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Items: 1 to 50 of 224

1.

Fool's gold? Why blinded trials are not always best.

Anand R, Norrie J, Bradley JM, McAuley DF, Clarke M.

BMJ. 2020 Jan 21;368:l6228. doi: 10.1136/bmj.l6228. No abstract available.

PMID:
31964628
2.

Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials.

Sinha P, Delucchi KL, McAuley DF, O'Kane CM, Matthay MA, Calfee CS.

Lancet Respir Med. 2020 Jan 13. pii: S2213-2600(19)30369-8. doi: 10.1016/S2213-2600(19)30369-8. [Epub ahead of print]

PMID:
31948926
3.

A 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis: a protocol for the CLEAR clinical trial.

Bradley JM, Anand R, O'Neill B, Ferguson K, Clarke M, Carroll M, Chalmers J, De Soyza A, Duckers J, Hill AT, Loebinger MR, Copeland F, Gardner E, Campbell C, Agus A, McGuire A, Boyle R, McKinney F, Dickson N, McAuley DF, Elborn S; CLEAR study group.

Trials. 2019 Dec 19;20(1):747. doi: 10.1186/s13063-019-3766-9.

4.

Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation.

Hellyer TP, McAuley DF, Walsh TS, Anderson N, Conway Morris A, Singh S, Dark P, Roy AI, Perkins GD, McMullan R, Emerson LM, Blackwood B, Wright SE, Kefala K, O'Kane CM, Baudouin SV, Paterson RL, Rostron AJ, Agus A, Bannard-Smith J, Robin NM, Welters ID, Bassford C, Yates B, Spencer C, Laha SK, Hulme J, Bonner S, Linnett V, Sonksen J, Van Den Broeck T, Boschman G, Keenan DJ, Scott J, Allen AJ, Phair G, Parker J, Bowett SA, Simpson AJ.

Lancet Respir Med. 2020 Feb;8(2):182-191. doi: 10.1016/S2213-2600(19)30367-4. Epub 2019 Dec 3.

5.

A Porcine Ex Vivo Lung Perfusion Model To Investigate Bacterial Pathogenesis.

Dumigan A, Fitzgerald M, Santos JSG, Hamid U, O'Kane CM, McAuley DF, Bengoechea JA.

mBio. 2019 Dec 3;10(6). pii: e02802-19. doi: 10.1128/mBio.02802-19.

6.

Interventions for oropharyngeal dysphagia in acute and critical care: a protocol for a systematic review and meta-analysis.

Duncan S, Gaughey JM, Fallis R, McAuley DF, Walshe M, Blackwood B.

Syst Rev. 2019 Nov 20;8(1):283. doi: 10.1186/s13643-019-1196-0.

7.

Mechanical Ventilation for ARDS During Extracorporeal Life Support: Research and Practice.

Abrams D, Schmidt M, Pham T, Beitler JR, Fan E, Goligher EC, McNamee JJ, Patroniti N, Wilcox ME, Combes A, Ferguson ND, McAuley DF, Pesenti A, Quintel M, Fraser J, Hodgson CL, Hough CL, Mercat A, Mueller T, Pellegrino V, Ranieri VM, Rowan K, Shekar K, Brochard L, Brodie D; International ECMO Network (ECMONet).

Am J Respir Crit Care Med. 2019 Nov 14. doi: 10.1164/rccm.201907-1283CI. [Epub ahead of print]

PMID:
31726013
8.

Sedation AND Weaning In Children (SANDWICH): protocol for a cluster randomised stepped wedge trial.

Blackwood B, Agus A, Boyle R, Clarke M, Hemming K, Jordan J, Macrae D, McAuley DF, McDowell C, McIlmurray L, Morris KP, Murray M, Parslow R, Peters MJ, Tume LN, Walsh T; Paediatric Intensive Care Society Study Group (PICS-SG).

BMJ Open. 2019 Nov 10;9(11):e031630. doi: 10.1136/bmjopen-2019-031630.

9.

Protocol for a systematic review and network meta-analysis of the management of new onset atrial fibrillation in critically unwell adult patients.

Johnston BW, Hill R, Duarte R, Chean CS, McAuley DF, Blackwood B, Pace N, Welters ID.

Syst Rev. 2019 Oct 28;8(1):242. doi: 10.1186/s13643-019-1149-7.

10.

Targeting Proteases in Cystic Fibrosis Lung Disease. Paradigms, Progress, and Potential.

McKelvey MC, Weldon S, McAuley DF, Mall MA, Taggart CC.

Am J Respir Crit Care Med. 2020 Jan 15;201(2):141-147. doi: 10.1164/rccm.201906-1190PP. No abstract available.

PMID:
31626562
11.

Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction: a subgroup analysis of the LeoPARDS randomised trial.

Antcliffe DB, Santhakumaran S, Orme RML, Ward JK, Al-Beidh F, O'Dea K, Perkins GD, Singer M, McAuley DF, Mason AJ, Cross M, Ashby D, Gordon AC.

Intensive Care Med. 2019 Oct;45(10):1392-1400. doi: 10.1007/s00134-019-05731-w. Epub 2019 Aug 19.

PMID:
31428804
12.

A Core Outcome Set for Critical Care Ventilation Trials.

Blackwood B, Ringrow S, Clarke M, Marshall JC, Connolly B, Rose L, McAuley DF.

Crit Care Med. 2019 Oct;47(10):1324-1331. doi: 10.1097/CCM.0000000000003904.

13.

Guidelines on the management of acute respiratory distress syndrome.

Griffiths MJD, McAuley DF, Perkins GD, Barrett N, Blackwood B, Boyle A, Chee N, Connolly B, Dark P, Finney S, Salam A, Silversides J, Tarmey N, Wise MP, Baudouin SV.

BMJ Open Respir Res. 2019 May 24;6(1):e000420. doi: 10.1136/bmjresp-2019-000420. eCollection 2019.

14.

CSF Beta-amyloid 1-42 Concentration Predicts Delirium Following Elective Arthroplasty Surgery in an Observational Cohort Study.

Cunningham EL, McGuinness B, McAuley DF, Toombs J, Mawhinney T, O'Brien S, Beverland D, Schott JM, Lunn MP, Zetterberg H, Passmore AP.

Ann Surg. 2019 Jun;269(6):1200-1205. doi: 10.1097/SLA.0000000000002684.

PMID:
31082921
15.

Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials.

Santhakumaran S, Gordon A, Prevost AT, O'Kane C, McAuley DF, Shankar-Hari M.

Crit Care. 2019 May 3;23(1):156. doi: 10.1186/s13054-019-2446-1.

16.

Mesenchymal stem cells may ameliorate inflammation in an ex vivo model of extracorporeal membrane oxygenation.

von Bahr V, Millar JE, Malfertheiner MV, Ki KK, Passmore MR, Bartnikowski N, Redd MA, Cavaye M, Suen JY, McAuley DF, Fraser JF.

Perfusion. 2019 Apr;34(1_suppl):15-21. doi: 10.1177/0267659119830857.

PMID:
30966907
17.

Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models.

Millar JE, Bartnikowski N, von Bahr V, Malfertheiner MV, Obonyo NG, Belliato M, Suen JY, Combes A, McAuley DF, Lorusso R, Fraser JF; European Extracorporeal Life Support Organisation (EuroELSO) Innovations Workgroup; National Health Medical Research Council Australia Centre of Research Excellence for Advanced Cardio-respiratory Therapies Improving Organ Support (NHMRC CREACTIONS).

Intensive Care Med Exp. 2019 Mar 25;7(1):18. doi: 10.1186/s40635-019-0232-7. Review.

18.

Respiratory viral infection: a potential "missing link" in the pathogenesis of COPD.

Linden D, Guo-Parke H, Coyle PV, Fairley D, McAuley DF, Taggart CC, Kidney J.

Eur Respir Rev. 2019 Mar 14;28(151). pii: 180063. doi: 10.1183/16000617.0063-2018. Print 2019 Mar 31. Review.

19.

Cerebrospinal Fluid Spermidine, Glutamine and Putrescine Predict Postoperative Delirium Following Elective Orthopaedic Surgery.

Pan X, Cunningham EL, Passmore AP, McGuinness B, McAuley DF, Beverland D, O'Brien S, Mawhinney T, Schott JM, Zetterberg H, Green BD.

Sci Rep. 2019 Mar 12;9(1):4191. doi: 10.1038/s41598-019-40544-3.

20.

Emerging drugs for treating the acute respiratory distress syndrome.

Shaw TD, McAuley DF, O'Kane CM.

Expert Opin Emerg Drugs. 2019 Mar;24(1):29-41. doi: 10.1080/14728214.2019.1591369. Epub 2019 Mar 18. Review.

PMID:
30841764
21.

Development of a Core Outcome Set for studies evaluating the effects of anaesthesia on perioperative morbidity and mortality following hip fracture surgery.

O'Donnell CM, Black N, McCourt KC, McBrien ME, Clarke M, Patterson CC, Blackwood B, McAuley DF, Shields MO.

Br J Anaesth. 2019 Jan;122(1):120-130. doi: 10.1016/j.bja.2018.08.017. Epub 2018 Oct 3.

22.

The effectiveness of non-pharmacological interventions in reducing the incidence and duration of delirium in critically ill patients: a systematic review and meta-analysis.

Bannon L, McGaughey J, Verghis R, Clarke M, McAuley DF, Blackwood B.

Intensive Care Med. 2019 Jan;45(1):1-12. doi: 10.1007/s00134-018-5452-x. Epub 2018 Nov 30.

PMID:
30506354
23.

Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future.

Boyle AJ, Sklar MC, McNamee JJ, Brodie D, Slutsky AS, Brochard L, McAuley DF; International ECMO Network (ECMONet).

Lancet Respir Med. 2018 Nov;6(11):874-884. doi: 10.1016/S2213-2600(18)30326-6. Review.

PMID:
30484429
24.

Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCT.

Gordon AC, Santhakumaran S, Al-Beidh F, Orme RML, Perkins GD, Singer M, McAuley DF, Mason AJ, Ward JK, O’Dea KP, Felton T, Cross M, Best-Lane J, Lexow J, Campbell A, Ashby D.

Southampton (UK): NIHR Journals Library; 2018 Nov.

25.

Where next for cell-based therapy in ARDS.

Boyle AJ, O'Kane CM, McAuley DF.

Thorax. 2019 Jan;74(1):13-15. doi: 10.1136/thoraxjnl-2018-212272. Epub 2018 Nov 12. No abstract available.

PMID:
30420408
26.

Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database.

Boyle AJ, Madotto F, Laffey JG, Bellani G, Pham T, Pesenti A, Thompson BT, O'Kane CM, Deane AM, McAuley DF; LUNG SAFE Investigators; ESICM Trials Group.

Crit Care. 2018 Oct 27;22(1):268. doi: 10.1186/s13054-018-2158-y.

27.

Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure: The Breathe Randomized Clinical Trial.

Perkins GD, Mistry D, Gates S, Gao F, Snelson C, Hart N, Camporota L, Varley J, Carle C, Paramasivam E, Hoddell B, McAuley DF, Walsh TS, Blackwood B, Rose L, Lamb SE, Petrou S, Young D, Lall R; Breathe Collaborators.

JAMA. 2018 Nov 13;320(18):1881-1888. doi: 10.1001/jama.2018.13763.

28.

Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study.

Sinha P, Delucchi KL, Thompson BT, McAuley DF, Matthay MA, Calfee CS; NHLBI ARDS Network.

Intensive Care Med. 2018 Nov;44(11):1859-1869. doi: 10.1007/s00134-018-5378-3. Epub 2018 Oct 5.

29.

Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.

Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF; Irish Critical Care Trials Group.

Lancet Respir Med. 2018 Sep;6(9):691-698. doi: 10.1016/S2213-2600(18)30177-2. Epub 2018 Aug 2.

30.

Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis.

Pinder EM, Rostron AJ, Hellyer TP, Ruchaud-Sparagano MH, Scott J, Macfarlane JG, Wiscombe S, Widdrington JD, Roy AI, Linnett VC, Baudouin SV, Wright SE, Chadwick T, Fouweather T, Juss JK, Chilvers ER, Bowett SA, Parker J, McAuley DF, Conway Morris A, Simpson AJ.

Thorax. 2018 Oct;73(10):918-925. doi: 10.1136/thoraxjnl-2017-211323. Epub 2018 Jul 31.

31.

Deresuscitation of Patients With Iatrogenic Fluid Overload Is Associated With Reduced Mortality in Critical Illness.

Silversides JA, Fitzgerald E, Manickavasagam US, Lapinsky SE, Nisenbaum R, Hemmings N, Nutt C, Trinder TJ, Pogson DG, Fan E, Ferguson AJ, McAuley DF, Marshall JC; Role of Active Deresuscitation After Resuscitation (RADAR) Investigators.

Crit Care Med. 2018 Oct;46(10):1600-1607. doi: 10.1097/CCM.0000000000003276.

PMID:
29985214
32.

A United Kingdom Register study of in-hospital outcomes of patients receiving extracorporeal carbon dioxide removal.

Cummins C, Bentley A, McAuley DF, McNamee JJ, Patrick H, Barrett NA.

J Intensive Care Soc. 2018 May;19(2):114-121. doi: 10.1177/1751143717739816. Epub 2017 Nov 13.

33.

Corrigendum to 'Perioperative outcomes in the context of mode of anaesthesia for patients undergoing hip fracture surgery: systematic review and meta-analysis' [Br J Anaesth 2018; 120: 37-50].

O'Donnell CM, McLoughlin L, Patterson CC, Clarke M, McCourt KC, McBrien ME, McAuley DF, Shields MO.

Br J Anaesth. 2018 Jun;120(6):1442-1444. doi: 10.1016/j.bja.2018.03.012. Epub 2018 Apr 16. No abstract available.

34.

Administration of mesenchymal stem cells during ECMO results in a rapid decline in oxygenator performance.

Millar JE, von Bahr V, Malfertheiner MV, Ki KK, Redd MA, Bartnikowski N, Suen JY, McAuley DF, Fraser JF.

Thorax. 2019 Feb;74(2):194-196. doi: 10.1136/thoraxjnl-2017-211439. Epub 2018 Apr 5.

PMID:
29622695
35.

Designing a nurse-delivered delirium bundle: What intensive care unit staff, survivors, and their families think?

Bannon L, McGaughey J, Clarke M, McAuley DF, Blackwood B.

Aust Crit Care. 2018 May;31(3):174-179. doi: 10.1016/j.aucc.2018.02.007. Epub 2018 Mar 23.

PMID:
29580965
36.

Simvastatin for the prevention and treatment of delirium in critically ill, mechanically ventilated patients (MoDUS): a cost-effectiveness analysis.

Agus A, Phair G, Page VJ, McAuley DF.

Lancet Respir Med. 2018 Mar;6(3):e9-e10. doi: 10.1016/S2213-2600(18)30070-5. No abstract available.

PMID:
29508709
37.

Simvastatin to reduce pulmonary dysfunction in patients with acute respiratory distress syndrome: the HARP-2 RCT.

McAuley DF, Laffey JG, O’Kane CM, Perkins GD, Mullan B, Trinder TJ, Johnston P, Hopkins PA, Johnston AJ, Murphy L, McNally C, Agus AM, McDowell C, Jackson C.

Southampton (UK): NIHR Journals Library; 2018 Jan.

38.

Perioperative outcomes in the context of mode of anaesthesia for patients undergoing hip fracture surgery: systematic review and meta-analysis.

O'Donnell CM, McLoughlin L, Patterson CC, Clarke M, McCourt KC, McBrien ME, McAuley DF, Shields MO.

Br J Anaesth. 2018 Jan;120(1):37-50. doi: 10.1016/j.bja.2017.09.002. Epub 2017 Nov 24. Erratum in: Br J Anaesth. 2018 Jun;120(6):1442-1444.

39.

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury.

Proudfoot A, Bayliffe A, O'Kane CM, Wright T, Serone A, Bareille PJ, Brown V, Hamid UI, Chen Y, Wilson R, Cordy J, Morley P, de Wildt R, Elborn S, Hind M, Chilvers ER, Griffiths M, Summers C, McAuley DF.

Thorax. 2018 Aug;73(8):723-730. doi: 10.1136/thoraxjnl-2017-210305. Epub 2018 Jan 29.

40.

Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study.

Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group.

Intensive Care Med. 2018 Jan;44(1):157-165. doi: 10.1007/s00134-017-4981-z.

PMID:
29138899
41.

Mechanical Ventilation in Adults with Acute Respiratory Distress Syndrome. Summary of the Experimental Evidence for the Clinical Practice Guideline.

Del Sorbo L, Goligher EC, McAuley DF, Rubenfeld GD, Brochard LJ, Gattinoni L, Slutsky AS, Fan E.

Ann Am Thorac Soc. 2017 Oct;14(Supplement_4):S261-S270. doi: 10.1513/AnnalsATS.201704-345OT. Review.

PMID:
28985479
42.

pRotective vEntilation with veno-venouS lung assisT in respiratory failure: A protocol for a multicentre randomised controlled trial of extracorporeal carbon dioxide removal in patients with acute hypoxaemic respiratory failure.

McNamee JJ, Gillies MA, Barrett NA, Agus AM, Beale R, Bentley A, Bodenham A, Brett SJ, Brodie D, Finney SJ, Gordon AJ, Griffiths M, Harrison D, Jackson C, McDowell C, McNally C, Perkins GD, Tunnicliffe W, Vuylsteke A, Walsh TS, Wise MP, Young D, McAuley DF.

J Intensive Care Soc. 2017 May;18(2):159-169. doi: 10.1177/1751143716681035. Epub 2016 Dec 19.

43.

Patients' Perceptions of an Exercise Program Delivered Following Discharge From Hospital After Critical Illness (the Revive Trial).

Ferguson K, Bradley JM, McAuley DF, Blackwood B, O'Neill B.

J Intensive Care Med. 2017 Jan 1:885066617724738. doi: 10.1177/0885066617724738. [Epub ahead of print]

PMID:
28826281
44.

Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching.

Trauer J, Muhi S, McBryde ES, Al Harbi SA, Arabi YM, Boyle AJ, Cartin-Ceba R, Chen W, Chen YT, Falcone M, Gajic O, Godsell J, Gong MN, Kor D, Lösche W, McAuley DF, O'Neal HR Jr, Osthoff M, Otto GP, Sossdorf M, Tsai MJ, Valerio-Rojas JC, van der Poll T, Violi F, Ware L, Widmer AF, Wiewel MA, Winning J, Eisen DP.

Crit Care Med. 2017 Nov;45(11):1871-1879. doi: 10.1097/CCM.0000000000002654.

45.

Late mortality after acute hypoxic respiratory failure.

Prescott HC, Sjoding MW, Langa KM, Iwashyna TJ, McAuley DF.

Thorax. 2017 Aug 5. pii: thoraxjnl-2017-210109. doi: 10.1136/thoraxjnl-2017-210109. [Epub ahead of print]

46.

Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation (MoDUS): a randomised, double-blind, placebo-controlled trial.

Page VJ, Casarin A, Ely EW, Zhao XB, McDowell C, Murphy L, McAuley DF.

Lancet Respir Med. 2017 Sep;5(9):727-737. doi: 10.1016/S2213-2600(17)30234-5. Epub 2017 Jul 19. Erratum in: Lancet Respir Med. 2018 Apr;6(4):e15.

PMID:
28734823
47.

Divide and conquer: identifying acute respiratory distress syndrome subphenotypes.

Shankar-Hari M, McAuley DF.

Thorax. 2017 Oct;72(10):867-869. doi: 10.1136/thoraxjnl-2017-210422. Epub 2017 Jul 17. No abstract available.

PMID:
28717034
48.

Characterisation of eppin function: expression and activity in the lung.

Scott A, Glasgow A, Small D, Carlile S, McCrudden M, McLean D, Brown R, Doherty D, Lundy FT, Hamid UI, O'Kane CM, McAuley DF, Brodlie M, Tunney M, Elborn JS, Irwin CR, Timson DJ, Taggart CC, Weldon S.

Eur Respir J. 2017 Jul 13;50(1). pii: 1601937. doi: 10.1183/13993003.01937-2016. Print 2017 Jul.

49.

Clinical trials in acute respiratory distress syndrome: challenges and opportunities.

Matthay MA, McAuley DF, Ware LB.

Lancet Respir Med. 2017 Jun;5(6):524-534. doi: 10.1016/S2213-2600(17)30188-1. Epub 2017 May 26. Review.

PMID:
28664851
50.

Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study.

Laffey JG, Madotto F, Bellani G, Pham T, Fan E, Brochard L, Amin P, Arabi Y, Bajwa EK, Bruhn A, Cerny V, Clarkson K, Heunks L, Kurahashi K, Laake JH, Lorente JA, McNamee L, Nin N, Palo JE, Piquilloud L, Qiu H, Jiménez JIS, Esteban A, McAuley DF, van Haren F, Ranieri M, Rubenfeld G, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group.

Lancet Respir Med. 2017 Aug;5(8):627-638. doi: 10.1016/S2213-2600(17)30213-8. Epub 2017 Jun 15.

PMID:
28624388

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