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MBD3L2 promotes Tet2 enzymatic activity for mediating 5-methylcytosine oxidation.
Peng L, Li Y, Xi Y, Li W, Li J, Lv R, Zhang L, Zou Q, Dong S, Luo H, Wu F, Yu W. Peng L, et al. J Cell Sci. 2016 Mar 1;129(5):1059-71. doi: 10.1242/jcs.179044. Epub 2016 Jan 14. J Cell Sci. 2016. PMID: 26769901
Moreover, MBD3L2 is more effective than MBD3 in promoting Tet2 enzymatic activity through strengthening the binding affinity between Tet2 and the methylated DNA target. ...Our data add new insights into the regulation of Tet2 activity by MBD3 and MBD3L2, and into ho …
Moreover, MBD3L2 is more effective than MBD3 in promoting Tet2 enzymatic activity through strengthening the binding affinity between …
MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.
Jin SG, Jiang CL, Rauch T, Li H, Pfeifer GP. Jin SG, et al. J Biol Chem. 2005 Apr 1;280(13):12700-9. doi: 10.1074/jbc.M413492200. Epub 2005 Jan 27. J Biol Chem. 2005. PMID: 15701600 Free article.
MBD3L2 acts as a transcriptional repressor when tethered to a GAL4-DNA binding domain. Repression by GAL4-MBD3L2 is relieved by MBD2 and vice versa, and repression by MBD2 from a methylated promoter is relieved by MBD3L2. ...
MBD3L2 acts as a transcriptional repressor when tethered to a GAL4-DNA binding domain. Repression by GAL4-MBD3L2 is relieved b …
Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.
Jin SG, Tsark W, Szabó PE, Pfeifer GP. Jin SG, et al. Dev Dyn. 2008 Nov;237(11):3435-43. doi: 10.1002/dvdy.21767. Dev Dyn. 2008. PMID: 18942147 Free PMC article.
Neither of these genes was able to promote reactivation of a methylation-silenced reporter gene. We created Mbd3l1 and Mbd3l2 knockout mice, which were viable and fertile. We show that demethylation of the paternal pronucleus in Mbd3l1-/- and Mbd3l2-/- mice is ident …
Neither of these genes was able to promote reactivation of a methylation-silenced reporter gene. We created Mbd3l1 and Mbd3l2 knockou …
Messenger RNA expression of Pabpnl1 and Mbd3l2 genes in oocytes and cleavage embryos.
Biase FH, Martelli L, Puga R, Giuliatti S, Santos-Biase WK, Fonseca Merighe GK, Meirelles FV. Biase FH, et al. Fertil Steril. 2010 May 15;93(8):2507-12. doi: 10.1016/j.fertnstert.2009.08.051. Epub 2009 Oct 12. Fertil Steril. 2010. PMID: 19819433 Free article.
MAIN OUTCOME MEASURE(S): Messenger RNA levels of poly(A)-binding protein nuclear-like 1 (Pabpnl1) and methyl-CpG-binding domain protein 3-like 2 (Mbd3l2). RESULT(S): Pabpnl1 mRNA was found to be expressed in oocytes, and Mbd3l2 transcripts were present in embryos. . …
MAIN OUTCOME MEASURE(S): Messenger RNA levels of poly(A)-binding protein nuclear-like 1 (Pabpnl1) and methyl-CpG-binding domain protein 3-li …
MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.
Jiang CL, Jin SG, Lee DH, Lan ZJ, Xu X, O'Connor TR, Szabó PE, Mann JR, Cooney AJ, Pfeifer GP. Jiang CL, et al. Genomics. 2002 Dec;80(6):621-9. doi: 10.1006/geno.2002.7001. Genomics. 2002. PMID: 12504854
This repression is independent of histone deacetylase inhibition. A homologue of MBD3L1, MBD3L2, was also identified and cloned. Expression of MBD3L2 was found in germ cell tumors and some somatic tissues. ...
This repression is independent of histone deacetylase inhibition. A homologue of MBD3L1, MBD3L2, was also identified and cloned. Expr …
Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer.
Zhang L, Farrell JJ, Zhou H, Elashoff D, Akin D, Park NH, Chia D, Wong DT. Zhang L, et al. Gastroenterology. 2010 Mar;138(3):949-57.e1-7. doi: 10.1053/j.gastro.2009.11.010. Epub 2009 Nov 18. Gastroenterology. 2010. PMID: 19931263 Free PMC article.
The logistic regression model with the combination of 4 messenger RNA biomarkers (KRAS, MBD3L2, ACRV1, and DPM1) could differentiate pancreatic cancer patients from noncancer subjects (chronic pancreatitis and healthy control), yielding a receiver operating characteristic …
The logistic regression model with the combination of 4 messenger RNA biomarkers (KRAS, MBD3L2, ACRV1, and DPM1) could differentiate …
Transcriptome analysis during human trophectoderm specification suggests new roles of metabolic and epigenetic genes.
Assou S, Boumela I, Haouzi D, Monzo C, Dechaud H, Kadoch IJ, Hamamah S. Assou S, et al. PLoS One. 2012;7(6):e39306. doi: 10.1371/journal.pone.0039306. Epub 2012 Jun 22. PLoS One. 2012. PMID: 22761758 Free PMC article.
Besides stemness genes such as NANOG and DPPA2, this signature included genes belonging to the NLR family (NALP4, 5, 9, 11 and 13), Ret finger protein-like family (RFPL1, 2 and 3), Melanoma Antigen family (MAGEA1, 2, 3, 5, 6 and 12) and previously unreported transcripts, such as …
Besides stemness genes such as NANOG and DPPA2, this signature included genes belonging to the NLR family (NALP4, 5, 9, 11 and 13), Ret fing …
DUX4 and DUX4 downstream target genes are expressed in fetal FSHD muscles.
Ferreboeuf M, Mariot V, Bessières B, Vasiljevic A, Attié-Bitach T, Collardeau S, Morere J, Roche S, Magdinier F, Robin-Ducellier J, Rameau P, Whalen S, Desnuelle C, Sacconi S, Mouly V, Butler-Browne G, Dumonceaux J. Ferreboeuf M, et al. Hum Mol Genet. 2014 Jan 1;23(1):171-81. doi: 10.1093/hmg/ddt409. Epub 2013 Aug 20. Hum Mol Genet. 2014. PMID: 23966205 Free article.
Interestingly, DUX4-FL expression level is much lower in trapezius than in quadriceps myotubes, which is confirmed by the level of expression of DUX4 downstream genes. We observed that TRIM43 and MBD3L2 are already overexpressed in FSHD1 fetal quadriceps biopsies, at simil …
Interestingly, DUX4-FL expression level is much lower in trapezius than in quadriceps myotubes, which is confirmed by the level of expressio …
Unique features of the anti-parallel, heterodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and GATA zinc finger domain containing 2A (GATAD2A/p66α).
Walavalkar NM, Gordon N, Williams DC Jr. Walavalkar NM, et al. J Biol Chem. 2013 Feb 1;288(5):3419-27. doi: 10.1074/jbc.M112.431346. Epub 2012 Dec 13. J Biol Chem. 2013. PMID: 23239876 Free PMC article.
To further characterize unique features of this complex that drive heterodimeric specificity and high affinity binding, we carried out biophysical analyses of MBD2 and the related homologues MBD3, MBD3-like protein 1 (MBD3L1), and MBD3-like protein 2 (MBD3L2) as well as sp …
To further characterize unique features of this complex that drive heterodimeric specificity and high affinity binding, we carried out bioph …