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Items: 50


Mitotic live-cell imaging at different timescales.

Olziersky AM, Smith CA, Burroughs N, McAinsh AD, Meraldi P.

Methods Cell Biol. 2018;145:1-27. doi: 10.1016/bs.mcb.2018.03.009.


Complete microtubule-kinetochore occupancy favours the segregation of merotelic attachments.

Dudka D, Noatynska A, Smith CA, Liaudet N, McAinsh AD, Meraldi P.

Nat Commun. 2018 May 23;9(1):2042. doi: 10.1038/s41467-018-04427-x.


Kif15 functions as an active mechanical ratchet.

McHugh T, Drechsler H, McAinsh AD, Carter NJ, Cross RA.

Mol Biol Cell. 2018 Jul 15;29(13):1743-1752. doi: 10.1091/mbc.E18-03-0151. Epub 2018 May 17.


Rapid production of pure recombinant actin isoforms in Pichia pastoris.

Hatano T, Alioto S, Roscioli E, Palani S, Clarke ST, Kamnev A, Hernandez-Fernaud JR, Sivashanmugam L, Chapa-Y-Lazo B, Jones AME, Robinson RC, Sampath K, Mishima M, McAinsh AD, Goode BL, Balasubramanian MK.

J Cell Sci. 2018 Apr 23;131(8). pii: jcs213827. doi: 10.1242/jcs.213827.


The Enterohemorrhagic Escherichia coli Effector EspW Triggers Actin Remodeling in a Rac1-Dependent Manner.

Sandu P, Crepin VF, Drechsler H, McAinsh AD, Frankel G, Berger CN.

Infect Immun. 2017 Aug 18;85(9). pii: e00244-17. doi: 10.1128/IAI.00244-17. Print 2017 Sep.


Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment.

Auckland P, Clarke NI, Royle SJ, McAinsh AD.

J Cell Biol. 2017 Jun 5;216(6):1623-1639. doi: 10.1083/jcb.201607096. Epub 2017 May 11.


Mps1 Regulates Kinetochore-Microtubule Attachment Stability via the Ska Complex to Ensure Error-Free Chromosome Segregation.

Maciejowski J, Drechsler H, Grundner-Culemann K, Ballister ER, Rodriguez-Rodriguez JA, Rodriguez-Bravo V, Jones MJK, Foley E, Lampson MA, Daub H, McAinsh AD, Jallepalli PV.

Dev Cell. 2017 Apr 24;41(2):143-156.e6. doi: 10.1016/j.devcel.2017.03.025.


Human kinetochores are swivel joints that mediate microtubule attachments.

Smith CA, McAinsh AD, Burroughs NJ.

Elife. 2016 Sep 3;5. pii: e16159. doi: 10.7554/eLife.16159.


KiT: a MATLAB package for kinetochore tracking.

Armond JW, Vladimirou E, McAinsh AD, Burroughs NJ.

Bioinformatics. 2016 Jun 15;32(12):1917-9. doi: 10.1093/bioinformatics/btw087. Epub 2016 Feb 15.


Kinesin-12 motors cooperate to suppress microtubule catastrophes and drive the formation of parallel microtubule bundles.

Drechsler H, McAinsh AD.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1635-44. doi: 10.1073/pnas.1516370113. Epub 2016 Mar 11.


KNL1-Bubs and RZZ Provide Two Separable Pathways for Checkpoint Activation at Human Kinetochores.

Silió V, McAinsh AD, Millar JB.

Dev Cell. 2015 Dec 7;35(5):600-613. doi: 10.1016/j.devcel.2015.11.012.


Inferring the Forces Controlling Metaphase Kinetochore Oscillations by Reverse Engineering System Dynamics.

Armond JW, Harry EF, McAinsh AD, Burroughs NJ.

PLoS Comput Biol. 2015 Nov 30;11(11):e1004607. doi: 10.1371/journal.pcbi.1004607. eCollection 2015 Nov.


Super-resolution kinetochore tracking reveals the mechanisms of human sister kinetochore directional switching.

Burroughs NJ, Harry EF, McAinsh AD.

Elife. 2015 Oct 13;4. pii: e09500. doi: 10.7554/eLife.09500.


Building an integrated model of chromosome congression.

Auckland P, McAinsh AD.

J Cell Sci. 2015 Sep 15;128(18):3363-74. doi: 10.1242/jcs.169367. Epub 2015 Sep 1. Review.


Probing microtubule polymerisation state at single kinetochores during metaphase chromosome motion.

Armond JW, Vladimirou E, Erent M, McAinsh AD, Burroughs NJ.

J Cell Sci. 2015 May 15;128(10):1991-2001. doi: 10.1242/jcs.168682. Epub 2015 Apr 23.


Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways.

Bancroft J, Auckland P, Samora CP, McAinsh AD.

J Cell Sci. 2015 Jan 1;128(1):171-84. doi: 10.1242/jcs.163659. Epub 2014 Nov 13.


How Kinetochores CCAN resist force.

McAinsh AD.

Dev Cell. 2014 Sep 29;30(6):637-8. doi: 10.1016/j.devcel.2014.09.007.


The Kinesin-12 Kif15 is a processive track-switching tetramer.

Drechsler H, McHugh T, Singleton MR, Carter NJ, McAinsh AD.

Elife. 2014 Mar 25;3:e01724. doi: 10.7554/eLife.01724.


Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase.

Vázquez-Novelle MD, Sansregret L, Dick AE, Smith CA, McAinsh AD, Gerlich DW, Petronczki M.

Curr Biol. 2014 Mar 17;24(6):638-45. doi: 10.1016/j.cub.2014.01.034. Epub 2014 Feb 27.


Nonautonomous movement of chromosomes in mitosis.

Vladimirou E, Mchedlishvili N, Gasic I, Armond JW, Samora CP, Meraldi P, McAinsh AD.

Dev Cell. 2013 Oct 14;27(1):60-71. doi: 10.1016/j.devcel.2013.08.004.


Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.

Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW.

Chromosome Res. 2013 Apr;21(2):101-6. doi: 10.1007/s10577-013-9347-y. Epub 2013 Apr 12.


Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension.

Cheeseman LP, Harry EF, McAinsh AD, Prior IA, Royle SJ.

J Cell Sci. 2013 May 1;126(Pt 9):2102-13. doi: 10.1242/jcs.124834. Epub 2013 Mar 26.


Exotic mitotic mechanisms.

Drechsler H, McAinsh AD.

Open Biol. 2012 Dec 5;2(12):120140. doi: 10.1098/rsob.120140. Review.


Dual pathway spindle assembly increases both the speed and the fidelity of mitosis.

Kaseda K, McAinsh AD, Cross RA.

Biol Open. 2012 Jan 15;1(1):12-8. doi: 10.1242/bio.2011012. Epub 2011 Oct 24.


Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex.

Eskat A, Deng W, Hofmeister A, Rudolphi S, Emmerth S, Hellwig D, Ulbricht T, Döring V, Bancroft JM, McAinsh AD, Cardoso MC, Meraldi P, Hoischen C, Leonhardt H, Diekmann S.

PLoS One. 2012;7(9):e44717. doi: 10.1371/journal.pone.0044717. Epub 2012 Sep 18.


Spindle centricity.

McAinsh AD, Straube A.

Cell Cycle. 2011 Dec 1;10(23):3989-91. doi: 10.4161/cc.10.23.18252. Epub 2011 Dec 1. No abstract available.


Dynamics of CENP-N kinetochore binding during the cell cycle.

Hellwig D, Emmerth S, Ulbricht T, Döring V, Hoischen C, Martin R, Samora CP, McAinsh AD, Carroll CW, Straight AF, Meraldi P, Diekmann S.

J Cell Sci. 2011 Nov 15;124(Pt 22):3871-83. doi: 10.1242/jcs.088625. Epub 2011 Nov 18.


The CCAN complex: linking centromere specification to control of kinetochore-microtubule dynamics.

McAinsh AD, Meraldi P.

Semin Cell Dev Biol. 2011 Dec;22(9):946-52. doi: 10.1016/j.semcdb.2011.09.016. Epub 2011 Oct 19. Review.


Mechanochemical cell biology.

Cross RA, McAinsh AD, Straube A.

Semin Cell Dev Biol. 2011 Dec;22(9):913-5. doi: 10.1016/j.semcdb.2011.10.002. Epub 2011 Oct 7.


MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis.

Samora CP, Mogessie B, Conway L, Ross JL, Straube A, McAinsh AD.

Nat Cell Biol. 2011 Aug 7;13(9):1040-50. doi: 10.1038/ncb2297.


Photoactivatable-GFP-α-tubulin as a tool to study microtubule plus-end turnover in living human cells.

Samora CP, McAinsh AD.

Methods Mol Biol. 2011;777:223-33. doi: 10.1007/978-1-61779-252-6_16.


Springs, clutches and motors: driving forward kinetochore mechanism by modelling.

Vladimirou E, Harry E, Burroughs N, McAinsh AD.

Chromosome Res. 2011 Apr;19(3):409-21. doi: 10.1007/s10577-011-9191-x. Review.


Molecular control of kinetochore-microtubule dynamics and chromosome oscillations.

Amaro AC, Samora CP, Holtackers R, Wang E, Kingston IJ, Alonso M, Lampson M, McAinsh AD, Meraldi P.

Nat Cell Biol. 2010 Apr;12(4):319-29. doi: 10.1038/ncb2033. Epub 2010 Mar 14.


Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases.

Jaqaman K, King EM, Amaro AC, Winter JR, Dorn JF, Elliott HL, McHedlishvili N, McClelland SE, Porter IM, Posch M, Toso A, Danuser G, McAinsh AD, Meraldi P, Swedlow JR.

J Cell Biol. 2010 Mar 8;188(5):665-79. doi: 10.1083/jcb.200909005.


Walking, hopping, diffusing and braking modes of kinesin-5.

Kaseda K, McAinsh AD, Cross RA.

Biochem Soc Trans. 2009 Oct;37(Pt 5):1045-9. doi: 10.1042/BST0371045.


Hydrodynamic analysis of human kinetochore complexes during mitosis.

McClelland SE, McAinsh AD.

Methods Mol Biol. 2009;545:81-98. doi: 10.1007/978-1-60327-993-2_5.


The kinesin-14 Klp2 organizes microtubules into parallel bundles by an ATP-dependent sorting mechanism.

Braun M, Drummond DR, Cross RA, McAinsh AD.

Nat Cell Biol. 2009 Jun;11(6):724-30. doi: 10.1038/ncb1878. Epub 2009 May 10.


Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly.

Toso A, Winter JR, Garrod AJ, Amaro AC, Meraldi P, McAinsh AD.

J Cell Biol. 2009 Feb 9;184(3):365-72. doi: 10.1083/jcb.200809055.


The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity.

McClelland SE, Borusu S, Amaro AC, Winter JR, Belwal M, McAinsh AD, Meraldi P.

EMBO J. 2007 Dec 12;26(24):5033-47. Epub 2007 Nov 15.


Bod1, a novel kinetochore protein required for chromosome biorientation.

Porter IM, McClelland SE, Khoudoli GA, Hunter CJ, Andersen JS, McAinsh AD, Blow JJ, Swedlow JR.

J Cell Biol. 2007 Oct 22;179(2):187-97. Epub 2007 Oct 15.


Molecular analysis of core kinetochore composition and assembly in Drosophila melanogaster.

Przewloka MR, Zhang W, Costa P, Archambault V, D'Avino PP, Lilley KS, Laue ED, McAinsh AD, Glover DM.

PLoS One. 2007 May 30;2(5):e478.


The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation.

McAinsh AD, Meraldi P, Draviam VM, Toso A, Sorger PK.

EMBO J. 2006 Sep 6;25(17):4033-49. Epub 2006 Aug 24. Erratum in: EMBO J. 2009 May 6;28(9):1374.


Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins.

Meraldi P, McAinsh AD, Rheinbay E, Sorger PK.

Genome Biol. 2006;7(3):R23. Epub 2006 Mar 22.


Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair.

Jazayeri A, McAinsh AD, Jackson SP.

Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1644-9. Epub 2004 Jan 7.


Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes.

De Wulf P, McAinsh AD, Sorger PK.

Genes Dev. 2003 Dec 1;17(23):2902-21. Epub 2003 Nov 21.


Structure, function, and regulation of budding yeast kinetochores.

McAinsh AD, Tytell JD, Sorger PK.

Annu Rev Cell Dev Biol. 2003;19:519-39. Review.


Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing.

Roy R, Meier B, McAinsh AD, Feldmann HM, Jackson SP.

J Biol Chem. 2004 Jan 2;279(1):86-94. Epub 2003 Oct 9.


DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p.

McAinsh AD, Scott-Drew S, Murray JA, Jackson SP.

Curr Biol. 1999 Sep 9;9(17):963-6.


Distribution of the voltage-dependent calcium channel alpha(1A) subunit throughout the mature rat brain and its relationship to neurotransmitter pathways.

Craig PJ, McAinsh AD, McCormack AL, Smith W, Beattie RE, Priestley JV, Yip JL, Averill S, Longbottom ER, Volsen SG.

J Comp Neurol. 1998 Jul 27;397(2):251-67.


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