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Items: 9

1.

CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1.

Silverman JM, Christy D, Shyu CC, Moon KM, Fernando S, Gidden Z, Cowan CM, Ban Y, Stacey RG, Grad LI, McAlary L, Mackenzie IR, Foster LJ, Cashman NR.

J Biol Chem. 2019 Mar 8;294(10):3744-3759. doi: 10.1074/jbc.RA118.004825. Epub 2019 Jan 11.

PMID:
30635404
2.

CuATSM Protects Against the In Vitro Cytotoxicity of Wild-Type-Like Copper-Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding.

Farrawell NE, Yerbury MR, Plotkin SS, McAlary L, Yerbury JJ.

ACS Chem Neurosci. 2019 Mar 20;10(3):1555-1564. doi: 10.1021/acschemneuro.8b00527. Epub 2018 Dec 7.

PMID:
30462490
3.

TryptophanĀ 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells.

Pokrishevsky E, McAlary L, Farrawell NE, Zhao B, Sher M, Yerbury JJ, Cashman NR.

Sci Rep. 2018 Oct 22;8(1):15590. doi: 10.1038/s41598-018-32835-y.

4.

SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS.

Farrawell NE, Lambert-Smith I, Mitchell K, McKenna J, McAlary L, Ciryam P, Vine KL, Saunders DN, Yerbury JJ.

J Cell Sci. 2018 Jun 12;131(11). pii: jcs209122. doi: 10.1242/jcs.209122.

5.

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.

Capper MJ, Wright GSA, Barbieri L, Luchinat E, Mercatelli E, McAlary L, Yerbury JJ, O'Neill PM, Antonyuk SV, Banci L, Hasnain SS.

Nat Commun. 2018 Apr 27;9(1):1693. doi: 10.1038/s41467-018-04114-x.

6.

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation.

Zeineddine R, Whiten DR, Farrawell NE, McAlary L, Hanspal MA, Kumita JR, Wilson MR, Yerbury JJ.

Prion. 2017 May 4;11(3):195-204. doi: 10.1080/19336896.2017.1314426. Epub 2017 May 9.

7.
8.

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking.

Whiten DR, San Gil R, McAlary L, Yerbury JJ, Ecroyd H, Wilson MR.

Sci Rep. 2016 Aug 12;6:31138. doi: 10.1038/srep31138.

9.

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