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Items: 33

1.

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.

McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr.

Cell. 2018 Sep 20;175(1):101-116.e25. doi: 10.1016/j.cell.2018.08.038. Epub 2018 Sep 13.

PMID:
30220459
2.

Altered exocrine function can drive adipose wasting in early pancreatic cancer.

Danai LV, Babic A, Rosenthal MH, Dennstedt EA, Muir A, Lien EC, Mayers JR, Tai K, Lau AN, Jones-Sali P, Prado CM, Petersen GM, Takahashi N, Sugimoto M, Yeh JJ, Lopez N, Bardeesy N, Fernandez-Del Castillo C, Liss AS, Koong AC, Bui J, Yuan C, Welch MW, Brais LK, Kulke MH, Dennis C, Clish CB, Wolpin BM, Vander Heiden MG.

Nature. 2018 Jun;558(7711):600-604. doi: 10.1038/s41586-018-0235-7. Epub 2018 Jun 20.

PMID:
29925948
3.

Metabolic markers as cancer clues.

Mayers JR.

Science. 2017 Dec 8;358(6368):1265. doi: 10.1126/science.aar2001. No abstract available.

PMID:
29217564
4.

SCD1 and SCD2 Form a Complex That Functions with the Exocyst and RabE1 in Exocytosis and Cytokinesis.

Mayers JR, Hu T, Wang C, Cárdenas JJ, Tan Y, Pan J, Bednarek SY.

Plant Cell. 2017 Oct;29(10):2610-2625. doi: 10.1105/tpc.17.00409. Epub 2017 Sep 29.

5.

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions.

Olivares O, Mayers JR, Gouirand V, Torrence ME, Gicquel T, Borge L, Lac S, Roques J, Lavaut MN, Berthezène P, Rubis M, Secq V, Garcia S, Moutardier V, Lombardo D, Iovanna JL, Tomasini R, Guillaumond F, Vander Heiden MG, Vasseur S.

Nat Commun. 2017 Jul 7;8:16031. doi: 10.1038/ncomms16031.

6.

Nature and Nurture: What Determines Tumor Metabolic Phenotypes?

Mayers JR, Vander Heiden MG.

Cancer Res. 2017 Jun 15;77(12):3131-3134. doi: 10.1158/0008-5472.CAN-17-0165. Epub 2017 Jun 5. Review.

7.

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors.

Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, Bar-Sagi D, Han J, Rabinowitz JD, Cima MJ, Langer R, Vander Heiden MG.

Nat Med. 2017 Feb;23(2):235-241. doi: 10.1038/nm.4256. Epub 2016 Dec 26.

8.

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.

Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG.

Science. 2016 Sep 9;353(6304):1161-5. doi: 10.1126/science.aaf5171.

9.

Circulating Metabolites and Survival Among Patients With Pancreatic Cancer.

Yuan C, Clish CB, Wu C, Mayers JR, Kraft P, Townsend MK, Zhang M, Tworoger SS, Bao Y, Qian ZR, Rubinson DA, Ng K, Giovannucci EL, Ogino S, Stampfer MJ, Gaziano JM, Ma J, Sesso HD, Anderson GL, Cochrane BB, Manson JE, Torrence ME, Kimmelman AC, Amundadottir LT, Vander Heiden MG, Fuchs CS, Wolpin BM.

J Natl Cancer Inst. 2016 Jan 11;108(6):djv409. doi: 10.1093/jnci/djv409. Print 2016 Jun.

10.

Famine versus feast: understanding the metabolism of tumors in vivo.

Mayers JR, Vander Heiden MG.

Trends Biochem Sci. 2015 Mar;40(3):130-40. doi: 10.1016/j.tibs.2015.01.004. Epub 2015 Jan 29. Review.

11.

Hrs and STAM function synergistically to bind ubiquitin-modified cargoes in vitro.

Takahashi H, Mayers JR, Wang L, Edwardson JM, Audhya A.

Biophys J. 2015 Jan 6;108(1):76-84. doi: 10.1016/j.bpj.2014.11.004.

12.

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.

Mayers JR, Wu C, Clish CB, Kraft P, Torrence ME, Fiske BP, Yuan C, Bao Y, Townsend MK, Tworoger SS, Davidson SM, Papagiannakopoulos T, Yang A, Dayton TL, Ogino S, Stampfer MJ, Giovannucci EL, Qian ZR, Rubinson DA, Ma J, Sesso HD, Gaziano JM, Cochrane BB, Liu S, Wactawski-Wende J, Manson JE, Pollak MN, Kimmelman AC, Souza A, Pierce K, Wang TJ, Gerszten RE, Fuchs CS, Vander Heiden MG, Wolpin BM.

Nat Med. 2014 Oct;20(10):1193-1198. doi: 10.1038/nm.3686. Epub 2014 Sep 28.

13.

The TPLATE adaptor complex drives clathrin-mediated endocytosis in plants.

Gadeyne A, Sánchez-Rodríguez C, Vanneste S, Di Rubbo S, Zauber H, Vanneste K, Van Leene J, De Winne N, Eeckhout D, Persiau G, Van De Slijke E, Cannoot B, Vercruysse L, Mayers JR, Adamowski M, Kania U, Ehrlich M, Schweighofer A, Ketelaar T, Maere S, Bednarek SY, Friml J, Gevaert K, Witters E, Russinova E, Persson S, De Jaeger G, Van Damme D.

Cell. 2014 Feb 13;156(4):691-704. doi: 10.1016/j.cell.2014.01.039.

14.

The midbody ring scaffolds the abscission machinery in the absence of midbody microtubules.

Green RA, Mayers JR, Wang S, Lewellyn L, Desai A, Audhya A, Oegema K.

J Cell Biol. 2013 Nov 11;203(3):505-20. doi: 10.1083/jcb.201306036.

15.

Budding and braking news about clathrin-mediated endocytosis.

Baisa GA, Mayers JR, Bednarek SY.

Curr Opin Plant Biol. 2013 Dec;16(6):718-25. doi: 10.1016/j.pbi.2013.09.005. Epub 2013 Oct 15. Review.

PMID:
24139529
16.

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells.

Fendt SM, Bell EL, Keibler MA, Olenchock BA, Mayers JR, Wasylenko TM, Vokes NI, Guarente L, Vander Heiden MG, Stephanopoulos G.

Nat Commun. 2013;4:2236. doi: 10.1038/ncomms3236.

17.

BCAT1 defines gliomas by IDH status.

Mayers JR, Vander Heiden MG.

Nat Med. 2013 Jul;19(7):816-7. doi: 10.1038/nm.3263. No abstract available.

PMID:
23836221
18.

Regulation of ubiquitin-dependent cargo sorting by multiple endocytic adaptors at the plasma membrane.

Mayers JR, Wang L, Pramanik J, Johnson A, Sarkeshik A, Wang Y, Saengsawang W, Yates JR 3rd, Audhya A.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11857-62. doi: 10.1073/pnas.1302918110. Epub 2013 Jul 1.

19.

Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, Pollak MN, Olumi AF, Vander Heiden MG, Stephanopoulos G.

Cancer Res. 2013 Jul 15;73(14):4429-38. doi: 10.1158/0008-5472.CAN-13-0080. Epub 2013 May 17.

20.

Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production.

Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS.

Cell Metab. 2013 May 7;17(5):768-78. doi: 10.1016/j.cmet.2013.04.012.

21.

Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform.

Morrison K, Witte K, Mayers JR, Schuh AL, Audhya A.

J Biol Chem. 2012 Nov 9;287(46):38824-34. doi: 10.1074/jbc.M112.391508. Epub 2012 Sep 24.

22.

Vesicle formation within endosomes: An ESCRT marks the spot.

Mayers JR, Audhya A.

Commun Integr Biol. 2012 Jan 1;5(1):50-6.

23.

A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue.

Green RA, Kao HL, Audhya A, Arur S, Mayers JR, Fridolfsson HN, Schulman M, Schloissnig S, Niessen S, Laband K, Wang S, Starr DA, Hyman AA, Schedl T, Desai A, Piano F, Gunsalus KC, Oegema K.

Cell. 2011 Apr 29;145(3):470-82. doi: 10.1016/j.cell.2011.03.037.

24.

TFG-1 function in protein secretion and oncogenesis.

Witte K, Schuh AL, Hegermann J, Sarkeshik A, Mayers JR, Schwarze K, Yates JR 3rd, Eimer S, Audhya A.

Nat Cell Biol. 2011 May;13(5):550-8. doi: 10.1038/ncb2225. Epub 2011 Apr 10.

25.

ESCRT-0 assembles as a heterotetrameric complex on membranes and binds multiple ubiquitinylated cargoes simultaneously.

Mayers JR, Fyfe I, Schuh AL, Chapman ER, Edwardson JM, Audhya A.

J Biol Chem. 2011 Mar 18;286(11):9636-45. doi: 10.1074/jbc.M110.185363. Epub 2010 Dec 30.

26.

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis.

Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow ME, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS.

Nat Med. 2009 Dec;15(12):1383-91. doi: 10.1038/nm.2067. Epub 2009 Nov 29. Erratum in: Nat Med. 2010 Feb;16(2):237.

27.

Analysis of centrosome function and microtubule dynamics by time-lapse microscopy in Xenopus egg extracts.

Wiese C, Mayers JR, Albee AJ.

Methods Mol Biol. 2009;586:89-113. doi: 10.1007/978-1-60761-376-3_5.

PMID:
19768426
28.

Resveratrol treatment in mice does not elicit the bradycardia and hypothermia associated with calorie restriction.

Mayers JR, Iliff BW, Swoap SJ.

FASEB J. 2009 Apr;23(4):1032-40. doi: 10.1096/fj.08-115923. Epub 2008 Dec 4.

29.

Models of noncoupled dinuclear copper centers in azurin.

Berry SM, Mayers JR, Zehm NA.

J Biol Inorg Chem. 2009 Jan;14(1):143-9. doi: 10.1007/s00775-008-0432-1. Epub 2008 Oct 2.

PMID:
18830721
30.

Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.

Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS.

Cell. 2008 Sep 19;134(6):933-44. doi: 10.1016/j.cell.2008.07.048.

31.

A school health service in a new Ontario health unit.

MAYERS JR.

Can J Public Health. 1959 May;50(5):217-8. No abstract available.

PMID:
13652005
32.

Some factors relating to breast feeding in New Brunswick.

MAYERS JR.

Can J Public Health. 1956 Jun;47(6):250-3. No abstract available.

PMID:
13329936
33.

Pre-natal education.

MAYERS JR.

Can Hosp. 1955 May;32(5):58; passim. No abstract available.

PMID:
14379071

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