Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 43

1.

Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity.

Elsebaei MM, Mohammad H, Samir A, Abutaleb NS, Norvil AB, Michie AR, Moustafa MM, Samy H, Gowher H, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2019 Aug 1;175:49-62. doi: 10.1016/j.ejmech.2019.04.063. Epub 2019 Apr 27.

PMID:
31075608
2.

Investigating the promiscuity of the chloramphenicol nitroreductase from Haemophilus influenzae towards the reduction of 4-nitrobenzene derivatives.

Green KD, Fosso MY, Mayhoub AS, Garneau-Tsodikova S.

Bioorg Med Chem Lett. 2019 May 1;29(9):1127-1132. doi: 10.1016/j.bmcl.2019.02.025. Epub 2019 Feb 21.

PMID:
30826292
3.

Naphthylthiazoles: Targeting Multidrug-Resistant and Intracellular Staphylococcus aureus with Biofilm Disruption Activity.

Hagras M, Abutaleb NS, Ali AO, Abdel-Aleem JA, Elsebaei MM, Seleem MN, Mayhoub AS.

ACS Infect Dis. 2018 Dec 14;4(12):1679-1691. doi: 10.1021/acsinfecdis.8b00172. Epub 2018 Oct 8.

PMID:
30247876
4.

Alkoxyphenylthiazoles with broad-spectrum activity against multidrug-resistant gram-positive bacterial pathogens.

ElAwamy M, Mohammad H, Hussien A, Abutaleb NS, Hagras M, Serya RAT, Taher AT, Abouzid KA, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2018 May 25;152:318-328. doi: 10.1016/j.ejmech.2018.04.049. Epub 2018 Apr 25.

PMID:
29734000
5.

Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity.

Kotb A, Abutaleb NS, Seleem MA, Hagras M, Mohammad H, Bayoumi A, Ghiaty A, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2018 May 10;151:110-120. doi: 10.1016/j.ejmech.2018.03.044. Epub 2018 Mar 19.

6.

Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis.

Ngo HX, Green KD, Gajadeera CS, Willby MJ, Holbrook SYL, Hou C, Garzan A, Mayhoub AS, Posey JE, Tsodikov OV, Garneau-Tsodikova S.

ACS Infect Dis. 2018 Jun 8;4(6):1030-1040. doi: 10.1021/acsinfecdis.8b00074. Epub 2018 Mar 30.

7.

Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA).

Elsebaei MM, Mohammad H, Abouf M, Abutaleb NS, Hegazy YA, Ghiaty A, Chen L, Zhang J, Malwal SR, Oldfield E, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2018 Mar 25;148:195-209. doi: 10.1016/j.ejmech.2018.02.031. Epub 2018 Feb 12.

8.

Reversal of Azole Resistance in Candida albicans by Sulfa Antibacterial Drugs.

Eldesouky HE, Mayhoub A, Hazbun TR, Seleem MN.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e00701-17. doi: 10.1128/AAC.00701-17. Print 2018 Mar.

9.

Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability.

Hagras M, Hegazy YA, Elkabbany AH, Mohammad H, Ghiaty A, Abdelghany TM, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2018 Jan 1;143:1448-1456. doi: 10.1016/j.ejmech.2017.10.048. Epub 2017 Oct 19.

10.

Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis.

Eid I, Elsebaei MM, Mohammad H, Hagras M, Peters CE, Hegazy YA, Cooper B, Pogliano J, Pogliano K, Abulkhair HS, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2017 Oct 20;139:665-673. doi: 10.1016/j.ejmech.2017.08.039. Epub 2017 Aug 18.

11.

Bacteriological profiling of diphenylureas as a novel class of antibiotics against methicillin-resistant Staphylococcus aureus.

Mohammad H, Younis W, Ezzat HG, Peters CE, AbdelKhalek A, Cooper B, Pogliano K, Pogliano J, Mayhoub AS, Seleem MN.

PLoS One. 2017 Aug 10;12(8):e0182821. doi: 10.1371/journal.pone.0182821. eCollection 2017.

12.

Investigating the Antibacterial Activity of Biphenylthiazoles against Methicillin- and Vancomycin-Resistant Staphylococcus aureus (MRSA and VRSA).

Hagras M, Mohammad H, Mandour MS, Hegazy YA, Ghiaty A, Seleem MN, Mayhoub AS.

J Med Chem. 2017 May 11;60(9):4074-4085. doi: 10.1021/acs.jmedchem.7b00392. Epub 2017 May 1.

PMID:
28436655
13.

Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus.

Eissa IH, Mohammad H, Qassem OA, Younis W, Abdelghany TM, Elshafeey A, Abd Rabo Moustafa MM, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2017 Apr 21;130:73-85. doi: 10.1016/j.ejmech.2017.02.044. Epub 2017 Feb 21.

PMID:
28249208
14.

Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci.

Mohammad H, Younis W, Chen L, Peters CE, Pogliano J, Pogliano K, Cooper B, Zhang J, Mayhoub A, Oldfield E, Cushman M, Seleem MN.

J Med Chem. 2017 Mar 23;60(6):2425-2438. doi: 10.1021/acs.jmedchem.6b01780. Epub 2017 Mar 15.

15.

In Vitro Screening of an FDA-Approved Library Against ESKAPE Pathogens.

Younis W, AbdelKhalek A, Mayhoub AS, Seleem MN.

Curr Pharm Des. 2017;23(14):2147-2157. doi: 10.2174/1381612823666170209154745.

16.

Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action.

Yahia E, Mohammad H, Abdelghany TM, Fayed E, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2017 Jan 27;126:604-613. doi: 10.1016/j.ejmech.2016.11.042. Epub 2016 Nov 22.

PMID:
27918995
17.

Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties.

Seleem MA, Disouky AM, Mohammad H, Abdelghany TM, Mancy AS, Bayoumi SA, Elshafeey A, El-Morsy A, Seleem MN, Mayhoub AS.

J Med Chem. 2016 May 26;59(10):4900-12. doi: 10.1021/acs.jmedchem.6b00233. Epub 2016 May 17.

PMID:
27187739
18.

Design and Synthesis of Imidazopyrazolopyridines as Novel Selective COX-2 Inhibitors.

Badrey MG, Abdel-Aziz HM, Gomha SM, Abdalla MM, Mayhoub AS.

Molecules. 2015 Aug 21;20(8):15287-303. doi: 10.3390/molecules200815287.

19.

Antibacterial Characterization of Novel Synthetic Thiazole Compounds against Methicillin-Resistant Staphylococcus pseudintermedius.

Mohammad H, Reddy PV, Monteleone D, Mayhoub AS, Cushman M, Hammac GK, Seleem MN.

PLoS One. 2015 Jun 18;10(6):e0130385. doi: 10.1371/journal.pone.0130385. eCollection 2015.

20.

Novel 4-heteroaryl-antipyrines as DPP-IV inhibitors.

Gomha SM, Eldebss TM, Badrey MG, Abdulla MM, Mayhoub AS.

Chem Biol Drug Des. 2015 Nov;86(5):1292-303. doi: 10.1111/cbdd.12593. Epub 2015 Jun 23.

PMID:
26032047
21.

Synthesis and antibacterial evaluation of a novel series of synthetic phenylthiazole compounds against methicillin-resistant Staphylococcus aureus (MRSA).

Mohammad H, Reddy PV, Monteleone D, Mayhoub AS, Cushman M, Seleem MN.

Eur J Med Chem. 2015 Apr 13;94:306-16. doi: 10.1016/j.ejmech.2015.03.015. Epub 2015 Mar 7.

22.

Anti-biofilm activity and synergism of novel thiazole compounds with glycopeptide antibiotics against multidrug-resistant staphylococci.

Mohammad H, Mayhoub AS, Cushman M, Seleem MN.

J Antibiot (Tokyo). 2015 Apr;68(4):259-66. doi: 10.1038/ja.2014.142. Epub 2014 Oct 15.

23.

Diphenylpyrroles: Novel p53 activators.

Gomha SM, Eldebss TM, Abdulla MM, Mayhoub AS.

Eur J Med Chem. 2014 Jul 23;82:472-9. doi: 10.1016/j.ejmech.2014.05.082. Epub 2014 Jun 3.

PMID:
24934571
24.

Discovery and characterization of potent thiazoles versus methicillin- and vancomycin-resistant Staphylococcus aureus.

Mohammad H, Mayhoub AS, Ghafoor A, Soofi M, Alajlouni RA, Cushman M, Seleem MN.

J Med Chem. 2014 Feb 27;57(4):1609-15. doi: 10.1021/jm401905m. Epub 2014 Jan 14.

25.

Amyloid-β probes: Review of structure-activity and brain-kinetics relationships.

Eckroat TJ, Mayhoub AS, Garneau-Tsodikova S.

Beilstein J Org Chem. 2013 May 28;9:1012-44. doi: 10.3762/bjoc.9.116. Print 2013.

26.

Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes.

Houghton JL, Green KD, Pricer RE, Mayhoub AS, Garneau-Tsodikova S.

J Antimicrob Chemother. 2013 Apr;68(4):800-5. doi: 10.1093/jac/dks497. Epub 2012 Dec 11.

27.

Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1).

Mayhoub AS, Marler L, Kondratyuk TP, Park EJ, Pezzuto JM, Cushman M.

Bioorg Med Chem. 2012 Dec 15;20(24):7030-9. doi: 10.1016/j.bmc.2012.10.006. Epub 2012 Oct 23.

28.

Biochemical and structural analysis of aminoglycoside acetyltransferase Eis from Anabaena variabilis.

Pricer RE, Houghton JL, Green KD, Mayhoub AS, Garneau-Tsodikova S.

Mol Biosyst. 2012 Oct 30;8(12):3305-13. doi: 10.1039/c2mb25341k.

29.

Hepatitis C RNA-dependent RNA polymerase inhibitors: a review of structure-activity and resistance relationships; different scaffolds and mutations.

Mayhoub AS.

Bioorg Med Chem. 2012 May 15;20(10):3150-61. doi: 10.1016/j.bmc.2012.03.049. Epub 2012 Mar 29. Review.

PMID:
22516671
30.

Recent advances in the therapeutic applications of pyrazolines.

Shaaban MR, Mayhoub AS, Farag AM.

Expert Opin Ther Pat. 2012 Mar;22(3):253-91. doi: 10.1517/13543776.2012.667403. Epub 2012 Mar 8. Review.

PMID:
22397588
31.

Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol.

Mayhoub AS, Marler L, Kondratyuk TP, Park EJ, Pezzuto JM, Cushman M.

Bioorg Med Chem. 2012 Apr 1;20(7):2427-34. doi: 10.1016/j.bmc.2012.01.047. Epub 2012 Feb 11.

PMID:
22386564
32.

Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets.

Mayhoub AS, Marler L, Kondratyuk TP, Park EJ, Pezzuto JM, Cushman M.

Bioorg Med Chem. 2012 Jan 1;20(1):510-20. doi: 10.1016/j.bmc.2011.09.031. Epub 2011 Sep 25.

33.

An unexpected synthesis of 3,5-diaryl-1,2,4-thiadiazoles from thiobenzamides and methyl bromocyanoacetate.

Mayhoub AS, Kiselev E, Cushman M.

Tetrahedron Lett. 2011 Sep 21;52(38):4941-4943.

34.

The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase (CYP19) and a potential lead compound for novel therapeutic agents.

Lu WJ, Xu C, Pei Z, Mayhoub AS, Cushman M, Flockhart DA.

Breast Cancer Res Treat. 2012 May;133(1):99-109. doi: 10.1007/s10549-011-1699-4. Epub 2011 Aug 4.

PMID:
21814747
35.

Single step synthesis of new fused pyrimidine derivatives and their evaluation as potent Aurora-A kinase inhibitors.

Shaaban MR, Saleh TS, Mayhoub AS, Farag AM.

Eur J Med Chem. 2011 Sep;46(9):3690-5. doi: 10.1016/j.ejmech.2011.05.033. Epub 2011 May 20.

PMID:
21664013
36.

An investigation of phenylthiazole antiflaviviral agents.

Mayhoub AS, Khaliq M, Botting C, Li Z, Kuhn RJ, Cushman M.

Bioorg Med Chem. 2011 Jun 15;19(12):3845-54. doi: 10.1016/j.bmc.2011.04.041. Epub 2011 May 3.

37.

Design, synthesis, and biological evaluation of thiazoles targeting flavivirus envelope proteins.

Mayhoub AS, Khaliq M, Kuhn RJ, Cushman M.

J Med Chem. 2011 Mar 24;54(6):1704-14. doi: 10.1021/jm1013538. Epub 2011 Feb 28.

PMID:
21355607
38.

Design, synthesis and structure-activity relationship study of novel pyrazole-based heterocycles as potential antitumor agents.

Farag AM, Ali KA, El-Debss TM, Mayhoub AS, Amr AG, Abdel-Hafez NA, Abdulla MM.

Eur J Med Chem. 2010 Dec;45(12):5887-98. doi: 10.1016/j.ejmech.2010.09.054. Epub 2010 Oct 1.

PMID:
20950898
39.

Synthesis and structure-activity relationship studies of pyrazole-based heterocycles as antitumor agents.

Farag AM, Mayhoub AS, Eldebss TM, Amr AG, Ali KA, Abdel-Hafez NA, Abdulla MM.

Arch Pharm (Weinheim). 2010 Jul;343(7):384-96. doi: 10.1002/ardp.200900176.

PMID:
20397210
40.

An oxidation of benzyl methyl ethers with nbs that selectively affords either aromatic aldehydes or aromatic methyl esters.

Mayhoub AS, Talukdar A, Cushman M.

J Org Chem. 2010 May 21;75(10):3507-10. doi: 10.1021/jo1004313.

41.

Synthesis and analgesic/anti-inflammatory evaluation of fused heterocyclic ring systems incorporating phenylsulfonyl moiety.

Shaaban MR, Saleh TS, Mayhoub AS, Mansour A, Farag AM.

Bioorg Med Chem. 2008 Jun 15;16(12):6344-52. doi: 10.1016/j.bmc.2008.05.011. Epub 2008 May 7.

PMID:
18502132
42.

Synthesis of new N-phenylpyrazole derivatives with potent antimicrobial activity.

Farag AM, Mayhoub AS, Barakat SE, Bayomi AH.

Bioorg Med Chem. 2008 Apr 15;16(8):4569-78. doi: 10.1016/j.bmc.2008.02.043. Epub 2008 Feb 15.

PMID:
18313934
43.

Regioselective synthesis and antitumor screening of some novel N-phenylpyrazole derivatives.

Farag AM, Mayhoub AS, Barakat SE, Bayomi AH.

Bioorg Med Chem. 2008 Jan 15;16(2):881-9. Epub 2007 Oct 12.

PMID:
17962022

Supplemental Content

Loading ...
Support Center