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Items: 1 to 50 of 112

1.

Associations Between Soluble LDLR and Lipoproteins in a White Cohort and the Effect of PCSK9 Loss-of-Function.

Mayne J, Ooi TC, Tepliakova L, Seebun D, Walker K, Mohottalage D, Ning Z, Abujrad H, Mbikay M, Wassef H, Chrétien M, Figeys D.

J Clin Endocrinol Metab. 2018 Sep 1;103(9):3486-3495. doi: 10.1210/jc.2018-00777.

PMID:
29982529
2.

Malaria severity: Possible influence of the E670G PCSK9 polymorphism: A preliminary case-control study in Malian children.

Arama C, Diarra I, Kouriba B, Sirois F, Fedoryak O, Thera MA, Coulibaly D, Lyke KE, Plowe CV, Chrétien M, Doumbo OK, Mbikay M.

PLoS One. 2018 Feb 15;13(2):e0192850. doi: 10.1371/journal.pone.0192850. eCollection 2018.

3.

Mice Fed a High-Cholesterol Diet Supplemented with Quercetin-3-Glucoside Show Attenuated Hyperlipidemia and Hyperinsulinemia Associated with Differential Regulation of PCSK9 and LDLR in their Liver and Pancreas.

Mbikay M, Mayne J, Sirois F, Fedoryak O, Raymond A, Noad J, Chrétien M.

Mol Nutr Food Res. 2018 May;62(9):e1700729. doi: 10.1002/mnfr.201700729. Epub 2018 Apr 23.

PMID:
29396908
4.
5.

Antiviral activity of quercetin-3-β-O-D-glucoside against Zika virus infection.

Wong G, He S, Siragam V, Bi Y, Mbikay M, Chretien M, Qiu X.

Virol Sin. 2017 Dec;32(6):545-547. doi: 10.1007/s12250-017-4057-9.

PMID:
28884445
6.

The Effect of PCSK9 Loss-of-Function Variants on the Postprandial Lipid and ApoB-Lipoprotein Response.

Ooi TC, Krysa JA, Chaker S, Abujrad H, Mayne J, Henry K, Cousins M, Raymond A, Favreau C, Taljaard M, Chrétien M, Mbikay M, Proctor SD, Vine DF.

J Clin Endocrinol Metab. 2017 Sep 1;102(9):3452-3460. doi: 10.1210/jc.2017-00684.

PMID:
28673045
7.

Comparing expression and activity of PCSK9 in SPRET/EiJ and C57BL/6J mouse strains shows lack of correlation with plasma cholesterol.

Sirois F, Chrétien M, Mbikay M.

Mol Genet Metab Rep. 2016 Dec 10;10:11-17. eCollection 2017 Mar.

8.

Prophylactic Efficacy of Quercetin 3-β-O-d-Glucoside against Ebola Virus Infection.

Qiu X, Kroeker A, He S, Kozak R, Audet J, Mbikay M, Chrétien M.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5182-8. doi: 10.1128/AAC.00307-16. Print 2016 Sep.

9.

60 YEARS OF POMC: From the prohormone theory to pro-opiomelanocortin and to proprotein convertases (PCSK1 to PCSK9).

Chrétien M, Mbikay M.

J Mol Endocrinol. 2016 May;56(4):T49-62. doi: 10.1530/JME-15-0261. Epub 2016 Jan 13. Review.

PMID:
26762158
10.

Relationship between testosterone, estradiol and circulating PCSK9: Cross-sectional and interventional studies in humans.

Ooi TC, Raymond A, Cousins M, Favreau C, Taljaard M, Gavin C, Jolly EE, Malone S, Eapen L, Chretien M, Mbikay M, Mayne J.

Clin Chim Acta. 2015 Jun 15;446:97-104. doi: 10.1016/j.cca.2015.03.036. Epub 2015 Apr 7.

PMID:
25858546
11.
12.

PCSK9: a key modulator of cardiovascular health.

Seidah NG, Awan Z, Chrétien M, Mbikay M.

Circ Res. 2014 Mar 14;114(6):1022-36. doi: 10.1161/CIRCRESAHA.114.301621. Review.

PMID:
24625727
13.

Variable effects of gender and Western diet on lipid and glucose homeostasis in aged PCSK9-deficient C57BL/6 mice CSK9PC57BL/6.

Mbikay M, Sirois F, Gyamera-Acheampong C, Wang GS, Rippstein P, Chen A, Mayne J, Scott FW, Chrétien M.

J Diabetes. 2015 Jan;7(1):74-84. doi: 10.1111/1753-0407.12139. Epub 2014 Mar 27.

PMID:
24548670
14.

The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.

Seidah NG, Sadr MS, Chrétien M, Mbikay M.

J Biol Chem. 2013 Jul 26;288(30):21473-81. doi: 10.1074/jbc.R113.481549. Epub 2013 Jun 17. Review.

15.

Proprotein convertases subtilisin/kexin type 9, an enzyme turned escort protein: hepatic and extra hepatic functions.

Mbikay M, Mayne J, Chrétien M.

J Diabetes. 2013 Dec;5(4):391-405. doi: 10.1111/1753-0407.12064. Epub 2013 Jul 8. Review.

PMID:
23714205
16.

Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations.

Mayne J, Ooi TC, Raymond A, Cousins M, Bernier L, Dewpura T, Sirois F, Mbikay M, Davignon J, Chrétien M.

Lipids Health Dis. 2013 May 10;12:70. doi: 10.1186/1476-511X-12-70.

17.

In vitro regulatory effect of epididymal serpin CRES on protease activity of proprotein convertase PC4/PCSK4.

Mishra P, Qiu Q, Gruslin A, Hidaka Y, Mbikay M, Basak A.

Curr Mol Med. 2012 Sep;12(8):1050-67.

PMID:
22827436
18.

Therapeutic Potential of Moringa oleifera Leaves in Chronic Hyperglycemia and Dyslipidemia: A Review.

Mbikay M.

Front Pharmacol. 2012 Mar 1;3:24. doi: 10.3389/fphar.2012.00024. eCollection 2012.

19.

Allelic clustering and ancestry-dependent frequencies of rs6232, rs6234, and rs6235 PCSK1 SNPs in a Northern Ontario population sample.

Sirois F, Kaefer N, Currie KA, Chrétien M, Nkongolo KK, Mbikay M.

J Community Genet. 2012 Oct;3(4):319-22. doi: 10.1007/s12687-012-0081-5. Epub 2012 Feb 4.

20.

Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity.

Mbikay M, Sirois F, Nkongolo KK, Basak A, Chrétien M.

Mol Genet Metab. 2011 Dec;104(4):682-7. doi: 10.1016/j.ymgme.2011.09.027. Epub 2011 Sep 24.

PMID:
22000902
21.

Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture.

Mayne J, Dewpura T, Raymond A, Bernier L, Cousins M, Ooi TC, Davignon J, Seidah NG, Mbikay M, Chrétien M.

Clin Chem. 2011 Oct;57(10):1415-23. doi: 10.1373/clinchem.2011.165191. Epub 2011 Aug 3.

22.

Regulation of 7B2 mRNA translation: dissecting the role of its 5'-untranslated region.

Tadros H, Schmidt G, Sirois F, Mbikay M.

Methods Mol Biol. 2011;768:217-30. doi: 10.1007/978-1-61779-204-5_11.

PMID:
21805245
23.

PCSK2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides.

Gagnon J, Mayne J, Chen A, Raymond A, Woulfe J, Mbikay M, Chrétien M.

Life Sci. 2011 Jan 31;88(5-6):212-7. doi: 10.1016/j.lfs.2010.11.010. Epub 2010 Nov 16.

PMID:
21092739
24.

The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone.

Gyamera-Acheampong C, Sirois F, Denis NJ, Mishra P, Figeys D, Basak A, Mbikay M.

Mol Cell Biochem. 2011 Feb;348(1-2):43-52. doi: 10.1007/s11010-010-0635-y. Epub 2010 Nov 16.

PMID:
21080038
25.

Genetic deficiency for proprotein convertase subtilisin/kexin type 2 in mice is associated with decreased adiposity and protection from dietary fat-induced body weight gain.

Anini Y, Mayne J, Gagnon J, Sherbafi J, Chen A, Kaefer N, Chrétien M, Mbikay M.

Int J Obes (Lond). 2010 Nov;34(11):1599-607. doi: 10.1038/ijo.2010.90. Epub 2010 May 25.

PMID:
20498660
26.

PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities.

Mbikay M, Sirois F, Mayne J, Wang GS, Chen A, Dewpura T, Prat A, Seidah NG, Chretien M, Scott FW.

FEBS Lett. 2010 Feb 19;584(4):701-6. doi: 10.1016/j.febslet.2009.12.018. Epub 2009 Dec 16.

27.

Fetal macrosomia and adolescence obesity: results from a longitudinal cohort study.

Wang Y, Gao E, Wu J, Zhou J, Yang Q, Walker MC, Mbikay M, Sigal RJ, Nair RC, Wen SW.

Int J Obes (Lond). 2009 Aug;33(8):923-8. doi: 10.1038/ijo.2009.131. Epub 2009 Jun 30.

PMID:
19564880
28.

PCSK4-null sperm display enhanced protein tyrosine phosphorylation and ADAM2 proteolytic processing during in vitro capacitation.

Gyamera-Acheampong C, Vasilescu J, Figeys D, Mbikay M.

Fertil Steril. 2010 Mar 1;93(4):1112-23. doi: 10.1016/j.fertnstert.2008.12.013. Epub 2009 Apr 1.

PMID:
19342015
29.

Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review.

Gyamera-Acheampong C, Mbikay M.

Hum Reprod Update. 2009 Mar-Apr;15(2):237-47. doi: 10.1093/humupd/dmn060. Epub 2008 Dec 24. Review.

PMID:
19109312
30.

Proprotein convertases as therapeutic targets.

Chrétien M, Seidah NG, Basak A, Mbikay M.

Expert Opin Ther Targets. 2008 Oct;12(10):1289-300. doi: 10.1517/14728222.12.10.1289 .

PMID:
18781827
31.

Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine.

Gagnon J, Mayne J, Mbikay M, Woulfe J, Chrétien M.

Regul Pept. 2009 Jan 8;152(1-3):54-60. doi: 10.1016/j.regpep.2008.07.006. Epub 2008 Jul 22.

PMID:
18706454
32.

Ethnic differences in the frequency of the cardioprotective C679X PCSK9 mutation in a West African population.

Sirois F, Gbeha E, Sanni A, Chretien M, Labuda D, Mbikay M.

Genet Test. 2008 Sep;12(3):377-80. doi: 10.1089/gte.2008.0013.

PMID:
18652535
33.
34.

Plasma PCSK9 levels are significantly modified by statins and fibrates in humans.

Mayne J, Dewpura T, Raymond A, Cousins M, Chaplin A, Lahey KA, Lahaye SA, Mbikay M, Ooi TC, Chrétien M.

Lipids Health Dis. 2008 Jun 11;7:22. doi: 10.1186/1476-511X-7-22.

35.

PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans.

Dewpura T, Raymond A, Hamelin J, Seidah NG, Mbikay M, Chrétien M, Mayne J.

FEBS J. 2008 Jul;275(13):3480-93. doi: 10.1111/j.1742-4658.2008.06495.x. Epub 2008 May 22.

36.

Recombinant proprotein convertase 4 (PC4) from Leishmania tarentolae expression system: purification, biochemical study and inhibitor design.

Basak A, Shervani NJ, Mbikay M, Kolajova M.

Protein Expr Purif. 2008 Aug;60(2):117-26. doi: 10.1016/j.pep.2008.03.013. Epub 2008 Mar 25.

PMID:
18485734
37.

Plasma PCSK9 levels correlate with cholesterol in men but not in women.

Mayne J, Raymond A, Chaplin A, Cousins M, Kaefer N, Gyamera-Acheampong C, Seidah NG, Mbikay M, Chrétien M, Ooi TC.

Biochem Biophys Res Commun. 2007 Sep 21;361(2):451-6. Epub 2007 Jul 18.

PMID:
17645871
38.

Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms.

Mbikay M, Mayne J, Seidah NG, Chrétien M.

Med Hypotheses. 2007;69(5):1010-7. Epub 2007 May 14.

PMID:
17502126
39.
40.

Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2.

Croissandeau G, Wahnon F, Yashpal K, Seidah NG, Coderre TJ, Chrétien M, Mbikay M.

Neurosci Lett. 2006 Oct 2;406(1-2):71-5. Epub 2006 Aug 14.

PMID:
16905251
41.

Differences of pancreatic expression of 7B2 between C57BL/6J and C3H/HeJ mice and genetic polymorphisms at its locus (Sgne1).

Schmidt G, Sirois F, Anini Y, Kauri LM, Gyamera-Acheampong C, Fleck E, Scott FW, Chrétien M, Mbikay M.

Diabetes. 2006 Feb;55(2):452-9.

42.

Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability.

Gyamera-Acheampong C, Tantibhedhyangkul J, Weerachatyanukul W, Tadros H, Xu H, van de Loo JW, Pelletier RM, Tanphaichitr N, Mbikay M.

Biol Reprod. 2006 Apr;74(4):666-73. Epub 2005 Dec 21.

PMID:
16371590
43.

Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse.

Essalmani R, Hamelin J, Marcinkiewicz J, Chamberland A, Mbikay M, Chrétien M, Seidah NG, Prat A.

Mol Cell Biol. 2006 Jan;26(1):354-61.

44.

Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.

St Germain C, Croissandeau G, Mayne J, Baltz JM, Chrétien M, Mbikay M.

Mol Reprod Dev. 2005 Dec;72(4):483-93.

PMID:
16163737
45.

The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases.

Nour N, Mayer G, Mort JS, Salvas A, Mbikay M, Morrison CJ, Overall CM, Seidah NG.

Mol Biol Cell. 2005 Nov;16(11):5215-26. Epub 2005 Aug 31.

46.

Role of pro-IGF-II processing by proprotein convertase 4 in human placental development.

Qiu Q, Basak A, Mbikay M, Tsang BK, Gruslin A.

Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11047-52. Epub 2005 Jul 22.

47.

Pituitary adenylate cyclase activating polypeptide-mediated intracrine signaling in the testicular germ cells.

Li M, Funahashi H, Mbikay M, Shioda S, Arimura A.

Endocrine. 2004 Feb;23(1):59-75.

PMID:
15034198
48.
49.

Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study.

Villeneuve P, Feliciangeli S, Croissandeau G, Seidah NG, Mbikay M, Kitabgi P, Beaudet A.

J Neurochem. 2002 Aug;82(4):783-93.

50.

Characterization of a repressor element in the promoter region of proprotein convertase 2 (PC2) gene.

Mbikay M, Raffin-Sanson ML, Sirois F, Kalenga L, Chrétien M, Seidah NG.

Brain Res Mol Brain Res. 2002 Jun 15;102(1-2):35-47.

PMID:
12191492

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