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Items: 42

1.

Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.

Clausse V, Tao D, Debnath S, Fang Y, Tagad HD, Wang Y, Sun H, LeClair CA, Mazur SJ, Lane K, Shi ZD, Vasalatiy O, Eells R, Baker LK, Henderson MJ, Webb MR, Shen M, Hall MD, Appella E, Appella DH, Coussens NP.

J Biol Chem. 2019 Nov 15;294(46):17654-17668. doi: 10.1074/jbc.RA119.010201. Epub 2019 Sep 3.

2.

A trapped human PPM1A-phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity.

Debnath S, Kosek D, Tagad HD, Durell SR, Appella DH, Acevedo R, Grishaev A, Dyda F, Appella E, Mazur SJ.

J Biol Chem. 2018 May 25;293(21):7993-8008. doi: 10.1074/jbc.RA117.001213. Epub 2018 Mar 30.

3.

Chemical Features Important for Activity in a Class of Inhibitors Targeting the Wip1 Flap Subdomain.

Tagad HD, Debnath S, Clausse V, Saha M, Mazur SJ, Appella E, Appella DH.

ChemMedChem. 2018 May 8;13(9):894-901. doi: 10.1002/cmdc.201700779. Epub 2018 Apr 6.

PMID:
29476592
4.

Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry.

Mazur SJ, Gallagher ES, Debnath S, Durell SR, Anderson KW, Miller Jenkins LM, Appella E, Hudgens JW.

Biochemistry. 2017 May 30;56(21):2676-2689. doi: 10.1021/acs.biochem.6b01220. Epub 2017 May 12.

5.

The Area Between Exchange Curves as a Measure of Conformational Differences in Hydrogen-Deuterium Exchange Mass Spectrometry Studies.

Mazur SJ, Weber DP.

J Am Soc Mass Spectrom. 2017 May;28(5):978-981. doi: 10.1007/s13361-017-1615-1. Epub 2017 Feb 24.

6.

Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.

Veschi V, Liu Z, Voss TC, Ozbun L, Gryder B, Yan C, Hu Y, Ma A, Jin J, Mazur SJ, Lam N, Souza BK, Giannini G, Hager GL, Arrowsmith CH, Khan J, Appella E, Thiele CJ.

Cancer Cell. 2017 Jan 9;31(1):50-63. doi: 10.1016/j.ccell.2016.12.002.

7.

Characterization of the p300 Taz2-p53 TAD2 complex and comparison with the p300 Taz2-p53 TAD1 complex.

Miller Jenkins LM, Feng H, Durell SR, Tagad HD, Mazur SJ, Tropea JE, Bai Y, Appella E.

Biochemistry. 2015 Mar 24;54(11):2001-10. doi: 10.1021/acs.biochem.5b00044. Epub 2015 Mar 16.

PMID:
25753752
8.

An acetyl-methyl switch drives a conformational change in p53.

Tong Q, Mazur SJ, Rincon-Arano H, Rothbart SB, Kuznetsov DM, Cui G, Liu WH, Gete Y, Klein BJ, Jenkins L, Mer G, Kutateladze AG, Strahl BD, Groudine M, Appella E, Kutateladze TG.

Structure. 2015 Feb 3;23(2):322-31. doi: 10.1016/j.str.2014.12.010.

9.
10.

p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes.

Mondal AM, Horikawa I, Pine SR, Fujita K, Morgan KM, Vera E, Mazur SJ, Appella E, Vojtesek B, Blasco MA, Lane DP, Harris CC.

J Clin Invest. 2013 Dec;123(12):5247-57. doi: 10.1172/JCI70355. Epub 2013 Nov 15.

11.

Genetic variants and mutations of PPM1D control the response to DNA damage.

Dudgeon C, Shreeram S, Tanoue K, Mazur SJ, Sayadi A, Robinson RC, Appella E, Bulavin DV.

Cell Cycle. 2013 Aug 15;12(16):2656-64. doi: 10.4161/cc.25694. Epub 2013 Jul 18.

12.

Binding of a third metal ion by the human phosphatases PP2Cα and Wip1 is required for phosphatase activity.

Tanoue K, Miller Jenkins LM, Durell SR, Debnath S, Sakai H, Tagad HD, Ishida K, Appella E, Mazur SJ.

Biochemistry. 2013 Aug 27;52(34):5830-43. doi: 10.1021/bi4005649. Epub 2013 Aug 16.

13.

The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis.

Lu X, Mazur SJ, Lin T, Appella E, Xu Y.

Oncogene. 2014 May 15;33(20):2655-64. doi: 10.1038/onc.2013.209. Epub 2013 Jun 17.

14.

Radioprobing the conformation of DNA in a p53-DNA complex.

Karamychev VN, Wang D, Mazur SJ, Appella E, Neumann RD, Zhurkin VB, Panyutin IG.

Int J Radiat Biol. 2012 Dec;88(12):1039-45. doi: 10.3109/09553002.2012.698030. Epub 2012 Jun 21.

15.

Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio.

Goloudina AR, Mazur SJ, Appella E, Garrido C, Demidov ON.

Cell Cycle. 2012 May 15;11(10):1883-7. doi: 10.4161/cc.19901. Epub 2012 May 15.

16.

p53 N-terminal phosphorylation: a defining layer of complex regulation.

Jenkins LM, Durell SR, Mazur SJ, Appella E.

Carcinogenesis. 2012 Aug;33(8):1441-9. doi: 10.1093/carcin/bgs145. Epub 2012 Apr 12. Review.

17.

Regulation of the Wip1 phosphatase and its effects on the stress response.

Lowe J, Cha H, Lee MO, Mazur SJ, Appella E, Fornace AJ Jr.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1480-98. Review.

18.

Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents.

Goloudina AR, Tanoue K, Hammann A, Fourmaux E, Le Guezennec X, Bulavin DV, Mazur SJ, Appella E, Garrido C, Demidov ON.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):E68-75. doi: 10.1073/pnas.1107017108. Epub 2011 Nov 7.

19.

UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells.

Oh KS, Bustin M, Mazur SJ, Appella E, Kraemer KH.

DNA Repair (Amst). 2011 Jan 2;10(1):5-15. doi: 10.1016/j.dnarep.2010.09.004. Epub 2010 Oct 13.

20.

Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation.

Feng H, Jenkins LM, Durell SR, Hayashi R, Mazur SJ, Cherry S, Tropea JE, Miller M, Wlodawer A, Appella E, Bai Y.

Structure. 2009 Feb 13;17(2):202-10. doi: 10.1016/j.str.2008.12.009.

21.

Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation.

Jenkins LM, Yamaguchi H, Hayashi R, Cherry S, Tropea JE, Miller M, Wlodawer A, Appella E, Mazur SJ.

Biochemistry. 2009 Feb 17;48(6):1244-55. doi: 10.1021/bi801716h.

22.

Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites.

Rossi M, Demidov ON, Anderson CW, Appella E, Mazur SJ.

Nucleic Acids Res. 2008 Dec;36(22):7168-80. doi: 10.1093/nar/gkn888. Epub 2008 Nov 10.

23.

Quantitative proteomics analysis of the effects of ionizing radiation in wild type and p53 K317R knock-in mouse thymocytes.

Jenkins LM, Mazur SJ, Rossi M, Gaidarenko O, Xu Y, Appella E.

Mol Cell Proteomics. 2008 Apr;7(4):716-27. doi: 10.1074/mcp.M700482-MCP200. Epub 2008 Jan 4.

24.

Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage.

Chao C, Wu Z, Mazur SJ, Borges H, Rossi M, Lin T, Wang JY, Anderson CW, Appella E, Xu Y.

Mol Cell Biol. 2006 Sep;26(18):6859-69.

25.

Studies on the mechanism of inactivation of the HIV-1 nucleocapsid protein NCp7 with 2-mercaptobenzamide thioesters.

Jenkins LM, Byrd JC, Hara T, Srivastava P, Mazur SJ, Stahl SJ, Inman JK, Appella E, Omichinski JG, Legault P.

J Med Chem. 2005 Apr 21;48(8):2847-58.

PMID:
15828823
26.

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression.

Lin T, Chao C, Saito S, Mazur SJ, Murphy ME, Appella E, Xu Y.

Nat Cell Biol. 2005 Feb;7(2):165-71. Epub 2004 Dec 26.

PMID:
15619621
27.
28.
29.

The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.

Yang Q, Zhang R, Wang XW, Spillare EA, Linke SP, Subramanian D, Griffith JD, Li JL, Hickson ID, Shen JC, Loeb LA, Mazur SJ, Appella E, Brosh RM Jr, Karmakar P, Bohr VA, Harris CC.

J Biol Chem. 2002 Aug 30;277(35):31980-7. Epub 2002 Jun 21.

30.

Benzamide-based thiolcarbamates: a new class of HIV-1 NCp7 inhibitors.

Goel A, Mazur SJ, Fattah RJ, Hartman TL, Turpin JA, Huang M, Rice WG, Appella E, Inman JK.

Bioorg Med Chem Lett. 2002 Mar 11;12(5):767-70.

PMID:
11858998
31.

Inactivation of HIV-1 nucleocapsid protein P7 by pyridinioalkanoyl thioesters. Characterization of reaction products and proposed mechanism of action.

Basrur V, Song Y, Mazur SJ, Higashimoto Y, Turpin JA, Rice WG, Inman JK, Appella E.

J Biol Chem. 2000 May 19;275(20):14890-7.

32.

Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain.

Mazur SJ, Sakaguchi K, Appella E, Wang XW, Harris CC, Bohr VA.

J Mol Biol. 1999 Sep 17;292(2):241-9.

PMID:
10493872
33.

Repair of oxidative DNA base lesions induced by fluorescent light is defective in xeroderma pigmentosum group A cells.

Lipinski LJ, Hoehr N, Mazur SJ, Dianov GL, Sentürker S, Dizdaroglu M, Bohr VA.

Nucleic Acids Res. 1999 Aug 1;27(15):3153-8.

34.

Inhibition of RNA polymerase II transcription in human cell extracts by cisplatin DNA damage.

Cullinane C, Mazur SJ, Essigmann JM, Phillips DR, Bohr VA.

Biochemistry. 1999 May 11;38(19):6204-12.

PMID:
10320349
36.

Efficient in vitro repair of 7-hydro-8-oxodeoxyguanosine by human cell extracts: involvement of multiple pathways.

Jaiswal M, Lipinski LJ, Bohr VA, Mazur SJ.

Nucleic Acids Res. 1998 May 1;26(9):2184-91.

37.
39.

Dynamics of the Escherichia coli nucleotide excision repair system.

Grossman L, Caron PR, Mazur SJ, Oh EY.

Ann Ist Super Sanita. 1989;25(1):75-9.

PMID:
2665605
40.

Repair of DNA-containing pyrimidine dimers.

Grossman L, Caron PR, Mazur SJ, Oh EY.

FASEB J. 1988 Aug;2(11):2696-701. Review.

PMID:
3294078
41.

Kinetics of nonspecific binding reactions of proteins with DNA flexible coils: site-based and molecule-based association reactions.

Mazur SJ, Record MT Jr.

Biopolymers. 1986 Jun;25(6):985-1008. No abstract available.

PMID:
3730520
42.

Double helical DNA: conformations, physical properties, and interactions with ligands.

Record MT Jr, Mazur SJ, Melançon P, Roe JH, Shaner SL, Unger L.

Annu Rev Biochem. 1981;50:997-1024. Review. No abstract available.

PMID:
7023371

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