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Items: 7

1.

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).

Chessum NEA, Sharp SY, Caldwell JJ, Pasqua AE, Wilding B, Colombano G, Collins I, Ozer B, Richards M, Rowlands M, Stubbs M, Burke R, McAndrew PC, Clarke PA, Workman P, Cheeseman MD, Jones K.

J Med Chem. 2018 Feb 8;61(3):918-933. doi: 10.1021/acs.jmedchem.7b01406. Epub 2018 Jan 5.

2.

Molecular mechanisms of human IRE1 activation through dimerization and ligand binding.

Joshi A, Newbatt Y, McAndrew PC, Stubbs M, Burke R, Richards MW, Bhatia C, Caldwell JJ, McHardy T, Collins I, Bayliss R.

Oncotarget. 2015 May 30;6(15):13019-35.

3.

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design.

Couty S, Westwood IM, Kalusa A, Cano C, Travers J, Boxall K, Chow CL, Burns S, Schmitt J, Pickard L, Barillari C, McAndrew PC, Clarke PA, Linardopoulos S, Griffin RJ, Aherne GW, Raynaud FI, Workman P, Jones K, van Montfort RL.

Oncotarget. 2013 Oct;4(10):1647-61.

4.

Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.

Newbatt Y, Hardcastle A, McAndrew PC, Strover JA, Mirza A, Morgan GJ, Burke R, Davies FE, Collins I, van Montfort RL.

J Biomol Screen. 2013 Mar;18(3):298-308. doi: 10.1177/1087057112465647. Epub 2012 Nov 8.

PMID:
23139381
5.

Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases.

Martin NG, McAndrew PC, Eve PD, Garrett MD.

FEBS J. 2008 Jun;275(12):3099-109. doi: 10.1111/j.1742-4658.2008.06463.x. Epub 2008 May 8.

6.

Requirements for chromatin modulation and transcription activation by the Pho4 acidic activation domain.

McAndrew PC, Svaren J, Martin SR, Hörz W, Goding CR.

Mol Cell Biol. 1998 Oct;18(10):5818-27.

7.

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