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Items: 1 to 50 of 184

1.

Tumor mutational burden quantification from targeted gene panels: major advancements and challenges.

Fancello L, Gandini S, Pelicci PG, Mazzarella L.

J Immunother Cancer. 2019 Jul 15;7(1):183. doi: 10.1186/s40425-019-0647-4. Review.

2.

The evolving landscape of 'next-generation' immune checkpoint inhibitors: A review.

Mazzarella L, Duso BA, Trapani D, Belli C, D'Amico P, Ferraro E, Viale G, Curigliano G.

Eur J Cancer. 2019 Aug;117:14-31. doi: 10.1016/j.ejca.2019.04.035. Epub 2019 Jun 21. Review.

PMID:
31229946
3.

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis.

Elgendy M, Cirò M, Hosseini A, Weiszmann J, Mazzarella L, Ferrari E, Cazzoli R, Curigliano G, DeCensi A, Bonanni B, Budillon A, Pelicci PG, Janssens V, Ogris M, Baccarini M, Lanfrancone L, Weckwerth W, Foiani M, Minucci S.

Cancer Cell. 2019 May 13;35(5):798-815.e5. doi: 10.1016/j.ccell.2019.03.007. Epub 2019 Apr 25.

PMID:
31031016
4.

p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value.

Santoro A, Vlachou T, Luzi L, Melloni G, Mazzarella L, D'Elia E, Aobuli X, Pasi CE, Reavie L, Bonetti P, Punzi S, Casoli L, Sabò A, Moroni MC, Dellino GI, Amati B, Nicassio F, Lanfrancone L, Pelicci PG.

Cell Rep. 2019 Jan 15;26(3):624-638.e8. doi: 10.1016/j.celrep.2018.12.071.

5.

Data on energy consumption and Nearly zero energy buildings (NZEBs) in Europe.

D'Agostino D, Mazzarella L.

Data Brief. 2018 Nov 23;21:2470-2474. doi: 10.1016/j.dib.2018.11.094. eCollection 2018 Dec.

6.

Liver toxicity in the era of immune checkpoint inhibitors: A practical approach.

Belli C, Zuin M, Mazzarella L, Trapani D, D'Amico P, Guerini-Rocco E, Achutti Duso B, Curigliano G.

Crit Rev Oncol Hematol. 2018 Dec;132:125-129. doi: 10.1016/j.critrevonc.2018.09.019. Epub 2018 Oct 3. Review.

PMID:
30447917
7.

Crystal structure of the ferric homotetrameric β4 human hemoglobin.

Mazzarella L, Merlino A, Balasco N, Balsamo A, Vergara A.

Biophys Chem. 2018 Sep;240:9-14. doi: 10.1016/j.bpc.2018.05.003. Epub 2018 May 23.

PMID:
29857171
8.

Infrared photocurrent management in monolithic perovskite/silicon heterojunction tandem solar cells by using a nanocrystalline silicon oxide interlayer.

Mazzarella L, Werth M, Jäger K, Jošt M, Korte L, Albrecht S, Schlatmann R, Stannowski B.

Opt Express. 2018 May 14;26(10):A487-A497. doi: 10.1364/OE.26.00A487.

PMID:
29801255
9.

Are we ready for routine precision medicine? Highlights from the Milan Summit on Precision Medicine, Milan, Italy, 8-9 February 2018.

Mazzarella L.

Ecancermedicalscience. 2018 Mar 5;12:817. doi: 10.3332/ecancer.2018.817. eCollection 2018.

10.

Cetuximab for treating non-small cell lung cancer.

Mazzarella L, Guida A, Curigliano G.

Expert Opin Biol Ther. 2018 Apr;18(4):483-493. doi: 10.1080/14712598.2018.1452906. Review.

11.

A new approach to assess drug sensitivity in cells for novel drug discovery.

Mazzarella L, Curigliano G.

Expert Opin Drug Discov. 2018 Apr;13(4):339-346. doi: 10.1080/17460441.2018.1437136. Epub 2018 Feb 7. Review.

PMID:
29415581
12.

Clinical efficacy of ribociclib as a first-line therapy for HR-positive, advanced breast cancer.

Duso BA, Trapani D, Viale G, Criscitiello C, D'Amico P, Belli C, Mazzarella L, Locatelli M, Minchella I, Curigliano G.

Expert Opin Pharmacother. 2018 Feb;19(3):299-305. doi: 10.1080/14656566.2018.1429407. Epub 2018 Jan 22.

PMID:
29355400
13.

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis.

Trabanelli S, Chevalier MF, Martinez-Usatorre A, Gomez-Cadena A, Salomé B, Lecciso M, Salvestrini V, Verdeil G, Racle J, Papayannidis C, Morita H, Pizzitola I, Grandclément C, Bohner P, Bruni E, Girotra M, Pallavi R, Falvo P, Leibundgut EO, Baerlocher GM, Carlo-Stella C, Taurino D, Santoro A, Spinelli O, Rambaldi A, Giarin E, Basso G, Tresoldi C, Ciceri F, Gfeller D, Akdis CA, Mazzarella L, Minucci S, Pelicci PG, Marcenaro E, McKenzie ANJ, Vanhecke D, Coukos G, Mavilio D, Curti A, Derré L, Jandus C.

Nat Commun. 2017 Sep 19;8(1):593. doi: 10.1038/s41467-017-00678-2.

14.

Entinostat for the treatment of breast cancer.

Trapani D, Esposito A, Criscitiello C, Mazzarella L, Locatelli M, Minchella I, Minucci S, Curigliano G.

Expert Opin Investig Drugs. 2017 Aug;26(8):965-971. doi: 10.1080/13543784.2017.1353077. Epub 2017 Jul 24. Review.

PMID:
28718331
15.

A knowledge-based framework for the discovery of cancer-predisposing variants using large-scale sequencing breast cancer data.

Melloni GEM, Mazzarella L, Bernard L, Bodini M, Russo A, Luzi L, Pelicci PG, Riva L.

Breast Cancer Res. 2017 May 31;19(1):63. doi: 10.1186/s13058-017-0854-1.

16.

Highlights from the 58th meeting of the American Society of Haematology, 1-6 December 2016, San Diego, USA.

Mazzarella L.

Ecancermedicalscience. 2017 Mar 9;11:725. doi: 10.3332/ecancer.2017.725. eCollection 2017.

17.

Fine Sampling of the R→T Quaternary-Structure Transition of a Tetrameric Hemoglobin.

Vitagliano L, Mazzarella L, Merlino A, Vergara A.

Chemistry. 2017 Jan 12;23(3):605-613. doi: 10.1002/chem.201603421. Epub 2016 Dec 7.

PMID:
27808442
18.

Maintenance of leukemic cell identity by the activity of the Polycomb complex PRC1 in mice.

Rossi A, Ferrari KJ, Piunti A, Jammula S, Chiacchiera F, Mazzarella L, Scelfo A, Pelicci PG, Pasini D.

Sci Adv. 2016 Oct 7;2(10):e1600972. eCollection 2016 Oct.

19.

Orlando Magic: report from the 57th meeting of the American Society of Haematology, 5-7 December 2015, Orlando, USA.

Mazzarella L.

Ecancermedicalscience. 2016 Jan 14;10:612. doi: 10.3332/ecancer.2016.612. eCollection 2016.

20.

Why does obesity promote cancer? Epidemiology, biology, and open questions.

Mazzarella L.

Ecancermedicalscience. 2015 Jul 23;9:554. doi: 10.3332/ecancer.2015.554. eCollection 2015. Review.

21.

DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes.

Melloni GE, Ogier AG, de Pretis S, Mazzarella L, Pelizzola M, Pelicci PG, Riva L.

Genome Med. 2014 Jun 10;6(6):44. doi: 10.1186/gm563. eCollection 2014.

22.

The genomic and epigenomic landscapes of AML.

Mazzarella L, Riva L, Luzi L, Ronchini C, Pelicci PG.

Semin Hematol. 2014 Oct;51(4):259-72. doi: 10.1053/j.seminhematol.2014.08.007. Epub 2014 Aug 26.

PMID:
25311739
23.

Rise of the mutants: report from the 19th conference of the European Haematology Association, Milan, 12-15 June 2014.

Mazzarella L.

Ecancermedicalscience. 2014 Aug 18;8:453. doi: 10.3332/ecancer.2014.453. eCollection 2014.

24.

Tales from the Jazz ASH: highlights from the 2013 American Society of Haematology meeting.

Mazzarella L.

Ecancermedicalscience. 2014 Jan 24;8:390. doi: 10.3332/ecancer.2014.390. eCollection 2014.

25.

A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex.

Russo Krauss I, Parkinson GN, Merlino A, Mattia CA, Randazzo A, Novellino E, Mazzarella L, Sica F.

Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):362-70. doi: 10.1107/S1399004713028095. Epub 2014 Jan 29.

PMID:
24531470
26.

Duplex-quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer.

Russo Krauss I, Pica A, Merlino A, Mazzarella L, Sica F.

Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2403-11. doi: 10.1107/S0907444913022269. Epub 2013 Nov 19.

PMID:
24311581
27.

Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase.

Pica A, Merlino A, Buell AK, Knowles TP, Pizzo E, D'Alessio G, Sica F, Mazzarella L.

Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):2116-23. doi: 10.1107/S0907444913020507. Epub 2013 Sep 20.

PMID:
24100329
28.

Obesity increases the incidence of distant metastases in oestrogen receptor-negative human epidermal growth factor receptor 2-positive breast cancer patients.

Mazzarella L, Disalvatore D, Bagnardi V, Rotmensz N, Galbiati D, Caputo S, Curigliano G, Pelicci PG.

Eur J Cancer. 2013 Nov;49(17):3588-97. doi: 10.1016/j.ejca.2013.07.016. Epub 2013 Aug 15.

29.

The structure of the CD3 ζζ transmembrane dimer in POPC and raft-like lipid bilayer: a molecular dynamics study.

Petruk AA, Varriale S, Coscia MR, Mazzarella L, Merlino A, Oreste U.

Biochim Biophys Acta. 2013 Nov;1828(11):2637-45. doi: 10.1016/j.bbamem.2013.07.019. Epub 2013 Jul 27.

30.

A novel interdomain interface in crystallins: structural characterization of the βγ-crystallin from Geodia cydonium at 0.99 Å resolution.

Vergara A, Grassi M, Sica F, Pizzo E, D'Alessio G, Mazzarella L, Merlino A.

Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):960-7. doi: 10.1107/S0907444913003569. Epub 2013 May 2.

PMID:
23695240
31.

Cytotoxic effect of (1-methyl-1H-imidazol-2-yl)-methanamine and its derivatives in Pt(II) complexes on human carcinoma cell lines: a comparative study with cisplatin.

Ferri N, Cazzaniga S, Mazzarella L, Curigliano G, Lucchini G, Zerla D, Gandolfi R, Facchetti G, Pellizzoni M, Rimoldi I.

Bioorg Med Chem. 2013 Apr 15;21(8):2379-2386. doi: 10.1016/j.bmc.2013.01.063. Epub 2013 Feb 5.

PMID:
23462712
32.

Role of tertiary structures on the Root effect in fish hemoglobins.

Ronda L, Merlino A, Bettati S, Verde C, Balsamo A, Mazzarella L, Mozzarelli A, Vergara A.

Biochim Biophys Acta. 2013 Sep;1834(9):1885-93. doi: 10.1016/j.bbapap.2013.01.031. Epub 2013 Feb 1.

PMID:
23376186
33.

Selective X-ray-induced NO photodissociation in haemoglobin crystals: evidence from a Raman-assisted crystallographic study.

Merlino A, Fuchs MR, Pica A, Balsamo A, Dworkowski FS, Pompidor G, Mazzarella L, Vergara A.

Acta Crystallogr D Biol Crystallogr. 2013 Jan;69(Pt 1):137-40. doi: 10.1107/S0907444912042229. Epub 2012 Dec 20.

PMID:
23275172
34.

ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus.

Coppola D, Abbruzzetti S, Nicoletti F, Merlino A, Gambacurta A, Giordano D, Howes BD, De Sanctis G, Vitagliano L, Bruno S, di Prisco G, Mazzarella L, Smulevich G, Coletta M, Viappiani C, Vergara A, Verde C.

Mol Biosyst. 2012 Oct 30;8(12):3295-304. doi: 10.1039/c2mb25210d.

PMID:
23086282
35.

High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity.

Russo Krauss I, Merlino A, Randazzo A, Novellino E, Mazzarella L, Sica F.

Nucleic Acids Res. 2012 Sep;40(16):8119-28. doi: 10.1093/nar/gks512. Epub 2012 Jun 4.

36.

Role of the tertiary and quaternary structure in the formation of bis-histidyl adducts in cold-adapted hemoglobins.

Balsamo A, Sannino F, Merlino A, Parrilli E, Tutino ML, Mazzarella L, Vergara A.

Biochimie. 2012 Apr;94(4):953-60. doi: 10.1016/j.biochi.2011.12.013. Epub 2012 Jan 11.

PMID:
22245705
37.

Increased BMI correlates with higher risk of disease relapse and differentiation syndrome in patients with acute promyelocytic leukemia treated with the AIDA protocols.

Breccia M, Mazzarella L, Bagnardi V, Disalvatore D, Loglisci G, Cimino G, Testi AM, Avvisati G, Petti MC, Minotti C, Latagliata R, Foà R, Pelicci PG, Lo-Coco F.

Blood. 2012 Jan 5;119(1):49-54. doi: 10.1182/blood-2011-07-369595. Epub 2011 Nov 2.

38.

Cytotoxic drugs for patients with breast cancer in the era of targeted treatment: back to the future?

Ribeiro JT, Macedo LT, Curigliano G, Fumagalli L, Locatelli M, Dalton M, Quintela A, Carvalheira JB, Manunta S, Mazzarella L, Brollo J, Goldhirsch A.

Ann Oncol. 2012 Mar;23(3):547-55. doi: 10.1093/annonc/mdr382. Epub 2011 Sep 6. Review.

PMID:
21896541
39.

Thrombin-aptamer recognition: a revealed ambiguity.

Russo Krauss I, Merlino A, Giancola C, Randazzo A, Mazzarella L, Sica F.

Nucleic Acids Res. 2011 Sep 1;39(17):7858-67. doi: 10.1093/nar/gkr522. Epub 2011 Jun 28.

40.

Polymerization of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhua.

Riccio A, Mangiapia G, Giordano D, Flagiello A, Tedesco R, Bruno S, Vergara A, Mazzarella L, di Prisco G, Pucci P, Paduano L, Verde C.

IUBMB Life. 2011 May;63(5):346-54. doi: 10.1002/iub.450. Epub 2011 Apr 13.

41.

Occurrence and formation of endogenous histidine hexa-coordination in cold-adapted hemoglobins.

Merlino A, Howes BD, Prisco Gd, Verde C, Smulevich G, Mazzarella L, Vergara A.

IUBMB Life. 2011 May;63(5):295-303. doi: 10.1002/iub.446. Epub 2011 Apr 13. Review.

42.

Protonation of histidine 55 affects the oxygen access to heme in the alpha chain of the hemoglobin from the Antarctic fish Trematomus bernacchii.

Boechi L, Martì MA, Vergara A, Sica F, Mazzarella L, Estrin DA, Merlino A.

IUBMB Life. 2011 Mar;63(3):175-82. doi: 10.1002/iub.436.

43.

A new RNase sheds light on the RNase/angiogenin subfamily from zebrafish.

Pizzo E, Merlino A, Turano M, Russo Krauss I, Coscia F, Zanfardino A, Varcamonti M, Furia A, Giancola C, Mazzarella L, Sica F, D'Alessio G.

Biochem J. 2011 Jan 15;433(2):345-55. doi: 10.1042/BJ20100892.

PMID:
21050179
44.

Crystallization, preliminary X-ray diffraction studies and Raman microscopy of the major haemoglobin from the sub-Antarctic fish Eleginops maclovinus in the carbomonoxy form.

Merlino A, Vitagliano L, Balsamo A, Nicoletti FP, Howes BD, Giordano D, Coppola D, di Prisco G, Verde C, Smulevich G, Mazzarella L, Vergara A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt 11):1536-40. doi: 10.1107/S1744309110038698. Epub 2010 Oct 29.

45.

An evolutionary conserved motif is responsible for immunoglobulin heavy chain packing in the B cell membrane.

Varriale S, Merlino A, Coscia MR, Mazzarella L, Oreste U.

Mol Phylogenet Evol. 2010 Dec;57(3):1238-44. doi: 10.1016/j.ympev.2010.09.022. Epub 2010 Oct 16.

PMID:
20937398
46.

Embryonic stem cell-derived hemangioblasts remain epigenetically plastic and require PRC1 to prevent neural gene expression.

Mazzarella L, Jørgensen HF, Soza-Ried J, Terry AV, Pearson S, Lacaud G, Kouskoff V, Merkenschlager M, Fisher AG.

Blood. 2011 Jan 6;117(1):83-7. doi: 10.1182/blood-2010-03-273128. Epub 2010 Sep 28.

47.

Crystallization and preliminary X-ray analysis of the complex of human alpha-thrombin with a modified thrombin-binding aptamer.

Russo Krauss I, Merlino A, Randazzo A, Mazzarella L, Sica F.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Aug 1;66(Pt 8):961-3. doi: 10.1107/S1744309110024632. Epub 2010 Jul 29.

48.

Epigenetic priming of a pre-B cell-specific enhancer through binding of Sox2 and Foxd3 at the ESC stage.

Liber D, Domaschenz R, Holmqvist PH, Mazzarella L, Georgiou A, Leleu M, Fisher AG, Labosky PA, Dillon N.

Cell Stem Cell. 2010 Jul 2;7(1):114-26. doi: 10.1016/j.stem.2010.05.020.

49.

An order-disorder transition plays a role in switching off the root effect in fish hemoglobins.

Vergara A, Vitagliano L, Merlino A, Sica F, Marino K, Verde C, di Prisco G, Mazzarella L.

J Biol Chem. 2010 Oct 15;285(42):32568-75. doi: 10.1074/jbc.M110.143537. Epub 2010 Jul 7.

50.

High rate of stem cell mobilization failure after thalidomide and oral cyclophosphamide induction therapy for multiple myeloma.

Auner HW, Mazzarella L, Cook L, Szydlo R, Saltarelli F, Pavlu J, Bua M, Giles C, Apperley JF, Rahemtulla A.

Bone Marrow Transplant. 2011 Mar;46(3):364-7. doi: 10.1038/bmt.2010.141. Epub 2010 Jun 21.

PMID:
20562926

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