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Items: 28

1.

Antimalarial benzo[c]phenanthridines.

Nyangulu JM, Hargreaves SL, Sharples SL, Mackay SP, Waigh RD, Duval O, Mberu EK, Watkins WM.

Bioorg Med Chem Lett. 2005 Apr 15;15(8):2007-10.

PMID:
15808457
2.

The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analyses.

Watkins WM, Mberu EK, Winstanley PA, Plowe CV.

Parasitol Today. 1997 Dec;13(12):459-64.

PMID:
15275132
3.

Sulfa drugs strike more than once.

Patel OG, Mberu EK, Nzila AM, Macreadie IG.

Trends Parasitol. 2004 Jan;20(1):1-3. No abstract available.

PMID:
14700578
4.

The effect of quinine on the electroretinograms of children with pediatric cerebral malaria.

Lochhead J, Movaffaghy A, Falsini B, Winstanley PA, Mberu EK, Riva CE, Molyneux ME, Taylor TE, Harding SP.

J Infect Dis. 2003 Apr 15;187(8):1342-5. Epub 2003 Apr 2.

PMID:
12696018
5.

Plasmodium falciparum: in vitro activity of sulfadoxine and dapsone in field isolates from Kenya: point mutations in dihydropteroate synthase may not be the only determinants in sulfa resistance.

Mberu EK, Nzila AM, Nduati E, Ross A, Monks SM, Kokwaro GO, Watkins WM, Hopkins Sibley C.

Exp Parasitol. 2002 Jun-Jul;101(2-3):90-6.

PMID:
12427462
6.

Genetic diversity of Plasmodium falciparum parasites from Kenya is not affected by antifolate drug selection.

Nzila AM, Mberu EK, Nduati E, Ross A, Watkins WM, Sibley CH.

Int J Parasitol. 2002 Nov;32(12):1469-76.

PMID:
12392912
7.

Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?

Sibley CH, Hyde JE, Sims PF, Plowe CV, Kublin JG, Mberu EK, Cowman AF, Winstanley PA, Watkins WM, Nzila AM.

Trends Parasitol. 2001 Dec;17(12):582-8. Review.

PMID:
11756042
8.

A new antiplasmodial coumarin from Toddalia asiatica roots.

Oketch-Rabah HA, Mwangi JW, Lisgarten J, Mberu EK.

Fitoterapia. 2000 Dec;71(6):636-40.

PMID:
11077169
9.

The changing in vitro susceptibility pattern to pyrimethamine/sulfadoxine in Plasmodium falciparum field isolates from Kilifi, Kenya.

Mberu EK, Mosobo MK, Nzila AM, Kokwaro GO, Sibley CH, Watkins WM.

Am J Trop Med Hyg. 2000 Mar;62(3):396-401.

PMID:
11037785
10.

Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum.

Nzila AM, Nduati E, Mberu EK, Hopkins Sibley C, Monks SA, Winstanley PA, Watkins WM.

J Infect Dis. 2000 Jun;181(6):2023-8. Epub 2000 Jun 5. Erratum in: J Infect Dis 2000 Sep;182(3):1011.

PMID:
10837185
11.
12.
13.

More on 'the efficacy of antifolate antimalarial combinations in Africa'.

Watkins WM, Mberu EK, Winstanley PA, Plowe CV.

Parasitol Today. 1999 Apr;15(4):131-2. No abstract available.

PMID:
10322331
14.
15.

Antimalarial activity in crude extracts of Malawian medicinal plants.

Connelly MP, Fabiano E, Patel IH, Kinyanjui SM, Mberu EK, Watkins WM.

Ann Trop Med Parasitol. 1996 Dec;90(6):597-602.

PMID:
9039271
16.

Measurement of physiological concentrations of dapsone and its monoacetyl metabolite: a miniaturised assay for liquid or filter paper-absorbed samples.

Mberu EK, Muhia DK, Minyiri GO, Njonge EW, Watkins WM.

J Chromatogr B Biomed Appl. 1996 Mar 3;677(2):385-7.

PMID:
8704946
17.

Cutaneous hypersensitivity reactions to thiacetazone, HIV infection and thiacetazone concentrations in plasma.

Watkins WM, Mungai M, Muhia DK, Mberu EK, Gathua S, Winstanley PA, Gilks CF, Nunn P.

Br J Clin Pharmacol. 1996 Feb;41(2):160-2.

18.

Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy.

Gakunju DM, Mberu EK, Dossaji SF, Gray AI, Waigh RD, Waterman PG, Watkins WM.

Antimicrob Agents Chemother. 1995 Dec;39(12):2606-9.

19.

Japanese poor metabolizers of proguanil do not have an increased risk of malaria chemoprophylaxis breakthrough.

Mberu EK, Wansor T, Sato H, Nishikawa Y, Watkins WM.

Trans R Soc Trop Med Hyg. 1995 Nov-Dec;89(6):658-9. No abstract available.

PMID:
8594689
20.

In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs.

Winstanley PA, Mberu EK, Szwandt IS, Breckenridge AM, Watkins WM.

Antimicrob Agents Chemother. 1995 Apr;39(4):948-52.

21.

Halofantrine pharmacokinetics in Kenyan children with non-severe and severe malaria.

Watkins WM, Winstanley PA, Mberu EK, Kokwaro G, Murphy SA, Newton CJ, Mwangi I, Forster D, Marsh K.

Br J Clin Pharmacol. 1995 Mar;39(3):283-7.

22.
23.

Towards optimal regimens of parenteral quinine for young African children with cerebral malaria: unbound quinine concentrations following a simple loading dose regimen.

Winstanley PA, Mberu EK, Watkins WM, Murphy SA, Lowe B, Marsh K.

Trans R Soc Trop Med Hyg. 1994 Sep-Oct;88(5):577-80.

PMID:
7992345
24.

Ferriprotoporphyrin catalysed decomposition of artemether: analytical and pharmacological implications.

Muhia DK, Thomas CG, Ward SA, Edwards G, Mberu EK, Watkins WM.

Biochem Pharmacol. 1994 Aug 30;48(5):889-95.

PMID:
8093101
25.

A single dose of intramuscular sulfadoxine-pyrimethamine as an adjunct to quinine in the treatment of severe malaria: pharmacokinetics and efficacy.

Newton CR, Winstanley PA, Watkins WM, Mwangi IN, Waruiru CM, Mberu EK, Warn PA, Nevill CG, Marsh K.

Trans R Soc Trop Med Hyg. 1993 Mar-Apr;87(2):207-10.

PMID:
8337731
27.

Measurement of quinine in filter paper-absorbed blood by high-performance liquid chromatography.

Mberu EK, Ward SA, Winstanley PA, Watkins WM.

J Chromatogr. 1991 Sep 18;570(1):180-4.

PMID:
1797824
28.

Variability in the metabolism of proguanil to the active metabolite cycloguanil in healthy Kenyan adults.

Watkins WM, Mberu EK, Nevill CG, Ward SA, Breckenridge AM, Koech DK.

Trans R Soc Trop Med Hyg. 1990 Jul-Aug;84(4):492-5.

PMID:
2091335

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