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Items: 11


A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells.

Mboge MY, Chen Z, Khokhar D, Wolff A, Ai L, Heldermon CD, Bozdag M, Carta F, Supuran CT, Brown KD, McKenna R, Frost CJ, Frost SC.

Biochem J. 2019 May 28;476(10):1497-1513. doi: 10.1042/BCJ20190177.


Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition.

Mboge MY, Chen Z, Wolff A, Mathias JV, Tu C, Brown KD, Bozdag M, Carta F, Supuran CT, McKenna R, Frost SC.

PLoS One. 2018 Nov 19;13(11):e0207417. doi: 10.1371/journal.pone.0207417. eCollection 2018.


Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors.

Mboge MY, Kota A, McKenna R, Frost SC.

Int J Med Chem. 2018 Jul 16;2018:2906519. doi: 10.1155/2018/2906519. eCollection 2018. Review.


Differential expression and function of CAIX and CAXII in breast cancer: A comparison between tumorgraft models and cells.

Chen Z, Ai L, Mboge MY, Tu C, McKenna R, Brown KD, Heldermon CD, Frost SC.

PLoS One. 2018 Jul 2;13(7):e0199476. doi: 10.1371/journal.pone.0199476. eCollection 2018.


Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site.

Singh S, Lomelino CL, Mboge MY, Frost SC, McKenna R.

Molecules. 2018 Apr 30;23(5). pii: E1045. doi: 10.3390/molecules23051045. Review.


UFH-001 cells: A novel triple negative, CAIX-positive, human breast cancer model system.

Chen Z, Ai L, Mboge MY, McKenna R, Frost CJ, Heldermon CD, Frost SC.

Cancer Biol Ther. 2018 Jul 3;19(7):598-608. doi: 10.1080/15384047.2018.1449612. Epub 2018 Apr 13.


Carbonic Anhydrases: Role in pH Control and Cancer.

Mboge MY, Mahon BP, McKenna R, Frost SC.

Metabolites. 2018 Feb 28;8(1). pii: E19. doi: 10.3390/metabo8010019. Review.


Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides.

Mboge MY, Mahon BP, Lamas N, Socorro L, Carta F, Supuran CT, Frost SC, McKenna R.

Eur J Med Chem. 2017 May 26;132:184-191. doi: 10.1016/j.ejmech.2017.03.026. Epub 2017 Mar 19.


The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis.

Mahon BP, Bhatt A, Socorro L, Driscoll JM, Okoh C, Lomelino CL, Mboge MY, Kurian JJ, Tu C, Agbandje-McKenna M, Frost SC, McKenna R.

Biochemistry. 2016 Aug 23;55(33):4642-53. doi: 10.1021/acs.biochem.6b00243. Epub 2016 Aug 5.


Advances in Anti-Cancer Drug Development Targeting Carbonic Anhydrase IX and XII.

Mboge MY, McKenna R, Frost SC.

Top Anticancer Res. 2015;5:3-42.


Characterization of a novel primary culture system of adult zebrafish brainstem cells.

Tapanes-Castillo A, Shabazz FS, Mboge MY, Vajn K, Oudega M, Plunkett JA.

J Neurosci Methods. 2014 Feb 15;223:11-9. doi: 10.1016/j.jneumeth.2013.11.022. Epub 2013 Dec 4.


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