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Glial gene networks associated with alcohol dependence.

Erickson EK, Blednov YA, Harris RA, Mayfield RD.

Sci Rep. 2019 Jul 29;9(1):10949. doi: 10.1038/s41598-019-47454-4.


Genome-wide association studies of the self-rating of effects of ethanol (SRE).

Lai D, Wetherill L, Kapoor M, Johnson EC, Schwandt M, Ramchandani VA, Goldman D, Joslyn G, Rao X, Liu Y, Farris S, Mayfield RD, Dick D, Hesselbrock V, Kramer J, McCutcheon VV, Nurnberger J, Tischfield J, Goate A, Edenberg HJ, Porjesz B, Agrawal A, Foroud T, Schuckit M.

Addict Biol. 2019 Jul 3:e12800. doi: 10.1111/adb.12800. [Epub ahead of print]


Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism.

Kapoor M, Wang JC, Farris SP, Liu Y, McClintick J, Gupta I, Meyers JL, Bertelsen S, Chao M, Nurnberger J, Tischfield J, Harari O, Zeran L, Hesselbrock V, Bauer L, Raj T, Porjesz B, Agrawal A, Foroud T, Edenberg HJ, Mayfield RD, Goate A.

Transl Psychiatry. 2019 Feb 14;9(1):89. doi: 10.1038/s41398-019-0384-y.


Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male mice.

Warden AS, Azzam M, DaCosta A, Mason S, Blednov YA, Messing RO, Mayfield RD, Harris RA.

Brain Behav Immun. 2019 Mar;77:55-65. doi: 10.1016/j.bbi.2018.12.004. Epub 2018 Dec 11.


Toll-like receptor 3 dynamics in female C57BL/6J mice: Regulation of alcohol intake.

Warden AS, Azzam M, DaCosta A, Mason S, Blednov YA, Messing RO, Mayfield RD, Harris RA.

Brain Behav Immun. 2019 Mar;77:66-76. doi: 10.1016/j.bbi.2018.12.006. Epub 2018 Dec 11.


Persistence of Drug Memories: Melting Transcriptomes.

Mayfield RD, Harris RA.

Biol Psychiatry. 2018 Dec 15;84(12):860-861. doi: 10.1016/j.biopsych.2018.09.023. No abstract available.


Ethanol and a rapid-acting antidepressant produce overlapping changes in exon expression in the synaptic transcriptome.

Wolfe SA, Farris SP, Mayfield JE, Heaney CF, Erickson EK, Harris RA, Mayfield RD, Raab-Graham KF.

Neuropharmacology. 2019 Mar 1;146:289-299. doi: 10.1016/j.neuropharm.2018.11.007. Epub 2018 Nov 9.


Cross-species molecular dissection across alcohol behavioral domains.

Farris SP, Riley BP, Williams RW, Mulligan MK, Miles MF, Lopez MF, Hitzemann R, Iancu OD, Colville A, Walter NAR, Darakjian P, Oberbeck DL, Daunais JB, Zheng CL, Searles RP, McWeeney SK, Grant KA, Mayfield RD.

Alcohol. 2018 Nov;72:19-31. doi: 10.1016/j.alcohol.2017.11.036. Epub 2017 Dec 6. Review.


Dissecting Brain Networks Underlying Alcohol Binge Drinking Using a Systems Genomics Approach.

Ferguson LB, Zhang L, Kircher D, Wang S, Mayfield RD, Crabbe JC, Morrisett RA, Harris RA, Ponomarev I.

Mol Neurobiol. 2019 Apr;56(4):2791-2810. doi: 10.1007/s12035-018-1252-0. Epub 2018 Jul 30.


A molecular mechanism for choosing alcohol over an alternative reward.

Augier E, Barbier E, Dulman RS, Licheri V, Augier G, Domi E, Barchiesi R, Farris S, Nätt D, Mayfield RD, Adermark L, Heilig M.

Science. 2018 Jun 22;360(6395):1321-1326. doi: 10.1126/science.aao1157.


Silencing synaptic MicroRNA-411 reduces voluntary alcohol consumption in mice.

Most D, Salem NA, Tiwari GR, Blednov YA, Mayfield RD, Harris RA.

Addict Biol. 2019 Jul;24(4):604-616. doi: 10.1111/adb.12625. Epub 2018 Apr 17.


From gene networks to drugs: systems pharmacology approaches for AUD.

Ferguson LB, Harris RA, Mayfield RD.

Psychopharmacology (Berl). 2018 Jun;235(6):1635-1662. doi: 10.1007/s00213-018-4855-2. Epub 2018 Mar 1. Review.


Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain.

Osterndorff-Kahanek EA, Tiwari GR, Lopez MF, Becker HC, Harris RA, Mayfield RD.

PLoS One. 2018 Jan 9;13(1):e0190841. doi: 10.1371/journal.pone.0190841. eCollection 2018.


Astrocyte-specific transcriptome responses to chronic ethanol consumption.

Erickson EK, Farris SP, Blednov YA, Mayfield RD, Harris RA.

Pharmacogenomics J. 2018 Jul;18(4):578-589. doi: 10.1038/s41397-017-0012-2. Epub 2018 Jan 5.


Genome-Wide Expression Profiles Drive Discovery of Novel Compounds that Reduce Binge Drinking in Mice.

Ferguson LB, Ozburn AR, Ponomarev I, Metten P, Reilly M, Crabbe JC, Harris RA, Mayfield RD.

Neuropsychopharmacology. 2018 May;43(6):1257-1266. doi: 10.1038/npp.2017.301. Epub 2017 Dec 18.


Microglial-specific transcriptome changes following chronic alcohol consumption.

McCarthy GM, Farris SP, Blednov YA, Harris RA, Mayfield RD.

Neuropharmacology. 2018 Jan;128:416-424. doi: 10.1016/j.neuropharm.2017.10.035. Epub 2017 Oct 31.


Emerging roles for ncRNAs in alcohol use disorders.

Mayfield RD.

Alcohol. 2017 May;60:31-39. doi: 10.1016/j.alcohol.2017.01.004. Epub 2017 Apr 15. Review.


Mechanistic insights into epigenetic modulation of ethanol consumption.

Ponomarev I, Stelly CE, Morikawa H, Blednov YA, Mayfield RD, Harris RA.

Alcohol. 2017 May;60:95-101. doi: 10.1016/j.alcohol.2017.01.016. Epub 2017 Mar 12.


Gene expression profiling in the human alcoholic brain.

Warden AS, Mayfield RD.

Neuropharmacology. 2017 Aug 1;122:161-174. doi: 10.1016/j.neuropharm.2017.02.017. Epub 2017 Mar 15. Review.


Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents.

Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE.

J Neurosci. 2017 Feb 1;37(5):1139-1155. doi: 10.1523/JNEUROSCI.2002-16.2016. Epub 2016 Dec 16.


The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies.

Warden A, Erickson E, Robinson G, Harris RA, Mayfield RD.

Pharmacogenomics. 2016 Dec;17(18):2081-2096. Epub 2016 Dec 5. Review.


Inhibition of IKKβ Reduces Ethanol Consumption in C57BL/6J Mice.

Truitt JM, Blednov YA, Benavidez JM, Black M, Ponomareva O, Law J, Merriman M, Horani S, Jameson K, Lasek AW, Harris RA, Mayfield RD.

eNeuro. 2016 Oct 31;3(5). pii: ENEURO.0256-16.2016. eCollection 2016 Sep-Oct.


Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor.

McCracken ML, Gorini G, McCracken LM, Mayfield RD, Harris RA, Trudell JR.

Front Mol Neurosci. 2016 Jun 14;9:45. doi: 10.3389/fnmol.2016.00045. eCollection 2016.


Localization of PPAR isotypes in the adult mouse and human brain.

Warden A, Truitt J, Merriman M, Ponomareva O, Jameson K, Ferguson LB, Mayfield RD, Harris RA.

Sci Rep. 2016 Jun 10;6:27618. doi: 10.1038/srep27618.


Synaptic microRNAs Coordinately Regulate Synaptic mRNAs: Perturbation by Chronic Alcohol Consumption.

Most D, Leiter C, Blednov YA, Harris RA, Mayfield RD.

Neuropsychopharmacology. 2016 Jan;41(2):538-48. doi: 10.1038/npp.2015.179. Epub 2015 Jun 24.


Applying the new genomics to alcohol dependence.

Farris SP, Pietrzykowski AZ, Miles MF, O'Brien MA, Sanna PP, Zakhari S, Mayfield RD, Harris RA.

Alcohol. 2015 Dec;49(8):825-36. doi: 10.1016/j.alcohol.2015.03.001. Epub 2015 Mar 28. Review.


Chronic ethanol exposure produces time- and brain region-dependent changes in gene coexpression networks.

Osterndorff-Kahanek EA, Becker HC, Lopez MF, Farris SP, Tiwari GR, Nunez YO, Harris RA, Mayfield RD.

PLoS One. 2015 Mar 24;10(3):e0121522. doi: 10.1371/journal.pone.0121522. eCollection 2015.


Transcriptome organization for chronic alcohol abuse in human brain.

Farris SP, Arasappan D, Hunicke-Smith S, Harris RA, Mayfield RD.

Mol Psychiatry. 2015 Nov;20(11):1438-47. doi: 10.1038/mp.2014.159. Epub 2014 Dec 2.


RNA-Seq reveals novel transcriptional reorganization in human alcoholic brain.

Farris SP, Mayfield RD.

Int Rev Neurobiol. 2014;116:275-300. doi: 10.1016/B978-0-12-801105-8.00011-4. Review.


The synaptoneurosome transcriptome: a model for profiling the emolecular effects of alcohol.

Most D, Ferguson L, Blednov Y, Mayfield RD, Harris RA.

Pharmacogenomics J. 2015 Apr;15(2):177-88. doi: 10.1038/tpj.2014.43. Epub 2014 Aug 19.


Neurobiological signatures of alcohol dependence revealed by protein profiling.

Gorini G, Roberts AJ, Mayfield RD.

PLoS One. 2013 Dec 16;8(12):e82656. doi: 10.1371/journal.pone.0082656. eCollection 2013.


Integration of miRNA and protein profiling reveals coordinated neuroadaptations in the alcohol-dependent mouse brain.

Gorini G, Nunez YO, Mayfield RD.

PLoS One. 2013 Dec 16;8(12):e82565. doi: 10.1371/journal.pone.0082565. eCollection 2013. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/6286be0f-d729-495a-8a72-78995e9ceda7.


Altered gamma-aminobutyric acid type B receptor subunit 1 splicing in alcoholics.

Lee C, Mayfield RD, Harris RA.

Biol Psychiatry. 2014 May 15;75(10):765-73. doi: 10.1016/j.biopsych.2013.08.028. Epub 2013 Oct 24.


Positively correlated miRNA-mRNA regulatory networks in mouse frontal cortex during early stages of alcohol dependence.

Nunez YO, Truitt JM, Gorini G, Ponomareva ON, Blednov YA, Harris RA, Mayfield RD.

BMC Genomics. 2013 Oct 22;14:725. doi: 10.1186/1471-2164-14-725.


Proteomic approaches and identification of novel therapeutic targets for alcoholism.

Gorini G, Harris RA, Mayfield RD.

Neuropsychopharmacology. 2014 Jan;39(1):104-30. doi: 10.1038/npp.2013.182. Epub 2013 Jul 31. Review.


RNaseIII and T4 polynucleotide Kinase sequence biases and solutions during RNA-seq library construction.

Lee C, Harris RA, Wall JK, Mayfield RD, Wilke CO.

Biol Direct. 2013 Jul 4;8:16. doi: 10.1186/1745-6150-8-16.


Chronic self-administration of alcohol results in elevated ΔFosB: comparison of hybrid mice with distinct drinking patterns.

Ozburn AR, Mayfield RD, Ponomarev I, Jones TA, Blednov YA, Harris RA.

BMC Neurosci. 2012 Oct 29;13:130. doi: 10.1186/1471-2202-13-130.


Understanding Alcoholism Through microRNA Signatures in Brains of Human Alcoholics.

Nunez YO, Mayfield RD.

Front Genet. 2012 Apr 3;3:43. doi: 10.3389/fgene.2012.00043. eCollection 2012.


Behavioral actions of alcohol: phenotypic relations from multivariate analysis of mutant mouse data.

Blednov YA, Mayfield RD, Belknap J, Harris RA.

Genes Brain Behav. 2012 Jun;11(4):424-35. doi: 10.1111/j.1601-183X.2012.00780.x. Epub 2012 Apr 6.


Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence.

Ponomarev I, Wang S, Zhang L, Harris RA, Mayfield RD.

J Neurosci. 2012 Feb 1;32(5):1884-97. doi: 10.1523/JNEUROSCI.3136-11.2012.


Identifying changes in the synaptic proteome of cirrhotic alcoholic superior frontal gyrus.

Etheridge N, Mayfield RD, Harris RA, Dodd PR.

Curr Neuropharmacol. 2011 Mar;9(1):122-8. doi: 10.2174/157015911795017164.


Up-regulation of microRNAs in brain of human alcoholics.

Lewohl JM, Nunez YO, Dodd PR, Tiwari GR, Harris RA, Mayfield RD.

Alcohol Clin Exp Res. 2011 Nov;35(11):1928-37. doi: 10.1111/j.1530-0277.2011.01544.x. Epub 2011 Jun 8.


Molecular profiles of drinking alcohol to intoxication in C57BL/6J mice.

Mulligan MK, Rhodes JS, Crabbe JC, Mayfield RD, Harris RA, Ponomarev I.

Alcohol Clin Exp Res. 2011 Apr;35(4):659-70. doi: 10.1111/j.1530-0277.2010.01384.x. Epub 2011 Jan 11.


Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening.

Gorini G, Bell RL, Mayfield RD.

Prog Mol Biol Transl Sci. 2011;98:293-347. doi: 10.1016/B978-0-12-385506-0.00007-7. Review.


Intron 4 containing novel GABAB1 isoforms impair GABAB receptor function.

Lee C, Mayfield RD, Harris RA.

PLoS One. 2010 Nov 18;5(11):e14044. doi: 10.1371/journal.pone.0014044.


Ethanol alters endosomal recycling of human dopamine transporters.

Methner DN, Mayfield RD.

J Biol Chem. 2010 Apr 2;285(14):10310-7. doi: 10.1074/jbc.M109.029561. Epub 2010 Feb 4.


Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes.

Gorini G, Ponomareva O, Shores KS, Person MD, Harris RA, Mayfield RD.

FEBS Lett. 2010 Mar 5;584(5):845-51. doi: 10.1016/j.febslet.2009.12.061. Epub 2010 Jan 29.


Synaptic proteome changes in the superior frontal gyrus and occipital cortex of the alcoholic brain.

Etheridge N, Lewohl JM, Mayfield RD, Harris RA, Dodd PR.

Proteomics Clin Appl. 2009 Jun 24;3(6):730-742.


Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumption.

Bell RL, Kimpel MW, McClintick JN, Strother WN, Carr LG, Liang T, Rodd ZA, Mayfield RD, Edenberg HJ, McBride WJ.

Pharmacol Biochem Behav. 2009 Nov;94(1):131-47. doi: 10.1016/j.pbb.2009.07.019. Epub 2009 Aug 8.


Gene expression profiling in blood: new diagnostics in alcoholism and addiction?

Mayfield RD, Harris RA.

Neuropsychopharmacology. 2009 Jan;34(1):250-1. doi: 10.1038/npp.2008.162. No abstract available.

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