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Items: 1 to 50 of 73

1.

The Post-Synaptic Function of Brca2.

Wang CX, Jimenez-Sainz J, Jensen RB, Mazin AV.

Sci Rep. 2019 Mar 14;9(1):4554. doi: 10.1038/s41598-019-41054-y.

2.

FANCA Promotes DNA Double-Strand Break Repair by Catalyzing Single-Strand Annealing and Strand Exchange.

Benitez A, Liu W, Palovcak A, Wang G, Moon J, An K, Kim A, Zheng K, Zhang Y, Bai F, Mazin AV, Pei XH, Yuan F, Zhang Y.

Mol Cell. 2018 Aug 16;71(4):621-628.e4. doi: 10.1016/j.molcel.2018.06.030. Epub 2018 Jul 26.

3.

Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells.

Sullivan-Reed K, Bolton-Gillespie E, Dasgupta Y, Langer S, Siciliano M, Nieborowska-Skorska M, Hanamshet K, Belyaeva EA, Bernhardy AJ, Lee J, Moore M, Zhao H, Valent P, Matlawska-Wasowska K, Müschen M, Bhatia S, Bhatia R, Johnson N, Wasik MA, Mazin AV, Skorski T.

Cell Rep. 2018 Jun 12;23(11):3127-3136. doi: 10.1016/j.celrep.2018.05.034.

4.

Reconstituting the 4-Strand DNA Strand Exchange.

Mazina OM, Mazin AV.

Methods Enzymol. 2018;600:285-305. doi: 10.1016/bs.mie.2017.11.013. Epub 2018 Feb 1.

5.

RAD54 N-terminal domain is a DNA sensor that couples ATP hydrolysis with branch migration of Holliday junctions.

Goyal N, Rossi MJ, Mazina OM, Chi Y, Moritz RL, Clurman BE, Mazin AV.

Nat Commun. 2018 Jan 2;9(1):34. doi: 10.1038/s41467-017-02497-x.

6.

Rad52 Inverse Strand Exchange Drives RNA-Templated DNA Double-Strand Break Repair.

Mazina OM, Keskin H, Hanamshet K, Storici F, Mazin AV.

Mol Cell. 2017 Jul 6;67(1):19-29.e3. doi: 10.1016/j.molcel.2017.05.019. Epub 2017 Jun 8.

7.

Characterization of the recombination activities of the Entamoeba histolytica Rad51 recombinase.

Kelso AA, Goodson SD, Chavan S, Say AF, Turchick A, Sharma D, Ledford LL, Ratterman E, Leskoske K, King AV, Attaway CC, Bandera Y, Foulger SH, Mazin AV, Temesvari LA, Sehorn MG.

Mol Biochem Parasitol. 2016 Nov - Dec;210(1-2):71-84. doi: 10.1016/j.molbiopara.2016.09.001. Epub 2016 Sep 24.

8.

Reappearance from Obscurity: Mammalian Rad52 in Homologous Recombination.

Hanamshet K, Mazina OM, Mazin AV.

Genes (Basel). 2016 Sep 14;7(9). pii: E63. doi: 10.3390/genes7090063. Review.

9.

BRCA2 regulates DMC1-mediated recombination through the BRC repeats.

Martinez JS, von Nicolai C, Kim T, Ehlén Å, Mazin AV, Kowalczykowski SC, Carreira A.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3515-20. doi: 10.1073/pnas.1601691113. Epub 2016 Mar 14.

10.

Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors.

Huang F, Goyal N, Sullivan K, Hanamshet K, Patel M, Mazina OM, Wang CX, An WF, Spoonamore J, Metkar S, Emmitte KA, Cocklin S, Skorski T, Mazin AV.

Nucleic Acids Res. 2016 May 19;44(9):4189-99. doi: 10.1093/nar/gkw087. Epub 2016 Feb 11.

11.

Transcript-RNA-templated DNA recombination and repair.

Keskin H, Shen Y, Huang F, Patel M, Yang T, Ashley K, Mazin AV, Storici F.

Nature. 2014 Nov 20;515(7527):436-9. doi: 10.1038/nature13682. Epub 2014 Sep 3.

12.

A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeutic agents in mouse xenografts.

Huang F, Mazin AV.

PLoS One. 2014 Jun 27;9(6):e100993. doi: 10.1371/journal.pone.0100993. eCollection 2014.

13.

HOP2-MND1 modulates RAD51 binding to nucleotides and DNA.

Bugreev DV, Huang F, Mazina OM, Pezza RJ, Voloshin ON, Camerini-Otero RD, Mazin AV.

Nat Commun. 2014 Jun 19;5:4198. doi: 10.1038/ncomms5198.

14.

Targeting the homologous recombination pathway by small molecule modulators.

Huang F, Mazin AV.

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3006-13. doi: 10.1016/j.bmcl.2014.04.088. Epub 2014 May 6. Review.

15.

A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair.

Shahar OD, Kalousi A, Eini L, Fisher B, Weiss A, Darr J, Mazina O, Bramson S, Kupiec M, Eden A, Meshorer E, Mazin AV, Brino L, Goldberg M, Soutoglou E.

Nucleic Acids Res. 2014 May;42(9):5689-701. doi: 10.1093/nar/gku217. Epub 2014 Mar 25.

16.

The dual role of HOP2 in mammalian meiotic homologous recombination.

Pezza RJ, Voloshin ON, Volodin AA, Boateng KA, Bellani MA, Mazin AV, Camerini-Otero RD.

Nucleic Acids Res. 2014 Feb;42(4):2346-57. doi: 10.1093/nar/gkt1234. Epub 2013 Dec 3.

17.

Analysis of the activities of RAD54, a SWI2/SNF2 protein, using a specific small-molecule inhibitor.

Deakyne JS, Huang F, Negri J, Tolliday N, Cocklin S, Mazin AV.

J Biol Chem. 2013 Nov 1;288(44):31567-80. doi: 10.1074/jbc.M113.502195. Epub 2013 Sep 16.

18.

Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.

Huang F, Mazina OM, Zentner IJ, Cocklin S, Mazin AV.

J Med Chem. 2012 Apr 12;55(7):3011-20. doi: 10.1021/jm201173g. Epub 2012 Mar 19.

PMID:
22380680
19.

Polarity and bypass of DNA heterology during branch migration of Holliday junctions by human RAD54, BLM, and RECQ1 proteins.

Mazina OM, Rossi MJ, Deakyne JS, Huang F, Mazin AV.

J Biol Chem. 2012 Apr 6;287(15):11820-32. doi: 10.1074/jbc.M112.341347. Epub 2012 Feb 22.

20.

Reconstituting the key steps of the DNA double-strand break repair in vitro.

Rossi MJ, Bugreev DV, Mazina OM, Mazin AV.

Methods Mol Biol. 2011;745:407-20. doi: 10.1007/978-1-61779-129-1_23.

PMID:
21660707
21.

Fanconi anemia: at the crossroads of DNA repair.

Deakyne JS, Mazin AV.

Biochemistry (Mosc). 2011 Jan;76(1):36-48. Review.

PMID:
21568838
22.

The RecA/RAD51 protein drives migration of Holliday junctions via polymerization on DNA.

Rossi MJ, Mazina OM, Bugreev DV, Mazin AV.

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6432-7. doi: 10.1073/pnas.1016072108. Epub 2011 Apr 4.

23.

Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening.

Huang F, Motlekar NA, Burgwin CM, Napper AD, Diamond SL, Mazin AV.

ACS Chem Biol. 2011 Jun 17;6(6):628-35. doi: 10.1021/cb100428c. Epub 2011 Mar 23.

24.

The resistance of DMC1 D-loops to dissociation may account for the DMC1 requirement in meiosis.

Bugreev DV, Pezza RJ, Mazina OM, Voloshin ON, Camerini-Otero RD, Mazin AV.

Nat Struct Mol Biol. 2011 Jan;18(1):56-60. doi: 10.1038/nsmb.1946. Epub 2010 Dec 12. Erratum in: Nat Struct Mol Biol. 2011 Sep;18(9):1084. Nat Struct Mol Biol. 2013 Feb;20(2):244.

25.

Cooperation of RAD51 and RAD54 in regression of a model replication fork.

Bugreev DV, Rossi MJ, Mazin AV.

Nucleic Acids Res. 2011 Mar;39(6):2153-64. doi: 10.1093/nar/gkq1139. Epub 2010 Nov 21.

26.

Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes.

Wu Y, Sommers JA, Suhasini AN, Leonard T, Deakyne JS, Mazin AV, Shin-Ya K, Kitao H, Brosh RM Jr.

Blood. 2010 Nov 11;116(19):3780-91. doi: 10.1182/blood-2009-11-256016. Epub 2010 Jul 16.

27.

Analyzing the branch migration activities of eukaryotic proteins.

Rossi MJ, Mazina OM, Bugreev DV, Mazin AV.

Methods. 2010 Jul;51(3):336-46. doi: 10.1016/j.ymeth.2010.02.010. Epub 2010 Feb 16.

28.

Rad54, the motor of homologous recombination.

Mazin AV, Mazina OM, Bugreev DV, Rossi MJ.

DNA Repair (Amst). 2010 Mar 2;9(3):286-302. doi: 10.1016/j.dnarep.2009.12.006. Epub 2010 Jan 20. Review.

29.

Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52-ssDNA complexes.

Grimme JM, Honda M, Wright R, Okuno Y, Rothenberg E, Mazin AV, Ha T, Spies M.

Nucleic Acids Res. 2010 May;38(9):2917-30. doi: 10.1093/nar/gkp1249. Epub 2010 Jan 16.

30.

Structure of the hDmc1-ssDNA filament reveals the principles of its architecture.

Okorokov AL, Chaban YL, Bugreev DV, Hodgkinson J, Mazin AV, Orlova EV.

PLoS One. 2010 Jan 6;5(1):e8586. doi: 10.1371/journal.pone.0008586.

31.

A role for SSRP1 in recombination-mediated DNA damage response.

Kumari A, Mazina OM, Shinde U, Mazin AV, Lu H.

J Cell Biochem. 2009 Oct 1;108(2):508-18. doi: 10.1002/jcb.22280.

PMID:
19639603
32.

Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism.

Bugreev DV, Mazina OM, Mazin AV.

J Biol Chem. 2009 Sep 25;284(39):26349-59. doi: 10.1074/jbc.M109.029371. Epub 2009 Jul 24.

33.

FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange.

Sommers JA, Rawtani N, Gupta R, Bugreev DV, Mazin AV, Cantor SB, Brosh RM Jr.

J Biol Chem. 2009 Mar 20;284(12):7505-17. doi: 10.1074/jbc.M809019200. Epub 2009 Jan 16.

34.

Human Rad54 protein stimulates human Mus81-Eme1 endonuclease.

Mazina OM, Mazin AV.

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18249-54. doi: 10.1073/pnas.0807016105. Epub 2008 Nov 18.

35.

Rad51 protein stimulates the branch migration activity of Rad54 protein.

Rossi MJ, Mazin AV.

J Biol Chem. 2008 Sep 5;283(36):24698-706. doi: 10.1074/jbc.M800839200. Epub 2008 Jul 10.

36.

RECQ1 possesses DNA branch migration activity.

Bugreev DV, Brosh RM Jr, Mazin AV.

J Biol Chem. 2008 Jul 18;283(29):20231-42. doi: 10.1074/jbc.M801582200. Epub 2008 May 21.

37.

Novel pro- and anti-recombination activities of the Bloom's syndrome helicase.

Bugreev DV, Yu X, Egelman EH, Mazin AV.

Genes Dev. 2007 Dec 1;21(23):3085-94. Epub 2007 Nov 14.

38.

Rad54 dissociates homologous recombination intermediates by branch migration.

Bugreev DV, Hanaoka F, Mazin AV.

Nat Struct Mol Biol. 2007 Aug;14(8):746-53. Epub 2007 Jul 29.

PMID:
17660833
39.

Interactions of human rad54 protein with branched DNA molecules.

Mazina OM, Rossi MJ, Thomaä NH, Mazin AV.

J Biol Chem. 2007 Jul 20;282(29):21068-80. Epub 2007 May 31.

40.

Rad54 protein promotes branch migration of Holliday junctions.

Bugreev DV, Mazina OM, Mazin AV.

Nature. 2006 Aug 3;442(7102):590-3. Epub 2006 Jul 2.

PMID:
16862129
41.

Activation of human meiosis-specific recombinase Dmc1 by Ca2+.

Bugreev DV, Golub EI, Stasiak AZ, Stasiak A, Mazin AV.

J Biol Chem. 2005 Jul 22;280(29):26886-95. Epub 2005 May 25.

42.

Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54.

Thomä NH, Czyzewski BK, Alexeev AA, Mazin AV, Kowalczykowski SC, Pavletich NP.

Nat Struct Mol Biol. 2005 Apr;12(4):350-6. Epub 2005 Apr 3.

PMID:
15806108
43.

Human Rad54 protein stimulates DNA strand exchange activity of hRad51 protein in the presence of Ca2+.

Mazina OM, Mazin AV.

J Biol Chem. 2004 Dec 10;279(50):52042-51. Epub 2004 Oct 4.

44.

Ca2+ activates human homologous recombination protein Rad51 by modulating its ATPase activity.

Bugreev DV, Mazin AV.

Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):9988-93. Epub 2004 Jun 28.

45.
46.

A novel function of Rad54 protein. Stabilization of the Rad51 nucleoprotein filament.

Mazin AV, Alexeev AA, Kowalczykowski SC.

J Biol Chem. 2003 Apr 18;278(16):14029-36. Epub 2003 Feb 3.

47.

Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro.

Lio YC, Mazin AV, Kowalczykowski SC, Chen DJ.

J Biol Chem. 2003 Jan 24;278(4):2469-78. Epub 2002 Nov 8.

48.

Rad54 protein is targeted to pairing loci by the Rad51 nucleoprotein filament.

Mazin AV, Bornarth CJ, Solinger JA, Heyer WD, Kowalczykowski SC.

Mol Cell. 2000 Sep;6(3):583-92.

49.

Tailed duplex DNA is the preferred substrate for Rad51 protein-mediated homologous pairing.

Mazin AV, Zaitseva E, Sung P, Kowalczykowski SC.

EMBO J. 2000 Mar 1;19(5):1148-56.

50.

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