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Items: 1 to 50 of 98

1.

A novel 6-pyrophosphorylating IP6 kinase (IP6-6K) discovered in the protozoon Trichomonas vaginalis.

Wundenberg T, Nalaskowski MM, Löser B, Fanick W, Hackl T, Fürnkranz U, Rehbach C, Lin H, Mayr GW.

Mol Biochem Parasitol. 2019 Jan;227:53-63. doi: 10.1016/j.molbiopara.2018.12.004. Epub 2018 Dec 26.

PMID:
30593849
2.

Inositol hexakisphosphate increases the size of platelet aggregates.

Brehm MA, Klemm U, Rehbach C, Erdmann N, Kolšek K, Lin H, Aponte-Santamaría C, Gräter F, Rauch BH, Riley AM, Mayr GW, Potter BVL, Windhorst S.

Biochem Pharmacol. 2019 Mar;161:14-25. doi: 10.1016/j.bcp.2018.12.011. Epub 2018 Dec 14.

3.

The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells.

Schröder D, Tödter K, Gonzalez B, Franco-Echevarría E, Rohaly G, Blecher C, Lin HY, Mayr GW, Windhorst S.

Biochem Pharmacol. 2015 Jul 15;96(2):143-50. doi: 10.1016/j.bcp.2015.05.004. Epub 2015 May 15.

PMID:
25986882
4.

Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio.

Wundenberg T, Grabinski N, Lin H, Mayr GW.

Biochem J. 2014 Aug 15;462(1):173-84. doi: 10.1042/BJ20130992.

PMID:
24865181
5.

Malignant H1299 tumour cells preferentially internalize iron-bound inositol hexakisphosphate.

Helmis C, Blechner C, Lin H, Schweizer M, Mayr GW, Nielsen P, Windhorst S.

Biosci Rep. 2013 Oct 22;33(5). pii: e00075. doi: 10.1042/BSR20130079.

6.

A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA.

Brehm MA, Wundenberg T, Williams J, Mayr GW, Shears SB.

J Cell Sci. 2013 Jan 15;126(Pt 2):437-44. doi: 10.1242/jcs.110031. Epub 2012 Nov 30.

7.

Tumour cells can employ extracellular Ins(1,2,3,4,5,6)P(6) and multiple inositol-polyphosphate phosphatase 1 (MINPP1) dephosphorylation to improve their proliferation.

Windhorst S, Lin H, Blechner C, Fanick W, Brandt L, Brehm MA, Mayr GW.

Biochem J. 2013 Feb 15;450(1):115-25. doi: 10.1042/BJ20121524.

PMID:
23186306
8.

A Plasmodium multi-domain protein possesses multiple inositol phosphate kinase activities.

Stritzke C, Nalaskowski MM, Fanick W, Lin H, Mayr GW.

Mol Biochem Parasitol. 2012 Dec;186(2):134-8. doi: 10.1016/j.molbiopara.2012.10.005. Epub 2012 Nov 1.

PMID:
23123170
9.

Synthesis and biological actions of diphosphoinositol phosphates (inositol pyrophosphates), regulators of cell homeostasis.

Wundenberg T, Mayr GW.

Biol Chem. 2012 Sep;393(9):979-98. doi: 10.1515/hsz-2012-0133. Review.

PMID:
22944697
10.

Nucleocytoplasmic shuttling of human inositol phosphate multikinase is influenced by CK2 phosphorylation.

Meyer R, Nalaskowski MM, Ehm P, Schröder C, Naj X, Brehm MA, Mayr GW.

Biol Chem. 2012 Mar;393(3):149-60. doi: 10.1515/hsz-2011-0209.

PMID:
22718630
11.

A toolkit for graded expression of green fluorescent protein fusion proteins in mammalian cells.

Nalaskowski MM, Ehm P, Giehler S, Mayr GW.

Anal Biochem. 2012 Sep 1;428(1):24-7. doi: 10.1016/j.ab.2012.06.001. Epub 2012 Jun 12.

PMID:
22698891
12.

Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells.

Schmidt A, Oberle N, Weiss EM, Vobis D, Frischbutter S, Baumgrass R, Falk CS, Haag M, Brügger B, Lin H, Mayr GW, Reichardt P, Gunzer M, Suri-Payer E, Krammer PH.

Sci Signal. 2011 Dec 20;4(204):ra90. doi: 10.1126/scisignal.2002179.

PMID:
22375050
13.

Inositol-1,4,5-trisphosphate 3-kinase A regulates dendritic morphology and shapes synaptic Ca2+ transients.

Windhorst S, Minge D, Bähring R, Hüser S, Schob C, Blechner C, Lin HY, Mayr GW, Kindler S.

Cell Signal. 2012 Mar;24(3):750-7. doi: 10.1016/j.cellsig.2011.11.010. Epub 2011 Nov 18.

PMID:
22120525
14.

A novel Entamoeba histolytica inositol phosphate kinase catalyzes the formation of 5PP-Ins(1,2,3,4,6)P(5).

Löser B, Nalaskowski MM, Fanick W, Lin H, Tannich E, Mayr GW.

Mol Biochem Parasitol. 2012 Jan;181(1):49-52. doi: 10.1016/j.molbiopara.2011.09.008. Epub 2011 Sep 29.

PMID:
22001062
15.

The inositol 5-phosphatase SHIP1 is a nucleo-cytoplasmic shuttling protein and enzymatically active in cell nuclei.

Nalaskowski MM, Metzner A, Brehm MA, Labiadh S, Brauer H, Grabinski N, Mayr GW, Jücker M.

Cell Signal. 2012 Mar;24(3):621-8. doi: 10.1016/j.cellsig.2011.07.012. Epub 2011 Aug 16.

PMID:
21864674
16.

Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.

Windhorst S, Kalinina T, Schmid K, Blechner C, Kriebitzsch N, Hinsch R, Chang L, Herich L, Schumacher U, Mayr GW.

Int J Cancer. 2011 Sep 15;129(6):1300-9. doi: 10.1002/ijc.25782. Epub 2011 Jan 6.

17.

Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.

Chang L, Schwarzenbach H, Meyer-Staeckling S, Brandt B, Mayr GW, Weitzel JM, Windhorst S.

Mol Cancer Res. 2011 Apr;9(4):497-506. doi: 10.1158/1541-7786.MCR-10-0556. Epub 2011 Apr 1.

18.

Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.

Nalaskowski MM, Fliegert R, Ernst O, Brehm MA, Fanick W, Windhorst S, Lin H, Giehler S, Hein J, Lin YN, Mayr GW.

J Biol Chem. 2011 Feb 11;286(6):4500-10. doi: 10.1074/jbc.M110.173062. Epub 2010 Dec 9.

19.

Synthesis and nonradioactive micro-analysis of diphosphoinositol phosphates by HPLC with postcolumn complexometry.

Lin H, Lindner K, Mayr GW.

Methods Mol Biol. 2010;645:103-22. doi: 10.1007/978-1-60327-175-2_7.

PMID:
20645184
20.

Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.

Windhorst S, Fliegert R, Blechner C, Möllmann K, Hosseini Z, Günther T, Eiben M, Chang L, Lin HY, Fanick W, Schumacher U, Brandt B, Mayr GW.

J Biol Chem. 2010 Feb 19;285(8):5541-54. doi: 10.1074/jbc.M109.047050. Epub 2009 Dec 17.

21.

Phosphoinositide and inositol phosphate analysis in lymphocyte activation.

Sauer K, Huang YH, Lin H, Sandberg M, Mayr GW.

Curr Protoc Immunol. 2009 Nov;Chapter 11:Unit11.1. doi: 10.1002/0471142735.im1101s87.

22.

Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D.

Metzner A, Precht C, Fehse B, Fiedler W, Stocking C, Günther A, Mayr GW, Jücker M.

Gene Ther. 2009 Apr;16(4):570-3. doi: 10.1038/gt.2008.184. Epub 2009 Jan 15.

PMID:
19148132
23.

Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.

Lin H, Fridy PC, Ribeiro AA, Choi JH, Barma DK, Vogel G, Falck JR, Shears SB, York JD, Mayr GW.

J Biol Chem. 2009 Jan 16;284(3):1863-72. doi: 10.1074/jbc.M805686200. Epub 2008 Nov 3.

24.

Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism.

Windhorst S, Blechner C, Lin HY, Elling C, Nalaskowski M, Kirchberger T, Guse AH, Mayr GW.

Biochem J. 2008 Sep 15;414(3):407-17. doi: 10.1042/BJ20080630.

PMID:
18498254
25.

Overexpression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase inhibits GM-CSF-dependent colony formation of CD34+ hematopoietic progenitor cells.

Hoxha E, Fehse B, Ortmeyer G, Stocking C, Mayr GW, Jücker M.

Leuk Lymphoma. 2008 Jun;49(6):1206-8. doi: 10.1080/10428190801993496. No abstract available.

PMID:
18452100
26.

Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase.

Brehm MA, Schenk TM, Zhou X, Fanick W, Lin H, Windhorst S, Nalaskowski MM, Kobras M, Shears SB, Mayr GW.

Biochem J. 2007 Dec 15;408(3):335-45.

27.

Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.

Metzner A, Horstmann MA, Fehse B, Ortmeyer G, Niemeyer CM, Stocking C, Mayr GW, Jücker M.

Gene Ther. 2007 Apr;14(8):699-703. Epub 2007 Feb 1.

PMID:
17268534
28.

Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.

Ehmann F, Horn S, Garcia-Palma L, Wegner W, Fiedler W, Giehl K, Mayr GW, Jücker M.

Leuk Lymphoma. 2006 Jul;47(7):1387-91.

PMID:
16923573
30.

Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1.

García-Palma L, Horn S, Haag F, Diessenbacher P, Streichert T, Mayr GW, Jücker M.

Br J Haematol. 2005 Dec;131(5):628-31.

PMID:
16351639
31.

Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase.

Mayr GW, Windhorst S, Hillemeier K.

J Biol Chem. 2005 Apr 8;280(14):13229-40. Epub 2005 Jan 19. Erratum in: J Biol Chem. 2007 Nov 30;282(48):35424.

32.
34.

Identification of the actin-binding domain of Ins(1,4,5)P3 3-kinase isoform B (IP3K-B).

Brehm MA, Schreiber I, Bertsch U, Wegner A, Mayr GW.

Biochem J. 2004 Aug 15;382(Pt 1):353-62.

35.

The families of kinases removing the Ca2+ releasing second messenger Ins(1,4,5)P3.

Nalaskowski MM, Mayr GW.

Curr Mol Med. 2004 May;4(3):277-90. Review.

PMID:
15101685
36.

Analysis of subcellular calcium signals in T-lymphocytes.

Kunerth S, Mayr GW, Koch-Nolte F, Guse AH.

Cell Signal. 2003 Aug;15(8):783-92.

PMID:
12781871
37.

Rat inositol 1,4,5-trisphosphate 3-kinase C is enzymatically specialized for basal cellular inositol trisphosphate phosphorylation and shuttles actively between nucleus and cytoplasm.

Nalaskowski MM, Bertsch U, Fanick W, Stockebrand MC, Schmale H, Mayr GW.

J Biol Chem. 2003 May 30;278(22):19765-76. Epub 2003 Mar 20.

38.

Knock-down of the type 3 ryanodine receptor impairs sustained Ca2+ signaling via the T cell receptor/CD3 complex.

Schwarzmann N, Kunerth S, Weber K, Mayr GW, Guse AH.

J Biol Chem. 2002 Dec 27;277(52):50636-42. Epub 2002 Sep 26.

39.

The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization.

Nalaskowski MM, Deschermeier C, Fanick W, Mayr GW.

Biochem J. 2002 Sep 1;366(Pt 2):549-56.

40.

Novel hydrolysis-resistant analogues of cyclic ADP-ribose: modification of the "northern" ribose and calcium release activity.

Guse AH, Cakir-Kiefer C, Fukuoka M, Shuto S, Weber K, Bailey VC, Matsuda A, Mayr GW, Oppenheimer N, Schuber F, Potter BV.

Biochemistry. 2002 May 28;41(21):6744-51.

PMID:
12022878
41.

Assay for ADP-ribosyl cyclase by reverse-phase high-performance liquid chromatography.

Schweitzer K, Mayr GW, Guse AH.

Anal Biochem. 2001 Dec 15;299(2):218-26.

PMID:
11730346
42.

Mechanisms involved in alpha6beta1-integrin-mediated Ca(2+) signalling.

Schöttelndreier H, Potter BV, Mayr GW, Guse AH.

Cell Signal. 2001 Dec;13(12):895-9.

PMID:
11728829
43.

Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase.

Yang SN, Yu J, Mayr GW, Hofmann F, Larsson O, Berggren PO.

FASEB J. 2001 Aug;15(10):1753-63.

PMID:
11481223
44.

Transient tyrosine phosphorylation of human ryanodine receptor upon T cell stimulation.

Guse AH, Tsygankov AY, Weber K, Mayr GW.

J Biol Chem. 2001 Sep 14;276(37):34722-7. Epub 2001 Jul 20.

45.
46.

Diphospho-myo-inositol phosphates during the life cycle of Dictyostelium and Polysphondylium.

Laussmann T, Pikzack C, Thiel U, Mayr GW, Vogel G.

Eur J Biochem. 2000 Apr;267(8):2447-51.

47.

Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase.

Oude Weernink PA, Schulte P, Guo Y, Wetzel J, Amano M, Kaibuchi K, Haverland S, Voss M, Schmidt M, Mayr GW, Jakobs KH.

J Biol Chem. 2000 Apr 7;275(14):10168-74.

48.

The second messenger binding site of inositol 1,4,5-trisphosphate 3-kinase is centered in the catalytic domain and related to the inositol trisphosphate receptor site.

Bertsch U, Deschermeier C, Fanick W, Girkontaite I, Hillemeier K, Johnen H, Weglöhner W, Emmrich F, Mayr GW.

J Biol Chem. 2000 Jan 21;275(3):1557-64.

49.

Pharmacological activation of the ryanodine receptor in Jurkat T-lymphocytes.

Hohenegger M, Berg I, Weigl L, Mayr GW, Potter BV, Guse AH.

Br J Pharmacol. 1999 Nov;128(6):1235-40.

50.

Enhanced hippocampal CA1 LTP but normal spatial learning in inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice.

Jun K, Choi G, Yang SG, Choi KY, Kim H, Chan GC, Storm DR, Albert C, Mayr GW, Lee CJ, Shin HS.

Learn Mem. 1998 Sep-Oct;5(4-5):317-30.

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