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Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES.

McBride JW, Malcolm RK, Dias N, Cameron D, Offord RE, Hartley O, Kett VL, Devlin B, Boyd P.

Int J Pharm. 2019 Jun 10;564:207-213. doi: 10.1016/j.ijpharm.2019.04.040. Epub 2019 Apr 15.


Vaginal rings with exposed cores for sustained delivery of the HIV CCR5 inhibitor 5P12-RANTES.

McBride JW, Boyd P, Dias N, Cameron D, Offord RE, Hartley O, Kett VL, Malcolm RK.

J Control Release. 2019 Mar 28;298:1-11. doi: 10.1016/j.jconrel.2019.02.003. Epub 2019 Feb 4.


Gene therapy with RALA/iNOS composite nanoparticles significantly enhances survival in a model of metastatic prostate cancer.

McCrudden CM, McBride JW, McCaffrey J, McErlean EM, Dunne NJ, Kett VL, Coulter JA, Robson T, McCarthy HO.

Cancer Nanotechnol. 2018;9(1):5. doi: 10.1186/s12645-018-0040-x. Epub 2018 Jun 1.


Ehrlichia chaffeensis TRP75 Interacts with Host Cell Targets Involved in Homeostasis, Cytoskeleton Organization, and Apoptosis Regulation To Promote Infection.

Luo T, Mitra S, McBride JW.

mSphere. 2018 Apr 11;3(2). pii: e00147-18. doi: 10.1128/mSphere.00147-18. Print 2018 Apr 25.


Ehrlichia chaffeensis TRP120 nucleomodulin binds DNA with disordered tandem repeat domain.

Klema VJ, Sepuru KM, Füllbrunn N, Farris TR, Dunphy PS, McBride JW, Rajarathnam K, Choi KH.

PLoS One. 2018 Apr 11;13(4):e0194891. doi: 10.1371/journal.pone.0194891. eCollection 2018.


DNA vaccination for cervical cancer: Strategic optimisation of RALA mediated gene delivery from a biodegradable microneedle system.

Cole G, Ali AA, McCrudden CM, McBride JW, McCaffrey J, Robson T, Kett VL, Dunne NJ, Donnelly RF, McCarthy HO.

Eur J Pharm Biopharm. 2018 Jun;127:288-297. doi: 10.1016/j.ejpb.2018.02.029. Epub 2018 Mar 3.


Ehrlichia chaffeensis TRP32 Nucleomodulin Function and Localization Is Regulated by NEDD4L-Mediated Ubiquitination.

Farris TR, Zhu B, Wang JY, McBride JW.

Front Cell Infect Microbiol. 2018 Jan 11;7:534. doi: 10.3389/fcimb.2017.00534. eCollection 2017.


Ehrlichia chaffeensis TRP120 Effector Targets and Recruits Host Polycomb Group Proteins for Degradation To Promote Intracellular Infection.

Mitra S, Dunphy PS, Das S, Zhu B, Luo T, McBride JW.

Infect Immun. 2018 Mar 22;86(4). pii: e00845-17. doi: 10.1128/IAI.00845-17. Print 2018 Apr.


Ehrlichia Activation of Wnt-PI3K-mTOR Signaling Inhibits Autolysosome Generation and Autophagic Destruction by the Mononuclear Phagocyte.

Lina TT, Luo T, Velayutham TS, Das S, McBride JW.

Infect Immun. 2017 Nov 17;85(12). pii: e00690-17. doi: 10.1128/IAI.00690-17. Print 2017 Dec.


Pharmacokinetics of the Protein Microbicide 5P12-RANTES in Sheep following Single-Dose Vaginal Gel Administration.

McBride JW, Dias N, Cameron D, Offord RE, Hartley O, Boyd P, Kett VL, Malcolm RK.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00965-17. doi: 10.1128/AAC.00965-17. Print 2017 Oct.


Ehrlichia chaffeensis TRP120 Moonlights as a HECT E3 Ligase Involved in Self- and Host Ubiquitination To Influence Protein Interactions and Stability for Intracellular Survival.

Zhu B, Das S, Mitra S, Farris TR, McBride JW.

Infect Immun. 2017 Aug 18;85(9). pii: e00290-17. doi: 10.1128/IAI.00290-17. Print 2017 Sep.


Engineering of obligate intracellular bacteria: progress, challenges and paradigms.

McClure EE, Chávez ASO, Shaw DK, Carlyon JA, Ganta RR, Noh SM, Wood DO, Bavoil PM, Brayton KA, Martinez JJ, McBride JW, Valdivia RH, Munderloh UG, Pedra JHF.

Nat Rev Microbiol. 2017 Sep;15(9):544-558. doi: 10.1038/nrmicro.2017.59. Epub 2017 Jun 19. Review.


Ehrlichia chaffeensis Tandem Repeat Effector Targets Differentially Influence Infection.

Luo T, Dunphy PS, McBride JW.

Front Cell Infect Microbiol. 2017 May 12;7:178. doi: 10.3389/fcimb.2017.00178. eCollection 2017.


Tick-Borne Emerging Infections: Ehrlichiosis and Anaplasmosis.

Ismail N, McBride JW.

Clin Lab Med. 2017 Jun;37(2):317-340. doi: 10.1016/j.cll.2017.01.006. Epub 2017 Mar 25. Review.


Systemic RALA/iNOS Nanoparticles: A Potent Gene Therapy for Metastatic Breast Cancer Coupled as a Biomarker of Treatment.

McCrudden CM, McBride JW, McCaffrey J, Ali AA, Dunne NJ, Kett VL, Coulter JA, Robson T, McCarthy HO.

Mol Ther Nucleic Acids. 2017 Mar 17;6:249-258. doi: 10.1016/j.omtn.2016.12.010. Epub 2016 Dec 31.


DNA vaccination for cervical cancer; a novel technology platform of RALA mediated gene delivery via polymeric microneedles.

Ali AA, McCrudden CM, McCaffrey J, McBride JW, Cole G, Dunne NJ, Robson T, Kissenpfennig A, Donnelly RF, McCarthy HO.

Nanomedicine. 2017 Apr;13(3):921-932. doi: 10.1016/j.nano.2016.11.019. Epub 2016 Dec 12.


Dissolving microneedles for DNA vaccination: Improving functionality via polymer characterization and RALA complexation.

Cole G, McCaffrey J, Ali AA, McBride JW, McCrudden CM, Vincente-Perez EM, Donnelly RF, McCarthy HO.

Hum Vaccin Immunother. 2017 Jan 2;13(1):50-62. doi: 10.1080/21645515.2016.1248008. Epub 2016 Nov 15.


Ehrlichia chaffeensis TRP32 is a Nucleomodulin that Directly Regulates Expression of Host Genes Governing Differentiation and Proliferation.

Farris TR, Dunphy PS, Zhu B, Kibler CE, McBride JW.

Infect Immun. 2016 Nov;84(11):3182-3194. doi: 10.1128/IAI.00657-16. Epub 2016 Aug 29.


The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.

Wang X, Shaw DK, Hammond HL, Sutterwala FS, Rayamajhi M, Shirey KA, Perkins DJ, Bonventre JV, Velayutham TS, Evans SM, Rodino KG, VieBrock L, Scanlon KM, Carbonetti NH, Carlyon JA, Miao EA, McBride JW, Kotsyfakis M, Pedra JH.

PLoS Pathog. 2016 Aug 2;12(8):e1005803. doi: 10.1371/journal.ppat.1005803. eCollection 2016 Aug.


Ehrlichia chaffeensis TRP120 Activates Canonical Notch Signaling To Downregulate TLR2/4 Expression and Promote Intracellular Survival.

Lina TT, Dunphy PS, Luo T, McBride JW.

MBio. 2016 Jul 5;7(4). pii: e00672-16. doi: 10.1128/mBio.00672-16.


Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy.

Lina TT, Farris T, Luo T, Mitra S, Zhu B, McBride JW.

Front Cell Infect Microbiol. 2016 May 31;6:58. doi: 10.3389/fcimb.2016.00058. eCollection 2016. Review.


Rapid identification of ubiquitination and SUMOylation target sites by microfluidic peptide array.

Zhu B, Farris TR, Milligan SL, Chen H, Zhu R, Hong A, Zhou X, Gao X, McBride JW.

Biochem Biophys Rep. 2016 Mar 1;5:430-438.


Potentiating the Anticancer Properties of Bisphosphonates by Nanocomplexation with the Cationic Amphipathic Peptide, RALA.

Massey AS, Pentlavalli S, Cunningham R, McCrudden CM, McErlean EM, Redpath P, Ali AA, Annett S, McBride JW, McCaffrey J, Robson T, Migaud ME, McCarthy HO.

Mol Pharm. 2016 Apr 4;13(4):1217-28. doi: 10.1021/acs.molpharmaceut.5b00670. Epub 2016 Mar 22.


Transcending epithelial and intracellular biological barriers; a prototype DNA delivery device.

McCaffrey J, McCrudden CM, Ali AA, Massey AS, McBride JW, McCrudden MT, Vicente-Perez EM, Coulter JA, Robson T, Donnelly RF, McCarthy HO.

J Control Release. 2016 Mar 28;226:238-47. doi: 10.1016/j.jconrel.2016.02.023. Epub 2016 Feb 13.


Development of TMTP-1 targeted designer biopolymers for gene delivery to prostate cancer.

McBride JW, Massey AS, McCaffrey J, McCrudden CM, Coulter JA, Dunne NJ, Robson T, McCarthy HO.

Int J Pharm. 2016 Mar 16;500(1-2):144-53. doi: 10.1016/j.ijpharm.2016.01.039. Epub 2016 Jan 21.


Ehrlichia chaffeensis Exploits Canonical and Noncanonical Host Wnt Signaling Pathways To Stimulate Phagocytosis and Promote Intracellular Survival.

Luo T, Dunphy PS, Lina TT, McBride JW.

Infect Immun. 2015 Dec 28;84(3):686-700. doi: 10.1128/IAI.01289-15.


Detection of genotype-specific Ehrlichia canis exposure in Brazilian dogs by TRP36 peptide ELISA.

Aguiar DM, Zhang X, Braga IA, Taques IIGG, McBride JW.

Ticks Tick Borne Dis. 2016 Feb;7(1):142-145. doi: 10.1016/j.ttbdis.2015.10.003. Epub 2015 Oct 16.


A simulation-based study on the influence of beam hardening in X-ray computed tomography for dimensional metrology.

Lifton JJ, Malcolm AA, McBride JW.

J Xray Sci Technol. 2015;23(1):65-82. doi: 10.3233/XST-140471.


Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival.

Dunphy PS, Luo T, McBride JW.

Infect Immun. 2014 Oct;82(10):4154-68. doi: 10.1128/IAI.01984-14. Epub 2014 Jul 21.


Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery.

McCarthy HO, McCaffrey J, McCrudden CM, Zholobenko A, Ali AA, McBride JW, Massey AS, Pentlavalli S, Chen KH, Cole G, Loughran SP, Dunne NJ, Donnelly RF, Kett VL, Robson T.

J Control Release. 2014 Sep 10;189:141-9. doi: 10.1016/j.jconrel.2014.06.048. Epub 2014 Jul 1.


A novel Ehrlichia genotype strain distinguished by the TRP36 gene naturally infects cattle in Brazil and causes clinical manifestations associated with ehrlichiosis.

Aguiar DM, Ziliani TF, Zhang X, Melo AL, Braga IA, Witter R, Freitas LC, Rondelli AL, Luis MA, Sorte EC, Jaune FW, Santarém VA, Horta MC, Pescador CA, Colodel EM, Soares HS, Pacheco RC, Onuma SS, Labruna MB, McBride JW.

Ticks Tick Borne Dis. 2014 Sep;5(5):537-44. doi: 10.1016/j.ttbdis.2014.03.010. Epub 2014 Jun 8.


Recombinant Ehrlichia P29 protein induces a protective immune response in a mouse model of ehrlichiosis.

Thirumalapura NR, Crocquet-Valdes PA, Saito TB, Thomas S, McBride JW, Walker DH.

Vaccine. 2013 Dec 5;31(50):5960-7. doi: 10.1016/j.vaccine.2013.10.036. Epub 2013 Oct 19.


Ehrlichia moonlighting effectors and interkingdom interactions with the mononuclear phagocyte.

Dunphy PS, Luo T, McBride JW.

Microbes Infect. 2013 Dec;15(14-15):1005-16. doi: 10.1016/j.micinf.2013.09.011. Epub 2013 Oct 18. Review.


The prevalence and impact of mortality of the acute respiratory distress syndrome on admissions of patients with ischemic stroke in the United States.

Rincon F, Maltenfort M, Dey S, Ghosh S, Vibbert M, Urtecho J, Jallo J, Ratliff JK, McBride JW, Bell R.

J Intensive Care Med. 2014 Nov-Dec;29(6):357-64. doi: 10.1177/0885066613491919. Epub 2013 Jun 6.


Genetic diversity of Ehrlichia canis in Brazil.

Aguiar DM, Zhang X, Melo AL, Pacheco TA, Meneses AM, Zanutto MS, Horta MC, Santarém VA, Camargo LM, McBride JW, Labruna MB.

Vet Microbiol. 2013 Jun 28;164(3-4):315-21. doi: 10.1016/j.vetmic.2013.02.015. Epub 2013 Feb 27.


Molecular basis of antibody mediated immunity against Ehrlichia chaffeensis involves species-specific linear epitopes in tandem repeat proteins.

Kuriakose JA, Zhang X, Luo T, McBride JW.

Microbes Infect. 2012 Oct;14(12):1054-63. doi: 10.1016/j.micinf.2012.05.012. Epub 2012 May 29.


Ehrlichia chaffeensis TRP32 interacts with host cell targets that influence intracellular survival.

Luo T, McBride JW.

Infect Immun. 2012 Jul;80(7):2297-306. doi: 10.1128/IAI.00154-12. Epub 2012 Apr 30.


Ehrlichia chaffeensis transcriptome in mammalian and arthropod hosts reveals differential gene expression and post transcriptional regulation.

Kuriakose JA, Miyashiro S, Luo T, Zhu B, McBride JW.

PLoS One. 2011;6(9):e24136. doi: 10.1371/journal.pone.0024136. Epub 2011 Sep 6.


Ehrlichia chaffeensis TRP120 interacts with a diverse array of eukaryotic proteins involved in transcription, signaling, and cytoskeleton organization.

Luo T, Kuriakose JA, Zhu B, Wakeel A, McBride JW.

Infect Immun. 2011 Nov;79(11):4382-91. doi: 10.1128/IAI.05608-11. Epub 2011 Aug 22.


Ehrlichia chaffeensis TRP120 binds a G+C-rich motif in host cell DNA and exhibits eukaryotic transcriptional activator function.

Zhu B, Kuriakose JA, Luo T, Ballesteros E, Gupta S, Fofanov Y, McBride JW.

Infect Immun. 2011 Nov;79(11):4370-81. doi: 10.1128/IAI.05422-11. Epub 2011 Aug 22.


Tyrosine-phosphorylated Ehrlichia chaffeensis and Ehrlichia canis tandem repeat orthologs contain a major continuous cross-reactive antibody epitope in lysine-rich repeats.

McBride JW, Zhang X, Wakeel A, Kuriakose JA.

Infect Immun. 2011 Aug;79(8):3178-87. doi: 10.1128/IAI.01347-10. Epub 2011 May 23.


Molecular and cellular pathobiology of Ehrlichia infection: targets for new therapeutics and immunomodulation strategies.

McBride JW, Walker DH.

Expert Rev Mol Med. 2011 Jan 31;13:e3. doi: 10.1017/S1462399410001730. Review.


Ehrlichia chaffeensis tandem repeat proteins and Ank200 are type 1 secretion system substrates related to the repeats-in-toxin exoprotein family.

Wakeel A, den Dulk-Ras A, Hooykaas PJ, McBride JW.

Front Cell Infect Microbiol. 2011 Dec 30;1:22. doi: 10.3389/fcimb.2011.00022. eCollection 2011.


Progress and obstacles in vaccine development for the ehrlichioses.

McBride JW, Walker DH.

Expert Rev Vaccines. 2010 Sep;9(9):1071-82. doi: 10.1586/erv.10.93. Review.


Optical fiber imaging for high speed plasma motion diagnostics: applied to low voltage circuit breakers.

McBride JW, Balestrero A, Ghezzi L, Tribulato G, Cross KJ.

Rev Sci Instrum. 2010 May;81(5):055109. doi: 10.1063/1.3428737.


Human ehrlichiosis and anaplasmosis.

Ismail N, Bloch KC, McBride JW.

Clin Lab Med. 2010 Mar;30(1):261-92. doi: 10.1016/j.cll.2009.10.004. Review.


New insights into molecular Ehrlichia chaffeensis-host interactions.

Wakeel A, Zhu B, Yu XJ, McBride JW.

Microbes Infect. 2010 May;12(5):337-45. doi: 10.1016/j.micinf.2010.01.009. Epub 2010 Jan 29. Review.


Molecular and clinical evidence of Ehrlichia chaffeensis infection in Cameroonian patients with undifferentiated febrile illness.

Ndip LM, Labruna M, Ndip RN, Walker DH, McBride JW.

Ann Trop Med Parasitol. 2009 Dec;103(8):719-25. doi: 10.1179/000349809X12554106963753.

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