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Items: 11


A multiplexed in vitro assay system for evaluating human skeletal muscle functionality in response to drug treatment.

Najjar SA, Smith AST, Long CJ, McAleer CW, Cai Y, Srinivasan B, Martin C, Vandenburgh HH, Hickman JJ.

Biotechnol Bioeng. 2019 Nov 23. doi: 10.1002/bit.27231. [Epub ahead of print]


A human in vitro platform for the evaluation of pharmacology strategies in cardiac ischemia.

Oleaga C, Jalilvand G, Legters G, Martin C, Ekman G, McAleer CW, Long CJ, Hickman JJ.

APL Bioeng. 2019 Aug 13;3(3):036103. doi: 10.1063/1.5089237. eCollection 2019 Sep.


On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships.

McAleer CW, Pointon A, Long CJ, Brighton RL, Wilkin BD, Bridges LR, Narasimhan Sriram N, Fabre K, McDougall R, Muse VP, Mettetal JT, Srivastava A, Williams D, Schnepper MT, Roles JL, Shuler ML, Hickman JJ, Ewart L.

Sci Rep. 2019 Jul 3;9(1):9619. doi: 10.1038/s41598-019-45656-4.


Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics.

McAleer CW, Long CJ, Elbrecht D, Sasserath T, Bridges LR, Rumsey JW, Martin C, Schnepper M, Wang Y, Schuler F, Roth AB, Funk C, Shuler ML, Hickman JJ.

Sci Transl Med. 2019 Jun 19;11(497). pii: eaav1386. doi: 10.1126/scitranslmed.aav1386.


Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system.

Oleaga C, Riu A, Rothemund S, Lavado A, McAleer CW, Long CJ, Persaud K, Narasimhan NS, Tran M, Roles J, Carmona-Moran CA, Sasserath T, Elbrecht DH, Kumanchik L, Bridges LR, Martin C, Schnepper MT, Ekman G, Jackson M, Wang YI, Note R, Langer J, Teissier S, Hickman JJ.

Biomaterials. 2018 Nov;182:176-190. doi: 10.1016/j.biomaterials.2018.07.062. Epub 2018 Aug 4.


Stem cell derived phenotypic human neuromuscular junction model for dose response evaluation of therapeutics.

Santhanam N, Kumanchik L, Guo X, Sommerhage F, Cai Y, Jackson M, Martin C, Saad G, McAleer CW, Wang Y, Lavado A, Long CJ, Hickman JJ.

Biomaterials. 2018 Jun;166:64-78. doi: 10.1016/j.biomaterials.2018.02.047. Epub 2018 Feb 27.


Self-contained, low-cost Body-on-a-Chip systems for drug development.

Wang YI, Oleaga C, Long CJ, Esch MB, McAleer CW, Miller PG, Hickman JJ, Shuler ML.

Exp Biol Med (Maywood). 2017 Nov;242(17):1701-1713. doi: 10.1177/1535370217694101. Epub 2017 Feb 17. Review.


A phenotypic in vitro model for the main determinants of human whole heart function.

Stancescu M, Molnar P, McAleer CW, McLamb W, Long CJ, Oleaga C, Prot JM, Hickman JJ.

Biomaterials. 2015 Aug;60:20-30. doi: 10.1016/j.biomaterials.2015.04.035. Epub 2015 May 14.


Functional myotube formation from adult rat satellite cells in a defined serum-free system.

McAleer CW, Rumsey JW, Stancescu M, Hickman JJ.

Biotechnol Prog. 2015 Jul-Aug;31(4):997-1003. doi: 10.1002/btpr.2063. Epub 2015 Mar 4.


Mechanistic investigation of adult myotube response to exercise and drug treatment in vitro using a multiplexed functional assay system.

McAleer CW, Smith AS, Najjar S, Pirozzi K, Long CJ, Hickman JJ.

J Appl Physiol (1985). 2014 Dec 1;117(11):1398-405. doi: 10.1152/japplphysiol.00612.2014. Epub 2014 Oct 9.


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