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COVID-19: consider cytokine storm syndromes and immunosuppression.

Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ; HLH Across Speciality Collaboration, UK.

Lancet. 2020 Mar 28;395(10229):1033-1034. doi: 10.1016/S0140-6736(20)30628-0. Epub 2020 Mar 16. No abstract available.


Relationship between norepinephrine dose, tachycardia and outcome in septic shock: A multicentre evaluation.

Domizi R, Calcinaro S, Harris S, Beilstein C, Boerma C, Chiche JD, D'Egidio A, Damiani E, Donati A, Koetsier PM, Madden MP, McAuley DF, Morelli A, Pelaia P, Royer P, Shankar-Hari M, Wickboldt N, Zolfaghari P, Singer M.

J Crit Care. 2020 Feb 28;57:185-190. doi: 10.1016/j.jcrc.2020.02.014. [Epub ahead of print]


Corticosteroids in acute respiratory distress syndrome: a step forward, but more evidence is needed.

Reddy K, O'Kane C, McAuley D.

Lancet Respir Med. 2020 Mar;8(3):220-222. doi: 10.1016/S2213-2600(20)30048-5. Epub 2020 Feb 7. No abstract available.


Fool's gold? Why blinded trials are not always best.

Anand R, Norrie J, Bradley JM, McAuley DF, Clarke M.

BMJ. 2020 Jan 21;368:l6228. doi: 10.1136/bmj.l6228. No abstract available.


Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials.

Sinha P, Delucchi KL, McAuley DF, O'Kane CM, Matthay MA, Calfee CS.

Lancet Respir Med. 2020 Mar;8(3):247-257. doi: 10.1016/S2213-2600(19)30369-8. Epub 2020 Jan 13.


A 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis: a protocol for the CLEAR clinical trial.

Bradley JM, Anand R, O'Neill B, Ferguson K, Clarke M, Carroll M, Chalmers J, De Soyza A, Duckers J, Hill AT, Loebinger MR, Copeland F, Gardner E, Campbell C, Agus A, McGuire A, Boyle R, McKinney F, Dickson N, McAuley DF, Elborn S; CLEAR study group.

Trials. 2019 Dec 19;20(1):747. doi: 10.1186/s13063-019-3766-9.


Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation.

Hellyer TP, McAuley DF, Walsh TS, Anderson N, Conway Morris A, Singh S, Dark P, Roy AI, Perkins GD, McMullan R, Emerson LM, Blackwood B, Wright SE, Kefala K, O'Kane CM, Baudouin SV, Paterson RL, Rostron AJ, Agus A, Bannard-Smith J, Robin NM, Welters ID, Bassford C, Yates B, Spencer C, Laha SK, Hulme J, Bonner S, Linnett V, Sonksen J, Van Den Broeck T, Boschman G, Keenan DJ, Scott J, Allen AJ, Phair G, Parker J, Bowett SA, Simpson AJ.

Lancet Respir Med. 2020 Feb;8(2):182-191. doi: 10.1016/S2213-2600(19)30367-4. Epub 2019 Dec 3.


A Porcine Ex Vivo Lung Perfusion Model To Investigate Bacterial Pathogenesis.

Dumigan A, Fitzgerald M, Santos JSG, Hamid U, O'Kane CM, McAuley DF, Bengoechea JA.

mBio. 2019 Dec 3;10(6). pii: e02802-19. doi: 10.1128/mBio.02802-19.


Interventions for oropharyngeal dysphagia in acute and critical care: a protocol for a systematic review and meta-analysis.

Duncan S, Gaughey JM, Fallis R, McAuley DF, Walshe M, Blackwood B.

Syst Rev. 2019 Nov 20;8(1):283. doi: 10.1186/s13643-019-1196-0.


Mechanical Ventilation for Acute Respiratory Distress Syndrome during Extracorporeal Life Support. Research and Practice.

Abrams D, Schmidt M, Pham T, Beitler JR, Fan E, Goligher EC, McNamee JJ, Patroniti N, Wilcox ME, Combes A, Ferguson ND, McAuley DF, Pesenti A, Quintel M, Fraser J, Hodgson CL, Hough CL, Mercat A, Mueller T, Pellegrino V, Ranieri VM, Rowan K, Shekar K, Brochard L, Brodie D.

Am J Respir Crit Care Med. 2020 Mar 1;201(5):514-525. doi: 10.1164/rccm.201907-1283CI.


Sedation AND Weaning In Children (SANDWICH): protocol for a cluster randomised stepped wedge trial.

Blackwood B, Agus A, Boyle R, Clarke M, Hemming K, Jordan J, Macrae D, McAuley DF, McDowell C, McIlmurray L, Morris KP, Murray M, Parslow R, Peters MJ, Tume LN, Walsh T; Paediatric Intensive Care Society Study Group (PICS-SG).

BMJ Open. 2019 Nov 10;9(11):e031630. doi: 10.1136/bmjopen-2019-031630.


Protocol for a systematic review and network meta-analysis of the management of new onset atrial fibrillation in critically unwell adult patients.

Johnston BW, Hill R, Duarte R, Chean CS, McAuley DF, Blackwood B, Pace N, Welters ID.

Syst Rev. 2019 Oct 28;8(1):242. doi: 10.1186/s13643-019-1149-7.


Targeting Proteases in Cystic Fibrosis Lung Disease. Paradigms, Progress, and Potential.

McKelvey MC, Weldon S, McAuley DF, Mall MA, Taggart CC.

Am J Respir Crit Care Med. 2020 Jan 15;201(2):141-147. doi: 10.1164/rccm.201906-1190PP. No abstract available.


Protocolised non-invasive compared with invasive weaning from mechanical ventilation for adults in intensive care: the Breathe RCT.

Perkins GD, Mistry D, Lall R, Gao-Smith F, Snelson C, Hart N, Camporota L, Varley J, Carle C, Paramasivam E, Hoddell B, de Paeztron A, Dosanjh S, Sampson J, Blair L, Couper K, McAuley D, Young JD, Walsh T, Blackwood B, Rose L, Lamb SE, Dritsaki M, Maredza M, Khan I, Petrou S, Gates S.

Health Technol Assess. 2019 Sep;23(48):1-114. doi: 10.3310/hta23480.


Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction: a subgroup analysis of the LeoPARDS randomised trial.

Antcliffe DB, Santhakumaran S, Orme RML, Ward JK, Al-Beidh F, O'Dea K, Perkins GD, Singer M, McAuley DF, Mason AJ, Cross M, Ashby D, Gordon AC.

Intensive Care Med. 2019 Oct;45(10):1392-1400. doi: 10.1007/s00134-019-05731-w. Epub 2019 Aug 19.


A Core Outcome Set for Critical Care Ventilation Trials.

Blackwood B, Ringrow S, Clarke M, Marshall JC, Connolly B, Rose L, McAuley DF.

Crit Care Med. 2019 Oct;47(10):1324-1331. doi: 10.1097/CCM.0000000000003904.


Guidelines on the management of acute respiratory distress syndrome.

Griffiths MJD, McAuley DF, Perkins GD, Barrett N, Blackwood B, Boyle A, Chee N, Connolly B, Dark P, Finney S, Salam A, Silversides J, Tarmey N, Wise MP, Baudouin SV.

BMJ Open Respir Res. 2019 May 24;6(1):e000420. doi: 10.1136/bmjresp-2019-000420. eCollection 2019.


Effectiveness of Multimodal imaging for the Evaluation of Retinal oedema And new vesseLs in Diabetic retinopathy (EMERALD).

Lois N, Cook J, Aldington S, Waugh N, Mistry H, Sones W, McAuley D, Aslam T, Bailey C, Chong V, Ghanchi F, Scanlon P, Sivaprasad S, Steel D, Styles C, McNally C, Rice R, Prior L, Azuara-Blanco A; EMERALD Study Group.

BMJ Open. 2019 Jun 28;9(6):e027795. doi: 10.1136/bmjopen-2018-027795.


CSF Beta-amyloid 1-42 Concentration Predicts Delirium Following Elective Arthroplasty Surgery in an Observational Cohort Study.

Cunningham EL, McGuinness B, McAuley DF, Toombs J, Mawhinney T, O'Brien S, Beverland D, Schott JM, Lunn MP, Zetterberg H, Passmore AP.

Ann Surg. 2019 Jun;269(6):1200-1205. doi: 10.1097/SLA.0000000000002684.


Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials.

Santhakumaran S, Gordon A, Prevost AT, O'Kane C, McAuley DF, Shankar-Hari M.

Crit Care. 2019 May 3;23(1):156. doi: 10.1186/s13054-019-2446-1.


Mesenchymal stem cells may ameliorate inflammation in an ex vivo model of extracorporeal membrane oxygenation.

von Bahr V, Millar JE, Malfertheiner MV, Ki KK, Passmore MR, Bartnikowski N, Redd MA, Cavaye M, Suen JY, McAuley DF, Fraser JF.

Perfusion. 2019 Apr;34(1_suppl):15-21. doi: 10.1177/0267659119830857.


Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models.

Millar JE, Bartnikowski N, von Bahr V, Malfertheiner MV, Obonyo NG, Belliato M, Suen JY, Combes A, McAuley DF, Lorusso R, Fraser JF; European Extracorporeal Life Support Organisation (EuroELSO) Innovations Workgroup; National Health Medical Research Council Australia Centre of Research Excellence for Advanced Cardio-respiratory Therapies Improving Organ Support (NHMRC CREACTIONS).

Intensive Care Med Exp. 2019 Mar 25;7(1):18. doi: 10.1186/s40635-019-0232-7. Review.


Respiratory viral infection: a potential "missing link" in the pathogenesis of COPD.

Linden D, Guo-Parke H, Coyle PV, Fairley D, McAuley DF, Taggart CC, Kidney J.

Eur Respir Rev. 2019 Mar 14;28(151). pii: 180063. doi: 10.1183/16000617.0063-2018. Print 2019 Mar 31. Review.


Cerebrospinal Fluid Spermidine, Glutamine and Putrescine Predict Postoperative Delirium Following Elective Orthopaedic Surgery.

Pan X, Cunningham EL, Passmore AP, McGuinness B, McAuley DF, Beverland D, O'Brien S, Mawhinney T, Schott JM, Zetterberg H, Green BD.

Sci Rep. 2019 Mar 12;9(1):4191. doi: 10.1038/s41598-019-40544-3.


IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo.

Harris AJ, Mirchandani AS, Lynch RW, Murphy F, Delaney L, Small D, Coelho P, Watts ER, Sadiku P, Griffith D, Dickinson RS, Clark E, Willson JA, Morrison T, Mazzone M, Carmeliet P, Ghesquiere B, O'Kane C, McAuley D, Jenkins SJ, Whyte MKB, Walmsley SR.

Am J Respir Crit Care Med. 2019 Jul 15;200(2):235-246. doi: 10.1164/rccm.201808-1599OC.


Emerging drugs for treating the acute respiratory distress syndrome.

Shaw TD, McAuley DF, O'Kane CM.

Expert Opin Emerg Drugs. 2019 Mar;24(1):29-41. doi: 10.1080/14728214.2019.1591369. Epub 2019 Mar 18. Review.


Diabetic macular oedema and diode subthreshold micropulse laser (DIAMONDS): study protocol for a randomised controlled trial.

Lois N, Gardner E, Waugh N, Azuara-Blanco A, Mistry H, McAuley D, Acharya N, Aslam TM, Bailey C, Chong V, Downey L, Eleftheriadis H, Fatum S, George S, Ghanchi F, Groppe M, Hamilton R, Menon G, Saad A, Sivaprasad S, Shiew M, Steel DH, Talks JS, Adams C, Campbell C, Mills M, Clarke M; DIAMONDS Study Group.

Trials. 2019 Feb 12;20(1):122. doi: 10.1186/s13063-019-3199-5.


Hypercapnic acidosis induces mitochondrial dysfunction and impairs the ability of mesenchymal stem cells to promote distal lung epithelial repair.

Fergie N, Todd N, McClements L, McAuley D, O'Kane C, Krasnodembskaya A.

FASEB J. 2019 Apr;33(4):5585-5598. doi: 10.1096/fj.201802056R. Epub 2019 Jan 16.


Development of a Core Outcome Set for studies evaluating the effects of anaesthesia on perioperative morbidity and mortality following hip fracture surgery.

O'Donnell CM, Black N, McCourt KC, McBrien ME, Clarke M, Patterson CC, Blackwood B, McAuley DF, Shields MO.

Br J Anaesth. 2019 Jan;122(1):120-130. doi: 10.1016/j.bja.2018.08.017. Epub 2018 Oct 3.


Prevention of post-operative complications by using a HMG-CoA reductase inhibitor in patients undergoing one-lung ventilation for non-cardiac surgery: study protocol for a randomised controlled trial.

Shyamsundar M, O'Kane C, Perkins GD, Kennedy G, Campbell C, Agus A, Phair G, McAuley D.

Trials. 2018 Dec 18;19(1):690. doi: 10.1186/s13063-018-3078-5.


The effectiveness of non-pharmacological interventions in reducing the incidence and duration of delirium in critically ill patients: a systematic review and meta-analysis.

Bannon L, McGaughey J, Verghis R, Clarke M, McAuley DF, Blackwood B.

Intensive Care Med. 2019 Jan;45(1):1-12. doi: 10.1007/s00134-018-5452-x. Epub 2018 Nov 30.


Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future.

Boyle AJ, Sklar MC, McNamee JJ, Brodie D, Slutsky AS, Brochard L, McAuley DF; International ECMO Network (ECMONet).

Lancet Respir Med. 2018 Nov;6(11):874-884. doi: 10.1016/S2213-2600(18)30326-6. Review.


Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCT.

Gordon AC, Santhakumaran S, Al-Beidh F, Orme RML, Perkins GD, Singer M, McAuley DF, Mason AJ, Ward JK, O’Dea KP, Felton T, Cross M, Best-Lane J, Lexow J, Campbell A, Ashby D.

Southampton (UK): NIHR Journals Library; 2018 Nov.


Where next for cell-based therapy in ARDS.

Boyle AJ, O'Kane CM, McAuley DF.

Thorax. 2019 Jan;74(1):13-15. doi: 10.1136/thoraxjnl-2018-212272. Epub 2018 Nov 12. No abstract available.


Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study.

van Haren F, Pham T, Brochard L, Bellani G, Laffey J, Dres M, Fan E, Goligher EC, Heunks L, Lynch J, Wrigge H, McAuley D; Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) Investigators.

Crit Care Med. 2019 Feb;47(2):229-238. doi: 10.1097/CCM.0000000000003519.


Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database.

Boyle AJ, Madotto F, Laffey JG, Bellani G, Pham T, Pesenti A, Thompson BT, O'Kane CM, Deane AM, McAuley DF; LUNG SAFE Investigators; ESICM Trials Group.

Crit Care. 2018 Oct 27;22(1):268. doi: 10.1186/s13054-018-2158-y.


Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure: The Breathe Randomized Clinical Trial.

Perkins GD, Mistry D, Gates S, Gao F, Snelson C, Hart N, Camporota L, Varley J, Carle C, Paramasivam E, Hoddell B, McAuley DF, Walsh TS, Blackwood B, Rose L, Lamb SE, Petrou S, Young D, Lall R; Breathe Collaborators.

JAMA. 2018 Nov 13;320(18):1881-1888. doi: 10.1001/jama.2018.13763.


Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study.

Sinha P, Delucchi KL, Thompson BT, McAuley DF, Matthay MA, Calfee CS; NHLBI ARDS Network.

Intensive Care Med. 2018 Nov;44(11):1859-1869. doi: 10.1007/s00134-018-5378-3. Epub 2018 Oct 5.


Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.

Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF; Irish Critical Care Trials Group.

Lancet Respir Med. 2018 Sep;6(9):691-698. doi: 10.1016/S2213-2600(18)30177-2. Epub 2018 Aug 2.


Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis.

Pinder EM, Rostron AJ, Hellyer TP, Ruchaud-Sparagano MH, Scott J, Macfarlane JG, Wiscombe S, Widdrington JD, Roy AI, Linnett VC, Baudouin SV, Wright SE, Chadwick T, Fouweather T, Juss JK, Chilvers ER, Bowett SA, Parker J, McAuley DF, Conway Morris A, Simpson AJ.

Thorax. 2018 Oct;73(10):918-925. doi: 10.1136/thoraxjnl-2017-211323. Epub 2018 Jul 31.


Deresuscitation of Patients With Iatrogenic Fluid Overload Is Associated With Reduced Mortality in Critical Illness.

Silversides JA, Fitzgerald E, Manickavasagam US, Lapinsky SE, Nisenbaum R, Hemmings N, Nutt C, Trinder TJ, Pogson DG, Fan E, Ferguson AJ, McAuley DF, Marshall JC; Role of Active Deresuscitation After Resuscitation (RADAR) Investigators.

Crit Care Med. 2018 Oct;46(10):1600-1607. doi: 10.1097/CCM.0000000000003276.


A United Kingdom Register study of in-hospital outcomes of patients receiving extracorporeal carbon dioxide removal.

Cummins C, Bentley A, McAuley DF, McNamee JJ, Patrick H, Barrett NA.

J Intensive Care Soc. 2018 May;19(2):114-121. doi: 10.1177/1751143717739816. Epub 2017 Nov 13.


Corrigendum to 'Perioperative outcomes in the context of mode of anaesthesia for patients undergoing hip fracture surgery: systematic review and meta-analysis' [Br J Anaesth 2018; 120: 37-50].

O'Donnell CM, McLoughlin L, Patterson CC, Clarke M, McCourt KC, McBrien ME, McAuley DF, Shields MO.

Br J Anaesth. 2018 Jun;120(6):1442-1444. doi: 10.1016/j.bja.2018.03.012. Epub 2018 Apr 16. No abstract available.


Administration of mesenchymal stem cells during ECMO results in a rapid decline in oxygenator performance.

Millar JE, von Bahr V, Malfertheiner MV, Ki KK, Redd MA, Bartnikowski N, Suen JY, McAuley DF, Fraser JF.

Thorax. 2019 Feb;74(2):194-196. doi: 10.1136/thoraxjnl-2017-211439. Epub 2018 Apr 5.


Designing a nurse-delivered delirium bundle: What intensive care unit staff, survivors, and their families think?

Bannon L, McGaughey J, Clarke M, McAuley DF, Blackwood B.

Aust Crit Care. 2018 May;31(3):174-179. doi: 10.1016/j.aucc.2018.02.007. Epub 2018 Mar 23.


Simvastatin for the prevention and treatment of delirium in critically ill, mechanically ventilated patients (MoDUS): a cost-effectiveness analysis.

Agus A, Phair G, Page VJ, McAuley DF.

Lancet Respir Med. 2018 Mar;6(3):e9-e10. doi: 10.1016/S2213-2600(18)30070-5. No abstract available.


Simvastatin to reduce pulmonary dysfunction in patients with acute respiratory distress syndrome: the HARP-2 RCT.

McAuley DF, Laffey JG, O’Kane CM, Perkins GD, Mullan B, Trinder TJ, Johnston P, Hopkins PA, Johnston AJ, Murphy L, McNally C, Agus AM, McDowell C, Jackson C.

Southampton (UK): NIHR Journals Library; 2018 Jan.


Perioperative outcomes in the context of mode of anaesthesia for patients undergoing hip fracture surgery: systematic review and meta-analysis.

O'Donnell CM, McLoughlin L, Patterson CC, Clarke M, McCourt KC, McBrien ME, McAuley DF, Shields MO.

Br J Anaesth. 2018 Jan;120(1):37-50. doi: 10.1016/j.bja.2017.09.002. Epub 2017 Nov 24. Erratum in: Br J Anaesth. 2018 Jun;120(6):1442-1444.


Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury.

Proudfoot A, Bayliffe A, O'Kane CM, Wright T, Serone A, Bareille PJ, Brown V, Hamid UI, Chen Y, Wilson R, Cordy J, Morley P, de Wildt R, Elborn S, Hind M, Chilvers ER, Griffiths M, Summers C, McAuley DF.

Thorax. 2018 Aug;73(8):723-730. doi: 10.1136/thoraxjnl-2017-210305. Epub 2018 Jan 29.


Building accountability into the Internet of Things: the IoT Databox model.

Crabtree A, Lodge T, Colley J, Greenhalgh C, Glover K, Haddadi H, Amar Y, Mortier R, Li Q, Moore J, Wang L, Yadav P, Zhao J, Brown A, Urquhart L, McAuley D.

J Reliab Intell Environ. 2018;4(1):39-55. doi: 10.1007/s40860-018-0054-5. Epub 2018 Jan 27.

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