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Items: 1 to 50 of 113

1.

Germline alterations in patients with biliary tract cancers: A spectrum of significant and previously underappreciated findings.

Maynard H, Stadler ZK, Berger MF, Solit DB, Ly M, Lowery MA, Mandelker D, Zhang L, Jordan E, El Dika I, Kemel Y, Ladanyi M, Robson ME, O'Reilly EM, Abou-Alfa GK.

Cancer. 2020 Feb 3. doi: 10.1002/cncr.32740. [Epub ahead of print]

PMID:
32012241
2.

Nuclease dead Cas9 is a programmable roadblock for DNA replication.

Whinn KS, Kaur G, Lewis JS, Schauer GD, Mueller SH, Jergic S, Maynard H, Gan ZY, Naganbabu M, Bruchez MP, O'Donnell ME, Dixon NE, van Oijen AM, Ghodke H.

Sci Rep. 2019 Sep 16;9(1):13292. doi: 10.1038/s41598-019-49837-z.

3.

Multivalent Cluster Nanomolecules for Inhibiting Protein-Protein Interactions.

Qian EA, Han Y, Messina MS, Maynard HD, Král P, Spokoyny AM.

Bioconjug Chem. 2019 Oct 16;30(10):2594-2603. doi: 10.1021/acs.bioconjchem.9b00526. Epub 2019 Sep 23.

PMID:
31498600
4.

Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection.

Fulcher JA, Tamshen K, Wollenberg AL, Kickhoefer VA, Mrazek J, Elliott J, Ibarrondo FJ, Anton PA, Rome LH, Maynard HD, Deming T, Yang OO.

Bioconjug Chem. 2019 Aug 21;30(8):2216-2227. doi: 10.1021/acs.bioconjchem.9b00451. Epub 2019 Jul 16.

PMID:
31265254
5.

Site-Specific Insulin-Trehalose Glycopolymer Conjugate by Grafting From Strategy Improves Bioactivity.

Mansfield KM, Maynard HD.

ACS Macro Lett. 2018 Mar 20;7(3):324-329. doi: 10.1021/acsmacrolett.7b00974. Epub 2018 Feb 20.

6.

A guide to maximizing the therapeutic potential of protein-polymer conjugates by rational design.

Ko JH, Maynard HD.

Chem Soc Rev. 2018 Dec 21;47(24):8998-9014. doi: 10.1039/c8cs00606g. Epub 2018 Nov 16. Review.

7.

PEG Analogs Synthesized by Ring-Opening Metathesis Polymerization for Reversible Bioconjugation.

Pelegri-O'Day EM, Matsumoto NM, Tamshen K, Raftery ED, Lau UY, Maynard HD.

Bioconjug Chem. 2018 Nov 21;29(11):3739-3745. doi: 10.1021/acs.bioconjchem.8b00635. Epub 2018 Oct 25.

PMID:
30358981
8.

Polymers at the Interface with Biology.

Deming TJ, Klok HA, Armes SP, Becker ML, Champion JA, Chen EY, Heilshorn SC, van Hest JCM, Irvine DJ, Johnson JA, Kiessling LL, Maynard HD, de la Cruz MO, Sullivan MO, Tirrell MV, Anseth KS, Lecommandoux S, Percec S, Zhong Z, Albertsson AC.

Biomacromolecules. 2018 Aug 13;19(8):3151-3162. doi: 10.1021/acs.biomac.8b01029. No abstract available.

PMID:
30099879
9.

Organometallic Gold(III) Reagents for Cysteine Arylation.

Messina MS, Stauber JM, Waddington MA, Rheingold AL, Maynard HD, Spokoyny AM.

J Am Chem Soc. 2018 Jun 13;140(23):7065-7069. doi: 10.1021/jacs.8b04115. Epub 2018 May 30.

10.

Tuning Molecular Interactions for Highly Reproducible and Efficient Formamidinium Perovskite Solar Cells via Adduct Approach.

Lee JW, Dai Z, Lee C, Lee HM, Han TH, De Marco N, Lin O, Choi CS, Dunn B, Koh J, Di Carlo D, Ko JH, Maynard HD, Yang Y.

J Am Chem Soc. 2018 May 23;140(20):6317-6324. doi: 10.1021/jacs.8b01037. Epub 2018 May 15.

PMID:
29723475
11.

Glucose-Responsive Trehalose Hydrogel for Insulin Stabilization and Delivery.

Lee J, Ko JH, Mansfield KM, Nauka PC, Bat E, Maynard HD.

Macromol Biosci. 2018 May;18(5):e1700372. doi: 10.1002/mabi.201700372. Epub 2018 Apr 17.

12.

Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms.

Lowery MA, Wong W, Jordan EJ, Lee JW, Kemel Y, Vijai J, Mandelker D, Zehir A, Capanu M, Salo-Mullen E, Arnold AG, Yu KH, Varghese AM, Kelsen DP, Brenner R, Kaufmann E, Ravichandran V, Mukherjee S, Berger MF, Hyman DM, Klimstra DS, Abou-Alfa GK, Tjan C, Covington C, Maynard H, Allen PJ, Askan G, Leach SD, Iacobuzio-Donahue CA, Robson ME, Offit K, Stadler ZK, O'Reilly EM.

J Natl Cancer Inst. 2018 Oct 1;110(10):1067-1074. doi: 10.1093/jnci/djy024.

13.

Phase 1 trial evaluating cisplatin, gemcitabine, and veliparib in 2 patient cohorts: Germline BRCA mutation carriers and wild-type BRCA pancreatic ductal adenocarcinoma.

O'Reilly EM, Lee JW, Lowery MA, Capanu M, Stadler ZK, Moore MJ, Dhani N, Kindler HL, Estrella H, Maynard H, Golan T, Segal A, Salo-Mullen EE, Yu KH, Epstein AS, Segal M, Brenner R, Do RK, Chen AP, Tang LH, Kelsen DP.

Cancer. 2018 Apr 1;124(7):1374-1382. doi: 10.1002/cncr.31218. Epub 2018 Jan 16.

14.

Synthesis and Biological Evaluation of a Degradable Trehalose Glycopolymer Prepared by RAFT Polymerization.

Lau UY, Pelegri-O'Day EM, Maynard HD.

Macromol Rapid Commun. 2018 Mar;39(5). doi: 10.1002/marc.201700652. Epub 2017 Dec 18.

15.

Phase II trial of veliparib in patients with previously treated BRCA-mutated pancreas ductal adenocarcinoma.

Lowery MA, Kelsen DP, Capanu M, Smith SC, Lee JW, Stadler ZK, Moore MJ, Kindler HL, Golan T, Segal A, Maynard H, Hollywood E, Moynahan M, Salo-Mullen EE, Do RKG, Chen AP, Yu KH, Tang LH, O'Reilly EM.

Eur J Cancer. 2018 Jan;89:19-26. doi: 10.1016/j.ejca.2017.11.004. Epub 2017 Dec 8.

PMID:
29223478
16.

Structure Activity Relationship of Heparin Mimicking Polymer p(SS-co-PEGMA): Effect of Sulfonation and Polymer Size on FGF2-Receptor Binding.

Paluck SJ, Maynard HD.

Polym Chem. 2017 Aug 20;8(31):4548-4556. doi: 10.1039/C7PY00861A. Epub 2017 Jul 5.

17.

Modular synthesis of 4-aminocarbonyl substituted 1,8-naphthalimides and application in single molecule fluorescence detection.

Hearn KN, Nalder TD, Cox RP, Maynard HD, Bell TDM, Pfeffer FM, Ashton TD.

Chem Commun (Camb). 2017 Nov 14;53(91):12298-12301. doi: 10.1039/c7cc07922b.

PMID:
29094133
18.

The importance of bladder volume in the ultrasound diagnosis of placenta accreta spectrum disorders.

Maynard H, Zamudio S, Jauniaux E, Collins SL.

Int J Gynaecol Obstet. 2018 Mar;140(3):332-337. doi: 10.1002/ijgo.12370. Epub 2017 Nov 26.

19.

Expanding the ROMP Toolbox: Synthesis of Air-Stable Benzonorbornadiene Polymers by Aryne Chemistry.

Medina JM, Ko JH, Maynard HD, Garg NK.

Macromolecules. 2017 Jan 24;50(2):580-586. doi: 10.1021/acs.macromol.6b02376. Epub 2017 Jan 4.

20.

Don't forget the hidden curriculum.

Maynard H, McGinn D, Knights HDJ.

Med Teach. 2018 Jan;40(1):105-106. doi: 10.1080/0142159X.2017.1369504. Epub 2017 Aug 25. No abstract available.

PMID:
28841808
21.

Design of modular dual enzyme-responsive peptides.

Boehnke N, Maynard HD.

Biopolymers. 2017 Sep;108(5). doi: 10.1002/bip.23035. Epub 2017 Aug 11.

22.

Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype.

Lowery MA, Jordan EJ, Basturk O, Ptashkin RN, Zehir A, Berger MF, Leach T, Herbst B, Askan G, Maynard H, Glassman D, Covington C, Schultz N, Abou-Alfa GK, Harding JJ, Klimstra DS, Hechtman JF, Hyman DM, Allen PJ, Jarnagin WR, Balachandran VP, Varghese AM, Schattner MA, Yu KH, Saltz LB, Solit DB, Iacobuzio-Donahue CA, Leach SD, O'Reilly EM.

Clin Cancer Res. 2017 Oct 15;23(20):6094-6100. doi: 10.1158/1078-0432.CCR-17-0899. Epub 2017 Jul 28.

23.

Atomically precise organomimetic cluster nanomolecules assembled via perfluoroaryl-thiol SNAr chemistry.

Qian EA, Wixtrom AI, Axtell JC, Saebi A, Jung D, Rehak P, Han Y, Moully EH, Mosallaei D, Chow S, Messina MS, Wang JY, Royappa AT, Rheingold AL, Maynard HD, Král P, Spokoyny AM.

Nat Chem. 2017 Apr;9(4):333-340. doi: 10.1038/nchem.2686. Epub 2016 Dec 19.

24.

Overall survival and clinical characteristics of BRCA mutation carriers with stage I/II pancreatic cancer.

Golan T, Sella T, O'Reilly EM, Katz MH, Epelbaum R, Kelsen DP, Borgida A, Maynard H, Kindler H, Friedmen E, Javle M, Gallinger S.

Br J Cancer. 2017 Mar 14;116(6):697-702. doi: 10.1038/bjc.2017.19. Epub 2017 Feb 9.

25.

Substituted Polyesters by Thiol-Ene Modification: Rapid Diversification for Therapeutic Protein Stabilization.

Pelegri-O'Day EM, Paluck SJ, Maynard HD.

J Am Chem Soc. 2017 Jan 25;139(3):1145-1154. doi: 10.1021/jacs.6b10776. Epub 2017 Jan 12.

26.

Trehalose Glycopolymer Enhances Both Solution Stability and Pharmacokinetics of a Therapeutic Protein.

Liu Y, Lee J, Mansfield KM, Ko JH, Sallam S, Wesdemiotis C, Maynard HD.

Bioconjug Chem. 2017 Mar 15;28(3):836-845. doi: 10.1021/acs.bioconjchem.6b00659. Epub 2017 Jan 3.

27.

Heparin-Mimicking Polymers: Synthesis and Biological Applications.

Paluck SJ, Nguyen TH, Maynard HD.

Biomacromolecules. 2016 Nov 14;17(11):3417-3440. Epub 2016 Oct 14. Review.

28.

Core/shell protein-reactive nanogels via a combination of RAFT polymerization and vinyl sulfone postmodification.

Vanparijs N, Nuhn L, Paluck SJ, Kokkinopoulou M, Lieberwirth I, Maynard HD, De Geest BG.

Nanomedicine (Lond). 2016 Oct;11(20):2631-2645. Epub 2016 Sep 15.

29.

Controlled Radical Polymerization as an Enabling Approach for the Next Generation of Protein-Polymer Conjugates.

Pelegri-O'Day EM, Maynard HD.

Acc Chem Res. 2016 Sep 20;49(9):1777-85. doi: 10.1021/acs.accounts.6b00258. Epub 2016 Sep 2.

PMID:
27588677
30.

A Heparin-Mimicking Block Copolymer Both Stabilizes and Increases the Activity of Fibroblast Growth Factor 2 (FGF2).

Paluck SJ, Nguyen TH, Lee JP, Maynard HD.

Biomacromolecules. 2016 Oct 10;17(10):3386-3395. Epub 2016 Sep 13.

31.

Objective Method for Presumptive Field-Testing of Illicit Drug Possession Using Centrifugal Microdevices and Smartphone Analysis.

Krauss ST, Remcho TP, Lipes SM, Aranda R 4th, Maynard HP 3rd, Shukla N, Li J, Tontarski RE Jr, Landers JP.

Anal Chem. 2016 Sep 6;88(17):8689-97. doi: 10.1021/acs.analchem.6b01982. Epub 2016 Aug 15.

PMID:
27525468
32.

Calculating the mean time to capture for tethered ligands and its effect on the chemical equilibrium of bound ligand pairs.

Shen L, Decker CG, Maynard HD, Levine AJ.

Data Brief. 2016 May 28;8:506-15. doi: 10.1016/j.dib.2016.05.050. eCollection 2016 Sep.

33.

Risk factors for i.v. compounding errors when using an automated workflow management system.

Deng Y, Lin AC, Hingl J, Huang G, Altaye M, Maynard H, Mayhaus D, Penm J.

Am J Health Syst Pharm. 2016 Jun 15;73(12):887-93. doi: 10.2146/ajhp150278.

PMID:
27261239
34.

Visible-Light-Induced Olefin Activation Using 3D Aromatic Boron-Rich Cluster Photooxidants.

Messina MS, Axtell JC, Wang Y, Chong P, Wixtrom AI, Kirlikovali KO, Upton BM, Hunter BM, Shafaat OS, Khan SI, Winkler JR, Gray HB, Alexandrova AN, Maynard HD, Spokoyny AM.

J Am Chem Soc. 2016 Jun 8;138(22):6952-5. doi: 10.1021/jacs.6b03568. Epub 2016 May 26.

35.

Enhancing Conjugation Yield of Brush Polymer-Protein Conjugates by Increasing Linker Length at the Polymer End-Group.

Nauka PC, Lee J, Maynard HD.

Polym Chem. 2016 Apr 7;7(13):2352-2357. Epub 2016 Mar 14.

36.

Encapsulated Hydrogels by E-beam Lithography and Their Use in Enzyme Cascade Reactions.

Mancini RJ, Paluck SJ, Bat E, Maynard HD.

Langmuir. 2016 Apr 26;32(16):4043-51. doi: 10.1021/acs.langmuir.6b00560. Epub 2016 Apr 14.

37.

Homodimeric Protein-Polymer Conjugates via the Tetrazine-trans-Cyclooctene Ligation.

Lorenzo MM, Decker CG, Kahveci MU, Paluck SJ, Maynard HD.

Macromolecules. 2016 Jan 12;49(1):30-37. Epub 2015 Dec 23.

38.

Fibroblast growth factor 2 dimer with superagonist in vitro activity improves granulation tissue formation during wound healing.

Decker CG, Wang Y, Paluck SJ, Shen L, Loo JA, Levine AJ, Miller LS, Maynard HD.

Biomaterials. 2016 Mar;81:157-168. doi: 10.1016/j.biomaterials.2015.12.003. Epub 2015 Dec 15.

39.

Direct Write Protein Patterns for Multiplexed Cytokine Detection from Live Cells Using Electron Beam Lithography.

Lau UY, Saxer SS, Lee J, Bat E, Maynard HD.

ACS Nano. 2016 Jan 26;10(1):723-9. doi: 10.1021/acsnano.5b05781. Epub 2015 Dec 21.

40.

Chemical biology: Protein modification in a trice.

Maynard H.

Nature. 2015 Oct 29;526(7575):646-7. doi: 10.1038/526646b. No abstract available.

PMID:
26511575
41.

Dual pH- and Temperature-Responsive Protein Nanoparticles.

Matsumoto NM, Buchman GW, Rome LH, Maynard HD.

Eur Polym J. 2015 Aug 1;69:532-539.

42.

Poly(vinyl sulfonate) Facilitates bFGF-Induced Cell Proliferation.

Nguyen TH, Paluck SJ, McGahran AJ, Maynard HD.

Biomacromolecules. 2015 Sep 14;16(9):2684-92. doi: 10.1021/acs.biomac.5b00557. Epub 2015 Aug 17.

43.

Imine Hydrogels with Tunable Degradability for Tissue Engineering.

Boehnke N, Cam C, Bat E, Segura T, Maynard HD.

Biomacromolecules. 2015 Jul 13;16(7):2101-8. doi: 10.1021/acs.biomac.5b00519. Epub 2015 Jul 1.

44.

Trehalose hydrogels for stabilization of enzymes to heat.

Lee J, Ko JH, Lin EW, Wallace P, Ruch F, Maynard HD.

Polym Chem. 2015 May 14;6(18):3443-3448.

45.

Degradable PEGylated Protein Conjugates Utilizing RAFT Polymerization.

Decker CG, Maynard HD.

Eur Polym J. 2015 Apr 1;65:305-312.

46.

Trehalose glycopolymer resists allow direct writing of protein patterns by electron-beam lithography.

Bat E, Lee J, Lau UY, Maynard HD.

Nat Commun. 2015 Mar 20;6:6654. doi: 10.1038/ncomms7654.

47.

Protein-polymer conjugation via ligand affinity and photoactivation of glutathione S-transferase.

Lin EW, Boehnke N, Maynard HD.

Bioconjug Chem. 2014 Oct 15;25(10):1902-9. doi: 10.1021/bc500380r. Epub 2014 Sep 27.

48.

Therapeutic protein-polymer conjugates: advancing beyond PEGylation.

Pelegri-O'Day EM, Lin EW, Maynard HD.

J Am Chem Soc. 2014 Oct 15;136(41):14323-32. doi: 10.1021/ja504390x. Epub 2014 Sep 30.

PMID:
25216406
49.

Synthesis of Nanogel-Protein Conjugates.

Matsumoto NM, González-Toro DC, Chacko RT, Maynard HD, Thayumanavan S.

Polym Chem. 2013 Apr 21;4(8):2464-2469. doi: 10.1039/C3PY00085K.

50.

Morphing hydrogel patterns by thermo-reversible fluorescence switching.

Bat E, Lin EW, Saxer S, Maynard HD.

Macromol Rapid Commun. 2014 Jul;35(14):1260-5. doi: 10.1002/marc.201400160. Epub 2014 Apr 17.

PMID:
24740924

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