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Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00766-17. doi: 10.1128/AAC.00766-17. Print 2017 Sep.

In Vitro Activity of Ceftolozane-Tazobactam and Other Antimicrobial Agents against Burkholderia cepacia Complex and Burkholderia gladioli.

Author information

1
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
2
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
3
Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, USA.
4
Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, USA jlipuma@umich.edu.

Abstract

We tested the activities of ceftolozane-tazobactam and 13 other antimicrobial agents against 221 strains of Burkholderia cepacia complex and Burkholderia gladioli Most strains (82%) were cultured from persons with cystic fibrosis, and most (85%) were recovered since 2011. The ceftolozane-tazobactam MIC was ≤8 μg/ml for 77% of the strains. However, the MIC range was broad (≤0.5 to >64 μg/ml; MIC50/90, 2/32 μg/ml). Significant differences in susceptibility to some antimicrobial agents were observed between species.

KEYWORDS:

Burkholderia; ceftolozane; cystic fibrosis

PMID:
28674053
PMCID:
PMC5571321
DOI:
10.1128/AAC.00766-17
[Indexed for MEDLINE]
Free PMC Article

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