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Retraction Note: Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability.

Li Y, Hadden C, Cooper A, Ahmed A, Wu H, Lupashin VV, Mayeux PR, Kilic F.

Sci Rep. 2019 Sep 27;9(1):14218. doi: 10.1038/s41598-019-50843-4.


A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome.

Bondu S, Alary AS, Lefèvre C, Houy A, Jung G, Lefebvre T, Rombaut D, Boussaid I, Bousta A, Guillonneau F, Perrier P, Alsafadi S, Wassef M, Margueron R, Rousseau A, Droin N, Cagnard N, Kaltenbach S, Winter S, Kubasch AS, Bouscary D, Santini V, Toma A, Hunault M, Stamatoullas A, Gyan E, Cluzeau T, Platzbecker U, Adès L, Puy H, Stern MH, Karim Z, Mayeux P, Nemeth E, Park S, Ganz T, Kautz L, Kosmider O, Fontenay M.

Sci Transl Med. 2019 Jul 10;11(500). pii: eaav5467. doi: 10.1126/scitranslmed.aav5467.


C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system.

Jaïs PH, Decroly E, Jacquet E, Le Boulch M, Jaïs A, Jean-Jean O, Eaton H, Ponien P, Verdier F, Canard B, Goncalves S, Chiron S, Le Gall M, Mayeux P, Shmulevitz M.

Nucleic Acids Res. 2019 Mar 18;47(5):2681-2698. doi: 10.1093/nar/gkz069.


Female mice exhibit less renal mitochondrial injury but greater mortality using a comorbid model of experimental sepsis.

MacMillan-Crow LA, Mayeux PR.

Intern Med Rev (Wash D C). 2018 Oct;4(10). doi: 10.18103/imr.v4i10.768.


Absolute proteome quantification of highly purified populations of circulating reticulocytes and mature erythrocytes.

Gautier EF, Leduc M, Cochet S, Bailly K, Lacombe C, Mohandas N, Guillonneau F, El Nemer W, Mayeux P.

Blood Adv. 2018 Oct 23;2(20):2646-2657. doi: 10.1182/bloodadvances.2018023515.


Finely-tuned regulation of AMP-activated protein kinase is crucial for human adult erythropoiesis.

Ladli M, Richard C, Aguilar LC, Ducamp S, Bondu S, Sujobert P, Tamburini J, Lacombe C, Azar N, Foretz M, Zermati Y, Mayeux P, Viollet B, Verdier F.

Haematologica. 2019 May;104(5):907-918. doi: 10.3324/haematol.2018.191403. Epub 2018 Oct 11.


A PIM-CHK1 signaling pathway regulates PLK1 phosphorylation and function during mitosis.

Adam K, Cartel M, Lambert M, David L, Yuan L, Besson A, Mayeux P, Manenti S, Didier C.

J Cell Sci. 2018 Aug 10;131(15). pii: jcs213116. doi: 10.1242/jcs.213116.


Impact of hydroxycarbamide and interferon-α on red cell adhesion and membrane protein expression in polycythemia vera.

Brusson M, De Grandis M, Cochet S, Bigot S, Marin M, Leduc M, Guillonneau F, Mayeux P, Peyrard T, Chomienne C, Le Van Kim C, Cassinat B, Kiladjian JJ, El Nemer W.

Haematologica. 2018 Jun;103(6):972-981. doi: 10.3324/haematol.2017.182303. Epub 2018 Mar 29.


RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia.

Hospital MA, Jacquel A, Mazed F, Saland E, Larrue C, Mondesir J, Birsen R, Green AS, Lambert M, Sujobert P, Gautier EF, Salnot V, Le Gall M, Decroocq J, Poulain L, Jacque N, Fontenay M, Kosmider O, Récher C, Auberger P, Mayeux P, Bouscary D, Sarry JE, Tamburini J.

Leukemia. 2018 Mar;32(3):597-605. doi: 10.1038/leu.2017.284. Epub 2017 Sep 15.


Rolipram Improves Outcome in a Rat Model of Infant Sepsis-Induced Cardiorenal Syndrome.

Sims CR, Singh SP, Mu S, Gokden N, Zakaria D, Nguyen TC, Mayeux PR.

Front Pharmacol. 2017 May 3;8:237. doi: 10.3389/fphar.2017.00237. eCollection 2017.


Enhanced calreticulin expression in red cells of polycythemia vera patients harboring the JAK2V617F mutation.

Brusson M, Cochet S, Leduc M, Guillonneau F, Mayeux P, Peyrard T, Chomienne C, Le Van Kim C, Cassinat B, Kiladjian JJ, El Nemer W.

Haematologica. 2017 Jul;102(7):e241-e244. doi: 10.3324/haematol.2016.161604. Epub 2017 Apr 6. No abstract available.


p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway.

Jeannot P, Nowosad A, Perchey RT, Callot C, Bennana E, Katsube T, Mayeux P, Guillonneau F, Manenti S, Besson A.

Elife. 2017 Mar 13;6. pii: e22207. doi: 10.7554/eLife.22207.


High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells.

Poulain L, Sujobert P, Zylbersztejn F, Barreau S, Stuani L, Lambert M, Palama TL, Chesnais V, Birsen R, Vergez F, Farge T, Chenevier-Gobeaux C, Fraisse M, Bouillaud F, Debeissat C, Herault O, Récher C, Lacombe C, Fontenay M, Mayeux P, Maciel TT, Portais JC, Sarry JE, Tamburini J, Bouscary D, Chapuis N.

Leukemia. 2017 Nov;31(11):2326-2335. doi: 10.1038/leu.2017.81. Epub 2017 Mar 10.


Comprehensive Proteomic Analysis of Human Erythropoiesis.

Gautier EF, Ducamp S, Leduc M, Salnot V, Guillonneau F, Dussiot M, Hale J, Giarratana MC, Raimbault A, Douay L, Lacombe C, Mohandas N, Verdier F, Zermati Y, Mayeux P.

Cell Rep. 2016 Aug 2;16(5):1470-1484. doi: 10.1016/j.celrep.2016.06.085. Epub 2016 Jul 21.


Renal Mitochondrial Lipid Peroxidation during Sepsis.

Singh P, Parajuli N, Mayeux PR, MacMillan-Crow LA.

J Kidney. 2016 Feb;2(1). pii: 116. Epub 2016 Feb 29.


Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability.

Li Y, Hadden C, Cooper A, Ahmed A, Wu H, Lupashin VV, Mayeux PR, Kilic F.

Sci Rep. 2016 Mar 9;6:22747. doi: 10.1038/srep22747. Retraction in: Sci Rep. 2019 Sep 27;9(1):14218.



Ince C, Mayeux PR, Nguyen T, Gomez H, Kellum JA, Ospina-Tascón GA, Hernandez G, Murray P, De Backer D; ADQI XIV Workgroup.

Shock. 2016 Mar;45(3):259-70. doi: 10.1097/SHK.0000000000000473. Review.


Could Biomarkers Direct Therapy for the Septic Patient?

Sims CR, Nguyen TC, Mayeux PR.

J Pharmacol Exp Ther. 2016 May;357(2):228-39. doi: 10.1124/jpet.115.230797. Epub 2016 Feb 8. Review.


Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia.

Green AS, Maciel TT, Hospital MA, Yin C, Mazed F, Townsend EC, Pilorge S, Lambert M, Paubelle E, Jacquel A, Zylbersztejn F, Decroocq J, Poulain L, Sujobert P, Jacque N, Adam K, So JC, Kosmider O, Auberger P, Hermine O, Weinstock DM, Lacombe C, Mayeux P, Vanasse GJ, Leung AY, Moura IC, Bouscary D, Tamburini J.

Sci Adv. 2015 Sep 18;1(8):e1500221. doi: 10.1126/sciadv.1500221. eCollection 2015 Sep.


Control of Pim2 kinase stability and expression in transformed human haematopoietic cells.

Adam K, Lambert M, Lestang E, Champenois G, Dusanter-Fourt I, Tamburini J, Bouscary D, Lacombe C, Zermati Y, Mayeux P.

Biosci Rep. 2015 Oct 23;35(6). pii: e00274. doi: 10.1042/BSR20150217.


Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition.

Jacque N, Ronchetti AM, Larrue C, Meunier G, Birsen R, Willems L, Saland E, Decroocq J, Maciel TT, Lambert M, Poulain L, Hospital MA, Sujobert P, Joseph L, Chapuis N, Lacombe C, Moura IC, Demo S, Sarry JE, Recher C, Mayeux P, Tamburini J, Bouscary D.

Blood. 2015 Sep 10;126(11):1346-56. doi: 10.1182/blood-2015-01-621870. Epub 2015 Jul 17.


Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia.

Sujobert P, Poulain L, Paubelle E, Zylbersztejn F, Grenier A, Lambert M, Townsend EC, Brusq JM, Nicodeme E, Decrooqc J, Nepstad I, Green AS, Mondesir J, Hospital MA, Jacque N, Christodoulou A, Desouza TA, Hermine O, Foretz M, Viollet B, Lacombe C, Mayeux P, Weinstock DM, Moura IC, Bouscary D, Tamburini J.

Cell Rep. 2015 Jun 9;11(9):1446-57. doi: 10.1016/j.celrep.2015.04.063. Epub 2015 May 21.


Erythropoiesis and transferrin receptors.

Moura IC, Hermine O, Lacombe C, Mayeux P.

Curr Opin Hematol. 2015 May;22(3):193-8. doi: 10.1097/MOH.0000000000000133. Review.


Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form.

Pagani A, Vieillevoye M, Nai A, Rausa M, Ladli M, Lacombe C, Mayeux P, Verdier F, Camaschella C, Silvestri L.

Haematologica. 2015 Apr;100(4):458-65. doi: 10.3324/haematol.2014.118521. Epub 2015 Jan 30.


Pharmacologic targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse.

Wang Z, Sims CR, Patil NK, Gokden N, Mayeux PR.

J Pharmacol Exp Ther. 2015 Jan;352(1):61-6. doi: 10.1124/jpet.114.219394. Epub 2014 Oct 29.


Targeting mitochondrial oxidants may facilitate recovery of renal function during infant sepsis.

Sims CR, MacMillan-Crow LA, Mayeux PR.

Clin Pharmacol Ther. 2014 Dec;96(6):662-4. doi: 10.1038/clpt.2014.170. Epub 2014 Aug 22.


Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury.

Patil NK, Parajuli N, MacMillan-Crow LA, Mayeux PR.

Am J Physiol Renal Physiol. 2014 Apr 1;306(7):F734-43. doi: 10.1152/ajprenal.00643.2013. Epub 2014 Feb 5.


Rolipram improves renal perfusion and function during sepsis in the mouse.

Holthoff JH, Wang Z, Patil NK, Gokden N, Mayeux PR.

J Pharmacol Exp Ther. 2013 Nov;347(2):357-64. doi: 10.1124/jpet.113.208520. Epub 2013 Sep 9.


Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia.

Willems L, Jacque N, Jacquel A, Neveux N, Maciel TT, Lambert M, Schmitt A, Poulain L, Green AS, Uzunov M, Kosmider O, Radford-Weiss I, Moura IC, Auberger P, Ifrah N, Bardet V, Chapuis N, Lacombe C, Mayeux P, Tamburini J, Bouscary D.

Blood. 2013 Nov 14;122(20):3521-32. doi: 10.1182/blood-2013-03-493163. Epub 2013 Sep 6.


Characterization of cytosolic proliferating cell nuclear antigen (PCNA) in neutrophils: antiapoptotic role of the monomer.

De Chiara A, Pederzoli-Ribeil M, Mocek J, Candalh C, Mayeux P, Millet A, Witko-Sarsat V.

J Leukoc Biol. 2013 Oct;94(4):723-31. doi: 10.1189/jlb.1212637. Epub 2013 Jul 3.


Tyrosine kinase inhibitors induce down-regulation of c-Kit by targeting the ATP pocket.

D'allard D, Gay J, Descarpentries C, Frisan E, Adam K, Verdier F, Floquet C, Dubreuil P, Lacombe C, Fontenay M, Mayeux P, Kosmider O.

PLoS One. 2013 Apr 23;8(4):e60961. doi: 10.1371/journal.pone.0060961. Print 2013.


Epigenetic control of NF-κB-dependent FAS gene transcription during progression of myelodysplastic syndromes.

Ettou S, Humbrecht C, Benet B, Billot K, d'Allard D, Mariot V, Goodhardt M, Kosmider O, Mayeux P, Solary E, Fontenay M.

Mol Cancer Res. 2013 Jul;11(7):724-35. doi: 10.1158/1541-7786.MCR-12-0607. Epub 2013 Apr 19.


A phase Ib GOELAMS study of the mTOR inhibitor RAD001 in association with chemotherapy for AML patients in first relapse.

Park S, Chapuis N, Saint Marcoux F, Recher C, Prebet T, Chevallier P, Cahn JY, Leguay T, Bories P, Witz F, Lamy T, Mayeux P, Lacombe C, Demur C, Tamburini J, Merlat A, Delepine R, Vey N, Dreyfus F, Béné MC, Ifrah N, Bouscary D; GOELAMS (Groupe Ouest Est d’Etude des Leucémies aiguës et Autres Maladies du Sang).

Leukemia. 2013 Jul;27(7):1479-86. doi: 10.1038/leu.2013.17. Epub 2013 Jan 16.


Sustained leukemia-free state and molecular response to sorafenib in a patient with chronic myelomonocytic leukemia in transformation driven by homozygous FLT3-ITD malignant hematopoiesis.

Kosmider O, Chapuis N, Kaltenbach S, Coriat R, Boudou Rouquette P, Willems L, Chesnais V, Radford-Weiss I, Bardet V, Mayeux P, Tamburini J, Fontenay M, Bouscary D.

Clin Lymphoma Myeloma Leuk. 2013 Jun;13(3):347-50. doi: 10.1016/j.clml.2012.11.007. No abstract available.


Mass spectrometry detection of G3m and IGHG3 alleles and follow-up of differential mother and neonate IgG3.

Dechavanne C, Guillonneau F, Chiappetta G, Sago L, Lévy P, Salnot V, Guitard E, Ehrenmann F, Broussard C, Chafey P, Le Port A, Vinh J, Mayeux P, Dugoujon JM, Lefranc MP, Migot-Nabias F.

PLoS One. 2012;7(9):e46097. doi: 10.1371/journal.pone.0046097. Epub 2012 Sep 25.


Fas expression at diagnosis as a biomarker of azacitidine activity in high-risk MDS and secondary AML.

Ettou S, Audureau E, Humbrecht C, Benet B, Jammes H, Clozel T, Bardet V, Lacombe C, Dreyfus F, Mayeux P, Solary E, Fontenay M.

Leukemia. 2012 Oct;26(10):2297-9. doi: 10.1038/leu.2012.152. Epub 2012 Jun 5. No abstract available.


Cotargeting signaling pathways driving survival and cell cycle circumvents resistance to Kit inhibitors in leukemia.

Buet D, Gallais I, Lauret E, Denis N, Lombard B, Guillonneau F, Kosmider O, Loew D, Dusanter-Fourt I, Guillouf C, Mayeux P, Moreau-Gachelin F.

Blood. 2012 May 3;119(18):4228-41. doi: 10.1182/blood-2011-07-368316. Epub 2012 Mar 20.


PI3K and mTOR signaling pathways in cancer: new data on targeted therapies.

Willems L, Tamburini J, Chapuis N, Lacombe C, Mayeux P, Bouscary D.

Curr Oncol Rep. 2012 Apr;14(2):129-38. doi: 10.1007/s11912-012-0227-y. Review.


The FLT3 and Pim kinases inhibitor SGI-1776 preferentially target FLT3-ITD AML cells.

Hospital MA, Green AS, Lacombe C, Mayeux P, Bouscary D, Tamburini J.

Blood. 2012 Feb 16;119(7):1791-2. doi: 10.1182/blood-2011-11-393066. No abstract available.


Pharmacological targets in the renal peritubular microenvironment: implications for therapy for sepsis-induced acute kidney injury.

Mayeux PR, MacMillan-Crow LA.

Pharmacol Ther. 2012 May;134(2):139-55. doi: 10.1016/j.pharmthera.2012.01.004. Epub 2012 Jan 16. Review.


Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis.

Mastrogiannaki M, Matak P, Mathieu JR, Delga S, Mayeux P, Vaulont S, Peyssonnaux C.

Haematologica. 2012 Jun;97(6):827-34. doi: 10.3324/haematol.2011.056119. Epub 2011 Dec 29.


Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.

Frisan E, Vandekerckhove J, de Thonel A, Pierre-Eugène C, Sternberg A, Arlet JB, Floquet C, Gyan E, Kosmider O, Dreyfus F, Gabet AS, Courtois G, Vyas P, Ribeil JA, Zermati Y, Lacombe C, Mayeux P, Solary E, Garrido C, Hermine O, Fontenay M.

Blood. 2012 Feb 9;119(6):1532-42. doi: 10.1182/blood-2011-03-343475. Epub 2011 Dec 12.


The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.

Willems L, Chapuis N, Puissant A, Maciel TT, Green AS, Jacque N, Vignon C, Park S, Guichard S, Herault O, Fricot A, Hermine O, Moura IC, Auberger P, Ifrah N, Dreyfus F, Bonnet D, Lacombe C, Mayeux P, Bouscary D, Tamburini J.

Leukemia. 2012 Jun;26(6):1195-202. doi: 10.1038/leu.2011.339. Epub 2011 Dec 6.


Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injury.

Wang Z, Holthoff JH, Seely KA, Pathak E, Spencer HJ 3rd, Gokden N, Mayeux PR.

Am J Pathol. 2012 Feb;180(2):505-16. doi: 10.1016/j.ajpath.2011.10.011. Epub 2011 Nov 24.


New variant of unclassified congenital dyserythropoietic anaemia: the concept of the erythroid regulator?

Gay J, Fournier M, Pierre-Eugène C, Fontenay M, Charpentier A, Mayeux P, Pissard S, Da Costa L, Beaumont C, Rose C.

Br J Haematol. 2012 Apr;157(1):148-51. doi: 10.1111/j.1365-2141.2011.08932.x. Epub 2011 Nov 11. No abstract available.


Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia.

Coulon S, Dussiot M, Grapton D, Maciel TT, Wang PH, Callens C, Tiwari MK, Agarwal S, Fricot A, Vandekerckhove J, Tamouza H, Zermati Y, Ribeil JA, Djedaini K, Oruc Z, Pascal V, Courtois G, Arnulf B, Alyanakian MA, Mayeux P, Leanderson T, Benhamou M, Cogné M, Monteiro RC, Hermine O, Moura IC.

Nat Med. 2011 Oct 23;17(11):1456-65. doi: 10.1038/nm.2462.


Role of mitochondrial oxidants in an in vitro model of sepsis-induced renal injury.

Pathak E, MacMillan-Crow LA, Mayeux PR.

J Pharmacol Exp Ther. 2012 Jan;340(1):192-201. doi: 10.1124/jpet.111.183756. Epub 2011 Oct 19.


The eukaryotic initiating factor 4E protein is overexpressed, but its level has no prognostic impact in acute myeloid leukaemia.

Green AS, Grabar S, Tulliez M, Park S, Al-Nawakil C, Chapuis N, Jacque N, Willems L, Azar N, Ifrah N, Dreyfus F, Lacombe C, Mayeux P, Bouscary D, Tamburini J.

Br J Haematol. 2012 Feb;156(4):547-50. doi: 10.1111/j.1365-2141.2011.08891.x. Epub 2011 Oct 14. No abstract available.


Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury.

Holthoff JH, Wang Z, Seely KA, Gokden N, Mayeux PR.

Kidney Int. 2012 Feb;81(4):370-8. doi: 10.1038/ki.2011.347. Epub 2011 Oct 5.

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