

Fragoso YD, Shearer KD, Sementilli A, de Carvalho LV, McCaffery PJ.

Brain Struct Funct. 2012 Apr;217(2):473-83. doi: 10.1007/s00429-011-0359-0. Epub 2011 Nov 11.


Retinoic acid and affective disorders: the evidence for an association.

Bremner JD, Shearer KD, McCaffery PJ.

J Clin Psychiatry. 2012 Jan;73(1):37-50. doi: 10.4088/JCP.10r05993. Epub 2011 Aug 23. Review.


Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex.

Crandall JE, Goodman T, McCarthy DM, Duester G, Bhide PG, Dräger UC, McCaffery P.

J Neurochem. 2011 Nov;119(4):723-35. doi: 10.1111/j.1471-4159.2011.07471.x. Epub 2011 Oct 11.


HPLC/MS(N) analysis of retinoids.

Evans JE, McCaffery P.

Methods Mol Biol. 2010;652:149-62. doi: 10.1007/978-1-60327-325-1_8.


Photoperiodic regulation of retinoic acid signaling in the hypothalamus.

Shearer KD, Goodman TH, Ross AW, Reilly L, Morgan PJ, McCaffery PJ.

J Neurochem. 2010 Jan;112(1):246-57. doi: 10.1111/j.1471-4159.2009.06455.x. Epub 2009 Oct 26.


Restricted patterns of Hoxd10 and Hoxd11 set segmental differences in motoneuron subtype complement in the lumbosacral spinal cord.

Misra M, Shah V, Carpenter E, McCaffery P, Lance-Jones C.

Dev Biol. 2009 Jun 1;330(1):54-72. doi: 10.1016/j.ydbio.2009.03.009. Epub 2009 Mar 21.


Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid.

Spiegl N, Didichenko S, McCaffery P, Langen H, Dahinden CA.

Blood. 2008 Nov 1;112(9):3762-71. doi: 10.1182/blood-2008-01-135251. Epub 2008 May 21.


Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development.

Silvestri C, Narimatsu M, von Both I, Liu Y, Tan NB, Izzi L, McCaffery P, Wrana JL, Attisano L.

Dev Cell. 2008 Mar;14(3):411-23. doi: 10.1016/j.devcel.2008.01.004. Erratum in: Dev Cell. 2008 Apr;14(4):633.


Prospective teratology of retinoic acid metabolic blocking agents (RAMBAs) and loss of CYP26 activity.

McCaffery P, Simons C.

Curr Pharm Des. 2007;13(29):3020-37. Review.


The neurobiology of retinoic acid in affective disorders.

Bremner JD, McCaffery P.

Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):315-31. Epub 2007 Jul 10. Review.


Characterization of retinaldehyde dehydrogenase-2 induction in NG2-positive glia after spinal cord contusion injury.

Kern J, Schrage K, Koopmans GC, Joosten EA, McCaffery P, Mey J.

Int J Dev Neurosci. 2007 Feb;25(1):7-16. Epub 2007 Jan 18.


Retinoic acid signaling and function in the adult hippocampus.

McCaffery P, Zhang J, Crandall JE.

J Neurobiol. 2006 Jun;66(7):780-91. Review.


Macrocephaly and the control of brain growth in autistic disorders.

McCaffery P, Deutsch CK.

Prog Neurobiol. 2005 Sep-Oct;77(1-2):38-56. Epub 2005 Nov 8. Review.


Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domain.

Tse SW, Broderick JA, Wei ML, Luo MH, Smith D, McCaffery P, Stamm S, Andreadis A.

Gene. 2005 Oct 10;359:63-72.


Retinoic acid influences the development of the inferior olivary nucleus in the rodent.

Yamamoto M, Fujinuma M, Hirano S, Hayakawa Y, Clagett-Dame M, Zhang J, McCaffery P.

Dev Biol. 2005 Apr 15;280(2):421-33.


Retinoic acid synthesis by a population of NG2-positive cells in the injured spinal cord.

Mey J, J Morassutti D, Brook G, Liu RH, Zhang YP, Koopmans G, McCaffery P.

Eur J Neurosci. 2005 Mar;21(6):1555-68.


Retinaldehyde dehydrogenase 2 and Hoxc8 are required in the murine brachial spinal cord for the specification of Lim1+ motoneurons and the correct distribution of Islet1+ motoneurons.

Vermot J, Schuhbaur B, Le Mouellic H, McCaffery P, Garnier JM, Hentsch D, Brûlet P, Niederreither K, Chambon P, Dollé P, Le Roux I.

Development. 2005 Apr;132(7):1611-21.


CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye development.

Sakai Y, Luo T, McCaffery P, Hamada H, Dräger UC.

Dev Biol. 2004 Dec 1;276(1):143-57.


Ethanol increases retinoic acid production in cerebellar astrocytes and in cerebellum.

McCaffery P, Koul O, Smith D, Napoli JL, Chen N, Ullman MD.

Brain Res Dev Brain Res. 2004 Nov 25;153(2):233-41.


Retinoic acid signaling in the nervous system of adult vertebrates.

Mey J, McCaffery P.

Neuroscientist. 2004 Oct;10(5):409-21. Review.


13-cis Retinoic acid (accutane) suppresses hippocampal cell survival in mice.

Sakai Y, Crandall JE, Brodsky J, McCaffery P.

Ann N Y Acad Sci. 2004 Jun;1021:436-40.


13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice.

Crandall J, Sakai Y, Zhang J, Koul O, Mineur Y, Crusio WE, McCaffery P.

Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5111-6. Epub 2004 Mar 29.

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