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Items: 1 to 50 of 84

1.

Intestinal infection triggers Parkinson's disease-like symptoms in Pink1-/- mice.

Matheoud D, Cannon T, Voisin A, Penttinen AM, Ramet L, Fahmy AM, Ducrot C, Laplante A, Bourque MJ, Zhu L, Cayrol R, Le Campion A, McBride HM, Gruenheid S, Trudeau LE, Desjardins M.

Nature. 2019 Jul 17. doi: 10.1038/s41586-019-1405-y. [Epub ahead of print]

PMID:
31316206
2.

The enigma of an interconnected mitochondrial reticulum: new insights into mitochondrial fusion.

Mattie S, Krols M, McBride HM.

Curr Opin Cell Biol. 2019 Jun 25;59:159-166. doi: 10.1016/j.ceb.2019.05.004. [Epub ahead of print] Review.

PMID:
31252211
3.

A brain-enriched Drp1 isoform associates with lysosomes, late endosomes, and the plasma membrane.

Itoh K, Adachi Y, Yamada T, Suzuki TL, Otomo T, McBride HM, Yoshimori T, Iijima M, Sesaki H.

J Biol Chem. 2018 Jul 27;293(30):11809-11822. doi: 10.1074/jbc.RA117.001253. Epub 2018 May 31.

PMID:
29853636
4.

Mitochondria and endomembrane origins.

McBride HM.

Curr Biol. 2018 Apr 23;28(8):R367-R372. doi: 10.1016/j.cub.2018.03.052.

5.

A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space.

Mattie S, Riemer J, Wideman JG, McBride HM.

J Cell Biol. 2018 Feb 5;217(2):507-515. doi: 10.1083/jcb.201611194. Epub 2017 Dec 6.

6.

Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers.

Stefan CJ, Trimble WS, Grinstein S, Drin G, Reinisch K, De Camilli P, Cohen S, Valm AM, Lippincott-Schwartz J, Levine TP, Iaea DB, Maxfield FR, Futter CE, Eden ER, Judith D, van Vliet AR, Agostinis P, Tooze SA, Sugiura A, McBride HM.

BMC Biol. 2017 Oct 31;15(1):102. doi: 10.1186/s12915-017-0432-0.

7.

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.

Morita M, Prudent J, Basu K, Goyon V, Katsumura S, Hulea L, Pearl D, Siddiqui N, Strack S, McGuirk S, St-Pierre J, Larsson O, Topisirovic I, Vali H, McBride HM, Bergeron JJ, Sonenberg N.

Mol Cell. 2017 Sep 21;67(6):922-935.e5. doi: 10.1016/j.molcel.2017.08.013. Epub 2017 Sep 14.

8.

The Keap1-Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1.

Sabouny R, Fraunberger E, Geoffrion M, Ng AC, Baird SD, Screaton RA, Milne R, McBride HM, Shutt TE.

Antioxid Redox Signal. 2017 Dec 20;27(18):1447-1459. doi: 10.1089/ars.2016.6855. Epub 2017 Jul 7.

PMID:
28494652
9.

The mitochondria-endoplasmic reticulum contact sites: a signalling platform for cell death.

Prudent J, McBride HM.

Curr Opin Cell Biol. 2017 Aug;47:52-63. doi: 10.1016/j.ceb.2017.03.007. Epub 2017 Apr 6. Review.

PMID:
28391089
10.

The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity.

Doiron K, Goyon V, Coyaud E, Rajapakse S, Raught B, McBride HM.

Sci Rep. 2017 Mar 7;7(1):107. doi: 10.1038/s41598-017-00151-6.

11.

Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes.

Sugiura A, Mattie S, Prudent J, McBride HM.

Nature. 2017 Feb 9;542(7640):251-254. doi: 10.1038/nature21375. Epub 2017 Feb 1.

PMID:
28146471
12.

Cell biology: Double agents for mitochondrial division.

McBride HM, Frost A.

Nature. 2016 Dec 1;540(7631):43-44. doi: 10.1038/nature20482. Epub 2016 Nov 23. No abstract available.

PMID:
27880759
13.

Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system.

McLelland GL, Lee SA, McBride HM, Fon EA.

J Cell Biol. 2016 Aug 1;214(3):275-91. doi: 10.1083/jcb.201603105. Epub 2016 Jul 25.

14.

SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome.

Janer A, Prudent J, Paupe V, Fahiminiya S, Majewski J, Sgarioto N, Des Rosiers C, Forest A, Lin ZY, Gingras AC, Mitchell G, McBride HM, Shoubridge EA.

EMBO Mol Med. 2016 Sep 1;8(9):1019-38. doi: 10.15252/emmm.201506159. Print 2016 Sep.

15.

Parkinson's Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation.

Matheoud D, Sugiura A, Bellemare-Pelletier A, Laplante A, Rondeau C, Chemali M, Fazel A, Bergeron JJ, Trudeau LE, Burelle Y, Gagnon E, McBride HM, Desjardins M.

Cell. 2016 Jul 14;166(2):314-327. doi: 10.1016/j.cell.2016.05.039. Epub 2016 Jun 23.

16.

Formation of mitochondrial-derived vesicles is an active and physiologically relevant mitochondrial quality control process in the cardiac system.

Cadete VJ, Deschênes S, Cuillerier A, Brisebois F, Sugiura A, Vincent A, Turnbull D, Picard M, McBride HM, Burelle Y.

J Physiol. 2016 Sep 15;594(18):5343-62. doi: 10.1113/JP272703. Epub 2016 Jul 24.

17.

Mitochondrial Dynamics: ER Actin Tightens the Drp1 Noose.

Prudent J, McBride HM.

Curr Biol. 2016 Mar 7;26(5):R207-9. doi: 10.1016/j.cub.2016.01.009.

18.

MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death.

Prudent J, Zunino R, Sugiura A, Mattie S, Shore GC, McBride HM.

Mol Cell. 2015 Sep 17;59(6):941-55. doi: 10.1016/j.molcel.2015.08.001.

19.

Open questions: seeking a holistic approach for mitochondrial research.

McBride HM.

BMC Biol. 2015 Feb 5;13:8. doi: 10.1186/s12915-015-0120-x.

20.

A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver.

Sood A, Jeyaraju DV, Prudent J, Caron A, Lemieux P, McBride HM, Laplante M, Tóth K, Pellegrini L.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16017-22. doi: 10.1073/pnas.1408061111. Epub 2014 Oct 28.

21.

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.

Patten DA, Wong J, Khacho M, Soubannier V, Mailloux RJ, Pilon-Larose K, MacLaurin JG, Park DS, McBride HM, Trinkle-Mulcahy L, Harper ME, Germain M, Slack RS.

EMBO J. 2014 Nov 18;33(22):2676-91. doi: 10.15252/embj.201488349. Epub 2014 Oct 8.

22.

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles.

Sugiura A, McLelland GL, Fon EA, McBride HM.

EMBO J. 2014 Oct 1;33(19):2142-56. doi: 10.15252/embj.201488104. Epub 2014 Aug 8. Review.

23.

SPG7 variant escapes phosphorylation-regulated processing by AFG3L2, elevates mitochondrial ROS, and is associated with multiple clinical phenotypes.

Almontashiri NA, Chen HH, Mailloux RJ, Tatsuta T, Teng AC, Mahmoud AB, Ho T, Stewart NA, Rippstein P, Harper ME, Roberts R, Willenborg C, Erdmann J; CARDIoGRAM Consortium, Pastore A, McBride HM, Langer T, Stewart AF.

Cell Rep. 2014 May 8;7(3):834-47. doi: 10.1016/j.celrep.2014.03.051. Epub 2014 Apr 24.

24.

ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics.

Norton M, Ng AC, Baird S, Dumoulin A, Shutt T, Mah N, Andrade-Navarro MA, McBride HM, Screaton RA.

Sci Signal. 2014 Jan 28;7(310):ra10. doi: 10.1126/scisignal.2004374.

PMID:
24473195
25.

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control.

McLelland GL, Soubannier V, Chen CX, McBride HM, Fon EA.

EMBO J. 2014 Feb 18;33(4):282-95. doi: 10.1002/embj.201385902. Epub 2014 Jan 20.

26.

Emerging roles of mitochondria in the evolution, biogenesis, and function of peroxisomes.

Mohanty A, McBride HM.

Front Physiol. 2013 Sep 26;4:268. doi: 10.3389/fphys.2013.00268. Review.

27.

Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy.

Lefebvre V, Du Q, Baird S, Ng AC, Nascimento M, Campanella M, McBride HM, Screaton RA.

Autophagy. 2013 Nov 1;9(11):1770-9. doi: 10.4161/auto.25413. Epub 2013 Aug 7.

PMID:
24005319
28.

Mitochondrial hyperfusion during oxidative stress is coupled to a dysregulation in calcium handling within a C2C12 cell model.

Redpath CJ, Bou Khalil M, Drozdzal G, Radisic M, McBride HM.

PLoS One. 2013 Jul 8;8(7):e69165. doi: 10.1371/journal.pone.0069165. Print 2013.

29.

MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2.

Sugiura A, Nagashima S, Tokuyama T, Amo T, Matsuki Y, Ishido S, Kudo Y, McBride HM, Fukuda T, Matsushita N, Inatome R, Yanagi S.

Mol Cell. 2013 Jul 11;51(1):20-34. doi: 10.1016/j.molcel.2013.04.023. Epub 2013 May 30.

30.

Reconstitution of mitochondria derived vesicle formation demonstrates selective enrichment of oxidized cargo.

Soubannier V, Rippstein P, Kaufman BA, Shoubridge EA, McBride HM.

PLoS One. 2012;7(12):e52830. doi: 10.1371/journal.pone.0052830. Epub 2012 Dec 26.

31.

The intracellular redox state is a core determinant of mitochondrial fusion.

Shutt T, Geoffrion M, Milne R, McBride HM.

EMBO Rep. 2012 Oct;13(10):909-15. doi: 10.1038/embor.2012.128. Epub 2012 Sep 4.

32.

Staying cool in difficult times: mitochondrial dynamics, quality control and the stress response.

Shutt TE, McBride HM.

Biochim Biophys Acta. 2013 Feb;1833(2):417-24. doi: 10.1016/j.bbamcr.2012.05.024. Epub 2012 Jun 7. Review.

33.

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment.

Greene AW, Grenier K, Aguileta MA, Muise S, Farazifard R, Haque ME, McBride HM, Park DS, Fon EA.

EMBO Rep. 2012 Apr;13(4):378-85. doi: 10.1038/embor.2012.14.

34.

A vesicular transport pathway shuttles cargo from mitochondria to lysosomes.

Soubannier V, McLelland GL, Zunino R, Braschi E, Rippstein P, Fon EA, McBride HM.

Curr Biol. 2012 Jan 24;22(2):135-41. doi: 10.1016/j.cub.2011.11.057. Epub 2012 Jan 5.

35.

Mitochondrial-ER tethering: the inheritance of a functional unit.

McBride HM.

Curr Biol. 2011 Dec 6;21(23):R949-51. doi: 10.1016/j.cub.2011.10.043. Epub 2011 Dec 5.

36.

Structural and mechanistic basis of Parl activity and regulation.

Jeyaraju DV, McBride HM, Hill RB, Pellegrini L.

Cell Death Differ. 2011 Sep;18(9):1531-9. doi: 10.1038/cdd.2011.22. Epub 2011 Mar 18.

37.

Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons.

Beug ST, Parks RJ, McBride HM, Wallace VA.

Mol Cell Neurosci. 2011 Mar;46(3):583-96. doi: 10.1016/j.mcn.2010.12.009. Epub 2010 Dec 21.

PMID:
21182949
38.

The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity.

Jahani-Asl A, Pilon-Larose K, Xu W, MacLaurin JG, Park DS, McBride HM, Slack RS.

J Biol Chem. 2011 Feb 11;286(6):4772-82. doi: 10.1074/jbc.M110.167155. Epub 2010 Nov 1.

39.

Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism.

Braschi E, McBride HM.

Bioessays. 2010 Nov;32(11):958-66. doi: 10.1002/bies.201000073. Epub 2010 Sep 7. Review.

40.

A novel cell-free mitochondrial fusion assay amenable for high-throughput screenings of fusion modulators.

Schauss AC, Huang H, Choi SY, Xu L, Soubeyrand S, Bilodeau P, Zunino R, Rippstein P, Frohman MA, McBride HM.

BMC Biol. 2010 Jul 26;8:100. doi: 10.1186/1741-7007-8-100.

41.

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.

Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, MacLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Chen CX, Fon EA, Slack RS, Harper ME, McBride HM, Mak TW, Park DS.

Hum Mol Genet. 2010 Oct 1;19(19):3734-46. doi: 10.1093/hmg/ddq288. Epub 2010 Jul 16.

PMID:
20639397
42.

Vps35 mediates vesicle transport between the mitochondria and peroxisomes.

Braschi E, Goyon V, Zunino R, Mohanty A, Xu L, McBride HM.

Curr Biol. 2010 Jul 27;20(14):1310-5. doi: 10.1016/j.cub.2010.05.066. Epub 2010 Jul 8.

43.

Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking.

Chamberlain MD, Oberg JC, Furber LA, Poland SF, Hawrysh AD, Knafelc SM, McBride HM, Anderson DH.

Cell Signal. 2010 Oct;22(10):1562-75. doi: 10.1016/j.cellsig.2010.05.025. Epub 2010 Jun 4.

PMID:
20570729
44.

Mitochondrial vesicles: an ancient process providing new links to peroxisomes.

Andrade-Navarro MA, Sanchez-Pulido L, McBride HM.

Curr Opin Cell Biol. 2009 Aug;21(4):560-7. doi: 10.1016/j.ceb.2009.04.005. Epub 2009 May 5. Review.

PMID:
19423315
45.

Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis.

Zunino R, Braschi E, Xu L, McBride HM.

J Biol Chem. 2009 Jun 26;284(26):17783-95. doi: 10.1074/jbc.M901902200. Epub 2009 May 1.

46.

MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission.

Braschi E, Zunino R, McBride HM.

EMBO Rep. 2009 Jul;10(7):748-54. doi: 10.1038/embor.2009.86. Epub 2009 May 1.

47.

Parkin mitochondria in the autophagosome.

McBride HM.

J Cell Biol. 2008 Dec 1;183(5):757-9. doi: 10.1083/jcb.200810184. Epub 2008 Nov 24.

48.

Positioning mitochondrial plasticity within cellular signaling cascades.

Soubannier V, McBride HM.

Biochim Biophys Acta. 2009 Jan;1793(1):154-70. doi: 10.1016/j.bbamcr.2008.07.008. Epub 2008 Jul 23. Review.

49.

The PINK1/Parkin pathway regulates mitochondrial morphology.

Poole AC, Thomas RE, Andrews LA, McBride HM, Whitworth AJ, Pallanck LJ.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1638-43. doi: 10.1073/pnas.0709336105. Epub 2008 Jan 29.

50.

Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers.

Neuspiel M, Schauss AC, Braschi E, Zunino R, Rippstein P, Rachubinski RA, Andrade-Navarro MA, McBride HM.

Curr Biol. 2008 Jan 22;18(2):102-8. doi: 10.1016/j.cub.2007.12.038.

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