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Items: 36

1.

Synthesis and anti-HCV activity of a series of β-d-2'-deoxy-2'-dibromo nucleosides and their corresponding phosphoramidate prodrugs.

Chen Z, Cox BD, Garnier-Amblard EC, McBrayer TR, Coats SJ, Schinazi RF, Amblard F.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5296-5299. doi: 10.1016/j.bmcl.2017.10.024. Epub 2017 Oct 12.

2.

Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase.

Ehteshami M, Zhou L, Amiralaei S, Shelton JR, Cho JH, Zhang H, Li H, Lu X, Ozturk T, Stanton R, Amblard F, McBrayer TR, Coats SJ, Schinazi RF.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00492-17. doi: 10.1128/AAC.00492-17. Print 2017 Aug.

3.

Synthesis and antiviral evaluation of 2',2',3',3'-tetrafluoro nucleoside analogs.

Sari O, Bassit L, Gavegnano C, McBrayer TR, McCormick L, Cox B, Coats SJ, Amblard F, Schinazi RF.

Tetrahedron Lett. 2017 Feb 15;58(7):642-644. doi: 10.1016/j.tetlet.2017.01.006. Epub 2017 Jan 4.

4.

Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates.

Mahmoud S, Li H, McBrayer TR, Bassit L, Hammad SF, Coats SJ, Amblard F, Schinazi RF.

Nucleosides Nucleotides Nucleic Acids. 2017 Jan 2;36(1):66-82. doi: 10.1080/15257770.2016.1218023. Epub 2016 Oct 19.

PMID:
27759481
5.

Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication.

Zhou L, Zhang H, Tao S, Ehteshami M, Cho JH, McBrayer TR, Tharnish P, Whitaker T, Amblard F, Coats SJ, Schinazi RF.

ACS Med Chem Lett. 2015 Nov 23;7(1):17-22. doi: 10.1021/acsmedchemlett.5b00402. eCollection 2016 Jan 14.

6.

Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors.

Boucle S, Tao S, Amblard F, Stanton RA, Nettles JH, Li C, McBrayer TR, Whitaker T, Coats SJ, Schinazi RF.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3711-5. doi: 10.1016/j.bmcl.2015.06.031. Epub 2015 Jun 15.

7.

β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.

Zhou L, Zhang HW, Tao S, Bassit L, Whitaker T, McBrayer TR, Ehteshami M, Amiralaei S, Pradere U, Cho JH, Amblard F, Bobeck D, Detorio M, Coats SJ, Schinazi RF.

J Med Chem. 2015 Apr 23;58(8):3445-58. doi: 10.1021/jm501874e. Epub 2015 Apr 7.

PMID:
25849312
8.

Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition.

Nettles JH, Stanton RA, Broyde J, Amblard F, Zhang H, Zhou L, Shi J, McBrayer TR, Whitaker T, Coats SJ, Kohler JJ, Schinazi RF.

J Med Chem. 2014 Dec 11;57(23):10031-43. doi: 10.1021/jm501291c. Epub 2014 Nov 3.

9.

Significance of endangered and threatened plant natural products in the control of human disease.

Ibrahim MA, Na M, Oh J, Schinazi RF, McBrayer TR, Whitaker T, Doerksen RJ, Newman DJ, Zachos LG, Hamann MT.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16832-7. doi: 10.1073/pnas.1311528110. Epub 2013 Sep 30.

10.

Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides.

Hamada M, Roy V, McBrayer TR, Whitaker T, Urbina-Blanco C, Nolan SP, Balzarini J, Snoeck R, Andrei G, Schinazi RF, Agrofoglio LA.

Eur J Med Chem. 2013 Sep;67:398-408. doi: 10.1016/j.ejmech.2013.06.053. Epub 2013 Jul 4.

PMID:
23911854
11.

Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.

Zhou L, Amblard F, Zhang H, McBrayer TR, Detorio MA, Whitaker T, Coats SJ, Schinazi RF.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3385-8. doi: 10.1016/j.bmcl.2013.03.077. Epub 2013 Mar 29.

12.

Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.

Amblard F, Zhang H, Zhou L, Shi J, Bobeck DR, Nettles JH, Chavre S, McBrayer TR, Tharnish P, Whitaker T, Coats SJ, Schinazi RF.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2031-4. doi: 10.1016/j.bmcl.2013.02.023. Epub 2013 Feb 13.

13.

Synthesis, evaluation of anti-HIV-1 and anti-HCV activity of novel 2',3'-dideoxy-2',2'-difluoro-4'-azanucleosides.

Martínez-Montero S, Fernández S, Sanghvi YS, Theodorakis EA, Detorio MA, McBrayer TR, Whitaker T, Schinazi RF, Gotor V, Ferrero M.

Bioorg Med Chem. 2012 Dec 1;20(23):6885-93. doi: 10.1016/j.bmc.2012.09.026. Epub 2012 Sep 23.

14.

Antiviral activity of nucleoside analogues against norovirus.

Costantini VP, Whitaker T, Barclay L, Lee D, McBrayer TR, Schinazi RF, Vinjé J.

Antivir Ther. 2012;17(6):981-91. doi: 10.3851/IMP2229. Epub 2012 Aug 14.

PMID:
22910194
15.

Synthesis and evaluation of novel potent HCV NS5A inhibitors.

Zhang H, Zhou L, Amblard F, Shi J, Bobeck DR, Tao S, McBrayer TR, Tharnish PM, Whitaker T, Coats SJ, Schinazi RF.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4864-8. doi: 10.1016/j.bmcl.2012.05.039. Epub 2012 May 24.

16.

Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors.

Shi J, Zhou L, Amblard F, Bobeck DR, Zhang H, Liu P, Bondada L, McBrayer TR, Tharnish PM, Whitaker T, Coats SJ, Schinazi RF.

Bioorg Med Chem Lett. 2012 May 15;22(10):3488-91. doi: 10.1016/j.bmcl.2012.03.089. Epub 2012 Mar 29.

PMID:
22507961
17.

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates.

Shi J, Zhou L, Zhang H, McBrayer TR, Detorio MA, Johns M, Bassit L, Powdrill MH, Whitaker T, Coats SJ, Götte M, Schinazi RF.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7094-8. doi: 10.1016/j.bmcl.2011.09.089. Epub 2011 Sep 29.

18.

Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.

Zhang HW, Zhou L, Coats SJ, McBrayer TR, Tharnish PM, Bondada L, Detorio M, Amichai SA, Johns MD, Whitaker T, Schinazi RF.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6788-92. doi: 10.1016/j.bmcl.2011.09.034. Epub 2011 Sep 20.

19.

3'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations.

Lin J, Roy V, Wang L, You L, Agrofoglio LA, Deville-Bonne D, McBrayer TR, Coats SJ, Schinazi RF, Eriksson S.

Bioorg Med Chem. 2010 May 1;18(9):3261-9. doi: 10.1016/j.bmc.2010.03.023. Epub 2010 Mar 15.

PMID:
20378362
20.

Synthesis and antiviral activity of purine 2',3'-dideoxy-2',3'-difluoro-D-arabinofuranosyl nucleosides.

Sivets GG, Kalinichenko EN, Mikhailopulo IA, Detorio MA, McBrayer TR, Whitaker T, Schinazi RF.

Nucleosides Nucleotides Nucleic Acids. 2009 May;28(5):519-36. doi: 10.1080/15257770903053979.

PMID:
20183600
21.

Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.

Rondla R, Coats SJ, McBrayer TR, Grier J, Johns M, Tharnish PM, Whitaker T, Zhou L, Schinazi RF.

Antivir Chem Chemother. 2009 Oct 19;20(2):99-106. doi: 10.3851/IMP1400.

PMID:
19843980
22.

Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.

Amblard F, Fromentin E, Detorio M, Obikhod A, Rapp KL, McBrayer TR, Whitaker T, Coats SJ, Schinazi RF.

Eur J Med Chem. 2009 Oct;44(10):3845-51. doi: 10.1016/j.ejmech.2009.04.003. Epub 2009 Apr 8.

23.

Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase.

Murakami E, Bao H, Ramesh M, McBrayer TR, Whitaker T, Micolochick Steuer HM, Schinazi RF, Stuyver LJ, Obikhod A, Otto MJ, Furman PA.

Antimicrob Agents Chemother. 2007 Feb;51(2):503-9. Epub 2006 Nov 13.

24.

Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.

Stuyver LJ, McBrayer TR, Tharnish PM, Clark J, Hollecker L, Lostia S, Nachman T, Grier J, Bennett MA, Xie MY, Schinazi RF, Morrey JD, Julander JL, Furman PA, Otto MJ.

Antivir Chem Chemother. 2006;17(2):79-87.

PMID:
17042329
25.

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.

Clark JL, Mason JC, Hollecker L, Stuyver LJ, Tharnish PM, McBrayer TR, Otto MJ, Furman PA, Schinazi RF, Watanabe KA.

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1712-5. Epub 2005 Dec 20.

PMID:
16368235
26.

Synthesis and anti-hepatitis C virus activity of nucleoside derivatives of N3, 5'-anhydro-4-(beta-D-ribofuranosyl)-8-aza-purin-2-ones.

Hassan AE, Wang P, McBrayer TR, Tharnish PM, Stuyver LJ, Schinazi RF, Otto MJ, Watanabe KA.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):961-4.

PMID:
16248072
27.

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents.

Wang P, Hollecker L, Pankiewicz KW, Patterson SE, Whitaker T, McBrayer TR, Tharnish PM, Stuyver LJ, Schinazi RF, Otto MJ, Watanabe KA.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):957-60.

PMID:
16248071
28.

Synthesis and in vitro anti-HCV activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides.

Shi J, Du J, Ma T, Pankiewicz KW, Patterson SE, Hassan AE, Tharnish PM, McBrayer TR, Lostia S, Stuyver LJ, Watanabe KA, Chu CK, Schinazi RF, Otto MJ.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):875-9.

PMID:
16248053
29.

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.

Clark JL, Hollecker L, Mason JC, Stuyver LJ, Tharnish PM, Lostia S, McBrayer TR, Schinazi RF, Watanabe KA, Otto MJ, Furman PA, Stec WJ, Patterson SE, Pankiewicz KW.

J Med Chem. 2005 Aug 25;48(17):5504-8.

PMID:
16107149
30.

Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system.

Shi J, Du J, Ma T, Pankiewicz KW, Patterson SE, Tharnish PM, McBrayer TR, Stuyver LJ, Otto MJ, Chu CK, Schinazi RF, Watanabe KA.

Bioorg Med Chem. 2005 Mar 1;13(5):1641-52.

PMID:
15698782
31.

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.

Wang P, Hollecker L, Pankiewicz KW, Patterson SE, Whitaker T, McBrayer TR, Tharnish PM, Sidwell RW, Stuyver LJ, Otto MJ, Schinazi RF, Watanabe KA.

J Med Chem. 2004 Nov 18;47(24):6100-3.

PMID:
15537363
32.

Potent antiviral effect of reverset in HIV-1-infected adults following a single oral dose.

Stuyver LJ, McBrayer TR, Schürmann D, Kravec I, Beard A, Cartee L, Schinazi RF, De La Rosa A, Murphy RL, Otto MJ.

Antivir Ther. 2004 Aug;9(4):529-36.

PMID:
15456084
33.

Synthesis of beta-enantiomers of N4-hydroxy-3'-deoxypyrimidine nucleosides and their evaluation against bovine viral diarrhoea virus and hepatitis C virus in cell culture.

Hollecker L, Choo H, Chong Y, Chu CK, Lostia S, McBrayer TR, Stuyver LJ, Mason JC, Du J, Rachakonda S, Shi J, Schinazi RF, Watanabe KA.

Antivir Chem Chemother. 2004 Jan;15(1):43-55.

PMID:
15074714
34.

Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine.

Stuyver LJ, McBrayer TR, Whitaker T, Tharnish PM, Ramesh M, Lostia S, Cartee L, Shi J, Hobbs A, Schinazi RF, Watanabe KA, Otto MJ.

Antimicrob Agents Chemother. 2004 Feb;48(2):651-4.

35.

Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites.

Stuyver LJ, McBrayer TR, Tharnish PM, Hassan AE, Chu CK, Pankiewicz KW, Watanabe KA, Schinazi RF, Otto MJ.

J Virol. 2003 Oct;77(19):10689-94.

36.

Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.

Stuyver LJ, Whitaker T, McBrayer TR, Hernandez-Santiago BI, Lostia S, Tharnish PM, Ramesh M, Chu CK, Jordan R, Shi J, Rachakonda S, Watanabe KA, Otto MJ, Schinazi RF.

Antimicrob Agents Chemother. 2003 Jan;47(1):244-54.

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