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Items: 1 to 50 of 180

1.

Beta-blockers: Historical perspective and mechanisms of action.

Oliver E, Mayor F Jr, D'Ocon P.

Rev Esp Cardiol (Engl Ed). 2019 Jun 6. pii: S1885-5857(19)30110-0. doi: 10.1016/j.rec.2019.04.006. [Epub ahead of print] English, Spanish.

PMID:
31178382
2.

Calpains mediate isoproterenol-induced hypertrophy through modulation of GRK2.

Aluja D, Inserte J, Penela P, Ramos P, Ribas C, Iñiguez MÁ, Mayor F Jr, Garcia-Dorado D.

Basic Res Cardiol. 2019 Mar 26;114(3):21. doi: 10.1007/s00395-019-0730-5.

PMID:
30915659
3.

G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases.

Murga C, Arcones AC, Cruces-Sande M, Briones AM, Salaices M, Mayor F Jr.

Front Pharmacol. 2019 Feb 19;10:112. doi: 10.3389/fphar.2019.00112. eCollection 2019. Review.

4.

CXCR4/ACKR3 phosphorylation and recruitment of interacting proteins: key mechanisms regulating their functional status.

Fumagalli A, Zarca A, Neves M, Caspar B, Hill SJ, Mayor F, Smit MJ, Marin P.

Mol Pharmacol. 2019 Mar 5. pii: mol.118.115360. doi: 10.1124/mol.118.115360. [Epub ahead of print]

5.

The role of ACKR3 in breast, lung and brain cancer.

Neves M, Fumagalli A, van den Bor J, Marin P, Smit MJ, Mayor F Jr.

Mol Pharmacol. 2019 Feb 11. pii: mol.118.115279. doi: 10.1124/mol.118.115279. [Epub ahead of print]

6.

Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans.

Cruces-Sande M, Vila-Bedmar R, Arcones AC, González-Rodríguez Á, Rada P, Gutiérrez-de-Juan V, Vargas-Castrillón J, Iruzubieta P, Sánchez-González C, Formentini L, Crespo J, García-Monzón C, Martínez-Chantar ML, Valverde ÁM, Mayor F Jr, Murga C.

Biochim Biophys Acta Mol Basis Dis. 2018 Dec;1864(12):3655-3667. doi: 10.1016/j.bbadis.2018.09.027. Epub 2018 Sep 24.

PMID:
30261289
7.

Phosphorylation of p38 by GRK2 at the Docking Groove Unveils a Novel Mechanism for Inactivating p38MAPK.

Peregrin S, Jurado-Pueyo M, Campos PM, Sanz-Moreno V, Ruiz-Gomez A, Crespo P, Mayor F Jr, Murga C.

Curr Biol. 2018 Aug 6;28(15):2513. doi: 10.1016/j.cub.2018.07.033. No abstract available.

PMID:
30086307
8.

HDAC6 at Crossroads of Infection and Innate Immunity.

Moreno-Gonzalo O, Mayor F Jr, Sánchez-Madrid F.

Trends Immunol. 2018 Aug;39(8):591-595. doi: 10.1016/j.it.2018.05.004. Epub 2018 Jun 21. Review.

PMID:
29937401
9.

G protein-coupled receptor kinases (GRKs) in tumorigenesis and cancer progression: GPCR regulators and signaling hubs.

Nogués L, Palacios-García J, Reglero C, Rivas V, Neves M, Ribas C, Penela P, Mayor F Jr.

Semin Cancer Biol. 2018 Feb;48:78-90. doi: 10.1016/j.semcancer.2017.04.013. Epub 2017 May 1. Review.

PMID:
28473253
10.

G protein-coupled receptor kinase 2 (GRK2) as an integrative signalling node in the regulation of cardiovascular function and metabolic homeostasis.

Mayor F Jr, Cruces-Sande M, Arcones AC, Vila-Bedmar R, Briones AM, Salaices M, Murga C.

Cell Signal. 2018 Jan;41:25-32. doi: 10.1016/j.cellsig.2017.04.002. Epub 2017 Apr 4. Review.

PMID:
28389415
11.

G-Protein-Coupled Receptor Kinase 2 as a Potential Modulator of the Hallmarks of Cancer.

Nogués L, Reglero C, Rivas V, Neves M, Penela P, Mayor F Jr.

Mol Pharmacol. 2017 Mar;91(3):220-228. doi: 10.1124/mol.116.107185. Epub 2016 Nov 28. Review. Erratum in: Mol Pharmacol. 2017 Dec;92 (6):628.

PMID:
27895163
12.

Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels.

Lucas E, Vila-Bedmar R, Arcones AC, Cruces-Sande M, Cachofeiro V, Mayor F Jr, Murga C.

Cardiovasc Diabetol. 2016 Nov 10;15(1):155.

13.

G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis.

Nogués L, Reglero C, Rivas V, Salcedo A, Lafarga V, Neves M, Ramos P, Mendiola M, Berjón A, Stamatakis K, Zhou XZ, Lu KP, Hardisson D, Mayor F Jr, Penela P.

EBioMedicine. 2016 Nov;13:132-145. doi: 10.1016/j.ebiom.2016.09.030. Epub 2016 Oct 1.

14.

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.

Singhmar P, Huo X, Eijkelkamp N, Berciano SR, Baameur F, Mei FC, Zhu Y, Cheng X, Hawke D, Mayor F Jr, Murga C, Heijnen CJ, Kavelaars A.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3036-41. doi: 10.1073/pnas.1516036113. Epub 2016 Feb 29.

15.

Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector.

Sánchez-Fernández G, Cabezudo S, Caballero Á, García-Hoz C, Tall GG, Klett J, Michnick SW, Mayor F Jr, Ribas C.

J Biol Chem. 2016 Apr 29;291(18):9513-25. doi: 10.1074/jbc.M115.684308. Epub 2016 Feb 17.

16.

Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2.

Lucas E, Cruces-Sande M, Briones AM, Salaices M, Mayor F Jr, Murga C, Vila-Bedmar R.

Arch Physiol Biochem. 2015;121(5):163-77. doi: 10.3109/13813455.2015.1107589. Epub 2015 Dec 7. Review.

17.

Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.

Vila-Bedmar R, Cruces-Sande M, Lucas E, Willemen HL, Heijnen CJ, Kavelaars A, Mayor F Jr, Murga C.

Sci Signal. 2015 Jul 21;8(386):ra73. doi: 10.1126/scisignal.aaa4374.

18.

Role of G protein-coupled receptor kinase 2 in tumoral angiogenesis.

Rivas V, Nogués L, Reglero C, Mayor F Jr, Penela P.

Mol Cell Oncol. 2014 Nov 11;1(4):e969166. doi: 10.4161/23723548.2014.969166. eCollection 2014 Oct-Dec. Review.

19.

Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns.

Lucas E, Jurado-Pueyo M, Fortuño MA, Fernández-Veledo S, Vila-Bedmar R, Jiménez-Borreguero LJ, Lazcano JJ, Gao E, Gómez-Ambrosi J, Frühbeck G, Koch WJ, Díez J, Mayor F Jr, Murga C.

Biochim Biophys Acta. 2014 Dec;1842(12 Pt A):2448-56. doi: 10.1016/j.bbadis.2014.09.004. Epub 2014 Sep 18.

20.

Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2.

Garcia-Guerra L, Vila-Bedmar R, Carrasco-Rando M, Cruces-Sande M, Martín M, Ruiz-Gómez A, Ruiz-Gómez M, Lorenzo M, Fernández-Veledo S, Mayor F Jr, Murga C, Nieto-Vázquez I.

J Mol Cell Biol. 2014 Aug;6(4):299-311. doi: 10.1093/jmcb/mju025. Epub 2014 Jun 13.

21.

Role of G protein-coupled receptor kinases in cell migration.

Penela P, Nogués L, Mayor F Jr.

Curr Opin Cell Biol. 2014 Apr;27:10-7. doi: 10.1016/j.ceb.2013.10.005. Epub 2013 Nov 16. Review.

22.

A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia.

Willemen HL, Campos PM, Lucas E, Morreale A, Gil-Redondo R, Agut J, González FV, Ramos P, Heijnen C, Mayor F Jr, Kavelaars A, Murga C.

Biochem J. 2014 May 1;459(3):427-39. doi: 10.1042/BJ20130172.

23.

β-Arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanism.

Fernández-Arenas E, Calleja E, Martínez-Martín N, Gharbi SI, Navajas R, García-Medel N, Penela P, Alcamí A, Mayor F Jr, Albar JP, Alarcón B.

EMBO J. 2014 Mar 18;33(6):559-77. doi: 10.1002/embj.201386022. Epub 2014 Feb 6.

24.

Gαq signalling: the new and the old.

Sánchez-Fernández G, Cabezudo S, García-Hoz C, Benincá C, Aragay AM, Mayor F Jr, Ribas C.

Cell Signal. 2014 May;26(5):833-48. doi: 10.1016/j.cellsig.2014.01.010. Epub 2014 Jan 17. Review.

PMID:
24440667
25.

ERK5 activation by Gq-coupled muscarinic receptors is independent of receptor internalization and β-arrestin recruitment.

Sánchez-Fernández G, Cabezudo S, García-Hoz C, Tobin AB, Mayor F Jr, Ribas C.

PLoS One. 2013 Dec 17;8(12):e84174. doi: 10.1371/journal.pone.0084174. eCollection 2013.

26.

Temporal correlation between wall shear stress and in-stent stenosis after Wingspan stent in swine model.

Fujimoto M, Takao H, Suzuki T, Shobayashi Y, Mayor F, Tateshima S, Yamamoto M, Murayama Y, Viñuela F.

AJNR Am J Neuroradiol. 2014 May;35(5):994-8. doi: 10.3174/ajnr.A3773. Epub 2013 Nov 14.

27.

Increased nitric oxide bioavailability in adult GRK2 hemizygous mice protects against angiotensin II-induced hypertension.

Avendaño MS, Lucas E, Jurado-Pueyo M, Martínez-Revelles S, Vila-Bedmar R, Mayor F Jr, Salaices M, Briones AM, Murga C.

Hypertension. 2014 Feb;63(2):369-75. doi: 10.1161/HYPERTENSIONAHA.113.01991. Epub 2013 Nov 4.

28.

Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2.

Rivas V, Carmona R, Muñoz-Chápuli R, Mendiola M, Nogués L, Reglero C, Miguel-Martín M, García-Escudero R, Dorn GW 2nd, Hardisson D, Mayor F Jr, Penela P.

J Clin Invest. 2013 Nov;123(11):4714-30. doi: 10.1172/JCI67333. Epub 2013 Oct 25.

29.

Effects of remote ischemic preconditioning on the coagulation profile of patients with aneurysmal subarachnoid hemorrhage: a case-control study.

Mayor F, Bilgin-Freiert A, Connolly M, Katsnelson M, Dusick JR, Vespa P, Koch S, Gonzalez NR.

Neurosurgery. 2013 Nov;73(5):808-15; discussion 815. doi: 10.1227/NEU.0000000000000098.

30.

Anaesthesia and orphan disease: difficult monitoring of neuromuscular blockade in a patient with severe Charcot-Marie-Tooth disease type I.

Gálvez-Cañellas JL, Errando CL, Martínez-Torrente F, Mayor F, Zasadowski M, Villanueva Y, Soria-Bretones C.

Eur J Anaesthesiol. 2013 Dec;30(12):772-5. doi: 10.1097/EJA.0b013e3283623dea. No abstract available.

PMID:
23698706
31.

Characterization of arterial thrombus composition by magnetic resonance imaging in a swine stroke model.

Fujimoto M, Salamon N, Mayor F, Yuki I, Takemoto K, Vinters HV, Viñuela F.

Stroke. 2013 May;44(5):1463-5. doi: 10.1161/STROKEAHA.111.000457. Epub 2013 Mar 14.

PMID:
23493736
32.

Intracranial arterial stenoses: current viewpoints, novel approaches, and surgical perspectives.

Gonzalez NR, Liebeskind DS, Dusick JR, Mayor F, Saver J.

Neurosurg Rev. 2013 Apr;36(2):175-84; discussion 184-5. doi: 10.1007/s10143-012-0432-z. Epub 2012 Oct 25. Review.

33.

The interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility.

Lafarga V, Mayor F Jr, Penela P.

Cell Adh Migr. 2012 Nov-Dec;6(6):495-501. doi: 10.4161/cam.21585. Epub 2012 Oct 17.

34.

Roles of GRK2 in cell signaling beyond GPCR desensitization: GRK2-HDAC6 interaction modulates cell spreading and motility.

Penela P, Lafarga V, Tapia O, Rivas V, Nogués L, Lucas E, Vila-Bedmar R, Murga C, Mayor F Jr.

Sci Signal. 2012 May 15;5(224):pt3. doi: 10.1126/scisignal.2003098.

PMID:
22589388
35.

GRK2 contribution to the regulation of energy expenditure and brown fat function.

Vila-Bedmar R, Garcia-Guerra L, Nieto-Vazquez I, Mayor F Jr, Lorenzo M, Murga C, Fernández-Veledo S.

FASEB J. 2012 Aug;26(8):3503-14. doi: 10.1096/fj.11-202267. Epub 2012 Apr 19.

PMID:
22516294
36.

Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts.

García-Hoz C, Sánchez-Fernández G, García-Escudero R, Fernández-Velasco M, Palacios-García J, Ruiz-Meana M, Díaz-Meco MT, Leitges M, Moscat J, García-Dorado D, Boscá L, Mayor F Jr, Ribas C.

J Biol Chem. 2012 Mar 2;287(10):7792-802. doi: 10.1074/jbc.M111.282210. Epub 2012 Jan 9.

37.

A novel GRK2/HDAC6 interaction modulates cell spreading and motility.

Lafarga V, Aymerich I, Tapia O, Mayor F Jr, Penela P.

EMBO J. 2012 Feb 15;31(4):856-69. doi: 10.1038/emboj.2011.466. Epub 2011 Dec 23.

38.

Real-time G-protein-coupled receptor imaging to understand and quantify receptor dynamics.

Aymerich MS, López-Azcárate J, Bonaventura J, Navarro G, Fernández-Suárez D, Casadó V, Mayor F, Lluís C, Valencia M, Artieda J, Franco R.

ScientificWorldJournal. 2011;11:1995-2010. doi: 10.1100/2011/690858. Epub 2011 Oct 26.

39.

G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance.

Mayor F Jr, Lucas E, Jurado-Pueyo M, Garcia-Guerra L, Nieto-Vazquez I, Vila-Bedmar R, Fernández-Veledo S, Murga C.

Arch Physiol Biochem. 2011 Jul;117(3):125-30. doi: 10.3109/13813455.2011.584693. Epub 2011 May 26. Review.

PMID:
21615207
40.

Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling.

Molnar C, Ruiz-Gómez A, Martín M, Rojo-Berciano S, Mayor F, de Celis JF.

PLoS Genet. 2011 Mar;7(3):e1001335. doi: 10.1371/journal.pgen.1001335. Epub 2011 Mar 17.

41.

Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2.

Nogués L, Salcedo A, Mayor F Jr, Penela P.

J Biol Chem. 2011 Jan 14;286(2):1165-73. doi: 10.1074/jbc.M110.203406. Epub 2010 Nov 16.

42.

G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity.

Garcia-Guerra L, Nieto-Vazquez I, Vila-Bedmar R, Jurado-Pueyo M, Zalba G, Díez J, Murga C, Fernández-Veledo S, Mayor F Jr, Lorenzo M.

Diabetes. 2010 Oct;59(10):2407-17. doi: 10.2337/db10-0771. Epub 2010 Jul 13.

43.

The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets.

Penela P, Murga C, Ribas C, Lafarga V, Mayor F Jr.

Br J Pharmacol. 2010 Jun;160(4):821-32. doi: 10.1111/j.1476-5381.2010.00727.x. Review.

44.

G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR).

García-Hoz C, Sánchez-Fernández G, Díaz-Meco MT, Moscat J, Mayor F, Ribas C.

J Biol Chem. 2010 Apr 30;285(18):13480-9. doi: 10.1074/jbc.M109.098699. Epub 2010 Mar 3.

45.

G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression.

Penela P, Rivas V, Salcedo A, Mayor F Jr.

Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1118-23. doi: 10.1073/pnas.0905778107. Epub 2009 Dec 28.

46.

New roles of G protein-coupled receptor kinase 2 (GRK2) in cell migration.

Penela P, Ribas C, Aymerich I, Mayor F Jr.

Cell Adh Migr. 2009 Jan-Mar;3(1):19-23. Epub 2009 Jan 8.

47.

GRK6, a gatekeeper of visceral hyperalgesia.

Murga C, Mayor F Jr.

Brain Behav Immun. 2009 Jan;23(1):16-7. doi: 10.1016/j.bbi.2008.10.002. Epub 2008 Oct 17. No abstract available.

PMID:
18977289
48.

G protein-coupled receptor kinase 2 (GRK2) in migration and inflammation.

Penela P, Murga C, Ribas C, Salcedo A, Jurado-Pueyo M, Rivas V, Aymerich I, Mayor F Jr.

Arch Physiol Biochem. 2008 Jul;114(3):195-200. doi: 10.1080/13813450802181039 . Review.

PMID:
18618354
49.

GRK2-dependent desensitization downstream of G proteins.

Jurado-Pueyo M, Campos PM, Mayor F, Murga C.

J Recept Signal Transduct Res. 2008;28(1-2):59-70. doi: 10.1080/10799890801941939 . Review.

PMID:
18437630
50.

G protein-coupled receptor kinase 2 positively regulates epithelial cell migration.

Penela P, Ribas C, Aymerich I, Eijkelkamp N, Barreiro O, Heijnen CJ, Kavelaars A, Sánchez-Madrid F, Mayor F Jr.

EMBO J. 2008 Apr 23;27(8):1206-18. doi: 10.1038/emboj.2008.55. Epub 2008 Mar 27.

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