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Items: 6


In vivo elongation of thin filaments results in heart failure.

Mi-Mi L, Farman GP, Mayfield RM, Strom J, Chu M, Pappas CT, Gregorio CC.

PLoS One. 2020 Jan 3;15(1):e0226138. doi: 10.1371/journal.pone.0226138. eCollection 2020.


Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy.

Ahrens-Nicklas RC, Pappas CT, Farman GP, Mayfield RM, Larrinaga TM, Medne L, Ritter A, Krantz ID, Murali C, Lin KY, Berger JH, Yum SW, Carreon CK, Gregorio CC.

Sci Adv. 2019 Sep 4;5(9):eaax2066. doi: 10.1126/sciadv.aax2066. eCollection 2019 Sep.


Cardiac-specific knockout of Lmod2 results in a severe reduction in myofilament force production and rapid cardiac failure.

Pappas CT, Farman GP, Mayfield RM, Konhilas JP, Gregorio CC.

J Mol Cell Cardiol. 2018 Sep;122:88-97. doi: 10.1016/j.yjmcc.2018.08.009. Epub 2018 Aug 11.


The N-terminal tropomyosin- and actin-binding sites are important for leiomodin 2's function.

Ly T, Moroz N, Pappas CT, Novak SM, Tolkatchev D, Wooldridge D, Mayfield RM, Helms G, Gregorio CC, Kostyukova AS.

Mol Biol Cell. 2016 Aug 15;27(16):2565-75. doi: 10.1091/mbc.E16-03-0200. Epub 2016 Jun 15.


Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytes.

Behunin SM, Lopez-Pier MA, Mayfield RM, Danilo CA, Lipovka Y, Birch C, Lehman S, Tardiff JC, Gregorio CC, Konhilas JP.

Arch Biochem Biophys. 2016 Jul 1;601:32-41. doi: 10.1016/ Epub 2016 Mar 10.


Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality.

Pappas CT, Mayfield RM, Henderson C, Jamilpour N, Cover C, Hernandez Z, Hutchinson KR, Chu M, Nam KH, Valdez JM, Wong PK, Granzier HL, Gregorio CC.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13573-8. doi: 10.1073/pnas.1508273112. Epub 2015 Oct 20.

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