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Items: 1 to 50 of 51

1.

Attenuation of NF-κB in intestinal epithelial cells is sufficient to mitigate the bone loss co-morbidity of experimental mouse colitis.

Ke K, Chen TH, Arra M, Mbalaviele G, Swarnkar G, Abu-Amer Y.

J Bone Miner Res. 2019 May 20. doi: 10.1002/jbmr.3759. [Epub ahead of print]

PMID:
31107556
2.

Inflammasomes in Bone Diseases.

Mbalaviele G, Veis DJ.

Exp Suppl. 2018;108:269-279. doi: 10.1007/978-3-319-89390-7_11. Review.

PMID:
30536175
3.

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice.

Xiao J, Wang C, Yao JC, Alippe Y, Xu C, Kress D, Civitelli R, Abu-Amer Y, Kanneganti TD, Link DC, Mbalaviele G.

PLoS Biol. 2018 Nov 2;16(11):e3000047. doi: 10.1371/journal.pbio.3000047. eCollection 2018 Nov.

4.

Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss.

Murali B, Ren Q, Luo X, Faget DV, Wang C, Johnson RM, Gruosso T, Flanagan KC, Fu Y, Leahy K, Alspach E, Su X, Ross MH, Burnette B, Weilbaecher KN, Park M, Mbalaviele G, Monahan JB, Stewart SA.

Cancer Res. 2018 Oct 1;78(19):5618-5630. doi: 10.1158/0008-5472.CAN-18-0234. Epub 2018 Aug 9.

PMID:
30093561
5.

Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.

Wang C, Hockerman S, Jacobsen EJ, Alippe Y, Selness SR, Hope HR, Hirsch JL, Mnich SJ, Saabye MJ, Hood WF, Bonar SL, Abu-Amer Y, Haimovich A, Hoffman HM, Monahan JB, Mbalaviele G.

J Exp Med. 2018 May 7;215(5):1315-1325. doi: 10.1084/jem.20172063. Epub 2018 Mar 16.

6.

NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis.

Swarnkar G, Chen TH, Arra M, Nasir AM, Mbalaviele G, Abu-Amer Y.

Sci Rep. 2017 Oct 3;7(1):12600. doi: 10.1038/s41598-017-12707-7.

7.

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation.

Alippe Y, Wang C, Ricci B, Xiao J, Qu C, Zou W, Novack DV, Abu-Amer Y, Civitelli R, Mbalaviele G.

Sci Rep. 2017 Jul 26;7(1):6630. doi: 10.1038/s41598-017-07014-0.

8.

Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells.

Wang C, Xu CX, Alippe Y, Qu C, Xiao J, Schipani E, Civitelli R, Abu-Amer Y, Mbalaviele G.

Sci Rep. 2017 Jul 7;7(1):4880. doi: 10.1038/s41598-017-05033-5.

9.

Inflammatory osteolysis: a conspiracy against bone.

Mbalaviele G, Novack DV, Schett G, Teitelbaum SL.

J Clin Invest. 2017 Jun 1;127(6):2030-2039. doi: 10.1172/JCI93356. Epub 2017 Jun 1. Review.

10.

N-cadherin Regulation of Bone Growth and Homeostasis Is Osteolineage Stage-Specific.

Fontana F, Hickman-Brecks CL, Salazar VS, Revollo L, Abou-Ezzi G, Grimston SK, Jeong SY, Watkins M, Fortunato M, Alippe Y, Link DC, Mbalaviele G, Civitelli R.

J Bone Miner Res. 2017 Jun;32(6):1332-1342. doi: 10.1002/jbmr.3112. Epub 2017 Mar 29.

11.

Myeloid Deletion of Nemo Causes Osteopetrosis in Mice Owing to Upregulation of Transcriptional Repressors.

Swarnkar G, Shim K, Nasir AM, Seehra K, Chen HP, Mbalaviele G, Abu-Amer Y.

Sci Rep. 2016 Jul 20;6:29896. doi: 10.1038/srep29896.

12.

Osteoclasts-Key Players in Skeletal Health and Disease.

Novack DV, Mbalaviele G.

Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.MCHD-0011-2015. Review.

13.

Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation.

Wang C, Qu C, Alippe Y, Bonar SL, Civitelli R, Abu-Amer Y, Hottiger MO, Mbalaviele G.

Cell Death Dis. 2016 Mar 24;7:e2153. doi: 10.1038/cddis.2016.58.

14.

ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β.

Robaszkiewicz A, Qu C, Wisnik E, Ploszaj T, Mirsaidi A, Kunze FA, Richards PJ, Cinelli P, Mbalaviele G, Hottiger MO.

Sci Rep. 2016 Feb 17;6:21131. doi: 10.1038/srep21131.

15.

Myeloid lineage skewing due to exacerbated NF-κB signaling facilitates osteopenia in Scurfy mice.

Chen TH, Swarnkar G, Mbalaviele G, Abu-Amer Y.

Cell Death Dis. 2015 Apr 16;6:e1723. doi: 10.1038/cddis.2015.87.

16.

Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling.

Swarnkar G, Karuppaiah K, Mbalaviele G, Chen TH, Abu-Amer Y.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):154-9. doi: 10.1073/pnas.1415213112. Epub 2014 Dec 22.

17.

NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.

Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G.

FASEB J. 2015 Apr;29(4):1269-79. doi: 10.1096/fj.14-264804. Epub 2014 Dec 4.

18.

N-cadherin restrains PTH activation of Lrp6/β-catenin signaling and osteoanabolic action.

Revollo L, Kading J, Jeong SY, Li J, Salazar V, Mbalaviele G, Civitelli R.

J Bone Miner Res. 2015 Feb;30(2):274-85. doi: 10.1002/jbmr.2323.

19.

Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.

Swarnkar G, Zhang K, Mbalaviele G, Long F, Abu-Amer Y.

PLoS One. 2014 Mar 11;9(3):e91421. doi: 10.1371/journal.pone.0091421. eCollection 2014.

20.

Renal effects induced by prolonged mPGES1 inhibition.

Salazar F, Vazquez ML, Masferrer JL, Mbalaviele G, Llinas MT, Saez F, Arhancet G, Salazar FJ.

Am J Physiol Renal Physiol. 2014 Jan 1;306(1):F68-74. doi: 10.1152/ajprenal.00492.2013. Epub 2013 Nov 6.

21.

Postnatal ablation of osteoblast Smad4 enhances proliferative responses to canonical Wnt signaling through interactions with β-catenin.

Salazar VS, Zarkadis N, Huang L, Watkins M, Kading J, Bonar S, Norris J, Mbalaviele G, Civitelli R.

J Cell Sci. 2013 Dec 15;126(Pt 24):5598-609. doi: 10.1242/jcs.132233. Epub 2013 Oct 7.

22.

Embryonic ablation of osteoblast Smad4 interrupts matrix synthesis in response to canonical Wnt signaling and causes an osteogenesis-imperfecta-like phenotype.

Salazar VS, Zarkadis N, Huang L, Norris J, Grimston SK, Mbalaviele G, Civitelli R.

J Cell Sci. 2013 Nov 1;126(Pt 21):4974-84. doi: 10.1242/jcs.131953. Epub 2013 Sep 4.

23.

Cadherin-mediated cell-cell adhesion and signaling in the skeleton.

Marie PJ, Haÿ E, Modrowski D, Revollo L, Mbalaviele G, Civitelli R.

Calcif Tissue Int. 2014 Jan;94(1):46-54. doi: 10.1007/s00223-013-9733-7. Epub 2013 May 9. Review.

24.

JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production.

LaBranche TP, Jesson MI, Radi ZA, Storer CE, Guzova JA, Bonar SL, Thompson JM, Happa FA, Stewart ZS, Zhan Y, Bollinger CS, Bansal PN, Wellen JW, Wilkie DP, Bailey SA, Symanowicz PT, Hegen M, Head RD, Kishore N, Mbalaviele G, Meyer DM.

Arthritis Rheum. 2012 Nov;64(11):3531-42. doi: 10.1002/art.34649.

25.

Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice.

Bonar SL, Brydges SD, Mueller JL, McGeough MD, Pena C, Chen D, Grimston SK, Hickman-Brecks CL, Ravindran S, McAlinden A, Novack DV, Kastner DL, Civitelli R, Hoffman HM, Mbalaviele G.

PLoS One. 2012;7(4):e35979. doi: 10.1371/journal.pone.0035979. Epub 2012 Apr 27.

26.

Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.

Mnich SJ, Blanner PM, Hu LG, Shaffer AF, Happa FA, O'Neil S, Ukairo O, Weiss D, Welsh E, Storer C, Mbalaviele G, Ichijo H, Monahan JB, Hardy MM, Eda H.

Int Immunopharmacol. 2010 Oct;10(10):1170-6. doi: 10.1016/j.intimp.2010.06.023. Epub 2010 Jul 6.

PMID:
20609399
27.

N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms.

Di Benedetto A, Watkins M, Grimston S, Salazar V, Donsante C, Mbalaviele G, Radice GL, Civitelli R.

J Cell Sci. 2010 Aug 1;123(Pt 15):2640-8. doi: 10.1242/jcs.067777. Epub 2010 Jul 6.

28.

Expression, purification and functional characterization of IkappaB kinase-2 (IKK-2) mutants.

Mathialagan S, Poda GI, Kurumbail RG, Selness SR, Hall T, Reitz BA, Weinberg RA, Kishore N, Mbalaviele G.

Protein Expr Purif. 2010 Aug;72(2):254-61. doi: 10.1016/j.pep.2010.02.009. Epub 2010 Feb 20.

PMID:
20176108
29.

Novel insights into the cellular mechanisms of the anti-inflammatory effects of NF-kappaB essential modulator binding domain peptides.

Baima ET, Guzova JA, Mathialagan S, Nagiec EE, Hardy MM, Song LR, Bonar SL, Weinberg RA, Selness SR, Woodard SS, Chrencik J, Hood WF, Schindler JF, Kishore N, Mbalaviele G.

J Biol Chem. 2010 Apr 30;285(18):13498-506. doi: 10.1074/jbc.M109.099895. Epub 2010 Feb 18.

30.

Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template.

Wang J, Limburg D, Carter J, Mbalaviele G, Gierse J, Vazquez M.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1604-9. doi: 10.1016/j.bmcl.2010.01.060. Epub 2010 Jan 25.

PMID:
20144869
31.

Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.

Mbalaviele G, Pauley AM, Shaffer AF, Zweifel BS, Mathialagan S, Mnich SJ, Nemirovskiy OV, Carter J, Gierse JK, Wang JL, Vazquez ML, Moore WM, Masferrer JL.

Biochem Pharmacol. 2010 May 15;79(10):1445-54. doi: 10.1016/j.bcp.2010.01.003. Epub 2010 Jan 11.

PMID:
20067770
32.

Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation.

Hope HR, Anderson GD, Burnette BL, Compton RP, Devraj RV, Hirsch JL, Keith RH, Li X, Mbalaviele G, Messing DM, Saabye MJ, Schindler JF, Selness SR, Stillwell LI, Webb EG, Zhang J, Monahan JB.

J Pharmacol Exp Ther. 2009 Dec;331(3):882-95. doi: 10.1124/jpet.109.158329. Epub 2009 Aug 31.

PMID:
19720877
33.

A novel, highly selective, tight binding IkappaB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-kappaB pathway in arthritis-relevant cells and animal models.

Mbalaviele G, Sommers CD, Bonar SL, Mathialagan S, Schindler JF, Guzova JA, Shaffer AF, Melton MA, Christine LJ, Tripp CS, Chiang PC, Thompson DC, Hu Y, Kishore N.

J Pharmacol Exp Ther. 2009 Apr;329(1):14-25. doi: 10.1124/jpet.108.143800. Epub 2009 Jan 23.

PMID:
19168710
34.

The pro-osteogenic action of beta-catenin requires interaction with BMP signaling, but not Tcf/Lef transcriptional activity.

Salazar VS, Mbalaviele G, Civitelli R.

J Cell Biochem. 2008 Jun 1;104(3):942-52. doi: 10.1002/jcb.21679.

35.

Mechanisms of the joint-protective effects of p38 MAPK inhibitors in rodent arthritis.

Mbalaviele G, Monahan JB.

Expert Opin Drug Discov. 2008 Feb;3(2):163-72. doi: 10.1517/17460441.3.2.163.

PMID:
23480220
36.

Accentuated ovariectomy-induced bone loss and altered osteogenesis in heterozygous N-cadherin null mice.

Lai CF, Cheng SL, Mbalaviele G, Donsante C, Watkins M, Radice GL, Civitelli R.

J Bone Miner Res. 2006 Dec;21(12):1897-906.

37.

Cell-cell adhesion and signaling through cadherins: connecting bone cells in their microenvironment.

Mbalaviele G, Shin CS, Civitelli R.

J Bone Miner Res. 2006 Dec;21(12):1821-7. Review. No abstract available.

38.

Inhibition of p38 mitogen-activated protein kinase prevents inflammatory bone destruction.

Mbalaviele G, Anderson G, Jones A, De Ciechi P, Settle S, Mnich S, Thiede M, Abu-Amer Y, Portanova J, Monahan J.

J Pharmacol Exp Ther. 2006 Jun;317(3):1044-53. Epub 2006 Feb 24.

PMID:
16501068
39.

Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation.

Mbalaviele G, Sheikh S, Stains JP, Salazar VS, Cheng SL, Chen D, Civitelli R.

J Cell Biochem. 2005 Feb 1;94(2):403-18.

40.

Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis.

Castro CH, Shin CS, Stains JP, Cheng SL, Sheikh S, Mbalaviele G, Szejnfeld VL, Civitelli R.

J Cell Sci. 2004 Jun 1;117(Pt 13):2853-64.

41.

A small molecule antagonist of the alpha(v)beta3 integrin suppresses MDA-MB-435 skeletal metastasis.

Harms JF, Welch DR, Samant RS, Shevde LA, Miele ME, Babu GR, Goldberg SF, Gilman VR, Sosnowski DM, Campo DA, Gay CV, Budgeon LR, Mercer R, Jewell J, Mastro AM, Donahue HJ, Erin N, Debies MT, Meehan WJ, Jones AL, Mbalaviele G, Nickols A, Christensen ND, Melly R, Beck LN, Kent J, Rader RK, Kotyk JJ, Pagel MD, Westlin WF, Griggs DW.

Clin Exp Metastasis. 2004;21(2):119-28.

PMID:
15168729
42.

Activation of peroxisome proliferator-activated receptor-gamma pathway inhibits osteoclast differentiation.

Mbalaviele G, Abu-Amer Y, Meng A, Jaiswal R, Beck S, Pittenger MF, Thiede MA, Marshak DR.

J Biol Chem. 2000 May 12;275(19):14388-93.

43.

Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase.

Jaiswal RK, Jaiswal N, Bruder SP, Mbalaviele G, Marshak DR, Pittenger MF.

J Biol Chem. 2000 Mar 31;275(13):9645-52.

44.

Human mesenchymal stem cells promote human osteoclast differentiation from CD34+ bone marrow hematopoietic progenitors.

Mbalaviele G, Jaiswal N, Meng A, Cheng L, Van Den Bos C, Thiede M.

Endocrinology. 1999 Aug;140(8):3736-43.

PMID:
10433234
45.

Cadherin-6 mediates the heterotypic interactions between the hemopoietic osteoclast cell lineage and stromal cells in a murine model of osteoclast differentiation.

Mbalaviele G, Nishimura R, Myoi A, Niewolna M, Reddy SV, Chen D, Feng J, Roodman D, Mundy GR, Yoneda T.

J Cell Biol. 1998 Jun 15;141(6):1467-76.

46.

E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model.

Mbalaviele G, Dunstan CR, Sasaki A, Williams PJ, Mundy GR, Yoneda T.

Cancer Res. 1996 Sep 1;56(17):4063-70.

47.

The role of cadherin in the generation of multinucleated osteoclasts from mononuclear precursors in murine marrow.

Mbalaviele G, Chen H, Boyce BF, Mundy GR, Yoneda T.

J Clin Invest. 1995 Jun;95(6):2757-65.

48.

Short-term local injections of transforming growth factor-beta 1 decrease ovariectomy-stimulated osteoclastic resorption in vivo in rats.

Beaudreuil J, Mbalaviele G, Cohen-Solal M, Morieux C, De Vernejoul MC, Orcel P.

J Bone Miner Res. 1995 Jun;10(6):971-7.

PMID:
7572322
49.

Osteoclast formation from human cord blood mononuclear cells co-cultured with mice embryonic metatarsals in the presence of M-CSF.

Mbalaviele G, Orcel P, Morieux C, Nijweide PJ, de Vernejoul MC.

Bone. 1995 Jan;16(1):171-7.

PMID:
7742078

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