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A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites.

Suarez C, Lentini G, Ramaswamy R, Maynadier M, Aquilini E, Berry-Sterkers L, Cipriano M, Chen AL, Bradley P, Striepen B, Boulanger MJ, Lebrun M.

Nat Commun. 2019 Sep 6;10(1):4041. doi: 10.1038/s41467-019-11979-z.


Mannose 6-phosphonate labelling: A key for processing the therapeutic enzyme in Pompe disease.

Godefroy A, Daurat M, Da Silva A, Basile I, El Cheikh K, Caillaud C, Sacconi S, Schoser B, Charbonné HV, Gary-Bobo M, Morère A, Garcia M, Maynadier M.

J Cell Mol Med. 2019 Sep;23(9):6499-6503. doi: 10.1111/jcmm.14516. Epub 2019 Jul 10.


Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor.

Bouffard E, Mauriello Jimenez C, El Cheikh K, Maynadier M, Basile I, Raehm L, Nguyen C, Gary-Bobo M, Garcia M, Durand JO, Morère A.

Int J Mol Sci. 2019 Jun 8;20(11). pii: E2809. doi: 10.3390/ijms20112809.


Biosafety of Mesoporous Silica Nanoparticles.

Rascol E, Pisani C, Dorandeu C, Nyalosaso JL, Charnay C, Daurat M, Da Silva A, Devoisselle JM, Gaillard JC, Armengaud J, Prat O, Maynadier M, Gary-Bobo M, Garcia M, Chopineau J, Guari Y.

Biomimetics (Basel). 2018 Aug 15;3(3). pii: E22. doi: 10.3390/biomimetics3030022.


A "Multi-Heavy-Atom" Approach toward Biphotonic Photosensitizers with Improved Singlet-Oxygen Generation Properties.

Galland M, Le Bahers T, Banyasz A, Lascoux N, Duperray A, Grichine A, Tripier R, Guyot Y, Maynadier M, Nguyen C, Gary-Bobo M, Andraud C, Monnereau C, Maury O.

Chemistry. 2019 Jul 5;25(38):9026-9034. doi: 10.1002/chem.201901047. Epub 2019 May 30.


Dendrimeric Nanoparticles for Two-Photon Photodynamic Therapy and Imaging: Synthesis, Photophysical Properties, Innocuousness in Daylight and Cytotoxicity under Two-Photon Irradiation in the NIR.

Sourdon A, Gary-Bobo M, Maynadier M, Garcia M, Majoral JP, Caminade AM, Mongin O, Blanchard-Desce M.

Chemistry. 2019 Mar 7;25(14):3637-3649. doi: 10.1002/chem.201805617. Epub 2019 Feb 7.


Contribution of the precursors and interplay of the pathways in the phospholipid metabolism of the malaria parasite.

Wein S, Ghezal S, Buré C, Maynadier M, Périgaud C, Vial HJ, Lefebvre-Tournier I, Wengelnik K, Cerdan R.

J Lipid Res. 2018 Aug;59(8):1461-1471. doi: 10.1194/jlr.M085589. Epub 2018 May 31.


G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents.

Belmonte-Reche E, Martínez-García M, Guédin A, Zuffo M, Arévalo-Ruiz M, Doria F, Campos-Salinas J, Maynadier M, López-Rubio JJ, Freccero M, Mergny JL, Pérez-Victoria JM, Morales JC.

J Med Chem. 2018 Feb 8;61(3):1231-1240. doi: 10.1021/acs.jmedchem.7b01672. Epub 2018 Jan 27.


Efficient therapy for refractory Pompe disease by mannose 6-phosphate analogue grafting on acid α-glucosidase.

Basile I, Da Silva A, El Cheikh K, Godefroy A, Daurat M, Harmois A, Perez M, Caillaud C, Charbonné HV, Pau B, Gary-Bobo M, Morère A, Garcia M, Maynadier M.

J Control Release. 2018 Jan 10;269:15-23. doi: 10.1016/j.jconrel.2017.10.043. Epub 2017 Nov 3.


Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles for two-photon photodynamic therapy or photoacoustic imaging.

Mauriello-Jimenez C, Henry M, Aggad D, Raehm L, Cattoën X, Wong Chi Man M, Charnay C, Alpugan S, Ahsen V, Tarakci DK, Maillard P, Maynadier M, Garcia M, Dumoulin F, Gary-Bobo M, Coll JL, Josserand V, Durand JO.

Nanoscale. 2017 Nov 9;9(43):16622-16626. doi: 10.1039/c7nr04677d.


Ribbon-like Foldamers for Cellular Uptake and Drug Delivery.

Vezenkov LL, Martin V, Bettache N, Simon M, Messerschmitt A, Legrand B, Bantignies JL, Subra G, Maynadier M, Bellet V, Garcia M, Martinez J, Amblard M.

Chembiochem. 2017 Nov 2;18(21):2110-2114. doi: 10.1002/cbic.201700455. Epub 2017 Sep 22.


Biological Fate of Fe₃O₄ Core-Shell Mesoporous Silica Nanoparticles Depending on Particle Surface Chemistry.

Rascol E, Daurat M, Da Silva A, Maynadier M, Dorandeu C, Charnay C, Garcia M, Lai-Kee-Him J, Bron P, Auffan M, Liu W, Angeletti B, Devoisselle JM, Guari Y, Gary-Bobo M, Chopineau J.

Nanomaterials (Basel). 2017 Jun 30;7(7). pii: E162. doi: 10.3390/nano7070162.


High Accumulation and In Vivo Recycling of the New Antimalarial Albitiazolium Lead to Rapid Parasite Death.

Wein S, Taudon N, Maynadier M, Tran Van Ba C, Margout D, Bordat Y, Fraisse L, Wengelnik K, Cerdan R, Bressolle-Gomeni F, Vial HJ.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00352-17. doi: 10.1128/AAC.00352-17. Print 2017 Aug.


Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6.

Traoré MDM, Zwick V, Simões-Pires CA, Nurisso A, Issa M, Cuendet M, Maynadier M, Wein S, Vial H, Jamet H, Wong YS.

ACS Omega. 2017 Apr 30;2(4):1550-1562. doi: 10.1021/acsomega.6b00481. Epub 2017 Apr 20.


Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake.

Francisco Hilário F, Traoré MD, Zwick V, Berry L, Simões-Pires CA, Cuendet M, Fantozzi N, Pereira de Freitas R, Maynadier M, Wein S, Vial H, Wong YS.

Org Lett. 2017 Feb 3;19(3):612-615. doi: 10.1021/acs.orglett.6b03776. Epub 2017 Jan 20.


Design of Potent Mannose 6-Phosphate Analogues for the Functionalization of Lysosomal Enzymes To Improve the Treatment of Pompe Disease.

El Cheikh K, Basile I, Da Silva A, Bernon C, Cérutti P, Salgues F, Perez M, Maynadier M, Gary-Bobo M, Caillaud C, Cérutti M, Garcia M, Morère A.

Angew Chem Int Ed Engl. 2016 Nov 14;55(47):14774-14777. doi: 10.1002/anie.201607824. Epub 2016 Oct 24.


Combination treatment with proteasome inhibitors and antiestrogens has a synergistic effect mediated by p21WAF1 in estrogen receptor-positive breast cancer.

Maynadier M, Basile I, Gallud A, Gary-Bobo M, Garcia M.

Oncol Rep. 2016 Aug;36(2):1127-34. doi: 10.3892/or.2016.4873. Epub 2016 Jun 14.


Multifunctional Gold-Mesoporous Silica Nanocomposites for Enhanced Two-Photon Imaging and Therapy of Cancer Cells.

Croissant JG, Qi C, Maynadier M, Cattoën X, Wong Chi Man M, Raehm L, Mongin O, Blanchard-Desce M, Garcia M, Gary-Bobo M, Durand JO.

Front Mol Biosci. 2016 Feb 3;3:1. doi: 10.3389/fmolb.2016.00001. eCollection 2016.


Structure-Activity Relationships of JMV4463, a Vectorized Cathepsin D Inhibitor with Antiproliferative Properties: The Unique Role of the AMPA-Based Vector.

Vezenkov LL, Sanchez CA, Bellet V, Martin V, Maynadier M, Bettache N, Lisowski V, Martinez J, Garcia M, Amblard M, Hernandez JF.

ChemMedChem. 2016 Feb 4;11(3):302-8. doi: 10.1002/cmdc.201500457. Epub 2015 Dec 7.


Why Anticancer Nanomedicine Needs Sugars?

Bouffard E, El Cheikh K, Gallud A, Da Silva A, Maynadier M, Basile I, Gary-Bobo M, Morere A, Garcia M.

Curr Med Chem. 2015;22(26):3014-24. Review.


Synthesis of disulfide-based biodegradable bridged silsesquioxane nanoparticles for two-photon imaging and therapy of cancer cells.

Croissant JG, Mauriello-Jimenez C, Maynadier M, Cattoën X, Wong Chi Man M, Raehm L, Mongin O, Blanchard-Desce M, Garcia M, Gary-Bobo M, Maillard P, Durand JO.

Chem Commun (Camb). 2015 Aug 7;51(61):12324-7. doi: 10.1039/c5cc03736k.


Controlled multiple functionalization of mesoporous silica nanoparticles: homogeneous implementation of pairs of functionalities communicating through energy or proton transfers.

Noureddine A, Lichon L, Maynadier M, Garcia M, Gary-Bobo M, Zink JI, Cattoën X, Wong Chi Man M.

Nanoscale. 2015 Jul 14;7(26):11444-52. doi: 10.1039/c5nr02620b.


Mannose-6-phosphate receptor: a target for theranostics of prostate cancer.

Vaillant O, El Cheikh K, Warther D, Brevet D, Maynadier M, Bouffard E, Salgues F, Jeanjean A, Puche P, Mazerolles C, Maillard P, Mongin O, Blanchard-Desce M, Raehm L, Rébillard X, Durand JO, Gary-Bobo M, Morère A, Garcia M.

Angew Chem Int Ed Engl. 2015 May 11;54(20):5952-6. doi: 10.1002/anie.201500286. Epub 2015 Mar 20.


Uncovering new structural insights for antimalarial activity from cost-effective aculeatin-like derivatives.

Winkler M, Maynadier M, Wein S, Lespinasse MA, Boumis G, Miele AE, Vial H, Wong YS.

Org Biomol Chem. 2015 Feb 21;13(7):2064-77. doi: 10.1039/c4ob02459a.


Two-photon excitation of porphyrin-functionalized porous silicon nanoparticles for photodynamic therapy.

Secret E, Maynadier M, Gallud A, Chaix A, Bouffard E, Gary-Bobo M, Marcotte N, Mongin O, El Cheikh K, Hugues V, Auffan M, Frochot C, Morère A, Maillard P, Blanchard-Desce M, Sailor MJ, Garcia M, Durand JO, Cunin F.

Adv Mater. 2014 Dec 3;26(45):7643-8. doi: 10.1002/adma.201403415. Epub 2014 Oct 17.


Enhanced two-photon fluorescence imaging and therapy of cancer cells via Gold@bridged silsesquioxane nanoparticles.

Croissant J, Maynadier M, Mongin O, Hugues V, Blanchard-Desce M, Chaix A, Cattoën X, Wong Chi Man M, Gallud A, Gary-Bobo M, Garcia M, Raehm L, Durand JO.

Small. 2015 Jan 21;11(3):295-9. doi: 10.1002/smll.201401759. Epub 2014 Sep 10.


Biodegradable ethylene-bis(propyl)disulfide-based periodic mesoporous organosilica nanorods and nanospheres for efficient in-vitro drug delivery.

Croissant J, Cattoën X, Man MW, Gallud A, Raehm L, Trens P, Maynadier M, Durand JO.

Adv Mater. 2014 Sep 17;26(35):6174-80. doi: 10.1002/adma.201401931. Epub 2014 Jul 17.


New insight into the mechanism of accumulation and intraerythrocytic compartmentation of albitiazolium, a new type of antimalarial.

Wein S, Tran Van Ba C, Maynadier M, Bordat Y, Perez J, Peyrottes S, Fraisse L, Vial HJ.

Antimicrob Agents Chemother. 2014 Sep;58(9):5519-27. doi: 10.1128/AAC.00040-14. Epub 2014 Jul 7.


Hybrid mesoporous silica nanoparticles with pH-operated and complementary H-bonding caps as an autonomous drug-delivery system.

Théron C, Gallud A, Carcel C, Gary-Bobo M, Maynadier M, Garcia M, Lu J, Tamanoi F, Zink JI, Wong Chi Man M.

Chemistry. 2014 Jul 21;20(30):9372-80. doi: 10.1002/chem.201402864. Epub 2014 Jul 1.


Design, synthesis and evaluation of new tricyclic endoperoxides as potential antiplasmodial agents.

Ruiz J, Mallet-Ladeira S, Maynadier M, Vial H, André-Barrès C.

Org Biomol Chem. 2014 Jul 28;12(28):5212-21. doi: 10.1039/c4ob00787e.


Two-photon-triggered drug delivery via fluorescent nanovalves.

Croissant J, Chaix A, Mongin O, Wang M, Clément S, Raehm L, Durand JO, Hugues V, Blanchard-Desce M, Maynadier M, Gallud A, Gary-Bobo M, Garcia M, Lu J, Tamanoi F, Ferris DP, Tarn D, Zink JI.

Small. 2014 May 14;10(9):1752-5. doi: 10.1002/smll.201400042. Epub 2014 Feb 20. No abstract available.


Imidazopyridine-fused [1,3]-diazepinones: synthesis and antiproliferative activity.

Gallud A, Vaillant O, Maillard LT, Arama DP, Dubois J, Maynadier M, Lisowski V, Garcia M, Martinez J, Masurier N.

Eur J Med Chem. 2014 Mar 21;75:382-90. doi: 10.1016/j.ejmech.2014.01.044. Epub 2014 Jan 30.


Development of the first oral bioprecursors of bis-alkylguanidine antimalarial drugs.

Degardin M, Wein S, Duckert JF, Maynadier M, Guy A, Durand T, Escale R, Vial H, Vo-Hoang Y.

ChemMedChem. 2014 Feb;9(2):300-4. doi: 10.1002/cmdc.201300419. Epub 2014 Jan 8.


Two-photon-triggered drug delivery in cancer cells using nanoimpellers.

Croissant J, Maynadier M, Gallud A, Peindy N'dongo H, Nyalosaso JL, Derrien G, Charnay C, Durand JO, Raehm L, Serein-Spirau F, Cheminet N, Jarrosson T, Mongin O, Blanchard-Desce M, Gary-Bobo M, Garcia M, Lu J, Tamanoi F, Tarn D, Guardado-Alvarez TM, Zink JI.

Angew Chem Int Ed Engl. 2013 Dec 16;52(51):13813-7. doi: 10.1002/anie.201308647. Epub 2013 Nov 7.


Cathepsin D stimulates the activities of secreted plasminogen activators in the breast cancer acidic environment.

Maynadier M, Farnoud R, Lamy PJ, Laurent-Matha V, Garcia M, Rochefort H.

Int J Oncol. 2013 Nov;43(5):1683-90. doi: 10.3892/ijo.2013.2095. Epub 2013 Sep 10.


A designed 5-fluorouracil-based bridged silsesquioxane as an autonomous acid-triggered drug-delivery system.

Giret S, Théron C, Gallud A, Maynadier M, Gary-Bobo M, Garcia M, Wong Chi Man M, Carcel C.

Chemistry. 2013 Sep 16;19(38):12806-14. doi: 10.1002/chem.201301081. Epub 2013 Aug 8.


Dipeptide mimic oligomer transporter mediates intracellular delivery of Cathepsin D inhibitors: a potential target for cancer therapy.

Maynadier M, Vezenkov LL, Amblard M, Martin V, Gandreuil C, Vaillant O, Gary-Bobo M, Basile I, Hernandez JF, Garcia M, Martinez J.

J Control Release. 2013 Oct 28;171(2):251-7. doi: 10.1016/j.jconrel.2013.07.017. Epub 2013 Jul 27.


Anionic porphyrin-grafted porous silicon nanoparticles for photodynamic therapy.

Secret E, Maynadier M, Gallud A, Gary-Bobo M, Chaix A, Belamie E, Maillard P, Sailor MJ, Garcia M, Durand JO, Cunin F.

Chem Commun (Camb). 2013 May 14;49(39):4202-4. doi: 10.1039/c3cc38837a. Epub 2013 Apr 5.


Flexible synthesis and evaluation of diverse anti-Apicomplexa cyclic peptides.

Traoré M, Mietton F, Maubon D, Peuchmaur M, Hilário FF, Pereira de Freitas R, Bougdour A, Curt A, Maynadier M, Vial H, Pelloux H, Hakimi MA, Wong YS.

J Org Chem. 2013 Apr 19;78(8):3655-75. doi: 10.1021/jo4001492. Epub 2013 Apr 4.


Targeting multiplicity: the key factor for anti-cancer nanoparticles.

Gary-Bobo M, Vaillant O, Maynadier M, Basile I, Gallud A, El Cheikh K, Bouffard E, Morère A, Rébillard X, Puche P, Nirdé P, Garcia M.

Curr Med Chem. 2013;20(15):1946-55. Review.


Roles of estrogen receptor and p21(Waf1) in bortezomib-induced growth inhibition in human breast cancer cells.

Maynadier M, Shi J, Vaillant O, Gary-Bobo M, Basile I, Gleizes M, Cathiard AM, Wah JL, Sheikh MS, Garcia M.

Mol Cancer Res. 2012 Nov;10(11):1473-81. doi: 10.1158/1541-7786.MCR-12-0133. Epub 2012 Sep 10.


Estrogens promote cell-cell adhesion of normal and malignant mammary cells through increased desmosome formation.

Maynadier M, Chambon M, Basile I, Gleizes M, Nirde P, Gary-Bobo M, Garcia M.

Mol Cell Endocrinol. 2012 Nov 25;364(1-2):126-33. doi: 10.1016/j.mce.2012.08.016. Epub 2012 Sep 3.


Disulfide prodrugs of albitiazolium (T3/SAR97276): synthesis and biological activities.

Caldarelli SA, Hamel M, Duckert JF, Ouattara M, Calas M, Maynadier M, Wein S, Périgaud C, Pellet A, Vial HJ, Peyrottes S.

J Med Chem. 2012 May 24;55(10):4619-28. doi: 10.1021/jm3000328. Epub 2012 May 16.


Multifunctionalized mesoporous silica nanoparticles for the in vitro treatment of retinoblastoma: Drug delivery, one and two-photon photodynamic therapy.

Gary-Bobo M, Mir Y, Rouxel C, Brevet D, Hocine O, Maynadier M, Gallud A, Da Silva A, Mongin O, Blanchard-Desce M, Richeter S, Loock B, Maillard P, Morère A, Garcia M, Raehm L, Durand JO.

Int J Pharm. 2012 Aug 1;432(1-2):99-104. doi: 10.1016/j.ijpharm.2012.04.056. Epub 2012 Apr 28.


Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate.

Wein S, Maynadier M, Bordat Y, Perez J, Maheshwari S, Bette-Bobillo P, Tran Van Ba C, Penarete-Vargas D, Fraisse L, Cerdan R, Vial H.

Br J Pharmacol. 2012 Aug;166(8):2263-76. doi: 10.1111/j.1476-5381.2012.01966.x.


Cancer therapy improvement with mesoporous silica nanoparticles combining targeting, drug delivery and PDT.

Gary-Bobo M, Hocine O, Brevet D, Maynadier M, Raehm L, Richeter S, Charasson V, Loock B, Morère A, Maillard P, Garcia M, Durand JO.

Int J Pharm. 2012 Feb 28;423(2):509-15. doi: 10.1016/j.ijpharm.2011.11.045. Epub 2011 Dec 8.


Mannose-functionalized mesoporous silica nanoparticles for efficient two-photon photodynamic therapy of solid tumors.

Gary-Bobo M, Mir Y, Rouxel C, Brevet D, Basile I, Maynadier M, Vaillant O, Mongin O, Blanchard-Desce M, Morère A, Garcia M, Durand JO, Raehm L.

Angew Chem Int Ed Engl. 2011 Nov 25;50(48):11425-9. doi: 10.1002/anie.201104765. Epub 2011 Oct 4. No abstract available.


Nanoscale coordination polymers exhibiting luminescence properties and NMR relaxivity.

Chelebaeva E, Larionova J, Guari Y, Ferreira RA, Carlos LD, Trifonov AA, Kalaivani T, Lascialfari A, Guérin C, Molvinger K, Datas L, Maynadier M, Gary-Bobo M, Garcia M.

Nanoscale. 2011 Mar;3(3):1200-10. doi: 10.1039/c0nr00709a. Epub 2011 Jan 24.


Forming spirocyclohexadienone-oxocarbenium cation species in the biomimetic synthesis of amomols.

Traoré M, Maynadier M, Souard F, Choisnard L, Vial H, Wong YS.

J Org Chem. 2011 Mar 4;76(5):1409-17. doi: 10.1021/jo102414s. Epub 2011 Jan 21.


Silicalites and Mesoporous Silica Nanoparticles for photodynamic therapy.

Hocine O, Gary-Bobo M, Brevet D, Maynadier M, Fontanel S, Raehm L, Richeter S, Loock B, Couleaud P, Frochot C, Charnay C, Derrien G, Smaïhi M, Sahmoune A, Morère A, Maillard P, Garcia M, Durand JO.

Int J Pharm. 2010 Dec 15;402(1-2):221-30. doi: 10.1016/j.ijpharm.2010.10.004. Epub 2010 Oct 8.


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