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Stability of peripheral blood immune markers in patients with asthma.

Shrestha Palikhe N, Bosonea AM, Laratta C, Gandhi VD, Nahirney D, Hillaby A, Bowen M, Bhutani M, Mayers I, Cameron L, Vliagoftis H.

Allergy Asthma Clin Immunol. 2019 Apr 29;15:30. doi: 10.1186/s13223-019-0343-4. eCollection 2019.


Real-life effectiveness of indacaterol-glycopyrronium after switching from tiotropium or salmeterol/fluticasone therapy in patients with symptomatic COPD: the POWER study.

Kaplan A, Chapman KR, Anees SM, Mayers I, Rochdi D, Djandji M, Préfontaine D, McIvor A.

Int J Chron Obstruct Pulmon Dis. 2019 Jan 18;14:249-260. doi: 10.2147/COPD.S185485. eCollection 2019.


Between-Visit Variability in FEV1 as a Diagnostic Test for Asthma in Adults.

Dean BW, Birnie EE, Whitmore GA, Vandemheen KL, Boulet LP, FitzGerald JM, Ainslie M, Gupta S, Lemiere C, Field SK, McIvor RA, Hernandez P, Mayers I, Aaron SD; Canadian Respiratory Research Network.

Ann Am Thorac Soc. 2018 Sep;15(9):1039-1046. doi: 10.1513/AnnalsATS.201803-211OC.


Considerations in establishing bioequivalence of inhaled compounds.

Mayers I, Bhutani M.

Expert Opin Drug Deliv. 2018 Feb;15(2):153-162. doi: 10.1080/17425247.2018.1381084. Epub 2017 Sep 21. Review.


Regulatory Approaches and Considerations in Establishing Bioequivalence of Inhaled Compounds.

Mayers I, Bhutani M.

J Aerosol Med Pulm Drug Deliv. 2018 Feb;31(1):18-24. doi: 10.1089/jamp.2017.1398. Epub 2017 Jul 14. Review.


Reevaluation of Diagnosis in Adults With Physician-Diagnosed Asthma.

Aaron SD, Vandemheen KL, FitzGerald JM, Ainslie M, Gupta S, Lemière C, Field SK, McIvor RA, Hernandez P, Mayers I, Mulpuru S, Alvarez GG, Pakhale S, Mallick R, Boulet LP; Canadian Respiratory Research Network.

JAMA. 2017 Jan 17;317(3):269-279. doi: 10.1001/jama.2016.19627.


Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses.

Gauvreau GM, Arm JP, Boulet LP, Leigh R, Cockcroft DW, Davis BE, Mayers I, FitzGerald JM, Dahlen B, Killian KJ, Laviolette M, Carlsten C, Lazarinis N, Watson RM, Milot J, Swystun V, Bowen M, Hui L, Lantz AS, Meiser K, Maahs S, Lowe PJ, Skerjanec A, Drollmann A, O'Byrne PM.

J Allergy Clin Immunol. 2016 Oct;138(4):1051-1059. doi: 10.1016/j.jaci.2016.02.027. Epub 2016 Apr 7.


Increased Protease-Activated Receptor-2 (PAR-2) Expression on CD14++CD16+ Peripheral Blood Monocytes of Patients with Severe Asthma.

Shrestha Palikhe N, Nahirney D, Laratta C, Gandhi VD, Vethanayagam D, Bhutani M, Mayers I, Cameron L, Vliagoftis H.

PLoS One. 2015 Dec 14;10(12):e0144500. doi: 10.1371/journal.pone.0144500. eCollection 2015.


Metabolomic profiling of asthma and chronic obstructive pulmonary disease: A pilot study differentiating diseases.

Adamko DJ, Nair P, Mayers I, Tsuyuki RT, Regush S, Rowe BH.

J Allergy Clin Immunol. 2015 Sep;136(3):571-580.e3. doi: 10.1016/j.jaci.2015.05.022. Epub 2015 Jul 4.


Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production.

Gauvreau GM, Harris JM, Boulet LP, Scheerens H, Fitzgerald JM, Putnam WS, Cockcroft DW, Davis BE, Leigh R, Zheng Y, Dahlén B, Wang Y, Maciuca R, Mayers I, Liao XC, Wu LC, Matthews JG, O'Byrne PM.

Sci Transl Med. 2014 Jul 2;6(243):243ra85. doi: 10.1126/scitranslmed.3008961.


Sleep laboratory test referrals in Canada: sleep apnea rapid response survey.

Evans J, Skomro R, Driver H, Graham B, Mayers I, McRae L, Reisman J, Rusu C, To T, Fleetham J.

Can Respir J. 2014 Jan-Feb;21(1):e4-10. Epub 2013 Nov 28.


OX40L blockade and allergen-induced airway responses in subjects with mild asthma.

Gauvreau GM, Boulet LP, Cockcroft DW, FitzGerald JM, Mayers I, Carlsten C, Laviolette M, Killian KJ, Davis BE, Larché M, Kipling C, Dua B, Mosesova S, Putnam W, Zheng Y, Scheerens H, McClintock D, Matthews JG, O'Byrne PM.

Clin Exp Allergy. 2014 Jan;44(1):29-37. doi: 10.1111/cea.12235.


Disconnect between sputum neutrophils and other measures of airway inflammation in asthma.

Arron JR, Choy DF, Laviolette M, Kelsen SG, Hatab A, Leigh R, Thomson NC, Bleecker ER, Olivenstein R, Avila PC, Jarjour NN, Castro M, Gauvreau GM, Good JT, Kline JN, Mansur A, Mayers I, Heaney LG, Hamid Q, Harris JM.

Eur Respir J. 2014 Feb;43(2):627-9. doi: 10.1183/09031936.00117013. Epub 2013 Oct 31. No abstract available.


Do we know the minimal clinically important difference (MCID) for COPD exacerbations?

Chapman KR, Bergeron C, Bhutani M, Bourbeau J, Grossman RF, Hernandez P, McIvor RA, Mayers I.

COPD. 2013 Apr;10(2):243-9. doi: 10.3109/15412555.2012.733463. Epub 2013 Mar 20. Review.


The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2.

Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C, Brenner D, Mayers I, Vliagoftis H, El-Sohemy A, Cameron L.

Allergy. 2012 Nov;67(11):1357-64. doi: 10.1111/all.12003. Epub 2012 Sep 5.


Introduction to the Canadian Scientific Advisory Committee on Respiratory and Allergy Therapies: in vivo evaluation for clinical testing in COPD and asthma therapy using generics.

Mayers I.

J Aerosol Med Pulm Drug Deliv. 2012 Aug;25(4):204-8. doi: 10.1089/jamp.2011.0913. Epub 2011 Oct 18. Review.


Managing dyspnea in patients with advanced chronic obstructive pulmonary disease: a Canadian Thoracic Society clinical practice guideline.

Marciniuk DD, Goodridge D, Hernandez P, Rocker G, Balter M, Bailey P, Ford G, Bourbeau J, O'Donnell DE, Maltais F, Mularski RA, Cave AJ, Mayers I, Kennedy V, Oliver TK, Brown C; Canadian Thoracic Society COPD Committee Dyspnea Expert Working Group.

Can Respir J. 2011 Mar-Apr;18(2):69-78. Review.


Cost-effectiveness of combination therapy for chronic obstructive pulmonary disease.

Chuck A, Jacobs P, Mayers I, Marciniuk D.

Can Respir J. 2008 Nov-Dec;15(8):437-43.


Urban and rural differences in the management of asthma amongst primary care physicians in Alberta.

Lum EY, Sharpe HM, Nilsson C, Andrews EM, Tsuyuki RT, Mayers I, Cowie RL.

Can J Clin Pharmacol. 2007 Fall;14(3):e275-82. Epub 2007 Nov 1.


The transcription factor Wilms tumor 1 regulates matrix metalloproteinase-9 through a nitric oxide-mediated pathway.

Marcet-Palacios M, Ulanova M, Duta F, Puttagunta L, Munoz S, Gibbings D, Radomski M, Cameron L, Mayers I, Befus AD.

J Immunol. 2007 Jul 1;179(1):256-65.


Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial.

Aaron SD, Vandemheen KL, Fergusson D, Maltais F, Bourbeau J, Goldstein R, Balter M, O'Donnell D, McIvor A, Sharma S, Bishop G, Anthony J, Cowie R, Field S, Hirsch A, Hernandez P, Rivington R, Road J, Hoffstein V, Hodder R, Marciniuk D, McCormack D, Fox G, Cox G, Prins HB, Ford G, Bleskie D, Doucette S, Mayers I, Chapman K, Zamel N, FitzGerald M; Canadian Thoracic Society/Canadian Respiratory Clinical Research Consortium.

Ann Intern Med. 2007 Apr 17;146(8):545-55. Epub 2007 Feb 19.


Effects of nocturnal noninvasive mechanical ventilation on heart rate variability of patients with advanced COPD.

Sin DD, Wong E, Mayers I, Lien DC, Feeny D, Cheung H, Gan WQ, Man SF.

Chest. 2007 Jan;131(1):156-63.


Phenomenal characteristics of autobiographical memories for social and non-social events in social phobia.

D'Argembeau A, Van der Linden M, d'Acremont M, Mayers I.

Memory. 2006 Jul;14(5):637-47.


Internet-based asthma education - a novel approach to compliance: a case report.

O'Hara C, Vethanayagam D, Majaesic C, Mayers I.

Can Respir J. 2006 Jan-Feb;13(1):30-2.


The current status of autotitrating continuous positive airway pressure systems in the management of obstructive sleep apnea.

Hailey D, Jacobs P, Mayers I, Mensinkai S.

Can Respir J. 2005 Jul-Aug;12(5):271-6. Review.


Role of combination inhaled corticosteroids and long acting beta agonists in the treatment of adult asthma.

Mayers I, Damant R.

Issues Emerg Health Technol. 2005 Jun;(68):1-4.


Inhaled nitric oxide treatment of patients with pulmonary tuberculosis evidenced by positive sputum smears.

Long R, Jones R, Talbot J, Mayers I, Barrie J, Hoskinson M, Light B.

Antimicrob Agents Chemother. 2005 Mar;49(3):1209-12.


Nitric oxide and cyclic GMP increase the expression of matrix metalloproteinase-9 in vascular smooth muscle.

Marcet-Palacios M, Graham K, Cass C, Befus AD, Mayers I, Radomski MW.

J Pharmacol Exp Ther. 2003 Oct;307(1):429-36. Epub 2003 Sep 3.


Pulmonary and systemic nitric oxide measurements during CCK-5-induced panic attacks.

Lara N, Chrapko WE, Archer SL, Bellavance F, Mayers I, Le Mellédo JM.

Neuropsychopharmacology. 2003 Oct;28(10):1840-5.


Increased matrix metalloproteinase activity after canine cardiopulmonary bypass is suppressed by a nitric oxide scavenger.

Mayers I, Hurst T, Radomski A, Johnson D, Fricker S, Bridger G, Cameron B, Darkes M, Radomski MW.

J Thorac Cardiovasc Surg. 2003 Mar;125(3):661-8.


Distribution of nitric oxide synthase in normal and cirrhotic human liver.

McNaughton L, Puttagunta L, Martinez-Cuesta MA, Kneteman N, Mayers I, Moqbel R, Hamid Q, Radomski MW.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17161-6. Epub 2002 Dec 13.


Doctors, medical societies and the pharmaceutical industry.

Mayers I.

Can Respir J. 2002 Sep-Oct;9(5):297-8, 301-2. English, French. No abstract available.


Predictors of survival following in-hospital adult cardiopulmonary resuscitation.

Brindley PG, Markland DM, Mayers I, Kutsogiannis DJ.

CMAJ. 2002 Aug 20;167(4):343-8.


Climate change, Kyoto and the Canadian Thoracic Society.

Mayers I.

Can Respir J. 2002 Jul-Aug;9(4):231-4. English, French. No abstract available.


To all members.

Mayers I.

Can Respir J. 2002 May-Jun;9(3):161-4. English, French. No abstract available.


A burning topic: tobacco and death.

Mayers I.

Can Respir J. 2002 Mar-Apr;9(2):91-2, 94-5. No abstract available.


A year of changes--a new year of opportunities.

Mayers I.

Can Respir J. 2002 Jan-Feb;9(1):19, 21. English, French. No abstract available.


Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis.

Bernard GR, Ely EW, Wright TJ, Fraiz J, Stasek JE Jr, Russell JA, Mayers I, Rosenfeld BA, Morris PE, Yan SB, Helterbrand JD.

Crit Care Med. 2001 Nov;29(11):2051-9.


Cardiac surgery increases the activity of matrix metalloproteinases and nitric oxide synthase in human hearts.

Mayers I, Hurst T, Puttagunta L, Radomski A, Mycyk T, Sawicki G, Johnson D, Radomski MW.

J Thorac Cardiovasc Surg. 2001 Oct;122(4):746-52.


Multiple organ dysfunction syndrome: a narrative review.

Johnson D, Mayers I.

Can J Anaesth. 2001 May;48(5):502-9. Review.


Matrix metalloproteinase 2 in tumor cell-induced platelet aggregation: regulation by nitric oxide.

Jurasz P, Sawicki G, Duszyk M, Sawicka J, Miranda C, Mayers I, Radomski MW.

Cancer Res. 2001 Jan 1;61(1):376-82.


Regional citrate anticoagulation in continuous venovenous hemodiafiltration.

Kutsogiannis DJ, Mayers I, Chin WD, Gibney RT.

Am J Kidney Dis. 2000 May;35(5):802-11.


Septic shock: treating more than just blood pressure.

Mayers I, Johnson D.

CMAJ. 2000 Feb 8;162(3):369-70. Review. No abstract available.


Increased nitric oxide synthase activity after canine cardiopulmonary bypass is suppressed by s-nitrosoglutathione.

Mayers I, Salas E, Hurst T, Johnson D, Radomski MW.

J Thorac Cardiovasc Surg. 1999 May;117(5):1009-16.


Systemic thermal injury in anesthetized rabbits causes early pulmonary vascular injury that is not ablated by lazaroids.

Miles D, Hurst TS, Saxena A, Mayers I, Johnson DH.

Can J Anaesth. 1999 Feb;46(2):142-7.


The nonspecific inflammatory response to injury.

Mayers I, Johnson D.

Can J Anaesth. 1998 Sep;45(9):871-9. Review.


Inhaled nitric oxide reduction in systolic pulmonary artery pressure is less in patients with decreased left ventricular ejection fraction.

Cujec B, Hurst T, McCuaig R, Antecol D, Mayers I, Johnson D.

Can J Cardiol. 1997 Sep;13(9):816-24.


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