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Items: 27


Genetic characterization of ABT-199 sensitivity in human AML.

Bisaillon R, Moison C, Thiollier C, Krosl J, Bordeleau ME, Lehnertz B, Lavallée VP, MacRae T, Mayotte N, Labelle C, Boucher G, Spinella JF, Boivin I, D'Angelo G, Lavallée S, Marinier A, Lemieux S, Hébert J, Sauvageau G.

Leukemia. 2019 Jul 12. doi: 10.1038/s41375-019-0485-x. [Epub ahead of print]


Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.

Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G.

Cancer Cell. 2019 Jul 8;36(1):84-99.e8. doi: 10.1016/j.ccell.2019.06.003.


Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition.

Moison C, Lavallée VP, Thiollier C, Lehnertz B, Boivin I, Mayotte N, Gareau Y, Fréchette M, Blouin-Chagnon V, Corneau S, Lavallée S, Lemieux S, Marinier A, Hébert J, Sauvageau G.

Blood Adv. 2019 Feb 26;3(4):552-563. doi: 10.1182/bloodadvances.2018028480.


H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations.

Lehnertz B, Zhang YW, Boivin I, Mayotte N, Tomellini E, Chagraoui J, Lavallée VP, Hébert J, Sauvageau G.

Blood. 2017 Nov 16;130(20):2204-2214. doi: 10.1182/blood-2017-03-774653. Epub 2017 Aug 30.


UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis.

Aucagne R, Girard S, Mayotte N, Lehnertz B, Lopes-Paciencia S, Gendron P, Boucher G, Chagraoui J, Sauvageau G.

FASEB J. 2017 Nov;31(11):5012-5018. doi: 10.1096/fj.201601219RRR. Epub 2017 Jul 28.


EPCR expression marks UM171-expanded CD34+ cord blood stem cells.

Fares I, Chagraoui J, Lehnertz B, MacRae T, Mayotte N, Tomellini E, Aubert L, Roux PP, Sauvageau G.

Blood. 2017 Jun 22;129(25):3344-3351. doi: 10.1182/blood-2016-11-750729. Epub 2017 Apr 13.


E4F1 is a master regulator of CHK1-mediated functions.

Grote D, Moison C, Duhamel S, Chagraoui J, Girard S, Yang J, Mayotte N, Coulombe Y, Masson JY, Brown GW, Meloche S, Sauvageau G.

Cell Rep. 2015 Apr 14;11(2):210-9. doi: 10.1016/j.celrep.2015.03.019. Epub 2015 Apr 2.


Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.

Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G.

Science. 2014 Sep 19;345(6203):1509-12. doi: 10.1126/science.1256337.


UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.

Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau M, Boutonnet C, Meloche S, Sauvageau G.

Blood. 2014 Oct 9;124(15):2362-9. doi: 10.1182/blood-2014-01-548651. Epub 2014 Sep 2.


RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity.

Cellot S, Hope KJ, Chagraoui J, Sauvageau M, Deneault É, MacRae T, Mayotte N, Wilhelm BT, Landry JR, Ting SB, Krosl J, Humphries K, Thompson A, Sauvageau G.

Blood. 2013 Aug 29;122(9):1545-55. doi: 10.1182/blood-2013-04-496281. Epub 2013 Jun 18.


Entinostat prevents leukemia maintenance in a collaborating oncogene-dependent model of cytogenetically normal acute myeloid leukemia.

Ramsey JM, Kettyle LM, Sharpe DJ, Mulgrew NM, Dickson GJ, Bijl JJ, Austin P, Mayotte N, Cellot S, Lappin TR, Zhang SD, Mills KI, Krosl J, Sauvageau G, Thompson A.

Stem Cells. 2013 Jul;31(7):1434-45. doi: 10.1002/stem.1398.


Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia.

Trost M, Sauvageau M, Hérault O, Deleris P, Pomiès C, Chagraoui J, Mayotte N, Meloche S, Sauvageau G, Thibault P.

Blood. 2012 Aug 23;120(8):e17-27. doi: 10.1182/blood-2011-12-397844. Epub 2012 Jul 16.


A role for GPx3 in activity of normal and leukemia stem cells.

Herault O, Hope KJ, Deneault E, Mayotte N, Chagraoui J, Wilhelm BT, Cellot S, Sauvageau M, Andrade-Navarro MA, Hébert J, Sauvageau G.

J Exp Med. 2012 May 7;209(5):895-901. doi: 10.1084/jem.20102386. Epub 2012 Apr 16.


Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2.

Ting SB, Deneault E, Hope K, Cellot S, Chagraoui J, Mayotte N, Dorn JF, Laverdure JP, Harvey M, Hawkins ED, Russell SM, Maddox PS, Iscove NN, Sauvageau G.

Blood. 2012 Mar 15;119(11):2510-22. doi: 10.1182/blood-2011-11-393272. Epub 2011 Dec 14.


Selectively weakened binding of methotrexate by human dihydrofolate reductase allows rapid ex vivo selection of mammalian cells.

Volpato JP, Mayotte N, Fossati E, Guerrero V, Sauvageau G, Pelletier JN.

J Mol Recognit. 2011 Mar-Apr;24(2):188-98. doi: 10.1002/jmr.1037.


Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions.

Fortier S, Bilodeau M, Macrae T, Laverdure JP, Azcoitia V, Girard S, Chagraoui J, Ringuette N, Hébert J, Krosl J, Mayotte N, Sauvageau G.

PLoS Genet. 2010 Dec 9;6(12):e1001241. doi: 10.1371/journal.pgen.1001241.


RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity.

Wilhelm BT, Briau M, Austin P, Faubert A, Boucher G, Chagnon P, Hope K, Girard S, Mayotte N, Landry JR, Hébert J, Sauvageau G.

Blood. 2011 Jan 13;117(2):e27-38. doi: 10.1182/blood-2010-07-293332. Epub 2010 Oct 27.


An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity.

Hope KJ, Cellot S, Ting SB, MacRae T, Mayotte N, Iscove NN, Sauvageau G.

Cell Stem Cell. 2010 Jul 2;7(1):101-13. doi: 10.1016/j.stem.2010.06.007.


Analysis of blood stem cell activity and cystatin gene expression in a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1.

Bilodeau M, MacRae T, Gaboury L, Laverdure JP, Hardy MP, Mayotte N, Paradis V, Harton S, Perreault C, Sauvageau G.

PLoS One. 2009 Oct 19;4(10):e7500. doi: 10.1371/journal.pone.0007500.


A functional screen to identify novel effectors of hematopoietic stem cell activity.

Deneault E, Cellot S, Faubert A, Laverdure JP, Fréchette M, Chagraoui J, Mayotte N, Sauvageau M, Ting SB, Sauvageau G.

Cell. 2009 Apr 17;137(2):369-79. doi: 10.1016/j.cell.2009.03.026.


Complementary and independent function for Hoxb4 and Bmi1 in HSC activity.

Faubert A, Chagraoui J, Mayotte N, Fréchette M, Iscove NN, Humphries RK, Sauvageau G.

Cold Spring Harb Symp Quant Biol. 2008;73:555-64. doi: 10.1101/sqb.2008.73.030. Epub 2008 Nov 6.


Evidence for Hox and E2A-PBX1 collaboration in mouse T-cell leukemia.

Bijl J, Krosl J, Lebert-Ghali CE, Vacher J, Mayotte N, Sauvageau G.

Oncogene. 2008 Oct 23;27(49):6356-64. doi: 10.1038/onc.2008.233. Epub 2008 Aug 4.


Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation.

Mamo A, Krosl J, Kroon E, Bijl J, Thompson A, Mayotte N, Girard S, Bisaillon R, Beslu N, Featherstone M, Sauvageau G.

Blood. 2006 Jul 15;108(2):622-9. Epub 2006 Feb 9.


Molecular interactions involved in HOXB4-induced activation of HSC self-renewal.

Beslu N, Krosl J, Laurin M, Mayotte N, Humphries KR, Sauvageau G.

Blood. 2004 Oct 15;104(8):2307-14. Epub 2004 Jun 29.


Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging culture system.

Mayotte N, Roy DC, Yao J, Kroon E, Sauvageau G.

Blood. 2002 Dec 1;100(12):4177-84. Epub 2002 Aug 1.


NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice.

Kroon E, Thorsteinsdottir U, Mayotte N, Nakamura T, Sauvageau G.

EMBO J. 2001 Feb 1;20(3):350-61.

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