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Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time.

Crosby P, Hamnett R, Putker M, Hoyle NP, Reed M, Karam CJ, Maywood ES, Stangherlin A, Chesham JE, Hayter EA, Rosenbrier-Ribeiro L, Newham P, Clevers H, Bechtold DA, O'Neill JS.

Cell. 2019 May 2;177(4):896-909.e20. doi: 10.1016/j.cell.2019.02.017. Epub 2019 Apr 25.


The Mammalian Circadian Timing System and the Suprachiasmatic Nucleus as Its Pacemaker.

Hastings MH, Maywood ES, Brancaccio M.

Biology (Basel). 2019 Mar 11;8(1). pii: E13. doi: 10.3390/biology8010013. Review.


Cell-autonomous clock of astrocytes drives circadian behavior in mammals.

Brancaccio M, Edwards MD, Patton AP, Smyllie NJ, Chesham JE, Maywood ES, Hastings MH.

Science. 2019 Jan 11;363(6423):187-192. doi: 10.1126/science.aat4104.


Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice.

Maywood ES, Elliott TS, Patton AP, Krogager TP, Chesham JE, Ernst RJ, Beránek V, Brancaccio M, Chin JW, Hastings MH.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12388-E12397. doi: 10.1073/pnas.1811438115. Epub 2018 Nov 28.


Synchronization and maintenance of circadian timing in the mammalian clockwork.

Maywood ES.

Eur J Neurosci. 2020 Jan;51(1):229-240. doi: 10.1111/ejn.14279. Epub 2018 Dec 5. Review.


Generation of circadian rhythms in the suprachiasmatic nucleus.

Hastings MH, Maywood ES, Brancaccio M.

Nat Rev Neurosci. 2018 Aug;19(8):453-469. doi: 10.1038/s41583-018-0026-z. Review.


Differential roles for cryptochromes in the mammalian retinal clock.

Wong JCY, Smyllie NJ, Banks GT, Pothecary CA, Barnard AR, Maywood ES, Jagannath A, Hughes S, van der Horst GTJ, MacLaren RE, Hankins MW, Hastings MH, Nolan PM, Foster RG, Peirson SN.

FASEB J. 2018 Aug;32(8):4302-4314. doi: 10.1096/fj.201701165RR. Epub 2018 Mar 21.


Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.

Brancaccio M, Patton AP, Chesham JE, Maywood ES, Hastings MH.

Neuron. 2017 Mar 22;93(6):1420-1435.e5. doi: 10.1016/j.neuron.2017.02.030. Epub 2017 Mar 9.


Genetic code expansion in the mouse brain.

Ernst RJ, Krogager TP, Maywood ES, Zanchi R, Beránek V, Elliott TS, Barry NP, Hastings MH, Chin JW.

Nat Chem Biol. 2016 Oct;12(10):776-778. doi: 10.1038/nchembio.2160. Epub 2016 Aug 29.


Visualizing and Quantifying Intracellular Behavior and Abundance of the Core Circadian Clock Protein PERIOD2.

Smyllie NJ, Pilorz V, Boyd J, Meng QJ, Saer B, Chesham JE, Maywood ES, Krogager TP, Spiller DG, Boot-Handford R, White MR, Hastings MH, Loudon AS.

Curr Biol. 2016 Jul 25;26(14):1880-6. doi: 10.1016/j.cub.2016.05.018. Epub 2016 Jun 30.


Temporally chimeric mice reveal flexibility of circadian period-setting in the suprachiasmatic nucleus.

Smyllie NJ, Chesham JE, Hamnett R, Maywood ES, Hastings MH.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3657-62. doi: 10.1073/pnas.1511351113. Epub 2016 Mar 10.


Rhythmic expression of cryptochrome induces the circadian clock of arrhythmic suprachiasmatic nuclei through arginine vasopressin signaling.

Edwards MD, Brancaccio M, Chesham JE, Maywood ES, Hastings MH.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2732-7. doi: 10.1073/pnas.1519044113. Epub 2016 Feb 22.


Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking.

Militi S, Maywood ES, Sandate CR, Chesham JE, Barnard AR, Parsons MJ, Vibert JL, Joynson GM, Partch CL, Hastings MH, Nolan PM.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2756-61. doi: 10.1073/pnas.1517549113. Epub 2016 Feb 22.


Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway.

Guo B, Yang N, Borysiewicz E, Dudek M, Williams JL, Li J, Maywood ES, Adamson A, Hastings MH, Bateman JF, White MR, Boot-Handford RP, Meng QJ.

Osteoarthritis Cartilage. 2015 Nov;23(11):1981-8. doi: 10.1016/j.joca.2015.02.020.


The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.

Parsons MJ, Brancaccio M, Sethi S, Maywood ES, Satija R, Edwards JK, Jagannath A, Couch Y, Finelli MJ, Smyllie NJ, Esapa C, Butler R, Barnard AR, Chesham JE, Saito S, Joynson G, Wells S, Foster RG, Oliver PL, Simon MM, Mallon AM, Hastings MH, Nolan PM.

Cell. 2015 Jul 30;162(3):607-21. doi: 10.1016/j.cell.2015.06.060.


Circadian factor BMAL1 in histaminergic neurons regulates sleep architecture.

Yu X, Zecharia A, Zhang Z, Yang Q, Yustos R, Jager P, Vyssotski AL, Maywood ES, Chesham JE, Ma Y, Brickley SG, Hastings MH, Franks NP, Wisden W.

Curr Biol. 2014 Dec 1;24(23):2838-44. doi: 10.1016/j.cub.2014.10.019. Epub 2014 Nov 13.


A specific role for the REV-ERBα-controlled L-Type Voltage-Gated Calcium Channel CaV1.2 in resetting the circadian clock in the late night.

Schmutz I, Chavan R, Ripperger JA, Maywood ES, Langwieser N, Jurik A, Stauffer A, Delorme JE, Moosmang S, Hastings MH, Hofmann F, Albrecht U.

J Biol Rhythms. 2014 Aug;29(4):288-98. doi: 10.1177/0748730414540453.


The Tau mutation of casein kinase 1ε sets the period of the mammalian pacemaker via regulation of Period1 or Period2 clock proteins.

Maywood ES, Chesham JE, Smyllie NJ, Hastings MH.

J Biol Rhythms. 2014 Apr;29(2):110-8. doi: 10.1177/0748730414520663.


Circadian pacemaking in cells and circuits of the suprachiasmatic nucleus.

Hastings MH, Brancaccio M, Maywood ES.

J Neuroendocrinol. 2014 Jan;26(1):2-10. doi: 10.1111/jne.12125. Review. Erratum in: J Neuroendocrinol. 2014 Feb;26(2):121.


Analysis of core circadian feedback loop in suprachiasmatic nucleus of mCry1-luc transgenic reporter mouse.

Maywood ES, Drynan L, Chesham JE, Edwards MD, Dardente H, Fustin JM, Hazlerigg DG, O'Neill JS, Codner GF, Smyllie NJ, Brancaccio M, Hastings MH.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9547-52. doi: 10.1073/pnas.1220894110. Epub 2013 May 20.


A Gq-Ca2+ axis controls circuit-level encoding of circadian time in the suprachiasmatic nucleus.

Brancaccio M, Maywood ES, Chesham JE, Loudon AS, Hastings MH.

Neuron. 2013 May 22;78(4):714-28. doi: 10.1016/j.neuron.2013.03.011. Epub 2013 Apr 25.


Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation.

Anand SN, Maywood ES, Chesham JE, Joynson G, Banks GT, Hastings MH, Nolan PM.

J Neurosci. 2013 Apr 24;33(17):7145-53. doi: 10.1523/JNEUROSCI.4950-12.2013.


Cellular mechanisms of circadian pacemaking: beyond transcriptional loops.

O'Neill JS, Maywood ES, Hastings MH.

Handb Exp Pharmacol. 2013;(217):67-103. doi: 10.1007/978-3-642-25950-0_4. Review.


Regulation of alternative splicing by the circadian clock and food related cues.

McGlincy NJ, Valomon A, Chesham JE, Maywood ES, Hastings MH, Ule J.

Genome Biol. 2012 Jun 21;13(6):R54. doi: 10.1186/gb-2012-13-6-r54.


Peroxiredoxins are conserved markers of circadian rhythms.

Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O'Neill JS, Reddy AB.

Nature. 2012 May 16;485(7399):459-64. doi: 10.1038/nature11088. Erratum in: Nature. 2012 Sep 27;489(7417):590.


Disrupted circadian rhythms in a mouse model of schizophrenia.

Oliver PL, Sobczyk MV, Maywood ES, Edwards B, Lee S, Livieratos A, Oster H, Butler R, Godinho SI, Wulff K, Peirson SN, Fisher SP, Chesham JE, Smith JW, Hastings MH, Davies KE, Foster RG.

Curr Biol. 2012 Feb 21;22(4):314-9. doi: 10.1016/j.cub.2011.12.051. Epub 2012 Jan 19.


Re-assembled botulinum neurotoxin inhibits CNS functions without systemic toxicity.

Ferrari E, Maywood ES, Restani L, Caleo M, Pirazzini M, Rossetto O, Hastings MH, Niranjan D, Schiavo G, Davletov B.

Toxins (Basel). 2011 Apr;3(4):345-55. doi: 10.3390/toxins3040345. Epub 2011 Mar 24.


A diversity of paracrine signals sustains molecular circadian cycling in suprachiasmatic nucleus circuits.

Maywood ES, Chesham JE, O'Brien JA, Hastings MH.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14306-11. doi: 10.1073/pnas.1101767108. Epub 2011 Jul 25.


Cyclic AMP signaling control of action potential firing rate and molecular circadian pacemaking in the suprachiasmatic nucleus.

Atkinson SE, Maywood ES, Chesham JE, Wozny C, Colwell CS, Hastings MH, Williams SR.

J Biol Rhythms. 2011 Jun;26(3):210-20. doi: 10.1177/0748730411402810.


Tuning the period of the mammalian circadian clock: additive and independent effects of CK1εTau and Fbxl3Afh mutations on mouse circadian behavior and molecular pacemaking.

Maywood ES, Chesham JE, Meng QJ, Nolan PM, Loudon AS, Hastings MH.

J Neurosci. 2011 Jan 26;31(4):1539-44. doi: 10.1523/JNEUROSCI.4107-10.2011.


Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.

Meng QJ, Maywood ES, Bechtold DA, Lu WQ, Li J, Gibbs JE, Dupré SM, Chesham JE, Rajamohan F, Knafels J, Sneed B, Zawadzke LE, Ohren JF, Walton KM, Wager TT, Hastings MH, Loudon AS.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15240-5. doi: 10.1073/pnas.1005101107. Epub 2010 Aug 9.


Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding.

Maywood ES, Fraenkel E, McAllister CJ, Wood N, Reddy AB, Hastings MH, Morton AJ.

J Neurosci. 2010 Jul 28;30(30):10199-204. doi: 10.1523/JNEUROSCI.1694-10.2010.


Proteomic analysis reveals the role of synaptic vesicle cycling in sustaining the suprachiasmatic circadian clock.

Deery MJ, Maywood ES, Chesham JE, Sládek M, Karp NA, Green EW, Charles PD, Reddy AB, Kyriacou CP, Lilley KS, Hastings MH.

Curr Biol. 2009 Dec 15;19(23):2031-6. doi: 10.1016/j.cub.2009.10.024. Epub 2009 Nov 12.


Differential testicular gene expression in seasonal fertility.

Maywood ES, Chahad-Ehlers S, Garabette ML, Pritchard C, Underhill P, Greenfield A, Ebling FJ, Akhtar RA, Kyriacou CP, Hastings MH, Reddy AB.

J Biol Rhythms. 2009 Apr;24(2):114-25. doi: 10.1177/0748730409332029.


Cellular circadian pacemaking and the role of cytosolic rhythms.

Hastings MH, Maywood ES, O'Neill JS.

Curr Biol. 2008 Sep 9;18(17):R805-R815. doi: 10.1016/j.cub.2008.07.021. Review.


Two decades of circadian time.

Hastings MH, Maywood ES, Reddy AB.

J Neuroendocrinol. 2008 Jun;20(6):812-9. doi: 10.1111/j.1365-2826.2008.01715.x. Review.


The biology of the circadian Ck1epsilon tau mutation in mice and Syrian hamsters: a tale of two species.

Loudon AS, Meng QJ, Maywood ES, Bechtold DA, Boot-Handford RP, Hastings MH.

Cold Spring Harb Symp Quant Biol. 2007;72:261-71. doi: 10.1101/sqb.2007.72.073. Review.


cAMP-dependent signaling as a core component of the mammalian circadian pacemaker.

O'Neill JS, Maywood ES, Chesham JE, Takahashi JS, Hastings MH.

Science. 2008 May 16;320(5878):949-53. doi: 10.1126/science.1152506.


Genetic and molecular analysis of the central and peripheral circadian clockwork of mice.

Maywood ES, O'Neill JS, Reddy AB, Chesham JE, Prosser HM, Kyriacou CP, Godinho SI, Nolan PM, Hastings MH.

Cold Spring Harb Symp Quant Biol. 2007;72:85-94. doi: 10.1101/sqb.2007.72.005. Review.


Loss of prokineticin receptor 2 signaling predisposes mice to torpor.

Jethwa PH, I'Anson H, Warner A, Prosser HM, Hastings MH, Maywood ES, Ebling FJ.

Am J Physiol Regul Integr Comp Physiol. 2008 Jun;294(6):R1968-79. doi: 10.1152/ajpregu.00778.2007. Epub 2008 Apr 16.


Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.

Meng QJ, Logunova L, Maywood ES, Gallego M, Lebiecki J, Brown TM, Sládek M, Semikhodskii AS, Glossop NRJ, Piggins HD, Chesham JE, Bechtold DA, Yoo SH, Takahashi JS, Virshup DM, Boot-Handford RP, Hastings MH, Loudon ASI.

Neuron. 2008 Apr 10;58(1):78-88. doi: 10.1016/j.neuron.2008.01.019.


Circadian clocks: regulators of endocrine and metabolic rhythms.

Hastings M, O'Neill JS, Maywood ES.

J Endocrinol. 2007 Nov;195(2):187-98. Review.


Minireview: The circadian clockwork of the suprachiasmatic nuclei--analysis of a cellular oscillator that drives endocrine rhythms.

Maywood ES, O'Neill JS, Chesham JE, Hastings MH.

Endocrinology. 2007 Dec;148(12):5624-34. Epub 2007 Sep 27. Review.


Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease.

Pallier PN, Maywood ES, Zheng Z, Chesham JE, Inyushkin AN, Dyball R, Hastings MH, Morton AJ.

J Neurosci. 2007 Jul 18;27(29):7869-78.


Glucocorticoid signaling synchronizes the liver circadian transcriptome.

Reddy AB, Maywood ES, Karp NA, King VM, Inoue Y, Gonzalez FJ, Lilley KS, Kyriacou CP, Hastings MH.

Hepatology. 2007 Jun;45(6):1478-88.


The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period.

Godinho SI, Maywood ES, Shaw L, Tucci V, Barnard AR, Busino L, Pagano M, Kendall R, Quwailid MM, Romero MR, O'neill J, Chesham JE, Brooker D, Lalanne Z, Hastings MH, Nolan PM.

Science. 2007 May 11;316(5826):897-900. Epub 2007 Apr 26.


Entrainment to feeding but not to light: circadian phenotype of VPAC2 receptor-null mice.

Sheward WJ, Maywood ES, French KL, Horn JM, Hastings MH, Seckl JR, Holmes MC, Harmar AJ.

J Neurosci. 2007 Apr 18;27(16):4351-8.


Circadian rhythms: per2bations in the liver clock.

Reddy AB, Maywood ES.

Curr Biol. 2007 Apr 17;17(8):R292-4.


Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei.

Prosser HM, Bradley A, Chesham JE, Ebling FJ, Hastings MH, Maywood ES.

Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):648-53. Epub 2007 Jan 3.

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