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Items: 1 to 50 of 204

1.

Activation of the VEGFC/VEGFR3 pathway induces tumor immune escape in colorectal cancer.

Tacconi C, Ungaro F, Correale C, Arena V, Massimino L, Detmar M, Spinelli A, Carvello M, Mazzone M, Oliveira AI, Rubbino F, Garlatti V, Spanò S, Lugli E, Colombo FS, Malesci A, Peyrin-Biroulet L, Vetrano S, Danese S, D'Alessio S.

Cancer Res. 2019 Jun 25. pii: canres.3657.2018. doi: 10.1158/0008-5472.CAN-18-3657. [Epub ahead of print]

PMID:
31239267
2.

Probing the role of an invariant active site His in family GH1 β-glycosidases.

Strazzulli A, Perugino G, Mazzone M, Rossi M, Withers SG, Moracci M.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):973-980. doi: 10.1080/14756366.2019.1608198.

3.

IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo.

Harris AJ, Mirchandani AS, Lynch RW, Murphy F, Delaney L, Small D, Coelho P, Watts ER, Sadiku P, Griffith D, Dickinson RS, Clark E, Willson JA, Morrison T, Mazzone M, Carmeliet P, Ghesquiere B, O'Kane C, McAuley D, Jenkins SJ, Whyte MKB, Walmsley SR.

Am J Respir Crit Care Med. 2019 Mar 8. doi: 10.1164/rccm.201808-1599OC. [Epub ahead of print]

PMID:
30849228
4.

Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells.

Travelli C, Consonni FM, Sangaletti S, Storto M, Morlacchi S, Grolla AA, Galli U, Tron GC, Portararo P, Rimassa L, Pressiani T, Mazzone M, Trovato R, Ugel S, Bronte V, Tripodo C, Colombo MP, Genazzani AA, Sica A.

Cancer Res. 2019 Apr 15;79(8):1938-1951. doi: 10.1158/0008-5472.CAN-18-1544. Epub 2019 Feb 18.

PMID:
30777853
5.

Tumor-associated macrophages: a short compendium.

Prenen H, Mazzone M.

Cell Mol Life Sci. 2019 Apr;76(8):1447-1458. doi: 10.1007/s00018-018-2997-3. Epub 2019 Feb 12. Review.

PMID:
30747250
6.

Regulation of Blood and Lymphatic Vessels by Immune Cells in Tumors and Metastasis.

Mazzone M, Bergers G.

Annu Rev Physiol. 2019 Feb 10;81:535-560. doi: 10.1146/annurev-physiol-020518-114721.

PMID:
30742781
7.

Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling.

Kugeratski FG, Atkinson SJ, Neilson LJ, Lilla S, Knight JRP, Serneels J, Juin A, Ismail S, Bryant DM, Markert EK, Machesky LM, Mazzone M, Sansom OJ, Zanivan S.

Sci Signal. 2019 Feb 5;12(567). pii: eaan8247. doi: 10.1126/scisignal.aan8247.

PMID:
30723174
8.

Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy.

Smeets D, Miller IS, O'Connor DP, Das S, Moran B, Boeckx B, Gaiser T, Betge J, Barat A, Klinger R, van Grieken NCT, Cremolini C, Prenen H, Mazzone M, Depreeuw J, Bacon O, Fender B, Brady J, Hennessy BT, McNamara DA, Kay E, Verheul HM, Maarten N, Gallagher WM, Murphy V, Prehn JHM, Koopman M, Punt CJA, Loupakis F, Ebert MPA, Ylstra B, Lambrechts D, Byrne AT.

Nat Commun. 2018 Oct 5;9(1):4112. doi: 10.1038/s41467-018-06567-6.

9.

Complement System and Age-Related Macular Degeneration: Implications of Gene-Environment Interaction for Preventive and Personalized Medicine.

Maugeri A, Barchitta M, Mazzone MG, Giuliano F, Agodi A.

Biomed Res Int. 2018 Aug 26;2018:7532507. doi: 10.1155/2018/7532507. eCollection 2018. Review.

10.

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis.

Kalucka J, Bierhansl L, Conchinha NV, Missiaen R, Elia I, Brüning U, Scheinok S, Treps L, Cantelmo AR, Dubois C, de Zeeuw P, Goveia J, Zecchin A, Taverna F, Morales-Rodriguez F, Brajic A, Conradi LC, Schoors S, Harjes U, Vriens K, Pilz GA, Chen R, Cubbon R, Thienpont B, Cruys B, Wong BW, Ghesquière B, Dewerchin M, De Bock K, Sagaert X, Jessberger S, Jones EAV, Gallez B, Lambrechts D, Mazzone M, Eelen G, Li X, Fendt SM, Carmeliet P.

Cell Metab. 2018 Dec 4;28(6):881-894.e13. doi: 10.1016/j.cmet.2018.07.016. Epub 2018 Aug 23.

PMID:
30146488
11.

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.

Bruning U, Morales-Rodriguez F, Kalucka J, Goveia J, Taverna F, Queiroz KCS, Dubois C, Cantelmo AR, Chen R, Loroch S, Timmerman E, Caixeta V, Bloch K, Conradi LC, Treps L, Staes A, Gevaert K, Tee A, Dewerchin M, Semenkovich CF, Impens F, Schilling B, Verdin E, Swinnen JV, Meier JL, Kulkarni RA, Sickmann A, Ghesquière B, Schoonjans L, Li X, Mazzone M, Carmeliet P.

Cell Metab. 2018 Dec 4;28(6):866-880.e15. doi: 10.1016/j.cmet.2018.07.019. Epub 2018 Aug 23.

PMID:
30146486
12.

Curcumin Modulates DNA Methyltransferase Functions in a Cellular Model of Diabetic Retinopathy.

Maugeri A, Mazzone MG, Giuliano F, Vinciguerra M, Basile G, Barchitta M, Agodi A.

Oxid Med Cell Longev. 2018 Jul 2;2018:5407482. doi: 10.1155/2018/5407482. eCollection 2018.

13.

Neutrophils enhance early Trypanosoma brucei infection onset.

Caljon G, Mabille D, Stijlemans B, De Trez C, Mazzone M, Tacchini-Cottier F, Malissen M, A Van Ginderachter J, Magez S, De Baetselier P, Van Den Abbeele J.

Sci Rep. 2018 Jul 25;8(1):11203. doi: 10.1038/s41598-018-29527-y.

14.

Resveratrol Modulates SIRT1 and DNMT Functions and Restores LINE-1 Methylation Levels in ARPE-19 Cells under Oxidative Stress and Inflammation.

Maugeri A, Barchitta M, Mazzone MG, Giuliano F, Basile G, Agodi A.

Int J Mol Sci. 2018 Jul 20;19(7). pii: E2118. doi: 10.3390/ijms19072118.

15.

Inhibition of prolyl hydroxylase domain proteins selectively enhances venous thrombus neovascularisation.

Grover SP, Saha P, Humphries J, Lyons OT, Patel AS, Serneels J, Modarai B, Mazzone M, Smith A.

Thromb Res. 2018 Sep;169:105-112. doi: 10.1016/j.thromres.2018.07.015. Epub 2018 Jul 11.

PMID:
30031289
16.

The reciprocal function and regulation of tumor vessels and immune cells offers new therapeutic opportunities in cancer.

Missiaen R, Mazzone M, Bergers G.

Semin Cancer Biol. 2018 Oct;52(Pt 2):107-116. doi: 10.1016/j.semcancer.2018.06.002. Epub 2018 Jun 20. Review.

PMID:
29935312
17.

Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis.

Martín-Pérez R, Yerbes R, Mora-Molina R, Cano-González A, Arribas J, Mazzone M, López-Rivas A, Palacios C.

Oncotarget. 2017 Oct 3;8(55):93688-93703. doi: 10.18632/oncotarget.21458. eCollection 2017 Nov 7.

18.

Loss of Caveolin-1 in Metastasis-Associated Macrophages Drives Lung Metastatic Growth through Increased Angiogenesis.

Celus W, Di Conza G, Oliveira AI, Ehling M, Costa BM, Wenes M, Mazzone M.

Cell Rep. 2017 Dec 5;21(10):2842-2854. doi: 10.1016/j.celrep.2017.11.034.

19.

Metabolism and TAM functions-it takes two to tango.

Mazzone M, Menga A, Castegna A.

FEBS J. 2018 Feb;285(4):700-716. doi: 10.1111/febs.14295. Epub 2017 Nov 8. Review.

20.

Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.

Glodde N, Bald T, van den Boorn-Konijnenberg D, Nakamura K, O'Donnell JS, Szczepanski S, Brandes M, Eickhoff S, Das I, Shridhar N, Hinze D, Rogava M, van der Sluis TC, Ruotsalainen JJ, Gaffal E, Landsberg J, Ludwig KU, Wilhelm C, Riek-Burchardt M, Müller AJ, Gebhardt C, Scolyer RA, Long GV, Janzen V, Teng MWL, Kastenmüller W, Mazzone M, Smyth MJ, Tüting T, Hölzel M.

Immunity. 2017 Oct 17;47(4):789-802.e9. doi: 10.1016/j.immuni.2017.09.012.

21.

Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth.

Mathivet T, Bouleti C, Van Woensel M, Stanchi F, Verschuere T, Phng LK, Dejaegher J, Balcer M, Matsumoto K, Georgieva PB, Belmans J, Sciot R, Stockmann C, Mazzone M, De Vleeschouwer S, Gerhardt H.

EMBO Mol Med. 2017 Dec;9(12):1629-1645. doi: 10.15252/emmm.201607445.

22.

Retinoid X receptor suppresses a metastasis-promoting transcriptional program in myeloid cells via a ligand-insensitive mechanism.

Kiss M, Czimmerer Z, Nagy G, Bieniasz-Krzywiec P, Ehling M, Pap A, Poliska S, Boto P, Tzerpos P, Horvath A, Kolostyak Z, Daniel B, Szatmari I, Mazzone M, Nagy L.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10725-10730. doi: 10.1073/pnas.1700785114. Epub 2017 Sep 18.

23.

Is There Merit for MET-Targeted Therapies in Gastroesophageal Cancer?

Mazzone M, Finisguerra V, Prenen H.

JAMA Oncol. 2018 Jan 1;4(1):131-132. doi: 10.1001/jamaoncol.2017.2725. No abstract available.

PMID:
28910432
24.

YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis.

Wang X, Freire Valls A, Schermann G, Shen Y, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann L, Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodóvar C.

Dev Cell. 2017 Sep 11;42(5):462-478.e7. doi: 10.1016/j.devcel.2017.08.002. Epub 2017 Aug 31.

25.

Efficacy of a Fixed Combination of Tetracycline, Chloramphenicol, and Colistimethate Sodium for Treatment of Candida albicans Keratitis.

Blanco AR, Nostro A, D'Angelo V, D'Arrigo M, Mazzone MG, Marino A.

Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4292-4298. doi: 10.1167/iovs.17-22047.

PMID:
28846777
26.

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis.

Palmieri EM, Menga A, Martín-Pérez R, Quinto A, Riera-Domingo C, De Tullio G, Hooper DC, Lamers WH, Ghesquière B, McVicar DW, Guarini A, Mazzone M, Castegna A.

Cell Rep. 2017 Aug 15;20(7):1654-1666. doi: 10.1016/j.celrep.2017.07.054.

27.

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.

Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, Maxwell PH, Chilvers ER, Mazzone M, Moral V, Pugh CW, Ratcliffe PJ, Schofield CJ, Ghesquiere B, Carmeliet P, Whyte MK, Walmsley SR.

J Clin Invest. 2017 Sep 1;127(9):3407-3420. doi: 10.1172/JCI90848. Epub 2017 Aug 14.

28.

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming.

Liu PS, Wang H, Li X, Chao T, Teav T, Christen S, Di Conza G, Cheng WC, Chou CH, Vavakova M, Muret C, Debackere K, Mazzone M, Huang HD, Fendt SM, Ivanisevic J, Ho PC.

Nat Immunol. 2017 Sep;18(9):985-994. doi: 10.1038/ni.3796. Epub 2017 Jul 17.

PMID:
28714978
29.

Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium.

Reid SE, Kay EJ, Neilson LJ, Henze AT, Serneels J, McGhee EJ, Dhayade S, Nixon C, Mackey JB, Santi A, Swaminathan K, Athineos D, Papalazarou V, Patella F, Román-Fernández Á, ElMaghloob Y, Hernandez-Fernaud JR, Adams RH, Ismail S, Bryant DM, Salmeron-Sanchez M, Machesky LM, Carlin LM, Blyth K, Mazzone M, Zanivan S.

EMBO J. 2017 Aug 15;36(16):2373-2389. doi: 10.15252/embj.201694912. Epub 2017 Jul 10.

30.

Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.

Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MK, Walmsley SR.

Sci Immunol. 2017 Feb 10;2(8). pii: eaal2861. doi: 10.1126/sciimmunol.aal2861.

31.

PHD2 Targeting Overcomes Breast Cancer Cell Death upon Glucose Starvation in a PP2A/B55α-Mediated Manner.

Di Conza G, Trusso Cafarello S, Zheng X, Zhang Q, Mazzone M.

Cell Rep. 2017 Mar 21;18(12):2836-2844. doi: 10.1016/j.celrep.2017.02.081.

32.

MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability.

Mancini F, Teveroni E, Di Conza G, Monteleone V, Arisi I, Pellegrino M, Buttarelli M, Pieroni L, D'Onofrio M, Urbani A, Pontecorvi A, Mazzone M, Moretti F.

Mol Cancer. 2017 Mar 7;16(1):55. doi: 10.1186/s12943-017-0626-7.

33.

The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia.

Di Conza G, Trusso Cafarello S, Loroch S, Mennerich D, Deschoemaeker S, Di Matteo M, Ehling M, Gevaert K, Prenen H, Zahedi RP, Sickmann A, Kietzmann T, Moretti F, Mazzone M.

Cell Rep. 2017 Feb 14;18(7):1699-1712. doi: 10.1016/j.celrep.2017.01.051.

34.

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

Hernandez-Fernaud JR, Ruengeler E, Casazza A, Neilson LJ, Pulleine E, Santi A, Ismail S, Lilla S, Dhayade S, MacPherson IR, McNeish I, Ennis D, Ali H, Kugeratski FG, Al Khamici H, van den Biggelaar M, van den Berghe PV, Cloix C, McDonald L, Millan D, Hoyle A, Kuchnio A, Carmeliet P, Valenzuela SM, Blyth K, Yin H, Mazzone M, Norman JC, Zanivan S.

Nat Commun. 2017 Feb 15;8:14206. doi: 10.1038/ncomms14206.

35.

SLC25A26 overexpression impairs cell function via mtDNA hypermethylation and rewiring of methyl metabolism.

Menga A, Palmieri EM, Cianciulli A, Infantino V, Mazzone M, Scilimati A, Palmieri F, Castegna A, Iacobazzi V.

FEBS J. 2017 Mar;284(6):967-984. doi: 10.1111/febs.14028. Epub 2017 Feb 21.

36.

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity.

Laoui D, Keirsse J, Morias Y, Van Overmeire E, Geeraerts X, Elkrim Y, Kiss M, Bolli E, Lahmar Q, Sichien D, Serneels J, Scott CL, Boon L, De Baetselier P, Mazzone M, Guilliams M, Van Ginderachter JA.

Nat Commun. 2016 Dec 23;7:13720. doi: 10.1038/ncomms13720.

37.

Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells.

Palmieri EM, Menga A, Lebrun A, Hooper DC, Butterfield DA, Mazzone M, Castegna A.

Antioxid Redox Signal. 2017 Mar 10;26(8):351-363. doi: 10.1089/ars.2016.6715. Epub 2016 Nov 2.

38.

Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis.

Wenes M, Shang M, Di Matteo M, Goveia J, Martín-Pérez R, Serneels J, Prenen H, Ghesquière B, Carmeliet P, Mazzone M.

Cell Metab. 2016 Nov 8;24(5):701-715. doi: 10.1016/j.cmet.2016.09.008. Epub 2016 Oct 20.

39.

Preclinical and clinical evaluation of MET functions in cancer cells and in the tumor stroma.

Finisguerra V, Prenen H, Mazzone M.

Oncogene. 2016 Oct 20;35(42):5457-5467. doi: 10.1038/onc.2016.36. Epub 2016 Mar 21. Review.

PMID:
26996670
40.

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis.

Verbeke L, Mannaerts I, Schierwagen R, Govaere O, Klein S, Vander Elst I, Windmolders P, Farre R, Wenes M, Mazzone M, Nevens F, van Grunsven LA, Trebicka J, Laleman W.

Sci Rep. 2016 Sep 16;6:33453. doi: 10.1038/srep33453.

41.

MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis.

Stijlemans B, Brys L, Korf H, Bieniasz-Krzywiec P, Sparkes A, Vansintjan L, Leng L, Vanbekbergen N, Mazzone M, Caljon G, Van Den Abbeele J, Odongo S, De Trez C, Magez S, Van Ginderachter JA, Beschin A, Bucala R, De Baetselier P.

PLoS Pathog. 2016 Sep 15;12(9):e1005862. doi: 10.1371/journal.ppat.1005862. eCollection 2016 Sep.

42.

Tumour hypoxia causes DNA hypermethylation by reducing TET activity.

Thienpont B, Steinbacher J, Zhao H, D'Anna F, Kuchnio A, Ploumakis A, Ghesquière B, Van Dyck L, Boeckx B, Schoonjans L, Hermans E, Amant F, Kristensen VN, Peng Koh K, Mazzone M, Coleman M, Carell T, Carmeliet P, Lambrechts D.

Nature. 2016 Sep 1;537(7618):63-68. doi: 10.1038/nature19081. Epub 2016 Aug 17.

43.

The impact of hypoxia on tumor-associated macrophages.

Henze AT, Mazzone M.

J Clin Invest. 2016 Oct 3;126(10):3672-3679. doi: 10.1172/JCI84427. Epub 2016 Aug 2. Review.

44.

Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia.

Marsch E, Demandt JA, Theelen TL, Tullemans BM, Wouters K, Boon MR, van Dijk TH, Gijbels MJ, Dubois LJ, Meex SJ, Mazzone M, Hung G, Fisher EA, Biessen EA, Daemen MJ, Rensen PC, Carmeliet P, Groen AK, Sluimer JC.

Eur Heart J. 2016 Oct 14;37(39):2993-2997. Epub 2016 Apr 28.

45.

Vessel Normalization in the Spot-LIGHT of Cancer Treatment.

Ehling M, Mazzone M.

Trends Mol Med. 2016 Feb;22(2):85-87. doi: 10.1016/j.molmed.2015.12.009. Epub 2016 Jan 7.

PMID:
26774932
46.

Phospholipase C gamma 1 (PLCG1) R707Q mutation is counterselected under targeted therapy in a patient with hepatic angiosarcoma.

Prenen H, Smeets D, Mazzone M, Lambrechts D, Sagaert X, Sciot R, Debiec-Rychter M.

Oncotarget. 2015 Nov 3;6(34):36418-25. doi: 10.18632/oncotarget.5503.

47.

FMAHealth and Academic Family Medicine: On the Frontlines or on the Sidelines?

Borkan J, James P, Mazzone M, Kuzel A.

Fam Med. 2015 Sep;47(8):652-4. No abstract available.

48.

Sixty shades of oxygen-an attractive opportunity for cancer immunotherapy.

Hasan A, Mazzone M.

Ann Transl Med. 2015 Aug;3(13):187. doi: 10.3978/j.issn.2305-5839.2015.07.25. No abstract available.

49.

PHD1 regulates p53-mediated colorectal cancer chemoresistance.

Deschoemaeker S, Di Conza G, Lilla S, Martín-Pérez R, Mennerich D, Boon L, Hendrikx S, Maddocks OD, Marx C, Radhakrishnan P, Prenen H, Schneider M, Myllyharju J, Kietzmann T, Vousden KH, Zanivan S, Mazzone M.

EMBO Mol Med. 2015 Oct;7(10):1350-65. doi: 10.15252/emmm.201505492.

50.

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts.

Kuchnio A, Moens S, Bruning U, Kuchnio K, Cruys B, Thienpont B, Broux M, Ungureanu AA, Leite de Oliveira R, Bruyère F, Cuervo H, Manderveld A, Carton A, Hernandez-Fernaud JR, Zanivan S, Bartic C, Foidart JM, Noel A, Vinckier S, Lambrechts D, Dewerchin M, Mazzone M, Carmeliet P.

Cell Rep. 2015 Aug 11;12(6):992-1005. doi: 10.1016/j.celrep.2015.07.010. Epub 2015 Jul 30.

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