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Integron Identification in Bacterial Genomes and Cassette Recombination Assays.

Vit C, Loot C, Escudero JA, Nivina A, Mazel D.

Methods Mol Biol. 2020;2075:189-208. doi: 10.1007/978-1-4939-9877-7_14.


RadD Contributes to R-Loop Avoidance in Sub-MIC Tobramycin.

Negro V, Krin E, Aguilar Pierlé S, Chaze T, Giai Gianetto Q, Kennedy SP, Matondo M, Mazel D, Baharoglu Z.

mBio. 2019 Jul 2;10(4). pii: e01173-19. doi: 10.1128/mBio.01173-19.


Engineered toxin-intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations.

López-Igual R, Bernal-Bayard J, Rodríguez-Patón A, Ghigo JM, Mazel D.

Nat Biotechnol. 2019 Jul;37(7):755-760. doi: 10.1038/s41587-019-0105-3. Epub 2019 Apr 15.


Enhanced emergence of antibiotic-resistant pathogenic bacteria after in vitro induction with cancer chemotherapy drugs.

Meunier A, Nerich V, Fagnoni-Legat C, Richard M, Mazel D, Adotevi O, Bertrand X, Hocquet D.

J Antimicrob Chemother. 2019 Jun 1;74(6):1572-1577. doi: 10.1093/jac/dkz070.


Structural heterogeneity of attC integron recombination sites revealed by optical tweezers.

Mukhortava A, Pöge M, Grieb MS, Nivina A, Loot C, Mazel D, Schlierf M.

Nucleic Acids Res. 2019 Feb 28;47(4):1861-1870. doi: 10.1093/nar/gky1258.


Vibrio cholerae chromosome 2 copy number is controlled by the methylation-independent binding of its monomeric initiator to the chromosome 1 crtS site.

de Lemos Martins F, Fournes F, Mazzuoli MV, Mazel D, Val ME.

Nucleic Acids Res. 2018 Nov 2;46(19):10145-10156. doi: 10.1093/nar/gky790.


Replicate Once Per Cell Cycle: Replication Control of Secondary Chromosomes.

Fournes F, Val ME, Skovgaard O, Mazel D.

Front Microbiol. 2018 Aug 7;9:1833. doi: 10.3389/fmicb.2018.01833. eCollection 2018. Review.


Expansion of the SOS regulon of Vibrio cholerae through extensive transcriptome analysis and experimental validation.

Krin E, Pierlé SA, Sismeiro O, Jagla B, Dillies MA, Varet H, Irazoki O, Campoy S, Rouy Z, Cruveiller S, Médigue C, Coppée JY, Mazel D.

BMC Genomics. 2018 May 21;19(1):373. doi: 10.1186/s12864-018-4716-8.


Genomic Plasticity of Vibrio cholerae.

Escudero JA, Mazel D.

Int Microbiol. 2017 Sep;20(3):138-148. doi: 10.2436/20.1501.01.295. Review.


Dynamic stepwise opening of integron attC DNA hairpins by SSB prevents toxicity and ensures functionality.

Grieb MS, Nivina A, Cheeseman BL, Hartmann A, Mazel D, Schlierf M.

Nucleic Acids Res. 2017 Oct 13;45(18):10555-10563. doi: 10.1093/nar/gkx670.


Recoding of synonymous genes to expand evolutionary landscapes requires control of secondary structure affecting translation.

Escudero JA, Nivina A, Cambray G, López-Igual R, Loot C, Mazel D.

Biotechnol Bioeng. 2018 Jan;115(1):184-191. doi: 10.1002/bit.26450. Epub 2017 Oct 16.


Multicopy plasmids potentiate the evolution of antibiotic resistance in bacteria.

San Millan A, Escudero JA, Gifford DR, Mazel D, MacLean RC.

Nat Ecol Evol. 2016 Nov 7;1(1):10. doi: 10.1038/s41559-016-0010.


An att site-based recombination reporter system for genome engineering and synthetic DNA assembly.

Bland MJ, Ducos-Galand M, Val ME, Mazel D.

BMC Biotechnol. 2017 Jul 14;17(1):62. doi: 10.1186/s12896-017-0382-1.


Differences in Integron Cassette Excision Dynamics Shape a Trade-Off between Evolvability and Genetic Capacitance.

Loot C, Nivina A, Cury J, Escudero JA, Ducos-Galand M, Bikard D, Rocha EP, Mazel D.

mBio. 2017 Mar 28;8(2). pii: e02296-16. doi: 10.1128/mBio.02296-16.


The Proximity of Ribosomal Protein Genes to oriC Enhances Vibrio cholerae Fitness in the Absence of Multifork Replication.

Soler-Bistué A, Timmermans M, Mazel D.

mBio. 2017 Feb 28;8(1). pii: e00097-17. doi: 10.1128/mBio.00097-17.


Efficiency of integron cassette insertion in correct orientation is ensured by the interplay of the three unpaired features of attC recombination sites.

Nivina A, Escudero JA, Vit C, Mazel D, Loot C.

Nucleic Acids Res. 2016 Sep 19;44(16):7792-803. doi: 10.1093/nar/gkw646. Epub 2016 Aug 5.


A checkpoint control orchestrates the replication of the two chromosomes of Vibrio cholerae.

Val ME, Marbouty M, de Lemos Martins F, Kennedy SP, Kemble H, Bland MJ, Possoz C, Koszul R, Skovgaard O, Mazel D.

Sci Adv. 2016 Apr 22;2(4):e1501914. doi: 10.1126/sciadv.1501914. eCollection 2016 Apr.


Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation.

Escudero JA, Loot C, Parissi V, Nivina A, Bouchier C, Mazel D.

Nat Commun. 2016 Mar 10;7:10937. doi: 10.1038/ncomms10937.


The emergence of Vibrio pathogens in Europe: ecology, evolution, and pathogenesis (Paris, 11-12th March 2015).

Le Roux F, Wegner KM, Baker-Austin C, Vezzulli L, Osorio CR, Amaro C, Ritchie JM, Defoirdt T, Destoumieux-Garzón D, Blokesch M, Mazel D, Jacq A, Cava F, Gram L, Wendling CC, Strauch E, Kirschner A, Huehn S.

Front Microbiol. 2015 Aug 13;6:830. doi: 10.3389/fmicb.2015.00830. eCollection 2015.


The Integron: Adaptation On Demand.

Escudero JA, Loot C, Nivina A, Mazel D.

Microbiol Spectr. 2015 Apr;3(2):MDNA3-0019-2014. doi: 10.1128/microbiolspec.MDNA3-0019-2014. Review.


Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron.

Iqbal N, Guérout AM, Krin E, Le Roux F, Mazel D.

J Bacteriol. 2015 Jul;197(13):2150-9. doi: 10.1128/JB.00108-15. Epub 2015 Apr 20.


Genomic location of the major ribosomal protein gene locus determines Vibrio cholerae global growth and infectivity.

Soler-Bistué A, Mondotte JA, Bland MJ, Val ME, Saleh MC, Mazel D.

PLoS Genet. 2015 Apr 13;11(4):e1005156. doi: 10.1371/journal.pgen.1005156. eCollection 2015 Apr. Erratum in: PLoS Genet. 2015 Jun;11(6):e1005320.


VIBRIO 2014 meeting report.

Mazel D, Colwell R, Klose K, Oliver J, Crumlish M, McDougald D, Bland MJ, Austin B.

Res Microbiol. 2014 Dec;165(10):857-64. doi: 10.1016/j.resmic.2014.10.009. Epub 2014 Oct 22. No abstract available.


Management of multipartite genomes: the Vibrio cholerae model.

Val ME, Soler-Bistué A, Bland MJ, Mazel D.

Curr Opin Microbiol. 2014 Dec;22:120-6. doi: 10.1016/j.mib.2014.10.003. Review.


A single regulatory gene is sufficient to alter Vibrio aestuarianus pathogenicity in oysters.

Goudenège D, Travers MA, Lemire A, Petton B, Haffner P, Labreuche Y, Tourbiez D, Mangenot S, Calteau A, Mazel D, Nicolas JL, Jacq A, Le roux F.

Environ Microbiol. 2015 Nov;17(11):4189-99. doi: 10.1111/1462-2920.12699. Epub 2015 Jan 27.


Influence of very short patch mismatch repair on SOS inducing lesions after aminoglycoside treatment in Escherichia coli.

Baharoglu Z, Mazel D.

Res Microbiol. 2014 Jul-Aug;165(6):476-80. doi: 10.1016/j.resmic.2014.05.039. Epub 2014 Jun 16.


SOS, the formidable strategy of bacteria against aggressions.

Baharoglu Z, Mazel D.

FEMS Microbiol Rev. 2014 Nov;38(6):1126-45. doi: 10.1111/1574-6976.12077. Epub 2014 Jun 30. Review.


The superintegron integrase and the cassette promoters are co-regulated in Vibrio cholerae.

Krin E, Cambray G, Mazel D.

PLoS One. 2014 Mar 10;9(3):e91194. doi: 10.1371/journal.pone.0091194. eCollection 2014.


Identification of genes involved in low aminoglycoside-induced SOS response in Vibrio cholerae: a role for transcription stalling and Mfd helicase.

Baharoglu Z, Babosan A, Mazel D.

Nucleic Acids Res. 2014 Feb;42(4):2366-79. doi: 10.1093/nar/gkt1259. Epub 2013 Dec 6.


Fuse or die: how to survive the loss of Dam in Vibrio cholerae.

Val ME, Kennedy SP, Soler-Bistué AJ, Barbe V, Bouchier C, Ducos-Galand M, Skovgaard O, Mazel D.

Mol Microbiol. 2014 Feb;91(4):665-78. doi: 10.1111/mmi.12483. Epub 2014 Jan 7.


The integron integrase efficiently prevents the melting effect of Escherichia coli single-stranded DNA-binding protein on folded attC sites.

Loot C, Parissi V, Escudero JA, Amarir-Bouhram J, Bikard D, Mazel D.

J Bacteriol. 2014 Feb;196(4):762-71. doi: 10.1128/JB.01109-13. Epub 2013 Dec 2.


Shuffling of DNA cassettes in a synthetic integron.

Bikard D, Mazel D.

Methods Mol Biol. 2013;1073:169-74. doi: 10.1007/978-1-62703-625-2_14.


Comparative genomics of pathogenic lineages of Vibrio nigripulchritudo identifies virulence-associated traits.

Goudenège D, Labreuche Y, Krin E, Ansquer D, Mangenot S, Calteau A, Médigue C, Mazel D, Polz MF, Le Roux F.

ISME J. 2013 Oct;7(10):1985-96. doi: 10.1038/ismej.2013.90. Epub 2013 Jun 6.


RpoS plays a central role in the SOS induction by sub-lethal aminoglycoside concentrations in Vibrio cholerae.

Baharoglu Z, Krin E, Mazel D.

PLoS Genet. 2013;9(4):e1003421. doi: 10.1371/journal.pgen.1003421. Epub 2013 Apr 11.


β-Lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity.

Gutierrez A, Laureti L, Crussard S, Abida H, Rodríguez-Rojas A, Blázquez J, Baharoglu Z, Mazel D, Darfeuille F, Vogel J, Matic I.

Nat Commun. 2013;4:1610. doi: 10.1038/ncomms2607.


Characterization of the phd-doc and ccd toxin-antitoxin cassettes from Vibrio superintegrons.

Guérout AM, Iqbal N, Mine N, Ducos-Galand M, Van Melderen L, Mazel D.

J Bacteriol. 2013 May;195(10):2270-83. doi: 10.1128/JB.01389-12. Epub 2013 Mar 8.


Multiple Pathways of Genome Plasticity Leading to Development of Antibiotic Resistance.

Baharoglu Z, Garriss G, Mazel D.

Antibiotics (Basel). 2013 May 30;2(2):288-315. doi: 10.3390/antibiotics2020288. Review.


Antibiotics as physiological stress inducers and bacterial response to the challenge.

Mazel D, Mobashery S.

Curr Opin Microbiol. 2012 Oct;15(5):553-4. doi: 10.1016/j.mib.2012.09.002. Epub 2012 Oct 9. No abstract available.


Replicative resolution of integron cassette insertion.

Loot C, Ducos-Galand M, Escudero JA, Bouvier M, Mazel D.

Nucleic Acids Res. 2012 Sep 1;40(17):8361-70. Epub 2012 Jun 26.


Evidence for induction of integron-based antibiotic resistance by the SOS response in a clinical setting.

Hocquet D, Llanes C, Thouverez M, Kulasekara HD, Bertrand X, Plésiat P, Mazel D, Miller SI.

PLoS Pathog. 2012;8(6):e1002778. doi: 10.1371/journal.ppat.1002778. Epub 2012 Jun 14.


A natural system of chromosome transfer in Yersinia pseudotuberculosis.

Lesic B, Zouine M, Ducos-Galand M, Huon C, Rosso ML, Prévost MC, Mazel D, Carniel E.

PLoS Genet. 2012;8(3):e1002529. doi: 10.1371/journal.pgen.1002529. Epub 2012 Mar 8.


Genome engineering in Vibrio cholerae: a feasible approach to address biological issues.

Val ME, Skovgaard O, Ducos-Galand M, Bland MJ, Mazel D.

PLoS Genet. 2012 Jan;8(1):e1002472. doi: 10.1371/journal.pgen.1002472. Epub 2012 Jan 12.


High-level gene cassette transcription prevents integrase expression in class 1 integrons.

Guérin E, Jové T, Tabesse A, Mazel D, Ploy MC.

J Bacteriol. 2011 Oct;193(20):5675-82. doi: 10.1128/JB.05246-11. Epub 2011 Aug 19.


Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons.

Cambray G, Sanchez-Alberola N, Campoy S, Guerin É, Da Re S, González-Zorn B, Ploy MC, Barbé J, Mazel D, Erill I.

Mob DNA. 2011 Apr 30;2(1):6. doi: 10.1186/1759-8753-2-6.


Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance.

Baharoglu Z, Mazel D.

Antimicrob Agents Chemother. 2011 May;55(5):2438-41. doi: 10.1128/AAC.01549-10. Epub 2011 Feb 7.


Folded DNA in action: hairpin formation and biological functions in prokaryotes.

Bikard D, Loot C, Baharoglu Z, Mazel D.

Microbiol Mol Biol Rev. 2010 Dec;74(4):570-88. doi: 10.1128/MMBR.00026-10. Review.


Conjugative DNA transfer induces the bacterial SOS response and promotes antibiotic resistance development through integron activation.

Baharoglu Z, Bikard D, Mazel D.

PLoS Genet. 2010 Oct 21;6(10):e1001165. doi: 10.1371/journal.pgen.1001165.


Silent mischief: bacteriophage Mu insertions contaminate products of Escherichia coli random mutagenesis performed using suicidal transposon delivery plasmids mobilized by broad-host-range RP4 conjugative machinery.

Ferrières L, Hémery G, Nham T, Guérout AM, Mazel D, Beloin C, Ghigo JM.

J Bacteriol. 2010 Dec;192(24):6418-27. doi: 10.1128/JB.00621-10. Epub 2010 Oct 8.


Virulence of an emerging pathogenic lineage of Vibrio nigripulchritudo is dependent on two plasmids.

Le Roux F, Labreuche Y, Davis BM, Iqbal N, Mangenot S, Goarant C, Mazel D, Waldor MK.

Environ Microbiol. 2011 Feb;13(2):296-306. doi: 10.1111/j.1462-2920.2010.02329.x. Epub 2010 Sep 6.

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