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Items: 28


Crosstalk between BPA and FXRα Signaling Pathways Lead to Alterations of Undifferentiated Germ Cell Homeostasis and Male Fertility Disorders.

Sèdes L, Desdoits-Lethimonier C, Rouaisnel B, Holota H, Thirouard L, Lesne L, Damon-Soubeyrand C, Martinot E, Saru JP, Mazaud-Guittot S, Caira F, Beaudoin C, Jégou B, Volle DH.

Stem Cell Reports. 2018 Oct 9;11(4):944-958. doi: 10.1016/j.stemcr.2018.08.018. Epub 2018 Sep 20.


Ibuprofen is deleterious for the development of first trimester human fetal ovary ex vivo.

Leverrier-Penna S, Mitchell RT, Becker E, Lecante L, Ben Maamar M, Homer N, Lavoué V, Kristensen DM, Dejucq-Rainsford N, Jégou B, Mazaud-Guittot S.

Hum Reprod. 2018 Mar 1;33(3):482-493. doi: 10.1093/humrep/dex383.


TOXsIgN: a cross-species repository for toxicogenomic signatures.

Darde TA, Gaudriault P, Beranger R, Lancien C, Caillarec-Joly A, Sallou O, Bonvallot N, Chevrier C, Mazaud-Guittot S, Jégou B, Collin O, Becker E, Rolland AD, Chalmel F.

Bioinformatics. 2018 Jun 15;34(12):2116-2122. doi: 10.1093/bioinformatics/bty040.


Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism.

Kristensen DM, Desdoits-Lethimonier C, Mackey AL, Dalgaard MD, De Masi F, Munkbøl CH, Styrishave B, Antignac JP, Le Bizec B, Platel C, Hay-Schmidt A, Jensen TK, Lesné L, Mazaud-Guittot S, Kristiansen K, Brunak S, Kjaer M, Juul A, Jégou B.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E715-E724. doi: 10.1073/pnas.1715035115. Epub 2018 Jan 8. Erratum in: Proc Natl Acad Sci U S A. 2018 Apr 16;:.


EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?

Arendrup FS, Mazaud-Guittot S, Jégou B, Kristensen DM.

Endocr Connect. 2018 Jan;7(1):149-158. doi: 10.1530/EC-17-0298. Epub 2018 Jan 5.


In utero and lactational exposure to low-doses of the pyrethroid insecticide cypermethrin leads to neurodevelopmental defects in male mice-An ethological and transcriptomic study.

Laugeray A, Herzine A, Perche O, Richard O, Montecot-Dubourg C, Menuet A, Mazaud-Guittot S, Lesné L, Jegou B, Mortaud S.

PLoS One. 2017 Oct 11;12(10):e0184475. doi: 10.1371/journal.pone.0184475. eCollection 2017.


Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants.

Gaudriault P, Mazaud-Guittot S, Lavoué V, Coiffec I, Lesné L, Dejucq-Rainsford N, Scholze M, Kortenkamp A, Jégou B.

Environ Health Perspect. 2017 Aug 4;125(8):087004. doi: 10.1289/EHP1014.


Embryonic exposure to the widely-used herbicide atrazine disrupts meiosis and normal follicle formation in female mice.

Gely-Pernot A, Saci S, Kernanec PY, Hao C, Giton F, Kervarrec C, Tevosian S, Mazaud-Guittot S, Smagulova F.

Sci Rep. 2017 Jun 14;7(1):3526. doi: 10.1038/s41598-017-03738-1.


Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis.

Desdoits-Lethimonier C, Lesné L, Gaudriault P, Zalko D, Antignac JP, Deceuninck Y, Platel C, Dejucq-Rainsford N, Mazaud-Guittot S, Jégou B.

Hum Reprod. 2017 Jul 1;32(7):1465-1473. doi: 10.1093/humrep/dex093.


Ibuprofen results in alterations of human fetal testis development.

Ben Maamar M, Lesné L, Hennig K, Desdoits-Lethimonier C, Kilcoyne KR, Coiffec I, Rolland AD, Chevrier C, Kristensen DM, Lavoué V, Antignac JP, Le Bizec B, Dejucq-Rainsford N, Mitchell RT, Mazaud-Guittot S, Jégou B.

Sci Rep. 2017 Mar 10;7:44184. doi: 10.1038/srep44184.


Analgesic use - prevalence, biomonitoring and endocrine and reproductive effects.

Kristensen DM, Mazaud-Guittot S, Gaudriault P, Lesné L, Serrano T, Main KM, Jégou B.

Nat Rev Endocrinol. 2016 Jul;12(7):381-93. doi: 10.1038/nrendo.2016.55. Epub 2016 May 6. Review.


Intrauterine Exposure to Paracetamol and Aniline Impairs Female Reproductive Development by Reducing Follicle Reserves and Fertility.

Holm JB, Mazaud-Guittot S, Danneskiold-Samsøe NB, Chalmey C, Jensen B, Nørregård MM, Hansen CH, Styrishave B, Svingen T, Vinggaard AM, Koch HM, Bowles J, Koopman P, Jégou B, Kristiansen K, Kristensen DM.

Toxicol Sci. 2016 Mar;150(1):178-89. doi: 10.1093/toxsci/kfv332. Epub 2016 Jan 5.


Aniline Is Rapidly Converted Into Paracetamol Impairing Male Reproductive Development.

Holm JB, Chalmey C, Modick H, Jensen LS, Dierkes G, Weiss T, Jensen BA, Nørregård MM, Borkowski K, Styrishave B, Martin Koch H, Mazaud-Guittot S, Jegou B, Kristiansen K, Kristensen DM.

Toxicol Sci. 2015 Nov;148(1):288-98. doi: 10.1093/toxsci/kfv179. Epub 2015 Aug 10.


An investigation of the endocrine-disruptive effects of bisphenol a in human and rat fetal testes.

Ben Maamar M, Lesné L, Desdoits-Lethimonier C, Coiffec I, Lassurguère J, Lavoué V, Deceuninck Y, Antignac JP, Le Bizec B, Perdu E, Zalko D, Pineau C, Chevrier C, Dejucq-Rainsford N, Mazaud-Guittot S, Jégou B.

PLoS One. 2015 Feb 23;10(2):e0117226. doi: 10.1371/journal.pone.0117226. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0128051.


Pre- and postnatal exposure to low dose glufosinate ammonium induces autism-like phenotypes in mice.

Laugeray A, Herzine A, Perche O, Hébert B, Aguillon-Naury M, Richard O, Menuet A, Mazaud-Guittot S, Lesné L, Briault S, Jegou B, Pichon J, Montécot-Dubourg C, Mortaud S.

Front Behav Neurosci. 2014 Nov 20;8:390. doi: 10.3389/fnbeh.2014.00390. eCollection 2014.


Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling.

Callier P, Calvel P, Matevossian A, Makrythanasis P, Bernard P, Kurosaka H, Vannier A, Thauvin-Robinet C, Borel C, Mazaud-Guittot S, Rolland A, Desdoits-Lethimonier C, Guipponi M, Zimmermann C, Stévant I, Kuhne F, Conne B, Santoni F, Lambert S, Huet F, Mugneret F, Jaruzelska J, Faivre L, Wilhelm D, Jégou B, Trainor PA, Resh MD, Antonarakis SE, Nef S.

PLoS Genet. 2014 May 1;10(5):e1004340. doi: 10.1371/journal.pgen.1004340. eCollection 2014 May.


Systemic compensatory response to neonatal estradiol exposure does not prevent depletion of the oocyte pool in the rat.

Chalmey C, Giton F, Chalmel F, Fiet J, Jégou B, Mazaud-Guittot S.

PLoS One. 2013 Dec 16;8(12):e82175. doi: 10.1371/journal.pone.0082175. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/2cd33d2f-684d-44ae-9888-bcac7d69c1e9. Giton, Franck [corrected to Giton, Frank].


GATA4 autoregulates its own expression in mouse gonadal cells via its distal 1b promoter.

Mazaud-Guittot S, Prud'homme B, Bouchard MF, Bergeron F, Daems C, Tevosian SG, Viger RS.

Biol Reprod. 2014 Feb 6;90(2):25. doi: 10.1095/biolreprod.113.113290. Print 2014 Feb.


Paracetamol, aspirin, and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent.

Mazaud-Guittot S, Nicolas Nicolaz C, Desdoits-Lethimonier C, Coiffec I, Ben Maamar M, Balaguer P, Kristensen DM, Chevrier C, Lavoué V, Poulain P, Dejucq-Rainsford N, Jégou B.

J Clin Endocrinol Metab. 2013 Nov;98(11):E1757-67. doi: 10.1210/jc.2013-2531. Epub 2013 Sep 12.


Dissecting the phthalate-induced Sertoli cell injury: the fragile balance of proteases and their inhibitors.

Mazaud-Guittot S.

Biol Reprod. 2011 Dec;85(6):1091-3. doi: 10.1095/biolreprod.111.095976. Epub 2011 Sep 7. No abstract available.


Phenotyping the claudin 11 deficiency in testis: from histology to immunohistochemistry.

Mazaud-Guittot S, Gow A, Le Magueresse-Battistoni B.

Methods Mol Biol. 2011;763:223-36. doi: 10.1007/978-1-61779-191-8_15.


Excess type I interferon signaling in the mouse seminiferous tubules leads to germ cell loss and sterility.

Satie AP, Mazaud-Guittot S, Seif I, Mahé D, He Z, Jouve G, Jégou B, Dejucq-Rainsford N.

J Biol Chem. 2011 Jul 1;286(26):23280-95. doi: 10.1074/jbc.M111.229120. Epub 2011 Apr 22.


Conserved usage of alternative 5' untranslated exons of the GATA4 gene.

Mazaud Guittot S, Bouchard MF, Robert-Grenon JP, Robert C, Goodyer CG, Silversides DW, Viger RS.

PLoS One. 2009 Dec 24;4(12):e8454. doi: 10.1371/journal.pone.0008454.


Claudin 11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testis.

Mazaud-Guittot S, Meugnier E, Pesenti S, Wu X, Vidal H, Gow A, Le Magueresse-Battistoni B.

Biol Reprod. 2010 Jan;82(1):202-13. doi: 10.1095/biolreprod.109.078907. Epub 2009 Sep 9.


A comprehensive survey of the laminins and collagens type IV expressed in mouse Leydig cells and their regulation by LH/hCG.

Mazaud Guittot S, Vérot A, Odet F, Chauvin MA, le Magueresse-Battistoni B.

Reproduction. 2008 Apr;135(4):479-88. doi: 10.1530/REP-07-0561.


The proximal Gata4 promoter directs reporter gene expression to sertoli cells during mouse gonadal development.

Mazaud Guittot S, Tétu A, Legault E, Pilon N, Silversides DW, Viger RS.

Biol Reprod. 2007 Jan;76(1):85-95. Epub 2006 Oct 4.


Consequences of fetal irradiation on follicle histogenesis and early follicle development in rat ovaries.

Mazaud Guittot S, Guigon CJ, Coudouel N, Magre S.

Biol Reprod. 2006 Nov;75(5):749-59. Epub 2006 Jul 19.


Follicular cells acquire sertoli cell characteristics after oocyte loss.

Guigon CJ, Coudouel N, Mazaud-Guittot S, Forest MG, Magre S.

Endocrinology. 2005 Jul;146(7):2992-3004. Epub 2005 Apr 7.


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