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Items: 48


Unfolding or aggregation, that is the question.

Bolten M, Bernardini JP, Mayor T.

J Biol Chem. 2019 Nov 8;294(45):16525-16526. doi: 10.1074/jbc.H119.011242.


Phase separation and clustering of an ABC transporter in Mycobacterium tuberculosis.

Heinkel F, Abraham L, Ko M, Chao J, Bach H, Hui LT, Li H, Zhu M, Ling YM, Rogalski JC, Scurll J, Bui JM, Mayor T, Gold MR, Chou KC, Av-Gay Y, McIntosh LP, Gsponer J.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16326-16331. doi: 10.1073/pnas.1820683116. Epub 2019 Jul 31.


Prion-dependent proteome remodeling in response to environmental stress is modulated by prion variant and genetic background.

Allwein B, Kelly C, Kammoonah S, Mayor T, Cameron DM.

Prion. 2019 Jan;13(1):53-64. doi: 10.1080/19336896.2019.1583041.


Exploring the Rampant Expansion of Ubiquitin Proteomics.

Rose A, Mayor T.

Methods Mol Biol. 2018;1844:345-362. doi: 10.1007/978-1-4939-8706-1_22. Review.


Insulin-like growth factor 1 receptor stabilizes the ETV6-NTRK3 chimeric oncoprotein by blocking its KPC1/Rnf123-mediated proteasomal degradation.

Tognon CE, Rafn B, Cetinbas NM, Kamura T, Trigo G, Rotblat B, Okumura F, Matsumoto M, Chow C, Davare M, Pollak M, Mayor T, Sorensen PH.

J Biol Chem. 2018 Aug 10;293(32):12502-12515. doi: 10.1074/jbc.RA117.000321. Epub 2018 Jun 14.


Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis.

Mugabo Y, Sadeghi M, Fang NN, Mayor T, Lim GE.

J Biol Chem. 2018 May 4;293(18):6736-6750. doi: 10.1074/jbc.M117.816272. Epub 2018 Mar 12.


[Molecular phylogenetic analysis of Diacyclops and Acanthocyclops (Copepoda: Cyclopoida) from Lake Baikal].

Mayor TY, Galimova YA, Sheveleva NG, Sukhanova LV, Kirilchik SV.

Genetika. 2017 Feb;53(2):233-9. Russian.


The [PSI +] yeast prion does not wildly affect proteome composition whereas selective pressure exerted on [PSI +] cells can promote aneuploidy.

Chan PHW, Lee L, Kim E, Hui T, Stoynov N, Nassar R, Moksa M, Cameron DM, Hirst M, Gsponer J, Mayor T.

Sci Rep. 2017 Aug 16;7(1):8442. doi: 10.1038/s41598-017-07999-8.


Mapping the Broad Structural and Mechanical Properties of Amyloid Fibrils.

Lamour G, Nassar R, Chan PHW, Bozkurt G, Li J, Bui JM, Yip CK, Mayor T, Li H, Wu H, Gsponer JA.

Biophys J. 2017 Feb 28;112(4):584-594. doi: 10.1016/j.bpj.2016.12.036.


[A simple and effective method for assessing chromatin diminution values in copepods using qPCR].

Teterina VI, Galimova YA, Sheveleva NG, Sukhanova LV, Mayor TY, Zaitseva AN, Kirilchik SV.

Genetika. 2016 Nov;52(11):1327-31. Russian.


Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress.

Fang NN, Zhu M, Rose A, Wu KP, Mayor T.

Nat Commun. 2016 Oct 4;7:12907. doi: 10.1038/ncomms12907.


Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase.

Bround MJ, Wambolt R, Cen H, Asghari P, Albu RF, Han J, McAfee D, Pourrier M, Scott NE, Bohunek L, Kulpa JE, Chen SR, Fedida D, Brownsey RW, Borchers CH, Foster LJ, Mayor T, Moore ED, Allard MF, Johnson JD.

J Biol Chem. 2016 Nov 4;291(45):23490-23505. Epub 2016 Sep 12.


Tuning the proteasome to brighten the end of the journey.

Mayor T, Sharon M, Glickman MH.

Am J Physiol Cell Physiol. 2016 Nov 1;311(5):C793-C804. doi: 10.1152/ajpcell.00198.2016. Epub 2016 Sep 7. Review.


Prefoldin Promotes Proteasomal Degradation of Cytosolic Proteins with Missense Mutations by Maintaining Substrate Solubility.

Comyn SA, Young BP, Loewen CJ, Mayor T.

PLoS Genet. 2016 Jul 22;12(7):e1006184. doi: 10.1371/journal.pgen.1006184. eCollection 2016 Jul.


Freezing the Nonclassical Crystal Growth of a Coordination Polymer Using Controlled Dynamic Gradients.

Rubio-Martinez M, Imaz I, Domingo N, Abrishamkar A, Mayor TS, Rossi RM, Carbonell C, deMello AJ, Amabilino DB, Maspoch D, PuigmartĂ­-Luis J.

Adv Mater. 2016 Oct;28(37):8150-8155. doi: 10.1002/adma.201506462. Epub 2016 Jul 12.


Ty1 Integrase Interacts with RNA Polymerase III-specific Subcomplexes to Promote Insertion of Ty1 Elements Upstream of Polymerase (Pol) III-transcribed Genes.

Cheung S, Ma L, Chan PH, Hu HL, Mayor T, Chen HT, Measday V.

J Biol Chem. 2016 Mar 18;291(12):6396-411. doi: 10.1074/jbc.M115.686840. Epub 2016 Jan 21.


Advanced modelling of the transport phenomena across horizontal clothing microclimates with natural convection.

Mayor TS, Couto S, Psikuta A, Rossi RM.

Int J Biometeorol. 2015 Dec;59(12):1875-89. doi: 10.1007/s00484-015-0994-x. Epub 2015 May 21.


A role for the budding yeast separase, Esp1, in Ty1 element retrotransposition.

Ho KL, Ma L, Cheung S, Manhas S, Fang N, Wang K, Young B, Loewen C, Mayor T, Measday V.

PLoS Genet. 2015 Mar 30;11(3):e1005109. doi: 10.1371/journal.pgen.1005109. eCollection 2015 Mar.


A feature analysis of lower solubility proteins in three eukaryotic systems.

Albu RF, Chan GT, Zhu M, Wong ET, Taghizadeh F, Hu X, Mehran AE, Johnson JD, Gsponer J, Mayor T.

J Proteomics. 2015 Apr 6;118:21-38. doi: 10.1016/j.jprot.2014.10.011. Epub 2014 Oct 25.


Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress.

Fang NN, Chan GT, Zhu M, Comyn SA, Persaud A, Deshaies RJ, Rotin D, Gsponer J, Mayor T.

Nat Cell Biol. 2014 Dec;16(12):1227-37. doi: 10.1038/ncb3054. Epub 2014 Oct 26.


Polarization of the endoplasmic reticulum by ER-septin tethering.

Chao JT, Wong AK, Tavassoli S, Young BP, Chruscicki A, Fang NN, Howe LJ, Mayor T, Foster LJ, Loewen CJ.

Cell. 2014 Jul 31;158(3):620-32. doi: 10.1016/j.cell.2014.06.033.


Perilous journey: a tour of the ubiquitin-proteasome system.

Kleiger G, Mayor T.

Trends Cell Biol. 2014 Jun;24(6):352-9. doi: 10.1016/j.tcb.2013.12.003. Epub 2014 Jan 20. Review.


False start: cotranslational protein ubiquitination and cytosolic protein quality control.

Comyn SA, Chan GT, Mayor T.

J Proteomics. 2014 Apr 4;100:92-101. doi: 10.1016/j.jprot.2013.08.005. Epub 2013 Aug 15. Review.


System-wide analysis reveals intrinsically disordered proteins are prone to ubiquitylation after misfolding stress.

Ng AH, Fang NN, Comyn SA, Gsponer J, Mayor T.

Mol Cell Proteomics. 2013 Sep;12(9):2456-67. doi: 10.1074/mcp.M112.023416. Epub 2013 May 28.


Proteomics propels protein degradation studies in San Diego.

Bennett EJ, Mayor T.

Mol Cell Proteomics. 2012 Dec;11(12):1523-8. doi: 10.1074/mcp.O112.020008. Epub 2012 Jul 12.


The yeast ubr1 ubiquitin ligase participates in a prominent pathway that targets cytosolic thermosensitive mutants for degradation.

Khosrow-Khavar F, Fang NN, Ng AH, Winget JM, Comyn SA, Mayor T.

G3 (Bethesda). 2012 May;2(5):619-28. doi: 10.1534/g3.111.001933. Epub 2012 May 1.


Hul5 ubiquitin ligase: good riddance to bad proteins.

Fang NN, Mayor T.

Prion. 2012 Jul 1;6(3):240-4. doi: 10.4161/pri.19929. Epub 2012 Jul 1. Review.


Navigating the ERAD interaction network.

Mayor T.

Nat Cell Biol. 2011 Dec 22;14(1):46-7. doi: 10.1038/ncb2412.


Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins.

Fang NN, Ng AH, Measday V, Mayor T.

Nat Cell Biol. 2011 Oct 9;13(11):1344-52. doi: 10.1038/ncb2343.


Managing the quality of life for proteins: focusing on the exit path. Introduction.

Ping P, Mayor T, Huang L.

Mol Cell Proteomics. 2011 May;10(5):O111.009969. doi: 10.1074/mcp.O111.009969. Epub 2011 Mar 26. No abstract available.


Proteomic characterization of aggregating proteins after the inhibition of the ubiquitin proteasome system.

Wilde IB, Brack M, Winget JM, Mayor T.

J Proteome Res. 2011 Mar 4;10(3):1062-72. doi: 10.1021/pr1008543. Epub 2011 Feb 7.


Niclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition.

Gies E, Wilde I, Winget JM, Brack M, Rotblat B, Novoa CA, Balgi AD, Sorensen PH, Roberge M, Mayor T.

PLoS One. 2010 Dec 23;5(12):e14410. doi: 10.1371/journal.pone.0014410.


The diversity of ubiquitin recognition: hot spots and varied specificity.

Winget JM, Mayor T.

Mol Cell. 2010 Jun 11;38(5):627-35. doi: 10.1016/j.molcel.2010.05.003. Review.


Quantitative profiling of ubiquitylated proteins reveals proteasome substrates and the substrate repertoire influenced by the Rpn10 receptor pathway.

Mayor T, Graumann J, Bryan J, MacCoss MJ, Deshaies RJ.

Mol Cell Proteomics. 2007 Nov;6(11):1885-95. Epub 2007 Jul 20.


Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets.

Mayor T, Lipford JR, Graumann J, Smith GT, Deshaies RJ.

Mol Cell Proteomics. 2005 Jun;4(6):741-51. Epub 2005 Feb 7.


Proteomic characterization of the human centrosome by protein correlation profiling.

Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M.

Nature. 2003 Dec 4;426(6966):570-4.


[A cryptic protease couples deubiquitination and degradation by the proteasome].

Mayor T.

Med Sci (Paris). 2003 Apr;19(4):401-3. French. No abstract available.


The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles.

Mayor T, Hacker U, Stierhof YD, Nigg EA.

J Cell Sci. 2002 Aug 15;115(Pt 16):3275-84.


The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion.

Mayor T, Stierhof YD, Tanaka K, Fry AM, Nigg EA.

J Cell Biol. 2000 Nov 13;151(4):837-46.


Regulating centrosomes by protein phosphorylation.

Fry AM, Mayor T, Nigg EA.

Curr Top Dev Biol. 2000;49:291-312. Review. No abstract available.


Protein kinases in control of the centrosome cycle.

Mayor T, Meraldi P, Stierhof YD, Nigg EA, Fry AM.

FEBS Lett. 1999 Jun 4;452(1-2):92-5. Review.


C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2.

Fry AM, Mayor T, Meraldi P, Stierhof YD, Tanaka K, Nigg EA.

J Cell Biol. 1998 Jun 29;141(7):1563-74.


How to fight child abuse.

Graham J, Mayor T.

Health Care Can. 1979 May;21(5):16-8. No abstract available.


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