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A Phase I/Ib Trial of the VEGFR-Sparing Multikinase RET Inhibitor RXDX-105.

Drilon A, Fu S, Patel MR, Fakih M, Wang D, Olszanski AJ, Morgensztern D, Liu SV, Cho BC, Bazhenova L, Rodriguez CP, Doebele RC, Wozniak A, Reckamp KL, Seery T, Nikolinakos P, Hu Z, Oliver JW, Trone D, McArthur K, Patel R, Multani PS, Ahn MJ.

Cancer Discov. 2019 Mar;9(3):384-395. doi: 10.1158/2159-8290.CD-18-0839. Epub 2018 Nov 28.


The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.

Vince JE, De Nardo D, Gao W, Vince AJ, Hall C, McArthur K, Simpson D, Vijayaraj S, Lindqvist LM, Bouillet P, Rizzacasa MA, Man SM, Silke J, Masters SL, Lessene G, Huang DCS, Gray DHD, Kile BT, Shao F, Lawlor KE.

Cell Rep. 2018 Nov 27;25(9):2339-2353.e4. doi: 10.1016/j.celrep.2018.10.103.


Apoptotic Caspases: Multiple or Mistaken Identities?

McArthur K, Kile BT.

Trends Cell Biol. 2018 Jun;28(6):475-493. doi: 10.1016/j.tcb.2018.02.003. Epub 2018 Mar 15. Review.


BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.

McArthur K, Whitehead LW, Heddleston JM, Li L, Padman BS, Oorschot V, Geoghegan ND, Chappaz S, Davidson S, San Chin H, Lane RM, Dramicanin M, Saunders TL, Sugiana C, Lessene R, Osellame LD, Chew TL, Dewson G, Lazarou M, Ramm G, Lessene G, Ryan MT, Rogers KL, van Delft MF, Kile BT.

Science. 2018 Feb 23;359(6378). pii: eaao6047. doi: 10.1126/science.aao6047.


Apoptosis in megakaryocytes and platelets: the life and death of a lineage.

McArthur K, Chappaz S, Kile BT.

Blood. 2018 Feb 8;131(6):605-610. doi: 10.1182/blood-2017-11-742684. Epub 2017 Dec 19. Review.


Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion.

Lindqvist LM, Frank D, McArthur K, Dite TA, Lazarou M, Oakhill JS, Kile BT, Vaux DL.

Cell Death Differ. 2018 Mar;25(4):782-794. doi: 10.1038/s41418-017-0017-z. Epub 2017 Dec 11.


Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia.

McArthur K, D'Cruz AA, Segal D, Lackovic K, Wilks AF, O'Donnell JA, Nowell CJ, Gerlic M, Huang DCS, Burns CJ, Croker BA.

Oncotarget. 2017 Jul 28;8(35):57948-57963. doi: 10.18632/oncotarget.19678. eCollection 2017 Aug 29.


Key Features of Structural and Functional Organization of Zebrafish Facial Motor Neurons Are Resilient to Disruption of Neuronal Migration.

McArthur KL, Fetcho JR.

Curr Biol. 2017 Jun 19;27(12):1746-1756.e5. doi: 10.1016/j.cub.2017.05.033. Epub 2017 Jun 9.


The reinvention of twentieth century microscopy for three-dimensional imaging.

Whitehead LW, McArthur K, Geoghegan ND, Rogers KL.

Immunol Cell Biol. 2017 Jul;95(6):520-524. doi: 10.1038/icb.2017.36. Epub 2017 Apr 27. Review.


Automating Venous Thromboembolism Risk Calculation Using Electronic Health Record Data upon Hospital Admission: The Automated Padua Prediction Score.

Elias P, Khanna R, Dudley A, Davies J, Jacolbia R, McArthur K, Auerbach AD.

J Hosp Med. 2017 Apr;12(4):231-237. doi: 10.12788/jhm.2714.


Activation of cGAS-dependent antiviral responses by DNA intercalating agents.

Pépin G, Nejad C, Thomas BJ, Ferrand J, McArthur K, Bardin PG, Williams BR, Gantier MP.

Nucleic Acids Res. 2017 Jan 9;45(1):198-205. doi: 10.1093/nar/gkw878. Epub 2016 Sep 29.


TRP channel mediated neuronal activation and ablation in freely behaving zebrafish.

Chen S, Chiu CN, McArthur KL, Fetcho JR, Prober DA.

Nat Methods. 2016 Feb;13(2):147-50. doi: 10.1038/nmeth.3691. Epub 2015 Dec 14.


Cerebral hyperperfusion on arterial spin labeling MRI during CADASIL migrainous encephalopathy.

Moreton FC, Santosh C, McArthur K, Muir KW.

Neurology. 2015 Dec 15;85(24):2177-9. doi: 10.1212/WNL.0000000000002214. Epub 2015 Nov 13. No abstract available.


Small Bowel Perforation as a Postoperative Complication from a Laminectomy.

Krieger RH, Wojcicki KM, Berry AC, Reuther WL 3rd, McArthur KD.

Case Rep Surg. 2015;2015:378218. doi: 10.1155/2015/378218. Epub 2015 Jul 8.


Increasing off-service resident productivity while on their emergency department rotation using shift cards.

Chakravarthy B, Posadas E, Ibrahim D, McArthur K, Osborn M, Hoonpongsimanont W, Wong A, Lotfipour S.

J Emerg Med. 2015 Apr;48(4):499-505. doi: 10.1016/j.jemermed.2014.11.001. Epub 2015 Jan 22.


HSP90 inhibition suppresses lipopolysaccharide-induced lung inflammation in vivo.

Lilja A, Weeden CE, McArthur K, Nguyen T, Donald A, Wong ZX, Dousha L, Bozinovski S, Vlahos R, Burns CJ, Asselin-Labat ML, Anderson GP.

PLoS One. 2015 Jan 23;10(1):e0114975. doi: 10.1371/journal.pone.0114975. eCollection 2015.


Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.

White MJ, McArthur K, Metcalf D, Lane RM, Cambier JC, Herold MJ, van Delft MF, Bedoui S, Lessene G, Ritchie ME, Huang DC, Kile BT.

Cell. 2014 Dec 18;159(7):1549-62. doi: 10.1016/j.cell.2014.11.036.


Autotransfusion in emergent operative trauma resuscitation.

Caliste XA, McArthur KA, Sava JA.

Eur J Trauma Emerg Surg. 2014 Oct;40(5):541-5. doi: 10.1007/s00068-013-0328-9. Epub 2014 Apr 12.


Screening and brief intervention delivery in the workplace to reduce alcohol-related harm: a pilot randomized controlled trial.

Watson H, Godfrey C, McFadyen A, McArthur K, Stevenson M, Holloway A.

Int J Nurs Stud. 2015 Jan;52(1):39-48. doi: 10.1016/j.ijnurstu.2014.06.013. Epub 2014 Jul 5.


Predictive value of newly detected atrial fibrillation paroxysms in patients with acute ischemic stroke, for atrial fibrillation after 90 days.

Higgins P, Dawson J, MacFarlane PW, McArthur K, Langhorne P, Lees KR.

Stroke. 2014 Jul;45(7):2134-6. doi: 10.1161/STROKEAHA.114.005405. Epub 2014 Jun 17.


Allopurinol reduces brachial and central blood pressure, and carotid intima-media thickness progression after ischaemic stroke and transient ischaemic attack: a randomised controlled trial.

Higgins P, Walters MR, Murray HM, McArthur K, McConnachie A, Lees KR, Dawson J.

Heart. 2014 Jul;100(14):1085-92. doi: 10.1136/heartjnl-2014-305683. Epub 2014 May 1.


Heart failure patients' perceptions and use of technology to manage disease symptoms.

Hall AK, Dodd V, Harris A, McArthur K, Dacso C, Colton LM.

Telemed J E Health. 2014 Apr;20(4):324-31. doi: 10.1089/tmj.2013.0146. Epub 2014 Jan 31.


The development and evaluation of options for improving future U.K. blood component labelling--outcome of the 2013 U.K. hospital survey.

Nightingale MJ, Brazier AM, McArthur K, Jones J, Cardigan R, Lodge L, Maclennan S; UK Blood Services Blood Component Label Steering and Work Groups.

Transfus Med. 2014 Apr;24(2):89-98. doi: 10.1111/tme.12098. Epub 2014 Jan 11.


Optimising outcome assessment to improve quality and efficiency of stroke trials.

McArthur K, Fan Y, Pei Z, Quinn T.

Expert Rev Pharmacoecon Outcomes Res. 2014 Feb;14(1):101-11. doi: 10.1586/14737167.2014.870479. Epub 2013 Dec 19. Review.


Robotic measurement of arm movements after stroke establishes biomarkers of motor recovery.

Krebs HI, Krams M, Agrafiotis DK, DiBernardo A, Chavez JC, Littman GS, Yang E, Byttebier G, Dipietro L, Rykman A, McArthur K, Hajjar K, Lees KR, Volpe BT.

Stroke. 2014 Jan;45(1):200-4. doi: 10.1161/STROKEAHA.113.002296. Epub 2013 Dec 12.


Improving the efficiency of stroke trials: feasibility and efficacy of group adjudication of functional end points.

McArthur KS, Johnson PC, Quinn TJ, Higgins P, Langhorne P, Walters MR, Weir CJ, Dawson J, Lees KR; CARS investigators.

Stroke. 2013 Dec;44(12):3422-8. doi: 10.1161/STROKEAHA.113.002266. Epub 2013 Sep 19.


Assessment scales in stroke: clinimetric and clinical considerations.

Harrison JK, McArthur KS, Quinn TJ.

Clin Interv Aging. 2013;8:201-11. doi: 10.2147/CIA.S32405. Epub 2013 Feb 18. Review.


InSpire to Promote Lung Assessment in Youth: Evolving the Self-Management Paradigms of Young People With Asthma.

Elias P, Rajan NO, McArthur K, Dacso CC.

Med 2 0. 2013 May 21;2(1):e1. doi: 10.2196/med20.2014. eCollection 2013 Jan-Jun.


Are emergency general surgery patients more work than trauma patients? Characterizing surgeon work in an acute care surgery practice.

Parent MB, McArthur K, Sava J.

J Trauma Acute Care Surg. 2013 Jan;74(1):289-93. doi: 10.1097/TA.0b013e318278935f.


NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells.

Masters SL, Gerlic M, Metcalf D, Preston S, Pellegrini M, O'Donnell JA, McArthur K, Baldwin TM, Chevrier S, Nowell CJ, Cengia LH, Henley KJ, Collinge JE, Kastner DL, Feigenbaum L, Hilton DJ, Alexander WS, Kile BT, Croker BA.

Immunity. 2012 Dec 14;37(6):1009-23. doi: 10.1016/j.immuni.2012.08.027. Epub 2012 Dec 6.


Prestroke modified rankin stroke scale has moderate interobserver reliability and validity in an acute stroke setting.

Fearon P, McArthur KS, Garrity K, Graham LJ, McGroarty G, Vincent S, Quinn TJ.

Stroke. 2012 Dec;43(12):3184-8. doi: 10.1161/STROKEAHA.112.670422. Epub 2012 Nov 13.


Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor.

Lindqvist LM, Vikström I, Chambers JM, McArthur K, Ann Anderson M, Henley KJ, Happo L, Cluse L, Johnstone RW, Roberts AW, Kile BT, Croker BA, Burns CJ, Rizzacasa MA, Strasser A, Huang DC.

Cell Death Dis. 2012 Oct 11;3:e409. doi: 10.1038/cddis.2012.149.


School-based humanistic counseling for psychological distress in young people: pilot randomized controlled trial.

McArthur K, Cooper M, Berdondini L.

Psychother Res. 2013;23(3):355-65. doi: 10.1080/10503307.2012.726750. Epub 2012 Oct 9.


Properties of proxy-derived modified Rankin Scale assessment.

McArthur K, Beagan ML, Degnan A, Howarth RC, Mitchell KA, McQuaige FB, Shannon MA, Stott DJ, Quinn TJ.

Int J Stroke. 2013 Aug;8(6):403-7. doi: 10.1111/j.1747-4949.2011.00759.x. Epub 2012 Feb 15.


Xanthine oxidase inhibition for the treatment of cardiovascular disease: a systematic review and meta-analysis.

Higgins P, Dawson J, Lees KR, McArthur K, Quinn TJ, Walters MR.

Cardiovasc Ther. 2012 Aug;30(4):217-26. doi: 10.1111/j.1755-5922.2011.00277.x. Epub 2011 Jun 12. Review.


Behavioral state modulates the activity of brainstem sensorimotor neurons.

McArthur KL, Dickman JD.

J Neurosci. 2011 Nov 16;31(46):16700-8. doi: 10.1523/JNEUROSCI.0891-11.2011.


miR-146a-Mediated extracellular matrix protein production in chronic diabetes complications.

Feng B, Chen S, McArthur K, Wu Y, Sen S, Ding Q, Feldman RD, Chakrabarti S.

Diabetes. 2011 Nov;60(11):2975-84. doi: 10.2337/db11-0478. Epub 2011 Sep 1.


Functional assessment in older people.

Quinn TJ, McArthur K, Ellis G, Stott DJ.

BMJ. 2011 Aug 22;343:d4681. doi: 10.1136/bmj.d4681. Review. No abstract available.


Spatial and temporal characteristics of vestibular convergence.

McArthur KL, Zakir M, Haque A, Dickman JD.

Neuroscience. 2011 Sep 29;192:361-71. doi: 10.1016/j.neuroscience.2011.06.070. Epub 2011 Jul 1.


IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3.

Croker BA, Kiu H, Pellegrini M, Toe J, Preston S, Metcalf D, O'Donnell JA, Cengia LH, McArthur K, Nicola NA, Alexander WS, Roberts AW.

Immunol Cell Biol. 2012 Jan;90(1):124-9. doi: 10.1038/icb.2011.29. Epub 2011 Apr 26.


Post-acute care and secondary prevention after ischaemic stroke.

McArthur KS, Quinn TJ, Higgins P, Langhorne P.

BMJ. 2011 Apr 8;342:d2083. doi: 10.1136/bmj.d2083. Review. No abstract available.


Diagnosis and management of transient ischaemic attack and ischaemic stroke in the acute phase.

McArthur KS, Quinn TJ, Dawson J, Walters MR.

BMJ. 2011 Mar 31;342:d1938. doi: 10.1136/bmj.d1938. Review. No abstract available.


MicroRNA-200b regulates vascular endothelial growth factor-mediated alterations in diabetic retinopathy.

McArthur K, Feng B, Wu Y, Chen S, Chakrabarti S.

Diabetes. 2011 Apr;60(4):1314-23. doi: 10.2337/db10-1557. Epub 2011 Feb 28.


Sensitivity of computed tomography in detection of perirectal abscess.

Caliste X, Nazir S, Goode T, Street JH 3rd, Hockstein M, McArthur K, Trankiem CT, Sava JA.

Am Surg. 2011 Feb;77(2):166-8.


State-dependent sensorimotor processing: gaze and posture stability during simulated flight in birds.

McArthur KL, Dickman JD.

J Neurophysiol. 2011 Apr;105(4):1689-700. doi: 10.1152/jn.00981.2010. Epub 2011 Feb 9.


Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs.

Obaidat A, Weiss J, Wahlgren B, Manam RR, Macherla VR, McArthur K, Chao TH, Palladino MA, Lloyd GK, Potts BC, Enna SJ, Neuteboom ST, Hagenbuch B.

J Pharmacol Exp Ther. 2011 May;337(2):479-86. doi: 10.1124/jpet.110.177824. Epub 2011 Feb 8.


Author Reply.

Dawson J, McArthur K.

Int J Stroke. 2011 Feb;6(1):90. doi: 10.1111/j.1747-4949.2010.00546_1.x. No abstract available.


Assessing the acceptability and usability of an interactive serious game in aiding treatment decisions for patients with localized prostate cancer.

Reichlin L, Mani N, McArthur K, Harris AM, Rajan N, Dacso CC.

J Med Internet Res. 2011 Jan 12;13(1):e4. doi: 10.2196/jmir.1519.


Reliability of structured modified rankin scale assessment.

Quinn TJ, McArthur K, Dawson J, Walters MR, Lees KR.

Stroke. 2010 Dec;41(12):e602; author reply e603. doi: 10.1161/STROKEAHA.110.590547. Epub 2010 Oct 28. No abstract available.


Randomised controlled trial of school-based humanistic counselling for emotional distress in young people: feasibility study and preliminary indications of efficacy.

Cooper M, Rowland N, McArthur K, Pattison S, Cromarty K, Richards K.

Child Adolesc Psychiatry Ment Health. 2010 Apr 22;4:12. doi: 10.1186/1753-2000-4-12.

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