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Items: 18


Electron cryomicroscopy observation of acyl carrier protein translocation in type I fungal fatty acid synthase.

Lou JW, Iyer KR, Hasan SMN, Cowen LE, Mazhab-Jafari MT.

Sci Rep. 2019 Sep 10;9(1):12987. doi: 10.1038/s41598-019-49261-3.


Molecular basis of human CD22 function and therapeutic targeting.

Ereño-Orbea J, Sicard T, Cui H, Mazhab-Jafari MT, Benlekbir S, Guarné A, Rubinstein JL, Julien JP.

Nat Commun. 2017 Oct 2;8(1):764. doi: 10.1038/s41467-017-00836-6.


Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase.

Mazhab-Jafari MT, Rohou A, Schmidt C, Bueler SA, Benlekbir S, Robinson CV, Rubinstein JL.

Nature. 2016 Nov 3;539(7627):118-122. doi: 10.1038/nature19828. Epub 2016 Oct 24.


Cryo-EM studies of the structure and dynamics of vacuolar-type ATPases.

Mazhab-Jafari MT, Rubinstein JL.

Sci Adv. 2016 Jul 22;2(7):e1600725. doi: 10.1126/sciadv.1600725. eCollection 2016 Jul. Review.


Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).

Fang Z, Marshall CB, Yin JC, Mazhab-Jafari MT, Gasmi-Seabrook GM, Smith MJ, Nishikawa T, Xu Y, Neel BG, Ikura M.

J Biol Chem. 2016 Jul 22;291(30):15641-52. doi: 10.1074/jbc.M116.714196. Epub 2016 May 18.


Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.

Mazhab-Jafari MT, Marshall CB, Smith MJ, Gasmi-Seabrook GM, Stathopulos PB, Inagaki F, Kay LE, Neel BG, Ikura M.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):6625-30. doi: 10.1073/pnas.1419895112. Epub 2015 May 4.


Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).

Mazhab-Jafari MT, Marshall CB, Ho J, Ishiyama N, Stambolic V, Ikura M.

J Biol Chem. 2014 May 2;289(18):12195-201. doi: 10.1074/jbc.C113.543736. Epub 2014 Mar 19.


A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues.

Long D, Marshall CB, Bouvignies G, Mazhab-Jafari MT, Smith MJ, Ikura M, Kay LE.

Angew Chem Int Ed Engl. 2013 Oct 4;52(41):10771-4. doi: 10.1002/anie.201305434. Epub 2013 Aug 22. No abstract available.


Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc.

Mazhab-Jafari MT, Marshall CB, Stathopulos PB, Kobashigawa Y, Stambolic V, Kay LE, Inagaki F, Ikura M.

J Am Chem Soc. 2013 Mar 6;135(9):3367-70. doi: 10.1021/ja312508w. Epub 2013 Feb 20.


The auto-inhibitory role of the EPAC hinge helix as mapped by NMR.

Selvaratnam R, Mazhab-Jafari MT, Das R, Melacini G.

PLoS One. 2012;7(11):e48707. doi: 10.1371/journal.pone.0048707. Epub 2012 Nov 21.


An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis.

Mazhab-Jafari MT, Marshall CB, Ishiyama N, Ho J, Di Palma V, Stambolic V, Ikura M.

Structure. 2012 Sep 5;20(9):1528-39. doi: 10.1016/j.str.2012.06.013. Epub 2012 Jul 19.


Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts.

Marshall CB, Meiri D, Smith MJ, Mazhab-Jafari MT, Gasmi-Seabrook GM, Rottapel R, Stambolic V, Ikura M.

Methods. 2012 Aug;57(4):473-85. doi: 10.1016/j.ymeth.2012.06.014. Epub 2012 Jun 28.


The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants.

Selvaratnam R, VanSchouwen B, Fogolari F, Mazhab-Jafari MT, Das R, Melacini G.

Biophys J. 2012 Feb 8;102(3):630-9. doi: 10.1016/j.bpj.2011.12.030. Epub 2012 Feb 7.


Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.

Mazhab-Jafari MT, Marshall CB, Smith M, Gasmi-Seabrook GM, Stambolic V, Rottapel R, Neel BG, Ikura M.

J Biol Chem. 2010 Feb 19;285(8):5132-6. doi: 10.1074/jbc.C109.064766. Epub 2009 Dec 14.


Dynamically driven ligand selectivity in cyclic nucleotide binding domains.

Das R, Chowdhury S, Mazhab-Jafari MT, Sildas S, Selvaratnam R, Melacini G.

J Biol Chem. 2009 Aug 28;284(35):23682-96. doi: 10.1074/jbc.M109.011700. Epub 2009 Apr 29.


Label-free assay for thermodynamic analysis of protein-ligand interactions: a multivariate strategy for allosteric ligand screening.

Gavina JM, Mazhab-Jafari MT, Melacini G, Britz-McKibbin P.

Biochemistry. 2009 Jan 20;48(2):223-5. doi: 10.1021/bi802121g.


Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP.

Das R, Mazhab-Jafari MT, Chowdhury S, SilDas S, Selvaratnam R, Melacini G.

J Biol Chem. 2008 Jul 11;283(28):19691-703. doi: 10.1074/jbc.M802164200. Epub 2008 Apr 14.


Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states.

Mazhab-Jafari MT, Das R, Fotheringham SA, SilDas S, Chowdhury S, Melacini G.

J Am Chem Soc. 2007 Nov 21;129(46):14482-92. Epub 2007 Oct 31.


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