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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2007 2
2008 3
2009 1
2010 1
2011 1
2015 3
2016 3
2017 2
2018 2
2019 1
2020 1
2021 1
2022 2
2023 6
2024 1

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28 results

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Page 1
Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones.
Liang D, Feng Y, Zandkarimi F, Wang H, Zhang Z, Kim J, Cai Y, Gu W, Stockwell BR, Jiang X. Liang D, et al. Cell. 2023 Jun 22;186(13):2748-2764.e22. doi: 10.1016/j.cell.2023.05.003. Epub 2023 Jun 1. Cell. 2023. PMID: 37267948
In this study, through a whole-genome CRISPR activation screen, followed by mechanistic investigation, we identified phospholipid-modifying enzymes MBOAT1 and MBOAT2 as ferroptosis suppressors. MBOAT1/2 inhibit ferroptosis by remodeling the cellular phospholipid pro …
In this study, through a whole-genome CRISPR activation screen, followed by mechanistic investigation, we identified phospholipid-modifying …
MBOAT1 homozygous missense variant causes nonobstructive azoospermia.
Wan YY, Guo L, Yao Y, Shi XY, Jiang H, Xu B, Hua J, Zhang XS. Wan YY, et al. Asian J Androl. 2022 Mar-Apr;24(2):186-190. doi: 10.4103/aja202160. Asian J Androl. 2022. PMID: 34596601 Free PMC article.
Bioinformatic analysis also showed that this variant was a pathogenic variant and that the amino acid residue in MBOAT1 was highly conserved in mammals. Quantitative polymerase chain reaction (Q-PCR) analysis showed that the mRNA level of MBOAT1 in the patient was 2 …
Bioinformatic analysis also showed that this variant was a pathogenic variant and that the amino acid residue in MBOAT1 was highly co …
Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest.
Rodencal J, Kim N, He A, Li VL, Lange M, He J, Tarangelo A, Schafer ZT, Olzmann JA, Long JZ, Sage J, Dixon SJ. Rodencal J, et al. Cell Chem Biol. 2024 Feb 15;31(2):234-248.e13. doi: 10.1016/j.chembiol.2023.10.011. Epub 2023 Nov 13. Cell Chem Biol. 2024. PMID: 37963466
Higher PUFA-PL abundance upon cell cycle arrest involves reduced expression of membrane-bound O-acyltransferase domain-containing 1 (MBOAT1) and epithelial membrane protein 2 (EMP2). A candidate orally bioavailable GPX4 inhibitor increases lipid peroxidation and shrinks tu …
Higher PUFA-PL abundance upon cell cycle arrest involves reduced expression of membrane-bound O-acyltransferase domain-containing 1 (MBOA …
Sex Hormone Signaling Suppresses Ferroptosis via Phospholipid Remodeling.
[No authors listed] [No authors listed] Cancer Discov. 2023 Aug 4;13(8):1759. doi: 10.1158/2159-8290.CD-RW2023-091. Cancer Discov. 2023. PMID: 37326388
ER+ breast and AR+ prostate cancers suppress ferroptosis through MBOAT1 and MBOAT2, respectively....
ER+ breast and AR+ prostate cancers suppress ferroptosis through MBOAT1 and MBOAT2, respectively....
A t(4;6)(q12;p23) translocation disrupts a membrane-associated O-acetyl transferase gene (MBOAT1) in a patient with a novel brachydactyly-syndactyly syndrome.
Dauwerse JG, de Vries BB, Wouters CH, Bakker E, Rappold G, Mortier GR, Breuning MH, Peters DJ. Dauwerse JG, et al. Eur J Hum Genet. 2007 Jul;15(7):743-51. doi: 10.1038/sj.ejhg.5201833. Epub 2007 Apr 18. Eur J Hum Genet. 2007. PMID: 17440500
One of the genes on chromosome 6, the membrane-associated O-acetyl transferase gene 1 (MBOAT1), was disrupted by the breakpoint. This gene consists of 13 exons and encodes a protein of 495 amino acids. MBOAT1 is predicted to be a transmembrane protein and belongs to …
One of the genes on chromosome 6, the membrane-associated O-acetyl transferase gene 1 (MBOAT1), was disrupted by the breakpoint. This …
A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2.
Rodencal J, Kim N, Li VL, He A, Lange M, He J, Tarangelo A, Schafer ZT, Olzmann JA, Sage J, Long JZ, Dixon SJ. Rodencal J, et al. bioRxiv [Preprint]. 2023 Jul 19:2023.07.19.549715. doi: 10.1101/2023.07.19.549715. bioRxiv. 2023. PMID: 37502927 Free PMC article. Preprint.
Integrated multi-omics reveals novel microbe-host lipid metabolism and immune interactions in the donkey hindgut.
Li Y, Ma Q, Shi X, Liu G, Wang C. Li Y, et al. Front Immunol. 2022 Nov 18;13:1003247. doi: 10.3389/fimmu.2022.1003247. eCollection 2022. Front Immunol. 2022. PMID: 36466834 Free PMC article.
Furthermore, we identified some interesting DEGs related to lipid metabolism (e.g., ME1, MBOAT1, ACOX1, ACOX2 and LIPH) and the immune system (e.g., MUC3B, mucin-2-like, IL17RC, IL1R2, IL33, C1QA, and MMP9) between the cecum and dorsal colon and found that the PPAR pathway …
Furthermore, we identified some interesting DEGs related to lipid metabolism (e.g., ME1, MBOAT1, ACOX1, ACOX2 and LIPH) and the immun …
Lysophosphatidylethanolamine acyltransferase 1/membrane-bound O-acyltransferase 1 regulates morphology and function of P19C6 cell-derived neurons.
Tabe S, Hikiji H, Ariyoshi W, Hashidate-Yoshida T, Shindou H, Okinaga T, Shimizu T, Tominaga K, Nishihara T. Tabe S, et al. FASEB J. 2016 Jul;30(7):2591-601. doi: 10.1096/fj.201500097R. Epub 2016 Apr 5. FASEB J. 2016. PMID: 27048541
LPEAT enzymatic activity increased with 16:0- and 18:1-CoA as acyl donors. When LPEAT1/MBOAT1 was knocked down with small interfering RNA (siRNA), outgrowth of neurites and expression of neuronal markers decreased in ATRA-treated P19C6 cells. Voltage-dependent calcium chan …
LPEAT enzymatic activity increased with 16:0- and 18:1-CoA as acyl donors. When LPEAT1/MBOAT1 was knocked down with small interfering …
Stem-Like Signature Predicting Disease Progression in Early Stage Bladder Cancer. The Role of E2F3 and SOX4.
Bellmunt J. Bellmunt J. Biomedicines. 2018 Aug 2;6(3):85. doi: 10.3390/biomedicines6030085. Biomedicines. 2018. PMID: 30072631 Free PMC article. Review.
CDKAL1, E2F3 and SOX4 are highly expressed in patients with the chromosomal 6p22 amplification aside from other six well known genes (ID4, MBOAT1, LINC00340, PRL, and HDGFL1). Based on that, SOX4, E2F3 or 6q22.3 amplifications might represent potential targets in this tumo …
CDKAL1, E2F3 and SOX4 are highly expressed in patients with the chromosomal 6p22 amplification aside from other six well known genes (ID4, …
28 results